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Volumn 70, Issue 2, 2016, Pages 323-331

Extracellular Vesicles and Their Role in Urologic Malignancies

Author keywords

Bladder cancer; Exosomes; Extracellular vesicles; Kidney cancer; Microvesicles; Prostate cancer

Indexed keywords

BIOLOGICAL MARKER; CELL PROTEIN; RNA; TUMOR MARKER;

EID: 84975688004     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2016.02.046     Document Type: Review
Times cited : (82)

References (76)
  • 1
    • 84874355076 scopus 로고    scopus 로고
    • Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies
    • [1] Akers, J.C., Gonda, D., Kim, R., Carter, B.S., Chen, C.C., Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol 113 (2013), 1–11.
    • (2013) J Neurooncol , vol.113 , pp. 1-11
    • Akers, J.C.1    Gonda, D.2    Kim, R.3    Carter, B.S.4    Chen, C.C.5
  • 2
    • 79953243174 scopus 로고    scopus 로고
    • Exosomes as biomarker treasure chests for prostate cancer
    • [2] Duijvesz, D., Luider, T., Bangma, C.H., Jenster, G., Exosomes as biomarker treasure chests for prostate cancer. Eur Urol 59 (2011), 823–831.
    • (2011) Eur Urol , vol.59 , pp. 823-831
    • Duijvesz, D.1    Luider, T.2    Bangma, C.H.3    Jenster, G.4
  • 3
    • 84938826085 scopus 로고    scopus 로고
    • Extracellular vesicles: composition, biological relevance, and methods of study
    • [3] Zaborowski, M.P., Balaj, L., Breakefield, X.O., Lai, C.P., Extracellular vesicles: composition, biological relevance, and methods of study. BioScience 65 (2015), 783–797.
    • (2015) BioScience , vol.65 , pp. 783-797
    • Zaborowski, M.P.1    Balaj, L.2    Breakefield, X.O.3    Lai, C.P.4
  • 4
    • 84955207408 scopus 로고    scopus 로고
    • Recent developments on the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles
    • [4] van der Pol, E., Boing, A.N., Gool, E.L., Nieuwland, R., Recent developments on the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles. J Thromb Haemost 14 (2016), 48–56.
    • (2016) J Thromb Haemost , vol.14 , pp. 48-56
    • van der Pol, E.1    Boing, A.N.2    Gool, E.L.3    Nieuwland, R.4
  • 5
    • 85013222187 scopus 로고    scopus 로고
    • Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles. In press.
    • [5] Witwer KW, Buzás EI, Bemis LT, et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles. In press. http://dx.doi.org/10.3402/jev.v2i0.20360.
    • Witwer, K.W.1    Buzás, E.I.2    Bemis, L.T.3
  • 6
    • 33646146422 scopus 로고    scopus 로고
    • Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
    • [6] Ratajczak, J., Miekus, K., Kucia, M., et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20 (2006), 847–856.
    • (2006) Leukemia , vol.20 , pp. 847-856
    • Ratajczak, J.1    Miekus, K.2    Kucia, M.3
  • 7
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • [7] Valadi, H., Ekstrom, K., Bossios, A., Sjostrand, M., Lee, J.J., Lotvall, J.O., Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9 (2007), 654–659.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 8
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • [8] Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F., Matsuki, Y., Ochiya, T., Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 285 (2010), 17442–17452.
    • (2010) J Biol Chem , vol.285 , pp. 17442-17452
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3    Takeshita, F.4    Matsuki, Y.5    Ochiya, T.6
  • 9
    • 84878665716 scopus 로고    scopus 로고
    • The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
    • [9] Katsuda, T., Kosaka, N., Takeshita, F., Ochiya, T., The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics 13 (2013), 1637–1653.
    • (2013) Proteomics , vol.13 , pp. 1637-1653
    • Katsuda, T.1    Kosaka, N.2    Takeshita, F.3    Ochiya, T.4
  • 10
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • [10] Skog, J., Wurdinger, T., van Rijn, S., et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10 (2008), 1470–1476.
    • (2008) Nat Cell Biol , vol.10 , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    van Rijn, S.3
  • 11
    • 77957037314 scopus 로고    scopus 로고
    • microRNA as a new immune-regulatory agent in breast milk
    • [11] Kosaka, N., Izumi, H., Sekine, K., Ochiya, T., microRNA as a new immune-regulatory agent in breast milk. Silence, 1, 2010, 7.
    • (2010) Silence , vol.1 , pp. 7
    • Kosaka, N.1    Izumi, H.2    Sekine, K.3    Ochiya, T.4
  • 12
    • 84930225521 scopus 로고    scopus 로고
    • In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior
    • [12] Zomer, A., Maynard, C., Verweij, F.J., et al. In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior. Cell 161 (2015), 1046–1057.
    • (2015) Cell , vol.161 , pp. 1046-1057
    • Zomer, A.1    Maynard, C.2    Verweij, F.J.3
  • 13
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • [13] Peinado, H., Aleckovic, M., Lavotshkin, S., et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 18 (2012), 883–891.
    • (2012) Nat Med , vol.18 , pp. 883-891
    • Peinado, H.1    Aleckovic, M.2    Lavotshkin, S.3
  • 14
    • 84875846330 scopus 로고    scopus 로고
    • BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression
    • [14] Roccaro, A.M., Sacco, A., Maiso, P., et al. BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J Clin Invest 123 (2013), 1542–1555.
    • (2013) J Clin Invest , vol.123 , pp. 1542-1555
    • Roccaro, A.M.1    Sacco, A.2    Maiso, P.3
  • 15
    • 84855519096 scopus 로고    scopus 로고
    • Competitive interactions of cancer cells and normal cells via secretory microRNAs
    • [15] Kosaka, N., Iguchi, H., Yoshioka, Y., Hagiwara, K., Takeshita, F., Ochiya, T., Competitive interactions of cancer cells and normal cells via secretory microRNAs. J Biol Chem 287 (2012), 1397–1405.
    • (2012) J Biol Chem , vol.287 , pp. 1397-1405
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3    Hagiwara, K.4    Takeshita, F.5    Ochiya, T.6
  • 16
    • 84903763537 scopus 로고    scopus 로고
    • Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells
    • [16] Ono, M., Kosaka, N., Tominaga, N., et al. Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci Signal, 7, 2014, ra63.
    • (2014) Sci Signal , vol.7 , pp. ra63
    • Ono, M.1    Kosaka, N.2    Tominaga, N.3
  • 17
    • 84857067796 scopus 로고    scopus 로고
    • Soluble serum CD81 is elevated in patients with chronic hepatitis C and correlates with alanine aminotransferase serum activity
    • [17] Welker, M.W., Reichert, D., Susser, S., et al. Soluble serum CD81 is elevated in patients with chronic hepatitis C and correlates with alanine aminotransferase serum activity. PLoS One, 7, 2012, e30796.
    • (2012) PLoS One , vol.7 , pp. e30796
    • Welker, M.W.1    Reichert, D.2    Susser, S.3
  • 18
    • 33746593662 scopus 로고    scopus 로고
    • Alzheimer's disease beta-amyloid peptides are released in association with exosomes
    • [18] Rajendran, L., Honsho, M., Zahn, T.R., et al. Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A 103 (2006), 11172–11177.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11172-11177
    • Rajendran, L.1    Honsho, M.2    Zahn, T.R.3
  • 19
    • 80052760391 scopus 로고    scopus 로고
    • Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage
    • [19] Kuwabara, Y., Ono, K., Horie, T., et al. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ Cardiovasc Genet 4 (2011), 446–454.
    • (2011) Circ Cardiovasc Genet , vol.4 , pp. 446-454
    • Kuwabara, Y.1    Ono, K.2    Horie, T.3
  • 20
    • 84874755851 scopus 로고    scopus 로고
    • Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma
    • [20] Tanaka, Y., Kamohara, H., Kinoshita, K., et al. Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma. Cancer 119 (2013), 1159–1167.
    • (2013) Cancer , vol.119 , pp. 1159-1167
    • Tanaka, Y.1    Kamohara, H.2    Kinoshita, K.3
  • 21
    • 84891372823 scopus 로고    scopus 로고
    • A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy
    • [21] Tian, Y., Li, S., Song, J., et al. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials 35 (2014), 2383–2390.
    • (2014) Biomaterials , vol.35 , pp. 2383-2390
    • Tian, Y.1    Li, S.2    Song, J.3
  • 22
    • 84884935709 scopus 로고    scopus 로고
    • Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors
    • [22] Jang, S.C., Kim, O.Y., Yoon, C.M., et al. Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. ACS Nano 7 (2013), 7698–7710.
    • (2013) ACS Nano , vol.7 , pp. 7698-7710
    • Jang, S.C.1    Kim, O.Y.2    Yoon, C.M.3
  • 23
    • 84899825335 scopus 로고    scopus 로고
    • A comprehensive overview of exosomes as drug delivery vehicles - endogenous nanocarriers for targeted cancer therapy
    • [23] Johnsen, K.B., Gudbergsson, J.M., Skov, M.N., