Mutation of aryl binding pocket residues results in an unexpected activity switch in an oryza sativa tyrosine aminomutase

Biochemistry

Volumn 55, Issue 25, 2016, Pages 3497-3503

  Walter, Tyler ^a   Wijewardena, Devinda ^a   Walker, Kevin D ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; SUBSTRATES;

BINDING POCKETS; DOUBLE MUTANTS; INTRINSIC REACTIVITY; ORYZA SATIVA; PHENYLALANINE AMMONIA-LYASE; SINGLE MUTANT; SUBSTRATE SELECTIVITY; TOTAL TURNOVER;

AMINO ACIDS;

AMMONIA LYASE; CINNAMIC ACID; COUMARIC ACID; ISOPROPYL THIOGALACTOSIDE; PHENYLALANINE; PHENYLALANINE AMMONIA LYASE; TYROSINE; TYROSINE AMINOMUTASE; UNCLASSIFIED DRUG; MUTASE; PLANT PROTEIN; TYROSINE 2,3-AMINOMUTASE;

ARTICLE; BINDING AFFINITY; CATALYST; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE MUTATION; ISOMER; KINETIC PARAMETERS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RICE; SEQUENCE ANALYSIS; TURNOVER TIME; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; ORYZA; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; BINDING SITES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, PLANT; INTRAMOLECULAR TRANSFERASES; MUTATION; ORYZA; PLANT PROTEINS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 84976526329     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.6b00331     Document Type: Article

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