메뉴 건너뛰기




Volumn 108, Issue 4, 2016, Pages 207-224

Proton-pump inhibitors adverse effects: A review of the evidence and position statement by the Sociedad Española de Patología Digestiva

(15)  de la Coba, Cristóbal a,b   Argüelles Arias, Federico c   Martín De Argila, Carlos d   Júdez, Javier a   Linares, Antonio e   Ortega Alonso, Aida f,g   Rodríguez, Enrique d   Rodríguez Téllez, Manuel c   Vera, Isabel h   Aguilera, Lara d   Álvarez, Ángel i   Andrade, Raúl J f   Bao, Fidencio j   Castro, Manuel k   Giganto, Froilán l  

a SEPD   (Spain)

Author keywords

Adverse effects; Guidelines as topic; Position statement; Proton pump inhibitors; SEPD

Indexed keywords

ESOMEPRAZOLE; LANSOPRAZOLE; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; RABEPRAZOLE; THIENOPYRIDINE DERIVATIVE;

EID: 84976444868     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: 10.17235/reed.2016.4232/2016     Document Type: Article
Times cited : (42)

References (173)
  • 1
    • 0347359186 scopus 로고    scopus 로고
    • Clinical pharmacology of proton pump inhibitors-What the practising physician needs to know
    • Robinson M, Horn J. Clinical pharmacology of proton pump inhibitors-What the practising physician needs to know. Drugs 2003;63:2739-54.
    • (2003) Drugs , vol.63 , pp. 2739-2754
    • Robinson, M.1    Horn, J.2
  • 2
    • 79954958239 scopus 로고    scopus 로고
    • Estudio de utilización de antiulcerosos en España (2000-2008)
    • García del Pozo J. Estudio de utilización de antiulcerosos en España (2000-2008). Inf Ter Sist Nac Salud 2009;33:49-54.
    • (2009) Inf Ter Sist Nac Salud , vol.33 , pp. 49-54
    • García Del Pozo, J.1
  • 3
    • 84976358529 scopus 로고    scopus 로고
    • Ministerio de Sanidad. Subgrupos ATC y Principios activos de mayor consumo en el Sistema Nacional de Salud en 2010.Inf Ter Sist Nac Salud
    • Ministerio de Sanidad. Subgrupos ATC y Principios activos de mayor consumo en el Sistema Nacional de Salud en 2010.Inf Ter Sist Nac Salud 2010;35:124-8.
    • (2010) , vol.35 , pp. 124-128
  • 4
    • 84879639662 scopus 로고    scopus 로고
    • Rationalizing the use of PPIs: An unresolved matter
    • Ponce J, Esplugues JV. Rationalizing the use of PPIs: An unresolved matter. Rev Esp Enferm Dig 2013;105:121-4. DOI: 10.4321/S1130-01082013000300001
    • (2013) Rev Esp Enferm Dig , vol.105 , pp. 121-124
    • Ponce, J.1    Esplugues, J.V.2
  • 5
    • 84862156278 scopus 로고    scopus 로고
    • Use of prescription drugs in Spain and Europe
    • Simo Minana J. Use of prescription drugs in Spain and Europe. Aten Primaria. 2012;44:335-47.
    • (2012) Aten Primaria , vol.44 , pp. 335-347
    • Simo Minana, J.1
  • 6
    • 19544382548 scopus 로고    scopus 로고
    • Long-term use of acid suppression started inappropriately during hospitalization
    • Zink DA, Pohlman M, Barnes M, et al. Long-term use of acid suppression started inappropriately during hospitalization. Aliment Pharmacol Ther 2005;21:1203-9. DOI: 10.1111/j.1365-2036.2005.02454.x
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 1203-1209
    • Zink, D.A.1    Pohlman, M.2    Barnes, M.3
  • 7
    • 78649799032 scopus 로고    scopus 로고
    • Patterns and predictors of proton pump inhibitor overuse among academic and non-academic hospitalists
    • Eid SM, Boueiz A, Paranji S, et al. Patterns and predictors of proton pump inhibitor overuse among academic and non-academic hospitalists. Intern Med 2010;49:2561-8. DOI: 10.2169/internalmedicine.49.4064
    • (2010) Intern Med , vol.49 , pp. 2561-2568
    • Eid, S.M.1    Boueiz, A.2    Paranji, S.3
  • 8
    • 0034952658 scopus 로고    scopus 로고
    • An evaluation of the use of proton pump inhibitors
    • Walker NM, McDonald J. An evaluation of the use of proton pump inhibitors. Pharm World Sci 2001;23:116-7.
    • (2001) Pharm World Sci , vol.23 , pp. 116-117
    • Walker, N.M.1    McDonald, J.2
  • 10
    • 42949150577 scopus 로고    scopus 로고
    • Assessing the use of proton pump inhibitors in an internal medicine department
    • Martin-Echevarria E, Pereira Julia A, Torralba M, et al. Assessing the use of proton pump inhibitors in an internal medicine department. Rev Esp Enferm Dig 2008;100:76-81.
    • (2008) Rev Esp Enferm Dig , vol.100 , pp. 76-81
    • Martin-Echevarria, E.1    Pereira Julia, A.2    Torralba, M.3
  • 11
    • 33846953184 scopus 로고    scopus 로고
    • Inappropriate prescribing of proton pump inhibitors in primary care
    • Batuwitage BT, Kingham JGC, Morgan NE, et al. Inappropriate prescribing of proton pump inhibitors in primary care. Postgrad Med J 2007;83:66-8. DOI: 10.1136/pgmj.2006.051151
    • (2007) Postgrad Med J , vol.83 , pp. 66-68
    • Batuwitage, B.T.1    Kingham, J.2    Morgan, N.E.3
  • 12
    • 78649318940 scopus 로고    scopus 로고
    • Appropriateness of treatment recommendations for PPI in hospital discharge letters
    • Ahrens D, Chenot J-F, Behrens G, et al. Appropriateness of treatment recommendations for PPI in hospital discharge letters. Eur J Clin Pharmacol 2010;66:1265-71. DOI: 10.1007/s00228-010-0871-9
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 1265-1271
    • Ahrens, D.1    Chenot, J.-F.2    Behrens, G.3
  • 13
    • 77950630869 scopus 로고    scopus 로고
    • Potentially inappropriate prescribing and cost outcomes for older people: A national population study
    • Cahir C, Fahey T, Teeling M, et al. Potentially inappropriate prescribing and cost outcomes for older people: a national population study. Brit J Clin Pharmacol 2010;69:543-52. DOI: 10.1111/j.1365-2125.2010.03628.x
    • (2010) Brit J Clin Pharmacol , vol.69 , pp. 543-552
    • Cahir, C.1    Fahey, T.2    Teeling, M.3
  • 14
    • 84951036570 scopus 로고    scopus 로고
    • Reasons for initiation of proton pump inhibitor therapy for hospitalised patients and its impact on outpatient prescription in primary care
    • Villamanan E, Ruano M, Lara C, et al. Reasons for initiation of proton pump inhibitor therapy for hospitalised patients and its impact on outpatient prescription in primary care. Rev Esp Enferm Dig 2015;107:652-8.
    • (2015) Rev Esp Enferm Dig , vol.107 , pp. 652-658
    • Villamanan, E.1    Ruano, M.2    Lara, C.3
  • 15
    • 79952279097 scopus 로고    scopus 로고
    • Overuse of PPIs in patients at admission, during treatment, and at discharge in a tertiary Spanish hospital
    • Ramirez E, Lei SH, Borobia AM, et al. Overuse of PPIs in patients at admission, during treatment, and at discharge in a tertiary Spanish hospital. Curr Clin Pharmacol 2010;5:288-97.
    • (2010) Curr Clin Pharmacol , vol.5 , pp. 288-297
    • Ramirez, E.1    Lei, S.H.2    Borobia, A.M.3
  • 16
    • 84863980029 scopus 로고    scopus 로고
    • Appropriateness of proton pump inhibitor recommendations at hospital discharge and continuation in primary care
    • Ahrens D, Behrens G, Himmel W, et al. Appropriateness of proton pump inhibitor recommendations at hospital discharge and continuation in primary care. Int J Clin Pract 2012; 66:767-73. DOI: 10.1111/j.1742-1241.2012.02973.x
    • (2012) Int J Clin Pract , vol.66 , pp. 767-773
    • Ahrens, D.1    Behrens, G.2    Himmel, W.3
  • 17
    • 0037358417 scopus 로고    scopus 로고
    • Current indications for proton pump inhibitors
    • Ponce Romero M, Berenguer Lapuerta J. Current indications for proton pump inhibitors. Rev Clin Esp 2003;203:136-8.
    • (2003) Rev Clin Esp , vol.203 , pp. 136-138
    • Ponce Romero, M.1    Berenguer Lapuerta, J.2
  • 18
    • 85052412605 scopus 로고    scopus 로고
    • Grupo de trabajo Sector Zaragoza I Salud. Empleo de los inhibidores de la bomba de protones en la prevención de gastropatías secundarias a fármacos. Guía de Práctica Clínica. Zaragoza: Guía Salud
    • Grupo de trabajo Sector Zaragoza I Salud. Empleo de los inhibidores de la bomba de protones en la prevención de gastropatías secundarias a fármacos. Guía de Práctica Clínica. Zaragoza: Guía Salud; 2012.
    • (2012)
  • 19
    • 84976342540 scopus 로고    scopus 로고
    • Product Characteristics. Spanish Agency of Medicines and Medical Devices
    • Product Characteristics. Spanish Agency of Medicines and Medical Devices.
  • 22
    • 64549101201 scopus 로고    scopus 로고
    • Intravenous esomeprazole for prevention of recurrent peptic ulcer bleeding-a randomized trial
    • Sung JJY, Barkun A, Kuipers EJ, et al. Intravenous esomeprazole for prevention of recurrent peptic ulcer bleeding-a randomized trial. Ann Intern Med 2009;150:455-64. DOI: 10.7326/0003-4819-150-7-200904070-00105
    • (2009) Ann Intern Med , vol.150 , pp. 455-464
    • Sung, J.1    Barkun, A.2    Kuipers, E.J.3
  • 23
    • 84924050697 scopus 로고    scopus 로고
    • Intermittent vs continuous proton pump inhibitor therapy for high-risk bleeding ulcers-a systematic review and meta-analysis
    • Sachar H, Vaidya K, Laine L. Intermittent vs continuous proton pump inhibitor therapy for high-risk bleeding ulcers-a systematic review and meta-analysis. JAMA Intern Med 2014;174:1755-62. DOI: 10.1001/jamainternmed.2014.4056
    • (2014) JAMA Intern Med , vol.174 , pp. 1755-1762
    • Sachar, H.1    Vaidya, K.2    Laine, L.3
  • 24
    • 84861946727 scopus 로고    scopus 로고
    • Oral versus intravenous proton pump inhibitors in preventing re-bleeding for patients with peptic ulcer bleeding after successful endoscopic therapy
    • Yen H-H, Yang C-W, Su W-W, et al. Oral versus intravenous proton pump inhibitors in preventing re-bleeding for patients with peptic ulcer bleeding after successful endoscopic therapy. BMC Gastroenterol 2012;12:66. DOI: 10.1186/1471-230X-12-66
    • (2012) BMC Gastroenterol , vol.12 , pp. 66
    • Yen, H.-H.1    Yang, C.-W.2    Su, W.-W.3
  • 25
    • 84870212516 scopus 로고    scopus 로고
    • Clinical practice guideline on the management of patients with dyspepsia. Update 2012
    • Pérez-Gisbert J, Calvet X, Ferrandiz J, et al. Clinical practice guideline on the management of patients with dyspepsia. Update 2012. Gastroenterol Hepatol 2012;35:725.e1-38.
