Vitamin B12 deficiency in hypersecretors during long-term acid suppression with proton pump inhibitors

Alimentary Pharmacology and Therapeutics

Volumn 27, Issue 11, 2008, Pages 1110-1121

  Hirschowitz, B I ^a,b   Worthington, J ^a   Mohnen, J ^a  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; HOMOCYSTEINE; LANSOPRAZOLE; METHYLMALONIC ACID; OMEPRAZOLE; PENTAGASTRIN;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; CYANOCOBALAMIN DEFICIENCY; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; HYPERCHLORHYDRIA; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STOMACH ACID SECRETION; SUBSTITUTION THERAPY; VITAMIN BLOOD LEVEL; ZOLLINGER ELLISON SYNDROME;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; FEMALE; GASTRIC ACID; GASTRIC ACIDITY DETERMINATION; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDDLE AGED; PROTON PUMP INHIBITORS; STATISTICS AS TOPIC; TIME FACTORS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY; ZOLLINGER-ELLISON SYNDROME;

EID: 42949085127     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2008.03658.x     Document Type: Article

References (42)

1. Hirschowitz BI, Simmons J, Mohnen J. Long-term lansoprazole control of gastric acid and pepsin secretion in ZE and non-ZE hypersecretors: a prospective 10-year study. Aliment Pharmacol Ther 2001 15 : 1795 806.
2. Hirschowitz BI, Simmons J, Mohnen J. Clinical outcome using lansoprazole in acid hypersecretors with and without Zollinger-Ellison syndrome: a 13-year prospective study. Clin Gastroenterol Hepatol 2005 3 : 39 48.
3. Howden CW. Vitamin B12 levels during prolonged treatment with proton pump inhibitors. J Clin Gastroenterol 2000 30 : 29 33.
4. Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med 1994 120 : 211 5.
5. Termanini B, Gibril F, Sutliff VE, Yu F, Venzon DJ, Jensen RT. Effect of long-term gastric acid suppressive therapy on serum vitamin B12 levels in patients with Zollinger-Ellison syndrome. Am J Med 1998 104 : 422 30.
6. Schenk BE, Festen HP, Kuipers EJ, Klinkenberg-Knol EC, Meuwissen SG. Effect of short- and long-term treatment with omeprazole on the absorption and serum levels of cobalamin. Aliment Pharmacol Ther 1996 10 : 541 5.
7. Koop H, Bachem MG. Serum iron, ferritin, and vitamin B12 during prolonged omeprazole therapy. J Clin Gastroenterol 1992 14 : 288 92.
8. Allen RH, Stabler SP, Savage DG, Lindenbaum J. Diagnosis of cobalamin deficiency I: usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990 34 : 90 8.
9. Andres E, Affenberger S, Vinzio S, et al. Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am J Med 2005 118 : 1154 9.
10. Carmel R. Subtle cobalamin deficiency. Ann Intern Med 1996 124 : 338 40.
11. Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med 1994 96 : 239 46.
12. Stabler SP, Lindenbaum J, Allen RH. Vitamin B-12 deficiency in the elderly: current dilemmas. Am J Clin Nutr 1997 66 : 741 9.
13. Sumner AE, Chin MM, Abrahm JL, et al. Elevated methylmalonic acid and total homocysteine levels show high prevalence of vitamin B12 deficiency after gastric surgery. Ann Intern Med 1996 124 : 469 76.
14. Stabler SP. Screening the older population for cobalamin (vitamin B12) deficiency. J Am Geriatr Soc 1995 43 : 1290 7.
15. Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol 1990 34 : 99 107.
16. Stabler SP, Lindenbaum J, Allen RH. The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency. J Nutr 1996 126 : 1266S 72S.
17. Wagner DA, Bolt DL, Curington CL, Cintron M, Toskes PP. Comparison of methylmalonic acid to B12 serology and a newly developed B12 breath test. Gastroenterology 2005 128 : A416.
18. Stabler SP. Vitamins, homocysteine, and cognition. Am J Clin Nutr 2003 78 : 359 60.
