Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse

Pharmacological Reports

Volumn 68, Issue 5, 2016, Pages 975-982

  He, Xuan li ^a   Yan, Ning ^b   Chen, Xiao shan ^a   Qi, Yun wen ^a   Yan, Yong ^a   Cai, Zhiyou ^c  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Alzheimer's; Hydrogen sulfide; Secretase; Secretase

Indexed keywords

ALPHA SECRETASE; BETA SECRETASE 1; GAMMA SECRETASE; HYDROGEN SULFIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; SECRETASE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; MALE; MEMORY DISORDER; MORRIS WATER MAZE TEST; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ALZHEIMER DISEASE; ANIMAL; BRAIN; DISEASE MODEL; DRUG EFFECTS; MEMORY DISORDERS; METABOLISM; TRANSGENIC MOUSE;

ADAM17 PROTEIN; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BRAIN; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HYDROGEN SULFIDE; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84976570679     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2016.05.006     Document Type: Article

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