    • Gastroenterol Hepatol , vol.725 , pp. e1-e38
    • Pérez-Gisbert, J.1    Calvet, X.2    Ferrandiz, J.3
  • 26
    • 84866439122 scopus 로고    scopus 로고
    • Diagnosis and management of eosinophilic esophagitis
    • Dellon ES. Diagnosis and management of eosinophilic esophagitis. Clin Gastroenterol Hepatol 2012;10:1066-78.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 1066-1078
    • Dellon, E.S.1
  • 27
    • 84957309475 scopus 로고    scopus 로고
    • Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: A systematic review and meta-analysis
    • Lucendo AJ, Arias Á, Molina-Infante J. Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: A systematic review and meta-analysis. Clin Gastroenterol Hepatol 2016;14:13-22.e1. DOI: 10.1016/j.cgh.2015.07.041
    • (2016) Clin Gastroenterol Hepatol , vol.14 , pp. 13-22
    • Lucendo, A.J.1    Arias, Á.2    Molina-Infante, J.3
  • 28
    • 84960338266 scopus 로고    scopus 로고
    • Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis. Gut 2015; (online first): pii: gutjnl-2015-310991
    • Molina-Infante J, Bredenoord AJ, Cheng E, et al. Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis. Gut 2015; (online first): pii: gutjnl-2015-310991. Accesible en: http://www.ncbi.nlm.nih.gov/pubmed/26685124 DOI: 10.1136/gutjnl-2015-310991
    • Molina-Infante, J.1    Bredenoord, A.J.2    Cheng, E.3
  • 29
    • 33745503604 scopus 로고    scopus 로고
    • Optimising the therapy of exocrine pancreatic insufficiency by the association of a proton pump inhibitor to enteric coated pancreatic extracts
    • Dominguez-Munoz JE, Iglesias-Garcia J, Iglesias-Rey M. Optimising the therapy of exocrine pancreatic insufficiency by the association of a proton pump inhibitor to enteric coated pancreatic extracts. Gut 2006;55:1056-7. DOI: 10.1136/gut.2006.094912
    • (2006) Gut , vol.55 , pp. 1056-1057
    • Dominguez-Munoz, J.E.1    Iglesias-Garcia, J.2    Iglesias-Rey, M.3
  • 30
    • 84872061155 scopus 로고    scopus 로고
    • Vitamin B-12 Deficiency
    • Stabler SP. Vitamin B-12 Deficiency. N Engl J Med 2013;368:149-60.
    • (2013) N Engl J Med , vol.368 , pp. 149-160
    • Stabler, S.P.1
  • 31
    • 84964303665 scopus 로고    scopus 로고
    • Association between vitamin B12 deficiency and long-term use of acid-lowering agents: A systematic review and meta-analysis
    • Jung SB, Nagaraja V, Kapur A, et al. Association between vitamin B12 deficiency and long-term use of acid-lowering agents: a systematic review and meta-analysis. Intern Med J 2015;45:409-16.
    • (2015) Intern Med J , vol.45 , pp. 409-416
    • Jung, S.B.1    Nagaraja, V.2    Kapur, A.3
  • 32
    • 84889821934 scopus 로고    scopus 로고
    • Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B-12 deficiency
    • Lam JR, Schneider JL, Zhao W, et al. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B-12 deficiency. JAMA 2013;310:2435-42. DOI: 10.1001/jama.2013.280490
    • (2013) JAMA , vol.310 , pp. 2435-2442
    • Lam, J.R.1    Schneider, J.L.2    Zhao, W.3
  • 33
    • 39149083393 scopus 로고    scopus 로고
    • Do acid-lowering agents affect vitamin B12 status in older adults?
    • Dharmarajan TS, Kanagala MR, Murakonda P, et al. Do acid-lowering agents affect vitamin B12 status in older adults? J Am Med Dir Assoc 2008;9:162-7. DOI: 10.1016/j.jamda.2007.10.004
    • (2008) J am Med Dir Assoc , vol.9 , pp. 162-167
    • Dharmarajan, T.S.1    Kanagala, M.R.2    Murakonda, P.3
  • 34
    • 2342539011 scopus 로고    scopus 로고
    • A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B-12 deficiency in older adults
    • Valuck RJ, Ruscin JM. A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B-12 deficiency in older adults. J Clin Epidemiol 2004;57:422-8. DOI: 10.1016/j.jclinepi.2003.08.015
    • (2004) J Clin Epidemiol , vol.57 , pp. 422-428
    • Valuck, R.J.1    Ruscin, J.M.2
  • 35
    • 0037380916 scopus 로고    scopus 로고
    • Increased vitamin B-12 requirement associated with chronic acid suppression therapy
    • Force RW, Meeker AD, Cady PS, et al. Increased vitamin B-12 requirement associated with chronic acid suppression therapy. Ann Pharmacother 2003;37:490-3.
    • (2003) Ann Pharmacother , vol.37 , pp. 490-493
    • Force, R.W.1    Meeker, A.D.2    Cady, P.S.3
  • 36
    • 0028178495 scopus 로고
    • Omeprazole therapy causes malabsorption of cyanocobalamin (Vitamin B12)
    • Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med 1994;120:211-5. DOI: 10.7326/0003-4819-120-3-199402010-00006
    • (1994) Ann Intern Med , vol.120 , pp. 211-215
    • Marcuard, S.P.1    Albernaz, L.2    Khazanie, P.G.3
  • 37
    • 0035030716 scopus 로고    scopus 로고
    • The association between antiulcer medication and initiation of cobalamin replacement in older persons
    • Mitchell SL, Rockwood K. The association between antiulcer medication and initiation of cobalamin replacement in older persons. J Clin Epidemiol 2001;54:531-4. DOI: 10.1016/S0895-4356(00)00340-1
    • (2001) J Clin Epidemiol , vol.54 , pp. 531-534
    • Mitchell, S.L.1    Rockwood, K.2
  • 38
    • 0026702856 scopus 로고
    • Review article: Metabolic consequences of long-term inhibition of acid secretion by omeprazole
    • Koop H. Review article: Metabolic consequences of long-term inhibition of acid secretion by omeprazole. Aliment Pharmacol Ther 1992;6:399-406. DOI: 10.1111/j.1365-2036.1992.tb00553.x
    • (1992) Aliment Pharmacol Ther , vol.6 , pp. 399-406
    • Koop, H.1
  • 39
    • 0032076634 scopus 로고    scopus 로고
    • Effect of long-term gastric acid suppressive therapy on serum vitamin B-12 levels in patients with Zollinger-Ellison syndrome
    • Termanini B, Gibril F, Sutliff VE, et al. Effect of long-term gastric acid suppressive therapy on serum vitamin B-12 levels in patients with Zollinger-Ellison syndrome. Am J Med 1998;104:422-30. DOI: 10.1016/S0002-9343(98)00087-4
    • (1998) Am J Med , vol.104 , pp. 422-430
    • Termanini, B.1    Gibril, F.2    Sutliff, V.E.3
  • 40
    • 77951034977 scopus 로고    scopus 로고
    • Vitamin B(12) deficiency is linked with long-term use of proton pump inhibitors in institutionalized older adults: Could a cyanocobalamin nasal spray be beneficial?
    • Rozgony NR, Fang C, Kuczmarski MF, et al. Vitamin B(12) deficiency is linked with long-term use of proton pump inhibitors in institutionalized older adults: could a cyanocobalamin nasal spray be beneficial? J Nutr Elder 2010;29:87-99. DOI: 10.1080/01639360903574734
    • (2010) J Nutr Elder , vol.29 , pp. 87-99
    • Rozgony, N.R.1    Fang, C.2    Kuczmarski, M.F.3
  • 41
    • 0026682916 scopus 로고
    • Serum iron, ferritin, and vitamin B12 during prolonged omeprazole therapy
    • Koop H, Bachem MG. Serum iron, ferritin, and vitamin B12 during prolonged omeprazole therapy. J Clin Gastroenterol 1992;14:288-92. DOI: 10.1097/00004836-199206000-00005
    • (1992) J Clin Gastroenterol , vol.14 , pp. 288-292
    • Koop, H.1    Bachem, M.G.2
  • 42
    • 0030016789 scopus 로고    scopus 로고
    • Effect of short-and long-term treatment with omeprazole on the absorption and serum levels of cobalamin
    • Schenk BE, Festen HPM, Kuipers EJ, et al. Effect of short-and long-term treatment with omeprazole on the absorption and serum levels of cobalamin. Aliment Pharmacol Ther 1996;10:541-5. DOI: 10.1046/j.1365-2036.1996.27169000.x
    • (1996) Aliment Pharmacol Ther , vol.10 , pp. 541-545
    • Schenk, B.E.1    Festen, H.2    Kuipers, E.J.3
  • 43
    • 39749203127 scopus 로고    scopus 로고
    • Long-term use of proton pump inhibitors and vitamin B12 status in elderly individuals
    • Den Elzen WPJ, Groeneveld Y, De Ruijter W, et al. Long-term use of proton pump inhibitors and vitamin B12 status in elderly individuals. Aliment Pharmacol Ther 2008;27:491-7. DOI: 10.1111/j.1365-2036.2008.03601.x
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 491-497
    • Den Elzen, W.1    Groeneveld, Y.2    De Ruijter, W.3
  • 44
    • 0034778736 scopus 로고    scopus 로고
    • Are children with cystic fibrosis who are treated with a proton-pump inhibitor at risk for vitamin B-12 deficiency?