19. Selhub J. The many facets of hyperhomocysteinemia: studies from the Framingham cohorts. J Nutr 2006 136 : 1726S 30S.
20. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997 337 : 230 6.
21. Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 2004 291 : 565 75.
22. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002 346 : 476 83.
23. Lonn E, Yusuf S, Arnold MJ, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006 354 : 1567 77.
24. Clarke R, et al. Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J 2006 151 : 282 7.
25. McMahon JA, Green TJ, Skeaff CM, Knight RG, Mann JI, Williams SM. A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 2006 354 : 2764 72.
26. Russell-Jones GJ, Alpers DH. Vitamin B12 transporters. Pharm Biotechnol 1999 12 : 493 520.
27. Halter F, Keller M. A comparison between intragastric titration and aspiration technique under basal conditions and after food or pentagastrin stimulation. Am J Dig Dis 1978 23 : 723 9.
28. Hirschowitz BI, Groarke J. Vagal effects on acid and pepsin secretion and serum gastrin in duodenal ulcer and controls. Dig Dis Sci 1993 38 : 1874 84.
29. Hirschowitz BI, Keeling D, Lewin M, et al. Pharmacological aspects of acid secretion. Dig Dis Sci 1995 40 : 3S 23S.
30. Hirschowitz BI, Haber MM. Helicobacter pylori effects on gastritis, gastrin and enterochromaffin-like cells in Zollinger-Ellison syndrome and non-Zollinger-Ellison syndrome acid hypersecretors treated long-term with lansoprazole. Aliment Pharmacol Ther 2001 15 : 87 103.
31. Oh R, Brown DL. Vitamin B12 deficiency. Am Fam Physician 2003 67 : 979 86.
32. Jensen RT. Consequences of long-term proton pump blockade: insights from studies of patients with gastrinomas. Basic Clin Pharmacol Toxicol 2006 98 : 4 19.
33. Alpers DH. What is new in vitamin B(12)? Curr Opin Gastroenterol 2005 21 : 183 6.
34. Del Corral A, Carmel R. Transfer of cobalamin from the cobalamin-binding protein of egg yolk to R binder of human saliva and gastric juice. Gastroenterology 1990 98 : 1460 6.
35. Fedosov SN, Fedosova NU, Berglund L, Moestrup SK, Nexo E, Petersen TE. Composite organization of the cobalamin binding and cubilin recognition sites of intrinsic factor. Biochemistry 2005 44 : 3604 14.
36. Carmel R. Malabsorption of food cobalamin. Baillieres Clin Haematol 1995 8 : 639 55.
37. Allen RH, Seetharam B, Allen NC, Podell ER, Alpers DH. Correction of cobalamin malabsorption in pancreatic insufficiency with a cobalamin analogue that binds with high affinity to R protein but not to intrinsic factor. In vivo evidence that a failure to partially degrade R protein is responsible for cobalamin malabsorption in pancreatic insufficiency. J Clin Invest 1978 61 : 1628 34.
38. Festen HP, Tuynman HA, Den Hollander W, Meuwissen SG. Repeated high oral doses of omeprazole do not affect intrinsic factor secretion: proof of a selective mode of action. Aliment Pharmacol Ther 1989 3 : 375 9.
39. Shimoda SS, Saunders DR, Rubin CE. The Zollinger-Ellison syndrome with steatorrhea. II. The mechanism of fat and vitamin B 12 malabsorption. Gastroenterology 1968 55 : 705 23.
40. Thorens J, Froehlich F, Schwizer W, et al. Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomised double blind study. Gut 1996 39 : 54 9.
41. Saltzman JR, Kowdley KV, Pedrosa MC, et al. Bacterial overgrowth without clinical malabsorption in elderly hypochlorhydric subjects. Gastroenterology 1994 106 : 615 23.
42. Splaver A, Lamas GA, Hennekens CH. Homocysteine and cardiovascular disease: biological mechanisms, observational epidemiology, and the need for randomized trials. Am Heart J 2004 148 : 34 40.