Reactivation of endogenous genes and epigenetic remodeling are barriers for generating transgene-free induced pluripotent stem cells in Pig

PLoS ONE

Volumn 11, Issue 6, 2016, Pages

  Choi, Kwang Hwan ^a   Park, Jin Kyu ^b   Son, Dongchan ^a   Hwang, Jae Yeon ^a,f   Lee, Dong Kyung ^a   Ka, Hakhyun ^c   Park, Joonghoon ^d   Lee, Chang Kyu ^a,e  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF MISSOURI   (United States)

^c Yonsei University Wonju   (South Korea)

^d LG Chemical Ltd   (South Korea)

^e Seoul National University   (South Korea)

^f Kangwon National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 17; EPITHELIAL CELL ADHESION MOLECULE; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; NEUROFILAMENT PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UVOMORULIN; VIMENTIN; BIOLOGICAL MARKER; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CDH1 GENE; CELL DIFFERENTIATION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA METHYLATION; DPPA2 GENE; EMBRYO; EPCAM GENE; EPIGENETIC REMODELING; EPIGENETICS; FETUS; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; INTRACELLULAR SIGNALING; KLF4 GENE; MESENCHYMAL TO EPITHELIAL TRANSITION; NANOG GENE; NONHUMAN; NUCLEAR REPROGRAMMING; OCLN GENE; OCT4 GENE; ONCOGENE MYC; PIG; POLYMERASE CHAIN REACTION; PROMOTER REGION; SOX2 GENE; STEM CELL SELF-RENEWAL; TRANSGENE; XIST GENE; ANIMAL; CELL CULTURE; CELL CULTURE TECHNIQUE; CYTOLOGY; DNA SEQUENCE; DRUG EFFECTS; FEMALE; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; TRANSCRIPTION INITIATION;

ANIMALS; BIOMARKERS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; CELLULAR REPROGRAMMING; EPIGENESIS, GENETIC; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; INDUCED PLURIPOTENT STEM CELLS; PROMOTER REGIONS, GENETIC; SEQUENCE ANALYSIS, DNA; SWINE; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSGENES;

EID: 84976564381     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0158046     Document Type: Article

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