    • ter Heide H, Hendriks HJE, Heijmans H, et al. Are children with cystic fibrosis who are treated with a proton-pump inhibitor at risk for vitamin B-12 deficiency? J Pediatr Gastroenterol Nutr 2001;33:342-5. DOI: 10.1097/00005176-200109000-00023
    • (2001) J Pediatr Gastroenterol Nutr , vol.33 , pp. 342-345
    • Ter Heide, H.1    Hendriks, H.2    Heijmans, H.3
  • 45
    • 38649091066 scopus 로고    scopus 로고
    • Long-term proton pump inhibitor use in children: A retrospective review of safety
    • Tolia V, Boyer K. Long-term proton pump inhibitor use in children: A retrospective review of safety. Dig Dis Sci 2008;53:385-93. DOI: 10.1007/s10620-007-9880-7
    • (2008) Dig Dis Sci , vol.53 , pp. 385-393
    • Tolia, V.1    Boyer, K.2
  • 46
    • 42949085127 scopus 로고    scopus 로고
    • Vitamin B12 deficiency in hypersecretors during long-term acid suppression with proton pump inhibitors
    • Hirschowitz BI, Worthington J, Mohnen J. Vitamin B12 deficiency in hypersecretors during long-term acid suppression with proton pump inhibitors. Aliment Pharmacol Ther 2008;27:1110-21. DOI: 10.1111/j.1365-2036.2008.03658.x
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 1110-1121
    • Hirschowitz, B.I.1    Worthington, J.2    Mohnen, J.3
  • 47
    • 84869784386 scopus 로고    scopus 로고
    • Vitamin B-12 deficiency associated with concomitant metformin and proton pump inhibitor use
    • Long AN, Atwell CL, Yoo W, et al. Vitamin B-12 deficiency associated with concomitant metformin and proton pump inhibitor use. Diabetes Care 2012;35:E84-E. DOI: 10.2337/dc12-0980
    • (2012) Diabetes Care , vol.35 , pp. E84-EE
    • Long, A.N.1    Atwell, C.L.2    Yoo, W.3
  • 48
    • 84929134452 scopus 로고    scopus 로고
    • Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: Data from the SOPRAN and LOTUS studies
    • Attwood SE, Ell C, Galmiche JP, et al. Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: data from the SOPRAN and LOTUS studies. Aliment Pharmacol Ther 2015;41:1162-74. DOI: 10.1111/apt.13194
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 1162-1174
    • Attwood, S.E.1    Ell, C.2    Galmiche, J.P.3
  • 49
    • 0029842475 scopus 로고    scopus 로고
    • Cobalamin deficiency with megaloblastic anaemia in one patient under long-term omeprazole therapy
    • Bellou A, AimoneGastin I, DeKorwin JD, et al. Cobalamin deficiency with megaloblastic anaemia in one patient under long-term omeprazole therapy. J Intern Med 1996;240:161-4. DOI: 10.1046/j.1365-2796.1996.20846000.x
    • (1996) J Intern Med , vol.240 , pp. 161-164
    • Bellou, A.1    Aimonegastin, I.2    Dekorwin, J.D.3
  • 50
    • 84930767056 scopus 로고    scopus 로고
    • Risk of dementia in elderly patients with the use of proton pump inhibitors
    • Haenisch B, von Holt K, Wiese B, et al. Risk of dementia in elderly patients with the use of proton pump inhibitors. Eur Arch Psychiatry Clin Neurosci 2015;265:419-28. DOI: 10.1007/s00406-014-0554-0
    • (2015) Eur Arch Psychiatry Clin Neurosci , vol.265 , pp. 419-428
    • Haenisch, B.1    Von Holt, K.2    Wiese, B.3
  • 51
    • 11144235305 scopus 로고    scopus 로고
    • Neuropathy associated with lansoprazole treatment
    • Rajabally YA, Jacob S. Neuropathy associated with lansoprazole treatment. Muscle Nerve 2005;31:124-5. DOI: 10.1002/mus.20155
    • (2005) Muscle Nerve , vol.31 , pp. 124-125
    • Rajabally, Y.A.1    Jacob, S.2
  • 52
    • 0025635958 scopus 로고
    • An unusual side effect of omeprazole: Case report
    • Sellapah S. An unusual side effect of omeprazole: case report. Br J Gen Pract 1990;40:389.
    • (1990) Br J Gen Pract , vol.40 , pp. 389
    • Sellapah, S.1
  • 53
    • 84875728378 scopus 로고    scopus 로고
    • Proton-pump inhibitor use is associated with low serum magnesium concentrations
    • Danziger J, William JH, Scott DJ, et al. Proton-pump inhibitor use is associated with low serum magnesium concentrations. Kidney Int 2013;83:692-9. DOI: 10.1038/ki.2012.452
    • (2013) Kidney Int , vol.83 , pp. 692-699
    • Danziger, J.1    William, J.H.2    Scott, D.J.3
  • 54
    • 84856844214 scopus 로고    scopus 로고
    • Proton pump inhibitors are associated with lower magnesium levels in older people with chronic kidney disease
    • Sumukadas D, McMurdo MET, Habicht D. Proton pump inhibitors are associated with lower magnesium levels in older people with chronic kidney disease. J Am Geriatr Soc 2012;60:392-3. DOI: 10.1111/j.1532-5415.2011.03808.x
    • (2012) J am Geriatr Soc , vol.60 , pp. 392-393
    • Sumukadas, D.1    McMurdo, M.2    Habicht, D.3
  • 55
    • 84862815496 scopus 로고    scopus 로고
    • Uses of proton pump inhibitors and hypomagnesemia
    • Gau J-T, Yang Y-X, Chen R, et al. Uses of proton pump inhibitors and hypomagnesemia. Pharmacoepidemiol Drug Saf 2012;21:553-9. DOI: 10.1002/pds.3224
    • (2012) Pharmacoepidemiol Drug Saf , vol.21 , pp. 553-559
    • Gau, J.-T.1    Yang, Y.-X.2    Chen, R.3
  • 56
    • 84959016813 scopus 로고    scopus 로고
    • Low prevalence of hypomagnesemia in long-term recipients of proton pump inhibitors in a managed care cohort
    • Sharara AI, Chalhoub JM, Hammoud N, et al. Low prevalence of hypomagnesemia in long-term recipients of proton pump inhibitors in a managed care cohort. Clin Gastroenterol Hepatol 2016;14:317-21. DOI: 10.1016/j.cgh.2015.10.012
    • (2016) Clin Gastroenterol Hepatol , vol.14 , pp. 317-321
    • Sharara, A.I.1    Chalhoub, J.M.2    Hammoud, N.3
  • 57
    • 84862908852 scopus 로고    scopus 로고
    • Recent safety concerns with proton pump inhibitors
    • Chen J, Yuan YC, Leontiadis GI, et al. Recent safety concerns with proton pump inhibitors. J Clin Gastroenterol 2012;46:93-114. DOI: 10.1097/MCG.0b013e3182333820
    • (2012) J Clin Gastroenterol , vol.46 , pp. 93-114
    • Chen, J.1    Yuan, Y.C.2    Leontiadis, G.I.3
  • 58
    • 33750320388 scopus 로고    scopus 로고
    • Proton-pump inhibitors and hypomagnesemic hypoparathyroidism
    • Epstein M, McGrath S, Law F. Proton-pump inhibitors and hypomagnesemic hypoparathyroidism. N Engl J Med 2006;355:1834-6. DOI: 10.1056/NEJMc066308
    • (2006) N Engl J Med , vol.355 , pp. 1834-1836
    • Epstein, M.1    McGrath, S.2    Law, F.3
  • 59
    • 85052413709 scopus 로고    scopus 로고
    • Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). Riesgo de hipomagnesemia asociado a los medicamentos inhibidores de la bomba de protones (IBP). Ref. MUH (FV), 27/2011
    • Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). Riesgo de hipomagnesemia asociado a los medicamentos inhibidores de la bomba de protones (IBP). Ref. MUH (FV), 27/2011. Accesible en: http://www.aemps.gob.es/informa/notasInformativas/medicamentosUso-Humano/seguridad/2011/docs/NI-MUH_27-2011.pdf. [visitado 23/12/15]
  • 60
    • 84976392547 scopus 로고    scopus 로고
    • FDA Drug Safety Communication. Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors. Washington, DC: US. Food and Drug Administration; 2011
    • FDA Drug Safety Communication. Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors. Washington, DC: US. Food and Drug Administration; 2011. Accesible en: http://www.fda.gov/Drugs/DrugSafety/ucm213206.htm.
  • 61
    • 79958786443 scopus 로고    scopus 로고
    • Administration TG. Risk of hypomagnesaemia with proton pump inhibitors. Medicines Safety Update, Australian Prescriber 2011;34:81
    • Administration TG. Risk of hypomagnesaemia with proton pump inhibitors. Medicines Safety Update Vol 2, Number 3. Australian Prescriber 2011;34:81. Accesible en: https://www.tga.gov.au/publicationissue/medicines-safety-update-vol-2-no-3-june-2011
    • , vol.2 , Issue.3
  • 62
    • 84911881647 scopus 로고    scopus 로고
    • The association between the use of proton pump inhibitors and the risk of hypomagnesemia: A systematic review and meta-analysis
    • Park CH, Kim EH, Roh YH, et al. The association between the use of proton pump inhibitors and the risk of hypomagnesemia: A systematic review and meta-analysis. PLoS One 2014;9:e112558. DOI: 10.1371/journal.pone.0112558
    • (2014) Plos One , pp. 9
    • Park, C.H.1    Kim, E.H.2    Roh, Y.H.3
  • 63
    • 84878515354 scopus 로고    scopus 로고
    • Proton pump inhibitor-associated hypomagnesemia: What do FDA data tell us?
