Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1

Translational Psychiatry

Volumn 6, Issue 6, 2016, Pages

  Kumsta, R ^a   Marzi, S J ^b   Viana, J ^c   Dempster, E L ^c   Crawford, B ^c   Rutter, M ^b   Mill, J ^b,c   Sonuga Barke, E J S ^d,e  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

^c UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2E1; DNA;

ADOLESCENT; ADOPTION; ARTICLE; CHEEK CELL; CHILD; CHILD NEGLECT; CHILD PSYCHOLOGY; CHROMOSOME 10; COMPARATIVE STUDY; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EARLY LIFE STRESS; EPIGENETICS; FOLLOW UP; GENETIC ASSOCIATION; HUMAN; INTELLECTUAL IMPAIRMENT; MAJOR CLINICAL STUDY; ORPHANAGE; PROMOTER REGION; SOCIAL COGNITION; SOCIAL ISOLATION; TRANSCRIPTION INITIATION SITE; CHILD ABUSE; COGNITIVE DEFECT; COHORT ANALYSIS; EMOTIONAL INTELLIGENCE; FEMALE; GENETIC EPIGENESIS; GENETICS; INFANT; MALE; ORPHANED CHILD; PRESCHOOL CHILD; PSYCHOLOGY; ROMANIA; SOCIAL ADAPTATION; TIME FACTOR;

ADOLESCENT; ADOPTION; CHILD; CHILD ABUSE; CHILD, ORPHANED; CHILD, PRESCHOOL; COGNITION DISORDERS; COHORT STUDIES; CYTOCHROME P-450 CYP2E1; DNA METHYLATION; EMOTIONAL INTELLIGENCE; EPIGENESIS, GENETIC; FEMALE; HUMANS; INFANT; MALE; PSYCHOSOCIAL DEPRIVATION; ROMANIA; SOCIAL ADJUSTMENT; TIME FACTORS; TRANSCRIPTION INITIATION SITE;

EID: 84976420244     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2016.95     Document Type: Article

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