The Influence of Hydroxylation on Maintaining CpG Methylation Patterns: A Hidden Markov Model Approach

PLoS Computational Biology

Volumn 12, Issue 5, 2016, Pages

  Giehr, Pascal ^a   Kyriakopoulos, Charalampos ^a   Ficz, Gabriella ^b   Wolf, Verena ^a   Walter, Jörn ^a  

^a UdS   (Germany)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; DNA; HIDDEN MARKOV MODELS; TRELLIS CODES;

DEMETHYLATION; DNA DEMETHYLATION; DNA METHYLATION; DNA METHYLATION PATTERN; DNA REPLICATIONS; EPIGENETIC MEMORY; HIDDEN-MARKOV MODELS; MODELING APPROACH; PATTERN FORMATION; STABLE PATTERNS;

METHYLATION;

5 HYDROXYMETHYL CYTOSINE; 5 METHYL CYTOSINE; CYTOSINE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; UNCLASSIFIED DRUG; 5 METHYLCYTOSINE; 5-HYDROXYMETHYLCYTOSINE; HYDROGEN SULFITE; SULFITE;

ANIMAL CELL; ARTICLE; CELL DIVISION; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; DNA REPLICATION; HIDDEN MARKOV MODEL; HIGH RESOLUTION HAIRPIN OXIDATIVE BISULFITE SEQUENCING; HYDROXYLATION; MOUSE; MOUSE EMBRYONIC STEM CELL; NONHUMAN; OXIDATION; SEQUENCE ANALYSIS; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; EMBRYONIC STEM CELL; MARKOV CHAIN; METABOLISM;

5-METHYLCYTOSINE; ANIMALS; CELL DIVISION; COMPUTATIONAL BIOLOGY; CPG ISLANDS; DNA METHYLATION; DNA REPLICATION; EMBRYONIC STEM CELLS; HYDROXYLATION; MARKOV CHAINS; MICE; MODELS, BIOLOGICAL; STOCHASTIC PROCESSES; SULFITES;

EID: 84975788875     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004905     Document Type: Article

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