    • Luk CP, Parsons R, Lee YP, et al. Proton pump inhibitor-associated hypomagnesemia: what do FDA data tell us? Ann Pharmacother 2013;47:773-80. DOI: 10.1345/aph.1R556
    • (2013) Ann Pharmacother , vol.47 , pp. 773-780
    • Luk, C.P.1    Parsons, R.2    Lee, Y.P.3
  • 64
    • 84941930462 scopus 로고    scopus 로고
    • Proton pump inhibitors linked to hypomagnesemia: A systematic review and meta-analysis of observational studies
    • Cheungpasitporn W, Thongprayoon C, Kittanamongkolchai W, et al. Proton pump inhibitors linked to hypomagnesemia: a systematic review and meta-analysis of observational studies. Ren Fail 2015;37:1237-41. DOI: 10.3109/0886022X.2015.1057800
    • (2015) Ren Fail , vol.37 , pp. 1237-1241
    • Cheungpasitporn, W.1    Thongprayoon, C.2    Kittanamongkolchai, W.3
  • 65
    • 33748105475 scopus 로고    scopus 로고
    • Proton pump inhibitors, histamine H-2 receptor antagonists, and other antacid medications and the risk of fracture
    • Vestergaard P, Rejnmark L, Mosekilde L. Proton pump inhibitors, histamine H-2 receptor antagonists, and other antacid medications and the risk of fracture. Calcif Tissue Int 2006;79:76-83. DOI: 10.1007/s00223-006-0021-7
    • (2006) Calcif Tissue Int , vol.79 , pp. 76-83
    • Vestergaard, P.1    Rejnmark, L.2    Mosekilde, L.3
  • 66
    • 33845864487 scopus 로고    scopus 로고
    • Long-term proton pump inhibitor therapy and risk of hip fracture
    • Yang Y-X, Lewis JD, Epstein S, et al. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006;296:2947-53. DOI: 10.1001/jama.296.24.2947
    • (2006) JAMA , vol.296 , pp. 2947-2953
    • Yang, Y.-X.1    Lewis, J.D.2    Epstein, S.3
  • 67
    • 49749141653 scopus 로고    scopus 로고
    • Use of proton pump inhibitors and risk of osteoporosis-related fractures
    • Targownik LE, Lix LM, Metge CJ, et al. Use of proton pump inhibitors and risk of osteoporosis-related fractures. Can Med Assoc J 2008;179:319-26. DOI: 10.1503/cmaj.071330
    • (2008) Can Med Assoc J , vol.179 , pp. 319-326
    • Targownik, L.E.1    Lix, L.M.2    Metge, C.J.3
  • 68
    • 48249103083 scopus 로고    scopus 로고
    • Proton pump inhibitor use and risk of hip fractures in patients without major risk factors
    • Kaye JA, Jick H. Proton pump inhibitor use and risk of hip fractures in patients without major risk factors. Pharmacotherapy 2008;28:951-9. DOI: 10.1592/phco.28.8.951
    • (2008) Pharmacotherapy , vol.28 , pp. 951-959
    • Kaye, J.A.1    Jick, H.2
  • 69
    • 54349103932 scopus 로고    scopus 로고
    • Acid-suppressive medications and risk of bone loss and fracture in older adults
    • Yu EW, Blackwell T, Ensrud KE, et al. Acid-suppressive medications and risk of bone loss and fracture in older adults. Calcif Tissue Int 2008;83:251-9. DOI: 10.1007/s00223-008-9170-1
    • (2008) Calcif Tissue Int , vol.83 , pp. 251-259
    • Yu, E.W.1    Blackwell, T.2    Ensrud, K.E.3
  • 70
    • 58149279436 scopus 로고    scopus 로고
    • Increase in vertebral fracture risk in postmenopausal women using omeprazole
    • Roux C, Briot K, Gossec L, et al. Increase in vertebral fracture risk in postmenopausal women using omeprazole. Calcif Tissue Int 2009;84:13-9. DOI: 10.1007/s00223-008-9188-4
    • (2009) Calcif Tissue Int , vol.84 , pp. 13-19
    • Roux, C.1    Briot, K.2    Gossec, L.3
  • 71
    • 77953880651 scopus 로고    scopus 로고
    • Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients
    • Corley DA, Kubo A, Zhao W, et al. Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients. Gastroenterology 2010;139:93-101. DOI: 10.1053/j.gastro.2010.03.055
    • (2010) Gastroenterology , vol.139 , pp. 93-101
    • Corley, D.A.1    Kubo, A.2    Zhao, W.3
  • 72
    • 77952115101 scopus 로고    scopus 로고
    • Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women results from the women’s health initiative
    • Gray SL, LaCroix AZ, Larson J, et al. Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women results from the women’s health initiative. Arch Intern Med 2010;170:765-71. DOI: 10.1001/archinternmed.2010.94
    • (2010) Arch Intern Med , vol.170 , pp. 765-771
    • Gray, S.L.1    Lacroix, A.Z.2    Larson, J.3
  • 73
    • 79951673896 scopus 로고    scopus 로고
    • Use of proton pump inhibitors and risk of hip/femur fracture: A population-based casecontrol study
    • Pouwels S, Lalmohamed A, Souverein P, et al. Use of proton pump inhibitors and risk of hip/femur fracture: a population-based casecontrol study. Osteoporos Int 2011;22:903-10.DOI: 10.1007/s00198-010-1337-8
    • (2011) Osteoporos Int , vol.22 , pp. 903-910
    • Pouwels, S.1    Lalmohamed, A.2    Souverein, P.3
  • 74
    • 84875030474 scopus 로고    scopus 로고
    • Use of proton pump inhibitors and risk of fragility hip fracture in a Mediterranean region
    • Reyes C, Formiga F, Coderch M, et al. Use of proton pump inhibitors and risk of fragility hip fracture in a Mediterranean region. Bone 2013;52:557-61. DOI: 10.1016/j.bone.2012.09.028
    • (2013) Bone , vol.52 , pp. 557-561
    • Reyes, C.1    Formiga, F.2    Coderch, M.3
  • 75
    • 84902154290 scopus 로고    scopus 로고
    • Study of the association between hip fracture and acid-suppressive drug use in a UK primary care setting
    • Cea Soriano L, Ruigomez A, Johansson S, et al. Study of the association between hip fracture and acid-suppressive drug use in a UK primary care setting. Pharmacotherapy 2014;34:570-81. DOI: 10.1002/phar.1410
    • (2014) Pharmacotherapy , vol.34 , pp. 570-581
    • Cea Soriano, L.1    Ruigomez, A.2    Johansson, S.3
  • 76
    • 84901981771 scopus 로고    scopus 로고
    • The relationship between proton pump inhibitor adherence and fracture risk in the elderly
    • Ding J, Heller DA, Ahern FM, et al. The relationship between proton pump inhibitor adherence and fracture risk in the elderly. Calcif Tissue Int 2014;94:597-607. DOI: 10.1007/s00223-014-9855-6
    • (2014) Calcif Tissue Int , vol.94 , pp. 597-607
    • Ding, J.1    Heller, D.A.2    Ahern, F.M.3
  • 77
    • 84943605631 scopus 로고    scopus 로고
    • The effect of dose and type of proton pump inhibitor use on risk of fractures and osteoporosis treatment in older Australian women: A prospective cohort study
    • van der Hoorn MMC, Tett SE, de Vries OJ, et al. The effect of dose and type of proton pump inhibitor use on risk of fractures and osteoporosis treatment in older Australian women: A prospective cohort study. Bone 2015;81:675-82. DOI: 10.1016/j.bone.2015.08.024
    • (2015) Bone , vol.81 , pp. 675-682
    • Van Der Hoorn, M.1    Tett, S.E.2    De Vries, O.J.3
  • 78
    • 84942371362 scopus 로고    scopus 로고
    • Use of proton pump inhibitors is associated with fractures in young adults: A populationbased study
    • Freedberg DE, Haynes K, Denburg MR, et al. Use of proton pump inhibitors is associated with fractures in young adults: a populationbased study. Osteoporos Int 2015; 26: 2501-7. DOI: 10.1007/s00198-015-3168-0
    • (2015) Osteoporos Int , vol.26 , pp. 2501-2507
    • Freedberg, D.E.1    Haynes, K.2    Denburg, M.R.3
  • 79
    • 84857621605 scopus 로고    scopus 로고
    • Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: A prospective cohort study
    • Khalili H, Huang ES, Jacobson BC, et al. Use of proton pump inhibitors and risk of hip fracture in relation to dietary and lifestyle factors: a prospective cohort study. Br Med J 2012;344. DOI: 10.1136/bmj.e372
    • (2012) Br Med J , pp. 344
    • Khalili, H.1    Huang, E.S.2    Jacobson, B.C.3
  • 80
    • 84895503731 scopus 로고    scopus 로고
    • Proton-pump inhibitor use and hip fractures in men: A population-based case-control study
    • Adams AL, Black MH, Zhang JL, et al. Proton-pump inhibitor use and hip fractures in men: a population-based case-control study. Ann Epidemiol 2014;24:286-90.
    • (2014) Ann Epidemiol , vol.24 , pp. 286-290
    • Adams, A.L.1    Black, M.H.2    Zhang, J.L.3
  • 81
    • 84923794694 scopus 로고    scopus 로고
    • Long-Term proton pump inhibitor therapy and falls and fractures in elderly women: A prospective cohort study
    • Lewis JR, Barre D, Zhu K, et al. Long-Term proton pump inhibitor therapy and falls and fractures in elderly women: A prospective cohort study. J Bone Miner Res 2014;29:2489-97. DOI: 10.1002/jbmr.2279
    • (2014) J Bone Miner Res , vol.29 , pp. 2489-2497
    • Lewis, J.R.1    Barre, D.2    Zhu, K.3
  • 82
    • 84904735229 scopus 로고    scopus 로고
    • Use of proton pump inhibitors (PPI) and history of earlier fracture are independent risk factors for fracture in postmenopausal women. The WHILA study
    • Moberg LME, Nilsson PM, Samsioe G, et al. Use of proton pump inhibitors (PPI) and history of earlier fracture are independent risk factors for fracture in postmenopausal women. The WHILA study. Maturitas 2014;78:310-5. DOI: 10.1016/j.maturitas.2014.05.019
    • (2014) Maturitas , vol.78 , pp. 310-315
    • Moberg, L.1    Nilsson, P.M.2    Samsioe, G.3
  • 83
    • 78049300965 scopus 로고    scopus 로고
    • Use of proton pump inhibitors increased the risk of hip fracture: A population-based case-control study
    • Chiu HF, Huang YW, Chang CC, et al. Use of proton pump inhibitors increased the risk of hip fracture: a population-based case-control study. Pharmacoepidemiol Drug Saf 2010;19:1131-6. DOI: 10.1002/pds.2026
    • (2010) Pharmacoepidemiol Drug Saf , vol.19 , pp. 1131-1136
    • Chiu, H.F.1    Huang, Y.W.2    Chang, C.C.3
  • 84
    • 84876466976 scopus 로고    scopus 로고
    • The effect of proton pump inhibitors on fracture risk: Report from the Canadian Multicenter Osteoporosis Study
    • Fraser LA, Leslie WD, Targownik LE, et al. The effect of proton pump inhibitors on fracture risk: report from the Canadian Multicenter Osteoporosis Study. Osteoporos Int 2013;24:1161-8.
    • (2013) Osteoporos Int , vol.24 , pp. 1161-1168
    • Fraser, L.A.1    Leslie, W.D.2    Targownik, L.E.3
  • 85
    • 79959285244 scopus 로고    scopus 로고
    • Proton pump inhibitor use and the antifracture efficacy of alendronate
    • Abrahamsen B, Eiken P, Eastell R. Proton pump inhibitor use and the antifracture efficacy of alendronate. Arch Intern Med 2011;171:998-1004. DOI: 10.1001/archinternmed.2011.20
    • (2011) Arch Intern Med , vol.171 , pp. 998-1004
    • Abrahamsen, B.1    Eiken, P.2    Eastell, R.3
  • 86
    • 71849099123 scopus 로고    scopus 로고
    • Fracture risk in patients receiving acid-suppressant medication alone and in combination with bisphosphonates
    • de Vries F, Cooper AL, Cockle SM, et al. Fracture risk in patients receiving acid-suppressant medication alone and in combination with bisphosphonates. Osteoporos Int 2009;20:1989-98. DOI: 10.1007/s00198-009-0891-4
    • (2009) Osteoporos Int , vol.20 , pp. 1989-1998
    • De Vries, F.1    Cooper, A.L.2    Cockle, S.M.3
  • 87
    • 84881447470 scopus 로고    scopus 로고
    • The effects of risedronate administered in combination with a proton pump inhibitor for the treatment of osteoporosis
    • Itoh S, Sekino Y, Shinomiya K-I, et al. The effects of risedronate administered in combination with a proton pump inhibitor for the treatment of osteoporosis. J Bone Miner Metab 2013;31:206-11. DOI: 10.1007/s00774-012-0406-9
    • (2013) J Bone Miner Metab , vol.31 , pp. 206-211
    • Itoh, S.1    Sekino, Y.2    Shinomiya, K.-I.3
  • 88
    • 84885434860 scopus 로고    scopus 로고
    • A population-based case-control study: Proton pump inhibition and risk of hip fracture by use of bisphosphonate
    • Lee J, Youn K, Choi NK, et al. A population-based case-control study: proton pump inhibition and risk of hip fracture by use of bisphosphonate. J Gastroenterol 2013;48:1016-22. DOI: 10.1007/s00535-012-0722-9
    • (2013) J Gastroenterol , vol.48 , pp. 1016-1022
    • Lee, J.1    Youn, K.2    Choi, N.K.3
  • 89
    • 79957583113 scopus 로고    scopus 로고
    • Use of acid-suppressive drugs and risk of fracture: A meta-analysis of observational studies
    • Eom C-S, Park SM, Myung S-K, et al. Use of acid-suppressive drugs and risk of fracture: A meta-analysis of observational studies. Ann Fam Med 2011;9:257-67. DOI: 10.1370/afm.1243
    • (2011) Ann Fam Med , vol.9 , pp. 257-267
    • Eom, C.-S.1    Park, S.M.2    Myung, S.-K.3
  • 90
    • 79960055410 scopus 로고    scopus 로고
    • Proton pump inhibitors and risk of fracture: A systematic review and meta-analysis of observational studies
    • Ngamruengphong S, Leontiadis GI, Radhi S, et al. Proton pump inhibitors and risk of fracture: a systematic review and meta-analysis of observational studies. Am J Gastroenterol 2011;106:1209-18. DOI: 10.1038/ajg.2011.113
    • (2011) Am J Gastroenterol , vol.106 , pp. 1209-1218
    • Ngamruengphong, S.1    Leontiadis, G.I.2    Radhi, S.3
  • 91
    • 79957520670 scopus 로고    scopus 로고
    • Proton pump inhibitors and risk of fractures: A meta-analysis of 11 international studies
    • Yu EW, Bauer SR, Bain PA, et al. Proton pump inhibitors and risk of fractures: A meta-analysis of 11 international studies. Am J Med 2011;124:519-26.
    • (2011) Am J Med , vol.124 , pp. 519-526
    • Yu, E.W.1    Bauer, S.R.2    Bain, P.A.3
  • 92
    • 84931282061 scopus 로고    scopus 로고
    • Bone fracture and the interaction between bisphosphonates and proton pump inhibitors: A meta-analysis
    • Yang S-D, Chen Q, Wei H-K, et al. Bone fracture and the interaction between bisphosphonates and proton pump inhibitors: a meta-analysis. Int J Clin Exp Med 2015; 8:4899-910.
    • (2015) Int J Clin Exp Med , vol.8 , pp. 4899-4910
    • Yang, S.-D.1    Chen, Q.2    Wei, H.-K.3
  • 93
    • 84955202062 scopus 로고    scopus 로고
    • Proton-pump inhibitors and risk of fractures: An update meta-analysis
    • Zhou B, Huang Y, Li H, et al. Proton-pump inhibitors and risk of fractures: an update meta-analysis. Osteoporos Int 2015. Accesible en: http://www.ncbi.nlm.nih.gov/pubmed/26462494
    • (2015) Osteoporos Int
    • Zhou, B.1    Huang, Y.2    Li, H.3
  • 94
    • 0031972975 scopus 로고    scopus 로고
    • Epidemiology of medication-related falls and fractures in the elderly
    • Cumming RG. Epidemiology of medication-related falls and fractures in the elderly. Drugs Aging 1998;12:43-53. DOI: 10.2165/00002512-199812010-00005
    • (1998) Drugs Aging , vol.12 , pp. 43-53
    • Cumming, R.G.1
  • 95
    • 73249116989 scopus 로고    scopus 로고
    • Meta-analysis of the impact of 9 medication classes on falls in elderly persons
    • Woolcott JC, Richardson KJ, Wiens MO, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med 2009;169:1952-60. DOI: 10.1001/archinternmed.2009.357
    • (2009) Arch Intern Med , vol.169 , pp. 1952-1960
    • Woolcott, J.C.1    Richardson, K.J.2    Wiens, M.O.3
  • 96
    • 84890908323 scopus 로고    scopus 로고
    • Predictors of fracture while on treatment with oral bisphosphonates: A populationbased cohort study
    • Prieto-Alhambra D, Pages-Castella A, Wallace G, et al. Predictors of fracture while on treatment with oral bisphosphonates: A populationbased cohort study. J Bone Miner Res 2014;29:268-74. DOI: 10.1002/jbmr.2011
    • (2014) J Bone Miner Res , vol.29 , pp. 268-274
    • Prieto-Alhambra, D.1    Pages-Castella, A.2    Wallace, G.3
  • 97
    • 21244436672 scopus 로고    scopus 로고
    • Effects of proton pump inhibitors on calcium carbonate absorption in women: A randomized crossover trial
    • O’Connell MB, Madden DM, Murray AM, et al. Effects of proton pump inhibitors on calcium carbonate absorption in women: A randomized crossover trial. Am J Med 2005;118:778-81. DOI: 10.1016/j.amjmed.2005.02.007
    • (2005) Am J Med , vol.118 , pp. 778-781
    • O’Connell, M.B.1    Madden, D.M.2    Murray, A.M.3
  • 98
    • 77957672464 scopus 로고    scopus 로고
    • Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: A randomized, crossover, controlled clinical trial
    • Wright MJ, Sullivan RR, Gaffney-Stomberg E, et al. Inhibiting gastric acid production does not affect intestinal calcium absorption in young, healthy individuals: A randomized, crossover, controlled clinical trial. J Bone Miner Res 2010;25:2205-11. DOI: 10.1002/jbmr.108
    • (2010) J Bone Miner Res , vol.25 , pp. 2205-2211
    • Wright, M.J.1    Sullivan, R.R.2    Gaffney-Stomberg, E.3
  • 99
    • 84866069886 scopus 로고    scopus 로고
    • The relationship between proton pump inhibitor use and longitudinal change in bone mineral density: A population-based from the Canadian Multicentre Osteoporosis Study (CaMos)
    • Targownik LE, Leslie WD, Davison KS, et al. The relationship between proton pump inhibitor use and longitudinal change in bone mineral density: A population-based from the Canadian Multicentre Osteoporosis Study (CaMos). Am J Gastroenterol 2012;107:1361-9. DOI: 10.1038/ajg.2012.200
    • (2012) Am J Gastroenterol , vol.107 , pp. 1361-1369
    • Targownik, L.E.1    Leslie, W.D.2    Davison, K.S.3
  • 100
    • 84860758216 scopus 로고    scopus 로고
    • Fracture risk and bone mineral density reduction associated with proton pump inhibitors
    • Lau YT, Ahmed NN. Fracture risk and bone mineral density reduction associated with proton pump inhibitors. Pharmacotherapy 2012;32:67-79. DOI: 10.1002/PHAR.1007
    • (2012) Pharmacotherapy , vol.32 , pp. 67-79
    • Lau, Y.T.1    Ahmed, N.N.2
  • 101
    • 84921780406 scopus 로고    scopus 로고
    • Bone mineral density changes among women initiating proton pump inhibitors or H2 receptor antagonists: A SWAN Cohort Study
    • Solomon DH, Diem SJ, Ruppert K, et al. Bone mineral density changes among women initiating proton pump inhibitors or H2 receptor antagonists: A SWAN Cohort Study. J Bone Miner Res 2015;30:232-9. DOI: 10.1002/jbmr.2344
    • (2015) J Bone Miner Res , vol.30 , pp. 232-239
    • Solomon, D.H.1    Diem, S.J.2    Ruppert, K.3
  • 102
    • 84942080295 scopus 로고    scopus 로고
    • A proton pump inhibitor’s effect on bone metabolism mediated by osteoclast action in old age: A prospective randomized study
    • Jo Y, Park E, Ahn SB, et al. A proton pump inhibitor’s effect on bone metabolism mediated by osteoclast action in old age: A prospective randomized study. Gut Liver 2015;9:607-14. DOI: 10.5009/gnl14135
    • (2015) Gut Liver , vol.9 , pp. 607-614
    • Jo, Y.1    Park, E.2    Ahn, S.B.3
  • 103
    • 84900371926 scopus 로고    scopus 로고
    • Canadian Association of Gastroenterology position statement: Hip fracture and proton pump inhibitor therapy-a 2013 update
    • Moayyedi P, Yuan Y, Leontiadis G, et al. Canadian Association of Gastroenterology position statement: Hip fracture and proton pump inhibitor therapy-a 2013 update. Can J Gastroenterol 2013;27:593-5. DOI: 10.1155/2013/321379
    • (2013) Can J Gastroenterol , vol.27 , pp. 593-595
    • Moayyedi, P.1    Yuan, Y.2    Leontiadis, G.3
  • 104
    • 84931826101 scopus 로고    scopus 로고
    • Proton pump inhibitors and risk of bone fractures
    • Leontiadis GI, Moayyedi P. Proton pump inhibitors and risk of bone fractures. Curr Treat Options Gastroenterol 2014;12:414-23. DOI: 10.1007/s11938-014-0030-y
    • (2014) Curr Treat Options Gastroenterol , vol.12 , pp. 414-423
    • Leontiadis, G.I.1    Moayyedi, P.2
  • 105
    • 34548142191 scopus 로고    scopus 로고
    • Systematic review of the risk of enteric infection in patients taking acid suppression
    • Leonard J, Marshall JK, Moayyedi P. Systematic review of the risk of enteric infection in patients taking acid suppression. Am J Gastroenterol 2007;102:2047-56. DOI: 10.1111/j.1572-0241.2007.01275.x
    • (2007) Am J Gastroenterol , vol.102 , pp. 2047-2056
    • Leonard, J.1    Marshall, J.K.2    Moayyedi, P.3
  • 106
    • 84943784037 scopus 로고    scopus 로고
    • Association between use of proton pump inhibitors and non-typhoidal salmonellosis identified following investigation into an outbreak of Salmonella Mikawasima in the UK, 2013
    • Freeman R, Dabrera G, Lane C, et al. Association between use of proton pump inhibitors and non-typhoidal salmonellosis identified following investigation into an outbreak of Salmonella Mikawasima in the UK, 2013. Epidemiol Infect 2015:1-8. DOI: 10.1017/S0950268815002332
    • (2015) Epidemiol Infect , pp. 1-8
    • Freeman, R.1    Dabrera, G.2    Lane, C.3
  • 107
    • 84924361604 scopus 로고    scopus 로고
    • Association between recent use of proton pump inhibitors and nontyphoid salmonellosis: A nested case-control study
    • Wu H-H, Chen Y-T, Shih C-J, et al. Association between recent use of proton pump inhibitors and nontyphoid salmonellosis: A nested case-control study. Clin Infect Dis 2014;59:1554-8. DOI: 10.1093/cid/ciu628
    • (2014) Clin Infect Dis , vol.59 , pp. 1554-1558
    • Wu, H.-H.1    Chen, Y.-T.2    Shih, C.-J.3
  • 109
    • 84863717616 scopus 로고    scopus 로고
    • Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: Meta-analysis
    • Kwok CS, Arthur AK, Anibueze CI, et al. Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: Meta-analysis. Am J Gastroenterol 2012;107:1011-9. DOI: 10.1038/ajg.2012.108
    • (2012) Am J Gastroenterol , vol.107 , pp. 1011-1019
    • Kwok, C.S.1    Arthur, A.K.2    Anibueze, C.I.3
  • 110
    • 84863726088 scopus 로고    scopus 로고
    • Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: A meta-analysis
    • Janarthanan S, Ditah I, Adler DG, et al. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: A meta-analysis. Am J Gastroenterol 2012;107:1001-10.DOI: 10.1038/ajg.2012.179
    • (2012) Am J Gastroenterol , vol.107 , pp. 1001-1010
    • Janarthanan, S.1    Ditah, I.2    Adler, D.G.3
  • 111
    • 84857189040 scopus 로고    scopus 로고
    • Association between proton pump inhibitor therapy and clostridium difficile infection in a metaanalysis
    • Deshpande A, Pant C, Pasupuleti V, et al. Association between proton pump inhibitor therapy and clostridium difficile infection in a metaanalysis. Clin Gastroenterol Hepatol 2012;10:225-33. DOI: 10.1016/j.cgh.2011.09.030
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 225-233
    • Deshpande, A.1    Pant, C.2    Pasupuleti, V.3
  • 112
    • 84929081231 scopus 로고    scopus 로고
    • Continuous proton pump inhibitor therapy and the associated risk of recurrent Clostridium difficile infection
    • McDonald EG, Milligan J, Frenette C, et al. Continuous proton pump inhibitor therapy and the associated risk of recurrent Clostridium difficile infection. JAMA Intern Med 2015;175:784-91. DOI: 10.1001/jamainternmed.2015.42
    • (2015) JAMA Intern Med , vol.175 , pp. 784-791
    • McDonald, E.G.1    Milligan, J.2    Frenette, C.3
  • 113
    • 84976389099 scopus 로고    scopus 로고
    • FDA Drug Safety Communication. Clostridium difficile-associated diarrhea can be associated with stomach acid drugs known as proton pump inhibitors (PPIs). Washington, DC: US. Food and Drug Administration
    • FDA Drug Safety Communication. Clostridium difficile-associated diarrhea can be associated with stomach acid drugs known as proton pump inhibitors (PPIs). Washington, DC: US. Food and Drug Administration; 2012. Accesible en: http://www.fda.gov/Drugs/DrugSafety/ucm290510.htm.
    • (2012)
  • 114
    • 6944247563 scopus 로고    scopus 로고
    • Risk of communityacquired pneumonia and use of gastric acid-suppressive drugs
    • Laheij RJF, Sturkenboom M, Hassing RJ, et al. Risk of communityacquired pneumonia and use of gastric acid-suppressive drugs. JAMA 2004;292:1955-60. DOI: 10.1001/jama.292.16.1955
    • (2004) JAMA , vol.292 , pp. 1955-1960
    • Laheij, R.1    Sturkenboom, M.2    Hassing, R.J.3
  • 115
    • 34248522811 scopus 로고    scopus 로고
    • Use of proton pump inhibitors and the risk of community-acquired pneumonia-A populationbased case-control study
    • Gulmez SE, Holm A, Frederiksen H, et al. Use of proton pump inhibitors and the risk of community-acquired pneumonia-A populationbased case-control study. Arch Intern Med 2007;167:950-5. DOI: 10.1001/archinte.167.9.950
    • (2007) Arch Intern Med , vol.167 , pp. 950-955
    • Gulmez, S.E.1    Holm, A.2    Frederiksen, H.3
  • 116
    • 51949090295 scopus 로고    scopus 로고
    • Proton-pump inhibitor use and the risk for community-acquired pneumonia
    • Sarkar M, Hennessy S, Yang Y-X. Proton-pump inhibitor use and the risk for community-acquired pneumonia. Ann Intern Med 2008;149:391-8.
    • (2008) Ann Intern Med , vol.149 , pp. 391-398
    • Sarkar, M.1    Hennessy, S.2    Yang, Y.-X.3
  • 117
    • 77951780214 scopus 로고    scopus 로고
    • Meta-analysis: Proton pump inhibitor use and the risk of community-acquired pneumonia
    • Johnstone J, Nerenberg K, Loeb M. Meta-analysis: proton pump inhibitor use and the risk of community-acquired pneumonia. Aliment Pharmacol Ther 2010;31:1165-77. DOI: 10.1111/j.1365-2036.2010.04284.x
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 1165-1177
    • Johnstone, J.1    Nerenberg, K.2    Loeb, M.3
  • 118
    • 84861432082 scopus 로고    scopus 로고
    • Are proton pump inhibitors associated with the development of community-acquired pneumonia? A meta-analysis
    • Giuliano C, Wilhelm SM, Kale-Pradhan PB. Are proton pump inhibitors associated with the development of community-acquired pneumonia? A meta-analysis. Expert Rev Clin Pharmacol 2012;5:337-45. DOI: 10.1586/ecp.12.20
    • (2012) Expert Rev Clin Pharmacol , vol.5 , pp. 337-345
    • Giuliano, C.1    Wilhelm, S.M.2    Kale-Pradhan, P.B.3
  • 119
    • 84934943578 scopus 로고    scopus 로고
    • Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: A systematic review and meta-analysis
    • Lambert AA, Lam JO, Paik JJ, et al. Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis. PLoS One 2015;10:e0128004. DOI: 10.1371/journal.pone.0128004
    • (2015) Plos One , pp. 10
    • Lambert, A.A.1    Lam, J.O.2    Paik, J.J.3
  • 120
    • 79951983392 scopus 로고    scopus 로고
    • Use of acid-suppressive drugs and risk of pneumonia: A systematic review and meta-analysis
    • Eom CS, Jeon CY, Lim JW, et al. Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis. CMAJ 2011;183:310-9. DOI: 10.1503/cmaj.092129
    • (2011) CMAJ , vol.183 , pp. 310-319
    • Eom, C.S.1    Jeon, C.Y.2    Lim, J.W.3
  • 121
    • 84873456413 scopus 로고    scopus 로고
    • Confounding in the association of proton pump inhibitor use with risk of community-acquired pneumonia
    • Jena AB, Sun E, Goldman DP. Confounding in the association of proton pump inhibitor use with risk of community-acquired pneumonia. J Gen Intern Med 2013;28:223-30. DOI: 10.1007/s11606-012-2211-5
    • (2013) J Gen Intern Med , vol.28 , pp. 223-230
    • Jena, A.B.1    Sun, E.2    Goldman, D.P.3
  • 122
    • 84895479775 scopus 로고    scopus 로고
    • Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: Replicated cohort studies with meta-analysis
    • Filion KB, Chateau D, Targownik LE, et al. Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis. Gut 2014;63:552-8. DOI: 10.1136/gutjnl-2013-304738
    • (2014) Gut , vol.63 , pp. 552-558
    • Filion, K.B.1    Chateau, D.2    Targownik, L.E.3
  • 123
    • 73149119363 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
    • Kazui M, Nishiya Y, Ishizuka T, et al. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos 2010;38:92-9. DOI: 10.1124/dmd.109.029132
    • (2010) Drug Metab Dispos , vol.38 , pp. 92-99
    • Kazui, M.1    Nishiya, Y.2    Ishizuka, T.3
  • 124
    • 84938966621 scopus 로고    scopus 로고
    • Omeprazole, pantoprazole, and CYP2C19 effects on clopidogrel pharmacokinetic-pharmacodynamic relationships in stable coronary artery disease patients
    • Simon N, Finzi J, Cayla G, et al. Omeprazole, pantoprazole, and CYP2C19 effects on clopidogrel pharmacokinetic-pharmacodynamic relationships in stable coronary artery disease patients. Eur J Clin Pharmacol 2015;71:1059-66. DOI: 10.1007/s00228-015-1882-3
    • (2015) Eur J Clin Pharmacol , vol.71 , pp. 1059-1066
    • Simon, N.1    Finzi, J.2    Cayla, G.3
  • 125
    • 67651097806 scopus 로고    scopus 로고
    • Drug-drug interaction between clopidogrel and the proton pump inhibitors
    • Norgard NB, Mathews KD, Wall GC. Drug-drug interaction between clopidogrel and the proton pump inhibitors. Ann Pharmacother 2009;43:1266-74. OI: 10.1345/aph.1M051
    • (2009) Ann Pharmacother , vol.43 , pp. 1266-1274
    • Norgard, N.B.1    Mathews, K.D.2    Wall, G.C.3
  • 126
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin
    • Gilard M, Arnaud B, Cornily J-C, et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin. J Am Coll Cardiol 2008;51:256-60. DOI: 10.1016/j.jacc.2007.06.064
    • (2008) J am Coll Cardiol , vol.51 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.-C.3
  • 127
    • 78149487926 scopus 로고    scopus 로고
    • Clopidogrel with or without omeprazole in coronary artery disease
    • Bhatt DL, Cryer BL, Contant CF, et al. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med 2010;363:1909-17.
    • (2010) N Engl J Med , vol.363 , pp. 1909-1917
    • Bhatt, D.L.1    Cryer, B.L.2    Contant, C.F.3
  • 128
    • 70249139788 scopus 로고    scopus 로고
    • Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: An analysis of two randomised trials
    • O’Donoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet 2009;374:989-97. DOI: 10.1016/S0140-6736(09)61525-7
    • (2009) Lancet , vol.374 , pp. 989-997
    • O’Donoghue, M.L.1    Braunwald, E.2    Antman, E.M.3
  • 129
    • 84857992585 scopus 로고    scopus 로고
    • Association of proton pump inhibitor use on cardiovascular outcomes with clopidogrel and ticagrelor insights from the platelet inhibition and patient outcomes trial
    • Goodman SG, Clare R, Pieper KS, et al. Association of proton pump inhibitor use on cardiovascular outcomes with clopidogrel and ticagrelor insights from the platelet inhibition and patient outcomes trial. Circulation 2012;125:978-86. DOI: 10.1161/CIRCULATIONAHA.111.032912
    • (2012) Circulation , vol.125 , pp. 978-986
    • Goodman, S.G.1    Clare, R.2    Pieper, K.S.3
  • 130
    • 78349244351 scopus 로고    scopus 로고
    • Effect of proton pump inhibitors on clinical outcome in patients treated with clopidogrel: A systematic review and meta-analysis
    • Siller-Matula JM, Jilma B, Schroer K, et al. Effect of proton pump inhibitors on clinical outcome in patients treated with clopidogrel: a systematic review and meta-analysis. J Thromb Haemost 2010;8:2624-41. DOI: 10.1111/j.1538-7836.2010.04049.x
    • (2010) J Thromb Haemost , vol.8 , pp. 2624-2641
    • Siller-Matula, J.M.1    Jilma, B.2    Schroer, K.3
  • 131
    • 77953896604 scopus 로고    scopus 로고
    • Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-offunction allele or proton pump inhibitor coadministration a systematic meta-analysis
    • Hulot J-S, Collet J-P, Silvain J, et al. Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-offunction allele or proton pump inhibitor coadministration a systematic meta-analysis. J Am Coll Cardiol 2010;56:134-43. DOI: 10.1016/j.jacc.2009.12.071
    • (2010) J am Coll Cardiol , vol.56 , pp. 134-143
    • Hulot, J.-S.1    Collet, J.-P.2    Silvain, J.3
  • 132
    • 77949690349 scopus 로고    scopus 로고
    • Meta-analysis: The effects of proton pump inhibitors on cardiovascular events and mortality in patients receiving clopidogrel
    • Kwok CS, Loke YK. Meta-analysis: the effects of proton pump inhibitors on cardiovascular events and mortality in patients receiving clopidogrel. Aliment Pharmacol Ther 2010;31:810-23. DOI: 10.1111/j.1365-2036.2010.04247.x
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 810-823
    • Kwok, C.S.1    Loke, Y.K.2
  • 133
    • 84875231630 scopus 로고    scopus 로고
    • No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: Meta-analysis
    • Kwok CS, Jeevanantham V, Dawn B, et al. No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: Meta-analysis. Int J Cardiol 2013;167:965-74. DOI: 10.1016/j.ijcard.2012.03.085
    • (2013) Int J Cardiol , vol.167 , pp. 965-974
    • Kwok, C.S.1    Jeevanantham, V.2    Dawn, B.3
  • 134
    • 84976349314 scopus 로고    scopus 로고
    • European Medicines Agency. Public statement: Interaction between clopidogrel and proton pump inhibitors. 2009; (29 may)
    • European Medicines Agency. Public statement: Interaction between clopidogrel and proton pump inhibitors. 2009; (29 may). Accesible en: http://www.ema.europa.eu/docs/en_GB/document_library/Public_statement/2009/11/WC500014409.pdf [visitado 23/12/15]
  • 135
    • 84976410962 scopus 로고    scopus 로고
    • European Medicines Agency. Public statement: Interaction between clopidogrel and proton pump inhibitors (update). 2010; (17 mar)
    • European Medicines Agency. Public statement: Interaction between clopidogrel and proton pump inhibitors (update). 2010; (17 mar). Accesible en: http://www.ema.europa.eu/docs/en_GB/document_library/Public_statement/2010/03/WC500076346.pdf [visitado 23/12/15]
  • 136
    • 84976373573 scopus 로고    scopus 로고
    • Food and Drug Administration. FDA reminder to avoid concomitant use of Plavix (clopidogrel) and omeprazole (27 oct). 2010
    • Food and Drug Administration. FDA reminder to avoid concomitant use of Plavix (clopidogrel) and omeprazole (27 oct). 2010.Accesible en: http://www.fda.gov/Drugs/DrugSafety/ucm231161.htm. [visitado 23/12/15]
  • 137
    • 85052413871 scopus 로고    scopus 로고
    • Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). Interacción de clopidogrel con los inhibidores de la bomba de protones: actualización de la información y recomendaciones de uso (Nota informativa)
    • Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). Interacción de clopidogrel con los inhibidores de la bomba de protones: actualización de la información y recomendaciones de uso (Nota informativa). 2010.Accesible en: http://www.aemps.gob.es/informa/notasInformativas/medicamentosUsoHumano/seguridad/2010/docs/NI_2010-04_clopidogrel.pdf. [visitado 23/12/15]
    • (2010)
  • 138
    • 79958001356 scopus 로고    scopus 로고
    • The use of antiplatelet therapy in the outpatient setting: Canadian Cardiovascular Society Guidelines Executive Summary
    • Bell AD, Roussin A, Cartier R, et al. The use of antiplatelet therapy in the outpatient setting: Canadian Cardiovascular Society Guidelines Executive Summary. Can J Cardiol 2011;27:208-21. DOI: 10.1016/j.cjca.2010.12.033
    • (2011) Can J Cardiol , vol.27 , pp. 208-221
    • Bell, A.D.1    Roussin, A.2    Cartier, R.3
  • 139
    • 84879068693 scopus 로고    scopus 로고
    • Expert position paper on the use of proton pump inhibitors in patients with cardiovascular disease and antithrombotic therapy
    • 13a-13b
    • Agewall S, Cattaneo M, Collet JP, et al. Expert position paper on the use of proton pump inhibitors in patients with cardiovascular disease and antithrombotic therapy. Eur Heart J 2013;34:1708-13,13a-13b. DOI: 10.1093/eurheartj/eht042
    • (2013) Eur Heart J , vol.34 , pp. 1708-1713
    • Agewall, S.1    Cattaneo, M.2    Collet, J.P.3
  • 140
    • 84936774522 scopus 로고    scopus 로고
    • Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population
    • Shah NH, LePendu P, Bauer-Mehren A, et al. Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. PLoS One 2015;10.DOI: 10.1371/journal.pone.0124653
    • (2015) Plos One , pp. 10
    • Shah, N.H.1    Lependu, P.2    Bauer-Mehren, A.3
  • 141
    • 70849121346 scopus 로고    scopus 로고
    • Comparison of outcomes twelve years after antireflux surgery or omeprazole maintenance therapy for reflux esophagitis
    • Lundell L, Miettinen P, Myrvold HE, et al. Comparison of outcomes twelve years after antireflux surgery or omeprazole maintenance therapy for reflux esophagitis. Clin Gastroenterol Hepatol 2009;7:1292-8. DOI: 10.1016/j.cgh.2009.05.021
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 1292-1298
    • Lundell, L.1    Miettinen, P.2    Myrvold, H.E.3
  • 142
    • 85013466928 scopus 로고    scopus 로고
    • Incidence of cardiovascular events and gastrointestinal bleeding in patients receiving clopidogrel with and without proton pump inhibitors: An updated meta-analysis
    • Cardoso RN, Benjo AM, DiNicolantonio JJ, et al. Incidence of cardiovascular events and gastrointestinal bleeding in patients receiving clopidogrel with and without proton pump inhibitors: an updated meta-analysis. Open Heart 2015;2:e000248-e. DOI: 10.1136/openhrt-2015-000248
    • (2015) Open Heart , vol.2
    • Cardoso, R.N.1    Benjo, A.M.2    Dinicolantonio, J.J.3
  • 143
    • 84976402228 scopus 로고    scopus 로고
    • Individual proton pump inhibitors and outcomes in patients with coronary artery disease on dual antiplatelet therapy: A systematic review
    • Sherwood MW, Melloni C, Jones WS, et al. Individual proton pump inhibitors and outcomes in patients with coronary artery disease on dual antiplatelet therapy: A systematic review. J Am Heart Assoc 2015;4. DOI: 10.1161/JAHA.115.002245
    • (2015) J am Heart Assoc , pp. 4
    • Sherwood, M.W.1    Melloni, C.2    Jones, W.S.3
  • 144
    • 84945897151 scopus 로고    scopus 로고
    • Proton pump inhibitors, platelet reactivity, and cardiovascular outcomes after drug-eluting stents in clopidogrel-treated patients: The ADAPT-DES Study
    • Weisz G, Smilowitz NR, Kirtane AJ, et al. Proton pump inhibitors, platelet reactivity, and cardiovascular outcomes after drug-eluting stents in clopidogrel-treated patients: The ADAPT-DES Study. Circ Cardiovasc Interv 2015;8.
    • (2015) Circ Cardiovasc Interv , pp. 8
    • Weisz, G.1    Smilowitz, N.R.2    Kirtane, A.J.3
  • 145
    • 84941939517 scopus 로고    scopus 로고
    • Concomitant proton-pump inhibitor use, platelet activity, and clinical outcomes in patients with acute coronary syndromes treated with prasugrel versus clopidogrel and managed without revascularization: Insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes trial
    • Nicolau JC, Bhatt DL, Roe MT, et al. Concomitant proton-pump inhibitor use, platelet activity, and clinical outcomes in patients with acute coronary syndromes treated with prasugrel versus clopidogrel and managed without revascularization: Insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes trial. Am Heart J 2015;170:683-94. e3. DOI: 10.1016/j.ahj.2015.05.017
    • (2015) Am Heart J , vol.170 , pp. 683-694
    • Nicolau, J.C.1    Bhatt, D.L.2    Roe, M.T.3
  • 146
    • 84943278807 scopus 로고    scopus 로고
    • Effects of clopidogrel and proton pump inhibitors on cardiovascular events in patients with type 2 diabetes mellitus after drug-eluting stent implantation: A Nationwide Cohort Study
    • Hsieh C-F, Huang W-F, Chiang Y-T, et al. Effects of clopidogrel and proton pump inhibitors on cardiovascular events in patients with type 2 diabetes mellitus after drug-eluting stent implantation: A Nationwide Cohort Study. PLoS One 2015;10:e0135915. DOI: 10.1371/journal.pone.0135915
    • (2015) Plos One , pp. 10
    • Hsieh, C.-F.1    Huang, W.-F.2    Chiang, Y.-T.3
  • 147
    • 84875242008 scopus 로고    scopus 로고
    • Concomitant use of clopidogrel and proton pump inhibitors: Impact on platelet function and clinical outcome-a systematic review
    • Focks JJ, Brouwer MA, van Oijen MG, et al. Concomitant use of clopidogrel and proton pump inhibitors: impact on platelet function and clinical outcome-a systematic review. Heart 2013;99:520-7. DOI: 10.1136/heartjnl-2012-302371
    • (2013) Heart , vol.99 , pp. 520-527
    • Focks, J.J.1    Brouwer, M.A.2    Van Oijen, M.G.3
  • 148
    • 84926353509 scopus 로고    scopus 로고
    • Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: Systematic review
    • Melloni C, Washam JB, Jones WS, et al. Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review. Circ Cardiovasc Qual Outcomes 2015;8:47-55. DOI: 10.1161/CIRCOUTCOMES.114.001177
    • (2015) Circ Cardiovasc Qual Outcomes , vol.8 , pp. 47-55
    • Melloni, C.1    Washam, J.B.2    Jones, W.S.3
  • 149
    • 84927593897 scopus 로고    scopus 로고
    • Should proton pump inhibitors be withheld from patients taking clopidogrel? The issue that has been giving me heartburn!
