메뉴 건너뛰기




Volumn 71, Issue , 2016, Pages 57-65

Blunted response of hippocampal AMPK associated with reduced neurogenesis in older versus younger mice

Author keywords

Aging; AMPK; BDNF; Hippocampus; Neurogenesis

Indexed keywords

ADENYLATE KINASE; BRAIN DERIVED NEUROTROPHIC FACTOR; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; ADENOSINE TRIPHOSPHATE; AICA RIBONUCLEOTIDE; ANTIDIABETIC AGENT; BROXURIDINE; DOUBLECORTIN PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MICROTUBULE ASSOCIATED PROTEIN; NEUROPEPTIDE; RIBONUCLEOTIDE;

EID: 84976309743     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2016.06.011     Document Type: Article
Times cited : (12)

References (43)
  • 1
    • 11844275246 scopus 로고    scopus 로고
    • The exercise-induced expression of BDNF within the hippocampus varies across life-span
    • Adlard, P.A., Perreau, V.M., Cotman, C.W., The exercise-induced expression of BDNF within the hippocampus varies across life-span. Neurobiol. Aging 26 (2005), 511–520, 10.1016/j.neurobiolaging.2004.05.006.
    • (2005) Neurobiol. Aging , vol.26 , pp. 511-520
    • Adlard, P.A.1    Perreau, V.M.2    Cotman, C.W.3
  • 2
    • 82155166723 scopus 로고    scopus 로고
    • Leptin induces neuroprotection neurogenesis and angiogenesis after stroke
    • (10.2174/156720211798120954)
    • Avraham, Y., Davidi, N., Lassri, V., Vorobiev, L., Kabesa, M., Dayan, M., et al. Leptin induces neuroprotection neurogenesis and angiogenesis after stroke. Curr. Neurovasc. Res. 8 (2011), 313–322 (10.2174/156720211798120954).
    • (2011) Curr. Neurovasc. Res. , vol.8 , pp. 313-322
    • Avraham, Y.1    Davidi, N.2    Lassri, V.3    Vorobiev, L.4    Kabesa, M.5    Dayan, M.6
  • 3
    • 84861199485 scopus 로고    scopus 로고
    • Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants
    • (10.1038/npp.2012.5)
    • Baj, G., D'Alessandro, V., Musazzi, L., Mallei, A., Sartori, C.R., Sciancalepore, M., et al. Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants. Neuropsychopharmacology 37 (2012), 1600–1611 (10.1038/npp.2012.5).
    • (2012) Neuropsychopharmacology , vol.37 , pp. 1600-1611
    • Baj, G.1    D'Alessandro, V.2    Musazzi, L.3    Mallei, A.4    Sartori, C.R.5    Sciancalepore, M.6
  • 4
    • 33645105249 scopus 로고    scopus 로고
    • Reduced hippocampal neurogenesis and number of hilar neurones in streptozotocin-induced diabetic mice: reversion by antidepressant treatment
    • Beauquis, J., Roig, P., Homo-Delarche, F., De Nicola, A., Saravia, F., Reduced hippocampal neurogenesis and number of hilar neurones in streptozotocin-induced diabetic mice: reversion by antidepressant treatment. Eur. J. Neurosci. 23 (2006), 1539–1546, 10.1111/j.1460-9568.2006.04691.x.
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 1539-1546
    • Beauquis, J.1    Roig, P.2    Homo-Delarche, F.3    De Nicola, A.4    Saravia, F.5
  • 5
    • 62649115914 scopus 로고    scopus 로고
    • Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription
    • Chen, Y., Zhou, K., Wang, R., Liu, Y., Kwak, Y.D., Ma, T., et al. Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proc. Natl. Acad. Sci. U. S. A. 106 (2009), 3907–3912, 10.1073/pnas.0807991106.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 3907-3912
    • Chen, Y.1    Zhou, K.2    Wang, R.3    Liu, Y.4    Kwak, Y.D.5    Ma, T.6
  • 6
    • 29644447464 scopus 로고    scopus 로고
    • Nutritional status, cognition, and survival a new role for leptin and AMP kinase
    • Dagon, Y., Avraham, Y., Magen, I., Gertler, A., Ben-Hur, T., Berry, E.M., Nutritional status, cognition, and survival a new role for leptin and AMP kinase. J. Biol. Chem. 280 (2005), 42142–42148, 10.1074/jbc.m507607200.
