Proton pump inhibitors linked to hypomagnesemia: A systematic review and meta-analysis of observational studies

Renal Failure

Volumn 37, Issue 7, 2015, Pages 1237-1241

  Cheungpasitporn, Wisit ^a   Thongprayoon, Charat ^a   Kittanamongkolchai, Wonngarm ^a   Srivali, Narat ^a   Edmonds, Peter J ^b   Ungprasert, Patompong ^a   O'Corragain, Oisin A ^c   Korpaisarn, Sira ^d   Erickson, Stephen B ^a  

^a MAYO CLINIC   (United States)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d METROWEST MEDICAL CENTER   (United States)

Author keywords

Electrolyte; hypomagnesemia; magnesium; meta analysis; proton pump inhibitors

Indexed keywords

PROTON PUMP INHIBITOR; MAGNESIUM;

ARTICLE; BIBLIOGRAPHIC DATABASE; DISEASE ASSOCIATION; HUMAN; HYPOMAGNESEMIA; META ANALYSIS; OBSERVATIONAL STUDY; PRIORITY JOURNAL; QUALITY CONTROL; RISK FACTOR; SYSTEMATIC REVIEW; BLOOD; ODDS RATIO; PUBLISHING;

HUMANS; MAGNESIUM; OBSERVATIONAL STUDIES AS TOPIC; ODDS RATIO; PROTON PUMP INHIBITORS; PUBLICATION BIAS;

EID: 84941930462     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2015.1057800     Document Type: Article

References (30)

1. Agus ZS. Hypomagnesemia. J Am Soc Nephrol. 1999;10: 1616-1622.
2. Moore MJ, Flink EB. Magnesium deficiency as a cause of serious arrhythmias. Arch Intern Med. 1978;138:825-826.
3. Vallee BL, Wacker WE, Ulmer DD. The magnesium-deficiency tetany syndrome in man. N Engl J Med. 1960;262:155-161.
4. Flink EB. Magnesium deficiency. Etiology and clinical spectrum. Acta Med Scand Suppl. 1981;647:125-137.
5. Danziger J, William JH, Scott DJ, et al. Proton-pump inhibitor use is associated with low serum magnesium concentrations. Kidney Int. 2013;83:692-699.
6. Sakaguchi Y, Fujii N, Shoji T, Hayashi T, Rakugi H, Isaka Y. Hypomagnesemia is a significant predictor of cardiovascular and non-cardiovascular mortality in patients undergoing hemodialysis. Kidney Int. 2014;85:174-181.
7. Reffelmann T, Ittermann T, Dorr M, et al. Low serum magnesium concentrations predict cardiovascular and all-cause mortality. Atherosclerosis. 2011;219:280-284.
8. Bo S, Pisu E. Role of dietary magnesium in cardiovascular disease prevention, insulin sensitivity and diabetes. Curr Opin Lipidol. 2008;19:50-56.
9. Liao F, Folsom AR, Brancati FL. Is low magnesium concentration a risk factor for coronary heart disease? The atherosclerosis risk in communities (Aric) study. Am Heart J. 1998;136:480-490.
10. Del Gobbo LC, Imamura F, Wu JH, de Oliveira Otto MC, Chiuve SE, Mozaffarian D. Circulating and dietary magnesium and risk of cardiovascular disease: A systematic review and meta-analysis of prospective studies. Am J Clin Nutr. 2013;98:160-173.
11. Alves SC, Tomasi CD, Constantino L, et al. Hypomagnesemia as a risk factor for the non-recovery of the renal function in critically ill patients with acute kidney injury. Nephrol Dial Transplant. 2013; 28:910-916.
12. Sierra F, Suarez M, Rey M, Vela MF. Systematic review: Proton pump inhibitor-associated acute interstitial nephritis. Aliment Pharmacol Ther. 2007;26:545-553.
13. Howell MD, Novack V, Grgurich P, et al. Iatrogenic gastric acid suppression and the risk of nosocomial clostridium difficile infection. Arch Intern Med. 2010;170:784-790.
14. Herzig SJ, Howell MD, Ngo LH, Marcantonio ER. Acid-suppressive medication use and the risk for hospital-acquired pneumonia. JAMA. 2009;301:2120-2128.
15. Yu EW, Bauer SR, Bain PA, Bauer DC. Proton pump inhibitors and risk of fractures: A meta-analysis of 11 international studies. Am J Med. 2011;124:519-526.
16. Hess MW, Hoenderop JG, Bindels RJ, Drenth JP. Systematic review: Hypomagnesaemia induced by proton pump inhibition. Aliment Pharmacol Ther. 2012;36:405-413.
17. US Department of Health and Human Services F DSC. Drug safety communication-Low magnesium levels can be associated with long-term use. Available from: http://www.fda.gov/Drugs/ DrugSafety/ucm245011.htm. Accessed March 3, 2011.
18. Gau JT, Yang YX, Chen R, Kao TC. Uses of proton pump inhibitors and hypomagnesemia. Pharmacoepidemiol Drug Saf. 2012;21: 553-559.
19. Kim S, Lee H, Park CH, et al. Clinical predictors associated with proton pump inhibitor-induced hypomagnesemia. Am J Ther. 2015;22:14-21.
20. Markovits N, Loebstein R, Halkin H, et al. The association of proton pump inhibitors and hypomagnesemia in the community setting. J Clin Pharmacol. 2014;54:889-895.
21. Smith K, Gatesman ML, Harpe SE, Clark W. Evaluation of electrolyte repletion in hematopoietic cell transplant patients receiving h-2 receptor antagonists or proton pump inhibitors. Bone Marrow Transplant. 2014;49:1106-1108.
22. El-Charabaty E, Saifan C, Abdallah M, et al. Effects of proton pump inhibitors and electrolyte disturbances on arrhythmias. Int J Gen Med. 2013;6:515-518.
23. Gil HW PS, Hong SY. Change in serum magnesium concentration after use of a proton pump inhibitor. 51st ERA-EDTA Congress, Amsterdam, Netherlands: Oxford University Press; 2014;29: iii180-iii181.
24. Koulouridis I, Alfayez M, Tighiouart H, et al. Out-of-hospital use of proton pump inhibitors and hypomagnesemia at hospital admission: A nested case-control study. Am J Kidney Dis. 2013; 62:730-737.
25. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in metaanalyses. Eur J Epidemiol. 2010;25:603-605.
26. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-188.
27. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-560.
28. Easterbrook PJ, Berlin JA, Gopalan R, Matthews DR. Publication bias in clinical research. Lancet. 1991;337:867-872.
29. Faulhaber GA, Ascoli BM, Lubini A, et al. Serum magnesium and proton-pump inhibitors use: A cross-sectional study. Rev Assoc Med Bras. 2013;59:276-279.
30. Perazella MA. Proton pump inhibitors and hypomagnesemia. A rare but serious complication. Kidney Int. 2013;83:553-556.