    • Berger PB. Should proton pump inhibitors be withheld from patients taking clopidogrel? The issue that has been giving me heartburn! Circ Cardiovasc Qual Outcomes 2015;8:6-7. DOI: 10.1161/CIRCOUTCOMES.114.001586
    • (2015) Circ Cardiovasc Qual Outcomes , vol.8 , pp. 6-7
    • Berger, P.B.1
  • 150
    • 66149152644 scopus 로고    scopus 로고
    • Acid-suppressive medication use and the risk for hospital-acquired pneumonia
    • Herzig SJ, Howell MD, Ngo LH, et al. Acid-suppressive medication use and the risk for hospital-acquired pneumonia. JAMA 2009; 301:2120-8. DOI: 10.1001/jama.2009.722
    • (2009) JAMA , vol.301 , pp. 2120-2128
    • Herzig, S.J.1    Howell, M.D.2    Ngo, L.H.3
  • 151
    • 77952196958 scopus 로고    scopus 로고
    • Proton pump inhibitors and risk for recurrent clostridium difficile infection
    • Linsky A, Gupta K, Lawler EV, et al. Proton pump inhibitors and risk for recurrent clostridium difficile infection. Arch Intern Med 2010;170:772-8. DOI: 10.1001/archinternmed.2010.73
    • (2010) Arch Intern Med , vol.170 , pp. 772-778
    • Linsky, A.1    Gupta, K.2    Lawler, E.V.3
  • 152
    • 66949151786 scopus 로고    scopus 로고
    • Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites
    • Bajaj JS, Zadvornova Y, Heuman DM, et al. Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites. Am J Gastroenterol 2009;104:1130-4. DOI: 10.1038/ajg.2009.80
    • (2009) Am J Gastroenterol , vol.104 , pp. 1130-1134
    • Bajaj, J.S.1    Zadvornova, Y.2    Heuman, D.M.3
  • 153
    • 84953716163 scopus 로고    scopus 로고
    • Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: A systematic review and meta-analysis
    • Xu HB, Wang HD, Li CH, et al. Proton pump inhibitor use and risk of spontaneous bacterial peritonitis in cirrhotic patients: a systematic review and meta-analysis. Genet Mol Res 2015;14:7490-501. DOI: 10.4238/2015.July.3.25
    • (2015) Genet Mol Res , vol.14 , pp. 7490-7501
    • Xu, H.B.1    Wang, H.D.2    Li, C.H.3
  • 154
    • 38649085352 scopus 로고    scopus 로고
    • Association between proton pump inhibitor use and spontaneous bacterial peritonitis
    • Campbell MS, Obstein K, Reddy KR, et al. Association between proton pump inhibitor use and spontaneous bacterial peritonitis. Dig Dis Sci 2008;53:394-8. DOI: 10.1007/s10620-007-9899-9
    • (2008) Dig Dis Sci , vol.53 , pp. 394-398
    • Campbell, M.S.1    Obstein, K.2    Reddy, K.R.3
  • 155
    • 79956089546 scopus 로고    scopus 로고
    • Association between proton pump inhibitors and spontaneous bacterial peritonitis in cirrhotic patients-a systematic review and meta-analysis
    • Trikudanathan G, Israel J, Cappa J, et al. Association between proton pump inhibitors and spontaneous bacterial peritonitis in cirrhotic patients-a systematic review and meta-analysis. Int J Clin Pract 2011;65(6):674-8. DOI: 10.1111/j.1742-1241.2011.02650.x
    • (2011) Int J Clin Pract , vol.65 , Issue.6 , pp. 674-678
    • Trikudanathan, G.1    Israel, J.2    Cappa, J.3
  • 156
    • 79954503170 scopus 로고    scopus 로고
    • Association between acid suppressive therapy and spontaneous bacterial peritonitis in cirrhotic patients with ascites
    • Choi EJ, Lee HJ, Kim KO, et al. Association between acid suppressive therapy and spontaneous bacterial peritonitis in cirrhotic patients with ascites. Scand J Gastroenterol 2011;46:616-20. DOI: 10.3109/00365521.2011.551891
    • (2011) Scand J Gastroenterol , vol.46 , pp. 616-620
    • Choi, E.J.1    Lee, H.J.2    Kim, K.O.3
  • 157
    • 84858703547 scopus 로고    scopus 로고
    • Increased rate of spontaneous bacterial peritonitis among cirrhotic patients receiving pharmacologic acid suppression
    • Goel GA, Deshpande A, Lopez R, et al. Increased rate of spontaneous bacterial peritonitis among cirrhotic patients receiving pharmacologic acid suppression. Clin Gastroenterol Hepatol 2012;10:422-7. DOI: 10.1016/j.cgh.2011.11.019
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 422-427
    • Goel, G.A.1    Deshpande, A.2    Lopez, R.3
  • 158
    • 84872793547 scopus 로고    scopus 로고
    • Acid-suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients: A meta-analysis
    • Deshpande A, Pasupuleti V, Thota P, et al. Acid-suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients: A meta-analysis. J Gastroenterol Hepatol 2013;28:235-42. DOI: 10.1111/jgh.12065
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 235-242
    • Deshpande, A.1    Pasupuleti, V.2    Thota, P.3
  • 159
    • 84883810972 scopus 로고    scopus 로고
    • Role of proton pump inhibitors in the occurrence and the prognosis of spontaneous bacterial peritonitis in cirrhotic patients with ascites
    • de Vos M, De Vroey B, Garcia BG, et al. Role of proton pump inhibitors in the occurrence and the prognosis of spontaneous bacterial peritonitis in cirrhotic patients with ascites. Liver Int 2013;33:1316-23. DOI: 10.1111/liv.12210
    • (2013) Liver Int , vol.33 , pp. 1316-1323
    • De Vos, M.1    De Vroey, B.2    Garcia, B.G.3
  • 160
    • 84901061202 scopus 로고    scopus 로고
    • Proton pump inhibitor use is associated with spontaneous bacterial peritonitis in patients with liver cirrhosis
    • Miura K, Tanaka A, Yamamoto T, et al. Proton pump inhibitor use is associated with spontaneous bacterial peritonitis in patients with liver cirrhosis. Intern Med 2014;53:1037-42. DOI: 10.2169/internalmedicine.53.2021
    • (2014) Intern Med , vol.53 , pp. 1037-1042
    • Miura, K.1    Tanaka, A.2    Yamamoto, T.3
  • 161
    • 84902652875 scopus 로고    scopus 로고
    • Association between proton pump inhibitor use and spontaneous bacterial peritonitis in cirrhotic patients with ascites
    • Ratelle M, Perreault S, Villeneuve JP, et al. Association between proton pump inhibitor use and spontaneous bacterial peritonitis in cirrhotic patients with ascites. Can J Gastroenterol Hepatol 2014;28:330-4. DOI: 10.1155/2014/751921
    • (2014) Can J Gastroenterol Hepatol , vol.28 , pp. 330-334
    • Ratelle, M.1    Perreault, S.2    Villeneuve, J.P.3
  • 162
    • 84906252848 scopus 로고    scopus 로고
    • Proton pump inhibitor use significantly increases the risk of spontaneous bacterial peritonitis in 1965 patients with cirrhosis and ascites: A propensity score matched cohort study
    • Min YW, Lim KS, Min BH, et al. Proton pump inhibitor use significantly increases the risk of spontaneous bacterial peritonitis in 1965 patients with cirrhosis and ascites: a propensity score matched cohort study. Aliment Pharmacol Ther 2014;40:695-704. DOI: 10.1111/apt.12875
    • (2014) Aliment Pharmacol Ther , vol.40 , pp. 695-704
    • Min, Y.W.1    Lim, K.S.2    Min, B.H.3
  • 163
    • 84930339290 scopus 로고    scopus 로고
    • Proton pump inhibitor intake neither predisposes to spontaneous bacterial peritonitis or other infections nor increases mortality in patients with cirrhosis and ascites
    • Mandorfer M, Bota S, Schwabl P, et al. Proton pump inhibitor intake neither predisposes to spontaneous bacterial peritonitis or other infections nor increases mortality in patients with cirrhosis and ascites. PLoS One 2014;9: e110503. DOI: 10.1371/journal.pone.0110503
    • (2014) Plos One , pp. 9
    • Mandorfer, M.1    Bota, S.2    Schwabl, P.3
  • 164
    • 84925198306 scopus 로고    scopus 로고
    • Long-term use of antibiotics and proton pump inhibitors predict development of infections in patients with cirrhosis
    • O’Leary JG, Reddy KR, Wong F, et al. Long-term use of antibiotics and proton pump inhibitors predict development of infections in patients with cirrhosis. Clin Gastroenterol Hepatol 2015;13:753-9. e1-2.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 753-759
    • O’Leary, J.G.1    Reddy, K.R.2    Wong, F.3
  • 165
    • 84927799218 scopus 로고    scopus 로고
    • Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: A multicenter prospective study
    • Terg R, Casciato P, Garbe C, et al. Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: A multicenter prospective study. J Hepatol 2015;62:1056-60. DOI: 10.1016/j.jhep.2014.11.036
    • (2015) J Hepatol , vol.62 , pp. 1056-1060
    • Terg, R.1    Casciato, P.2    Garbe, C.3
  • 166
    • 84941008249 scopus 로고    scopus 로고
    • Risk of spontaneous bacterial peritonitis associated with gastric Acid suppression
    • Chang SS, Lai CC, Lee MT, et al. Risk of spontaneous bacterial peritonitis associated with gastric Acid suppression. Medicine (Baltimore) 2015;94:e944. DOI: 10.1097/MD.0000000000000944
    • (2015) Medicine (Baltimore) , pp. 94
    • Chang, S.S.1    Lai, C.C.2    Lee, M.T.3
  • 167
    • 84896344690 scopus 로고    scopus 로고
    • Mortality associated with proton pump inhibitors in cirrhotic patients with spontaneous bacterial peritonitis
    • Kwon JH, Koh S-J, Kim W, et al. Mortality associated with proton pump inhibitors in cirrhotic patients with spontaneous bacterial peritonitis. J Gastroenterol Hepatol 2014;29:775-81. DOI: 10.1111/jgh.12426
    • (2014) J Gastroenterol Hepatol , vol.29 , pp. 775-781
    • Kwon, J.H.1    Koh, S.-J.2    Kim, W.3
  • 168
    • 84921601756 scopus 로고    scopus 로고
    • The chronic use of betablockers and proton pump inhibitors may affect the rate of bacterial infections in cirrhosis
    • Merli M, Lucidi C, Di Gregorio V, et al. The chronic use of betablockers and proton pump inhibitors may affect the rate of bacterial infections in cirrhosis. Liver Int 2015;35:362-9. DOI: 10.1111/liv.12593
    • (2015) Liver Int , vol.35 , pp. 362-369
    • Merli, M.1    Lucidi, C.2    Di Gregorio, V.3
  • 169
    • 84862634309 scopus 로고    scopus 로고
    • Bacterial infections in cirrhosis: Role of proton pump inhibitors and intestinal permeability
    • van Vlerken LG, Huisman EJ, van Hoek B, et al. Bacterial infections in cirrhosis: role of proton pump inhibitors and intestinal permeability. European Journal of Clinical Investigation 2012;42:760-7. DOI: 10.1111/j.1365-2362.2011.02643.x
    • (2012) European Journal of Clinical Investigation , vol.42 , pp. 760-767
    • Van Vlerken, L.G.1    Huisman, E.J.2    Van Hoek, B.3
  • 170
    • 84921909302 scopus 로고    scopus 로고
    • Proton pump inhibitor treatment is associated with the severity of liver disease and increased mortality in patients with cirrhosis
    • Dultz G, Piiper A, Zeuzem S, et al. Proton pump inhibitor treatment is associated with the severity of liver disease and increased mortality in patients with cirrhosis. Aliment Pharmacol Ther 2015;41:459-66. DOI: 10.1111/apt.13061
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 459-466
    • Dultz, G.1    Piiper, A.2    Zeuzem, S.3
  • 171
    • 84976406399 scopus 로고    scopus 로고
    • Adverse drug reactions due to drugdrug interactions with proton pump inhibitors: Assessment of systematic reviews with AMSTAR method
    • Emre Y, Mesut S, Aylin Y, et al. Adverse drug reactions due to drugdrug interactions with proton pump inhibitors: assessment of systematic reviews with AMSTAR method. Expert Opin Drug Saf 2015. Accesible en: http://www.ncbi.nlm.nih.gov/pubmed/26635063
    • (2015) Expert Opin Drug Saf
    • Emre, Y.1    Mesut, S.2    Aylin, Y.3
  • 172
    • 84962727528 scopus 로고    scopus 로고
    • Drug-Drug Interactions With Novel All Oral Interferon-Free Antiviral Agents in a Large Real-World Cohort
    • Honer Zu Siederdissen C, Maasoumy B, Marra F, et al. Drug-Drug Interactions With Novel All Oral Interferon-Free Antiviral Agents in a Large Real-World Cohort. Clin Infect Dis 2015. Accesible en: http://www.ncbi.nlm.nih.gov/pubmed/26611779
    • (2015) Clin Infect Dis
    • Honer Zu Siederdissen, C.1    Maasoumy, B.2    Marra, F.3
  • 173
    • 84957998974 scopus 로고    scopus 로고
    • Proton pump inhibitor use and the risk of chronic kidney disease
    • Lazarus B, Chen Y, Wilson FP, et al. Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern Med 2016;176: 238-46.
    • (2016) JAMA Intern Med , vol.176 , pp. 238-246
    • Lazarus, B.1    Chen, Y.2    Wilson, F.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.