    • (2005) J. Biol. Chem. , vol.280 , pp. 42142-42148
    • Dagon, Y.1    Avraham, Y.2    Magen, I.3    Gertler, A.4    Ben-Hur, T.5    Berry, E.M.6
  • 7
    • 4644271811 scopus 로고    scopus 로고
    • Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment
    • De Foubert, G., Carney, S., Robinson, C., Destexhe, E., Tomlinson, R., Hicks, C., et al. Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment. Neuroscience 128 (2004), 597–604, 10.1016/j.neuroscience.2004.06.054.
    • (2004) Neuroscience , vol.128 , pp. 597-604
    • De Foubert, G.1    Carney, S.2    Robinson, C.3    Destexhe, E.4    Tomlinson, R.5    Hicks, C.6
  • 8
    • 84914703322 scopus 로고    scopus 로고
    • AMPK activation ameliorates Alzheimer's disease-like pathology and spatial memory impairment in a streptozotocin-induced Alzheimer's disease model in rats
    • Du, L.-L., Chai, D.-M., Zhao, L.-N., Li, X.-H., Zhang, F.-C., Zhang, H.-B., et al. AMPK activation ameliorates Alzheimer's disease-like pathology and spatial memory impairment in a streptozotocin-induced Alzheimer's disease model in rats. J. Alzheimers Dis. 43 (2015), 775–784, 10.3233/JAD-140564.
    • (2015) J. Alzheimers Dis. , vol.43 , pp. 775-784
    • Du, L.-L.1    Chai, D.-M.2    Zhao, L.-N.3    Li, X.-H.4    Zhang, F.-C.5    Zhang, H.-B.6
  • 9
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie, D.G., Ross, F.A., Hawley, S.A., AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13 (2012), 251–262, 10.1038/nrm3311.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 10
    • 0035834343 scopus 로고    scopus 로고
    • Changes in BDNF-immunoreactive structures in the hippocampal formation of the aged macaque monkey
    • Hayashi, M., Mistunaga, F., Ohira, K., Shimizu, K., Changes in BDNF-immunoreactive structures in the hippocampal formation of the aged macaque monkey. Brain Res. 918 (2001), 191–196, 10.1016/s0006-8993(01)03002-5.
    • (2001) Brain Res. , vol.918 , pp. 191-196
    • Hayashi, M.1    Mistunaga, F.2    Ohira, K.3    Shimizu, K.4
  • 11
    • 84873462892 scopus 로고    scopus 로고
    • Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of alpha-synuclein oligomers and decrease of neurites
    • Jiang, P., Gan, M., Ebrahim, A.S., Castanedes-Casey, M., Dickson, D.W., Yen, S.H., Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of alpha-synuclein oligomers and decrease of neurites. Neurobiol. Aging 34 (2013), 1504–1515, 10.1016/j.neurobiolaging.2012.11.001.
    • (2013) Neurobiol. Aging , vol.34 , pp. 1504-1515
    • Jiang, P.1    Gan, M.2    Ebrahim, A.S.3    Castanedes-Casey, M.4    Dickson, D.W.5    Yen, S.H.6
  • 12
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn, B.B., Alquier, T., Carling, D., Hardie, D.G., AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1 (2005), 15–25, 10.1016/j.cmet.2004.12.003.
    • (2005) Cell Metab. , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 13
    • 78751566697 scopus 로고    scopus 로고
    • Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease
    • Kapogiannis, D., Mattson, M.P., Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease. Lancet Neurol. 10 (2011), 187–198, 10.1016/s1474-4422(10)70277-5.
    • (2011) Lancet Neurol. , vol.10 , pp. 187-198
    • Kapogiannis, D.1    Mattson, M.P.2
  • 14
    • 84962583506 scopus 로고    scopus 로고
    • Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction
    • Kim, D.-M., Leem, Y.-H., Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction. Neuroscience 324 (2016), 271–285, 10.1016/j.neuroscience.2016.03.019.
    • (2016) Neuroscience , vol.324 , pp. 271-285
    • Kim, D.-M.1    Leem, Y.-H.2
  • 15
    • 84856559876 scopus 로고    scopus 로고
    • AMPK gamma2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age
    • Kim, E., Lee, S.H., Lee, K.S., Cheong, H.K., Namkoong, K., Hong, C.H., et al. AMPK gamma2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age. Psychoneuroendocrinology 37 (2012), 358–365, 10.1016/j.psyneuen.2011.07.005.
    • (2012) Psychoneuroendocrinology , vol.37 , pp. 358-365
    • Kim, E.1    Lee, S.H.2    Lee, K.S.3    Cheong, H.K.4    Namkoong, K.5    Hong, C.H.6
  • 16
    • 79251500654 scopus 로고    scopus 로고
    • Endurance factors improve hippocampal neurogenesis and spatial memory in mice
    • Kobilo, T., Yuan, C., van Praag, H., Endurance factors improve hippocampal neurogenesis and spatial memory in mice. Learn. Mem. 18 (2011), 103–107, 10.1101/lm.2001611.
    • (2011) Learn. Mem. , vol.18 , pp. 103-107
    • Kobilo, T.1    Yuan, C.2    van Praag, H.3
  • 17
    • 84894286799 scopus 로고    scopus 로고
    • AMPK agonist AICAR improves cognition and motor coordination in young and aged mice
    • Kobilo, T., Guerrieri, D., Zhang, Y., Collica, S.C., Becker, K.G., van Praag, H., AMPK agonist AICAR improves cognition and motor coordination in young and aged mice. Learn. Mem. 21 (2014), 119–126, 10.1101/lm.033332.113.
    • (2014) Learn. Mem. , vol.21 , pp. 119-126
    • Kobilo, T.1    Guerrieri, D.2    Zhang, Y.3    Collica, S.C.4    Becker, K.G.5    van Praag, H.6
  • 18
    • 0029863342 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
    • Kuhn, H.G., Dickinson-Anson, H., Gage, F.H., Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 16 (1996), 2027–2033.
    • (1996) J. Neurosci. , vol.16 , pp. 2027-2033
    • Kuhn, H.G.1    Dickinson-Anson, H.2    Gage, F.H.3
  • 19
    • 56449117024 scopus 로고    scopus 로고
    • AMPK: a metabolic gauge regulating whole-body energy homeostasis
    • Lage, R., Dieguez, C., Vidal-Puig, A., Lopez, M., AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol. Med. 14 (2008), 539–549, 10.1016/j.molmed.2008.09.007.
    • (2008) Trends Mol. Med. , vol.14 , pp. 539-549
    • Lage, R.1    Dieguez, C.2    Vidal-Puig, A.3    Lopez, M.4
  • 20
    • 0036488190 scopus 로고    scopus 로고
    • Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice
    • Lee, J., Seroogy, K.B., Mattson, M.P., Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J. Neurochem. 80 (2002), 539–547, 10.1046/j.0022-3042.2001.00747.x.
    • (2002) J. Neurochem. , vol.80 , pp. 539-547
    • Lee, J.1    Seroogy, K.B.2    Mattson, M.P.3
  • 21
    • 84870756683 scopus 로고    scopus 로고
    • Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise
    • Li, M., Verdijk, L.B., Sakamoto, K., Ely, B., van Loon, L.J., Musi, N., Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. Mech. Ageing Dev. 133 (2012), 655–664, 10.1016/j.mad.2012.09.001.
    • (2012) Mech. Ageing Dev. , vol.133 , pp. 655-664
    • Li, M.1    Verdijk, L.B.2    Sakamoto, K.3    Ely, B.4    van Loon, L.J.5    Musi, N.6
  • 22
    • 0035965708 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
    • Lichtenwalner, R., Forbes, M., Bennett, S., Lynch, C., Sonntag, W., Riddle, D., Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience 107 (2001), 603–613, 10.1016/s0306-4522(01)00378-5.
    • (2001) Neuroscience , vol.107 , pp. 603-613
    • Lichtenwalner, R.1    Forbes, M.2    Bennett, S.3    Lynch, C.4    Sonntag, W.5    Riddle, D.6
  • 24
    • 84888803842 scopus 로고    scopus 로고
    • Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats
    • Liu, D., Zhang, Q., Gu, J., Wang, X., Xie, K., Xian, X., et al. Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 49 (2014), 21–29, 10.1016/j.pnpbp.2013.10.017.
    • (2014) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.49 , pp. 21-29
    • Liu, D.1    Zhang, Q.2    Gu, J.3    Wang, X.4    Xie, K.5    Xian, X.6
  • 25
    • 84878881481 scopus 로고    scopus 로고
    • Obesity and psychiatric disorders: commonalities in dysregulated biological pathways and their implications for treatment
    • Lopresti, A.L., Drummond, P.D., Obesity and psychiatric disorders: commonalities in dysregulated biological pathways and their implications for treatment. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 45 (2013), 92–99, 10.1016/j.pnpbp.2013.05.005.
    • (2013) Prog. Neuro-Psychopharmacol. Biol. Psychiatry , vol.45 , pp. 92-99
    • Lopresti, A.L.1    Drummond, P.D.2
  • 26
    • 84876078566 scopus 로고    scopus 로고
    • The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Abeta oligomers through Tau phosphorylation
    • Mairet-Coello, G., Courchet, J., Pieraut, S., Courchet, V., Maximov, A., Polleux, F., The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Abeta oligomers through Tau phosphorylation. Neuron 78 (2013), 94–108, 10.1016/j.neuron.2013.02.003.
    • (2013) Neuron , vol.78 , pp. 94-108
    • Mairet-Coello, G.1    Courchet, J.2    Pieraut, S.3    Courchet, V.4    Maximov, A.5    Polleux, F.6
  • 27
    • 0025352013 scopus 로고
    • Adenosinergic modulation of homocysteine-induced seizures in mice
    • Marangos, P., Loftus, T., Wiesner, J., Lowe, T., Rossi, E., Browne, C., et al. Adenosinergic modulation of homocysteine-induced seizures in mice. Epilepsia 31 (1990), 239–246, 10.1111/j.1528-1157.1990.tb05371.x.
    • (1990) Epilepsia , vol.31 , pp. 239-246
    • Marangos, P.1    Loftus, T.2    Wiesner, J.3    Lowe, T.4    Rossi, E.5    Browne, C.6
  • 28
    • 20144368904 scopus 로고    scopus 로고
    • Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke
    • McCullough, L.D., Zeng, Z., Li, H., Landree, L.E., McFadden, J., Ronnett, G.V., Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke. J. Biol. Chem. 280 (2005), 20493–20502, 10.1074/jbc.m409985200.
    • (2005) J. Biol. Chem. , vol.280 , pp. 20493-20502
    • McCullough, L.D.1    Zeng, Z.2    Li, H.3    Landree, L.E.4    McFadden, J.5    Ronnett, G.V.6
  • 29
  • 30
    • 14644419596 scopus 로고    scopus 로고
    • Aging elevates basal adenosine monophosphate-activated protein kinase (AMPK) activity and eliminates hypoxic activation of AMPK in mouse liver
    • Mulligan, J.D., Gonzalez, A.A., Kumar, R., Davis, A.J., Saupe, K.W., Aging elevates basal adenosine monophosphate-activated protein kinase (AMPK) activity and eliminates hypoxic activation of AMPK in mouse liver. J. Gerontol. A Biol. Sci. Med. Sci. 60 (2005), 21–27, 10.1093/gerona/60.1.21.
    • (2005) J. Gerontol. A Biol. Sci. Med. Sci. , vol.60 , pp. 21-27
    • Mulligan, J.D.1    Gonzalez, A.A.2    Kumar, R.3    Davis, A.J.4    Saupe, K.W.5
  • 31
    • 84951054459 scopus 로고    scopus 로고
    • Purinergic receptors in embryonic and adult neurogenesis
    • Oliveira, Á., Illes, P., Ulrich, H., Purinergic receptors in embryonic and adult neurogenesis. Neuropharmacology 15 (2015), 30131–30133, 10.1016/j.neuropharm.2015.10.008.
    • (2015) Neuropharmacology , vol.15 , pp. 30131-30133
    • Oliveira, Á.1    Illes, P.2    Ulrich, H.3
  • 32
    • 78650589408 scopus 로고    scopus 로고
    • Energy metabolism in adult neural stem cell fate
    • Rafalski, V.A., Brunet, A., Energy metabolism in adult neural stem cell fate. Prog. Neurobiol. 93 (2011), 182–203, 10.1016/j.pneurobio.2010.10.007.
    • (2011) Prog. Neurobiol. , vol.93 , pp. 182-203
    • Rafalski, V.A.1    Brunet, A.2
  • 33
    • 33745215883 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in mitochondrial biogenesis
    • Reznick, R.M., Shulman, G.I., The role of AMP-activated protein kinase in mitochondrial biogenesis. J. Physiol. Lond. 574 (2006), 33–39, 10.1113/jphysiol.2006.109512.
    • (2006) J. Physiol. Lond. , vol.574 , pp. 33-39
    • Reznick, R.M.1    Shulman, G.I.2
  • 34
    • 33846580517 scopus 로고    scopus 로고
    • Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
    • Reznick, R.M., Zong, H., Li, J., Morino, K., Moore, I.K., Yu, H.J., et al. Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab. 5 (2007), 151–156, 10.1016/j.cmet.2007.01.008.
    • (2007) Cell Metab. , vol.5 , pp. 151-156
    • Reznick, R.M.1    Zong, H.2    Li, J.3    Morino, K.4    Moore, I.K.5    Yu, H.J.6
  • 35
    • 33749479230 scopus 로고    scopus 로고
    • AMP-activated protein kinase: role in metabolism and therapeutic implications
    • Schimmack, G., DeFronzo, R.A., Musi, N., AMP-activated protein kinase: role in metabolism and therapeutic implications. Diabetes Obes. Metab. 8 (2006), 591–602, 10.1111/j.1463-1326.2005.00561.x.
    • (2006) Diabetes Obes. Metab. , vol.8 , pp. 591-602
    • Schimmack, G.1    DeFronzo, R.A.2    Musi, N.3
  • 36
    • 68949107216 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons
    • (10.1177/1073858408327805)
    • Spasić, M.R., Callaerts, P., Norga, K.K., AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons. Neuroscientist 15 (2009), 309–316 (10.1177/1073858408327805).
    • (2009) Neuroscientist , vol.15 , pp. 309-316
    • Spasić, M.R.1    Callaerts, P.2    Norga, K.K.3
  • 37
    • 67650914230 scopus 로고    scopus 로고
    • AMPK in health and disease
    • Steinberg, G.R., Kemp, B.E., AMPK in health and disease. Physiol. Rev. 89 (2009), 1025–1078, 10.1152/physrev.00011.2008.
    • (2009) Physiol. Rev. , vol.89 , pp. 1025-1078
    • Steinberg, G.R.1    Kemp, B.E.2
  • 38
    • 67649306717 scopus 로고    scopus 로고
    • Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring
    • Tozuka, Y., Wada, E., Wada, K., Diet-induced obesity in female mice leads to peroxidized lipid accumulations and impairment of hippocampal neurogenesis during the early life of their offspring. FASEB J. 23 (2009), 1920–1934, 10.1096/fj.08-124784.
    • (2009) FASEB J. , vol.23 , pp. 1920-1934
    • Tozuka, Y.1    Wada, E.2    Wada, K.3
  • 39
    • 25444533023 scopus 로고    scopus 로고
    • Exercise enhances learning and hippocampal neurogenesis in aged mice
    • Van Praag, H., Shubert, T., Zhao, C., Gage, F.H., Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 25 (2005), 8680–8685, 10.1523/jneurosci.1731-05.2005.
    • (2005) J. Neurosci. , vol.25 , pp. 8680-8685
    • Van Praag, H.1    Shubert, T.2    Zhao, C.3    Gage, F.H.4
  • 40
    • 0032792665 scopus 로고    scopus 로고
    • AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes
    • Winder, W.W., Hardie, D.G., AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am. J. Phys. 277 (1999), E1–E10.
    • (1999) Am. J. Phys. , vol.277 , pp. E1-E10
    • Winder, W.W.1    Hardie, D.G.2
  • 41
    • 84882752632 scopus 로고    scopus 로고
    • The activation of adenosine monophosphate-activated protein kinase in rat hippocampus contributes to the rapid antidepressant effect of ketamine
    • Xu, S.X., Zhou, Z.Q., Li, X.M., Ji, M.H., Zhang, G.F., Yang, J.J., The activation of adenosine monophosphate-activated protein kinase in rat hippocampus contributes to the rapid antidepressant effect of ketamine. Behav. Brain Res. 253 (2013), 305–309, 10.1016/j.bbr.2013.07.032.
    • (2013) Behav. Brain Res. , vol.253 , pp. 305-309
    • Xu, S.X.1    Zhou, Z.Q.2    Li, X.M.3    Ji, M.H.4    Zhang, G.F.5    Yang, J.J.6
  • 42
    • 84914674938 scopus 로고    scopus 로고
    • Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin
    • Yau, S.Y., Li, A., Hoo, R.L., Ching, Y.P., Christie, B.R., Lee, T.M., et al. Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proc. Natl. Acad. Sci. U. S. A. 111 (2014), 15810–15815, 10.1073/pnas.1415219111.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 15810-15815
    • Yau, S.Y.1    Li, A.2    Hoo, R.L.3    Ching, Y.P.4    Christie, B.R.5    Lee, T.M.6
  • 43
    • 43549095680 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase by kainic acid mediates brain-derived neurotrophic factor expression through a NF-kappaB dependent mechanism in C6 glioma cells
    • Yoon, H., Oh, Y.T., Lee, J.Y., Choi, J.H., Lee, J.H., Baik, H.H., et al. Activation of AMP-activated protein kinase by kainic acid mediates brain-derived neurotrophic factor expression through a NF-kappaB dependent mechanism in C6 glioma cells. Biochem. Biophys. Res. Commun. 371 (2008), 495–500, 10.1016/j.bbrc.2008.04.102.
    • (2008) Biochem. Biophys. Res. Commun. , vol.371 , pp. 495-500
    • Yoon, H.1    Oh, Y.T.2    Lee, J.Y.3    Choi, J.H.4    Lee, J.H.5    Baik, H.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.