Mechanistic, mutational, and structural evaluation of a taxus phenylalanine aminomutase

Biochemistry

Volumn 50, Issue 14, 2011, Pages 2919-2930

  Feng, Lei ^a   Wanninayake, Udayanga ^a   Strom, Susan ^a   Geiger, James ^a   Walker, Kevin D ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE ARCHITECTURE; AROMATIC RINGS; CINNAMATES; CLASS I; HYDROPHOBIC INTERACTIONS; IMIDAZOL; STERICALLY DEMANDING; STRUCTURAL EVALUATION; SUBSTRATE RECOGNITION;

CATALYST ACTIVITY; HYDROPHOBICITY; REACTION INTERMEDIATES; STEREOCHEMISTRY; SUBSTRATES;

AMINO ACIDS;

4 METHYLIDENE 1H IMIDAZOL 5 (4H)ONE; CINNAMIC ACID; IMIDAZOLE DERIVATIVE; ISOMERASE; LEUCINE; PHENYLALANINE; PHENYLALANINE AMINOMUTASE; UNCLASSIFIED DRUG;

ARTICLE; BIOCATALYST; BIOSYNTHESIS; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HYDROPHOBICITY; ISOMERIZATION; MASS FRAGMENTOGRAPHY; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY; STREPTOMYCES; STREPTOMYCES GLOBISPORUS; STRUCTURE ANALYSIS; TAXUS;

AMINO ACID SEQUENCE; BIOCATALYSIS; CATALYTIC DOMAIN; CINNAMATES; CRYSTALLOGRAPHY, X-RAY; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; PHENYLALANINE; PHENYLALANINE AMMONIA-LYASE; PLANT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TAXUS;

STREPTOMYCES GLOBISPORUS; TAXUS; TAXUS CANADENSIS;

EID: 79953711463     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi102067r     Document Type: Article

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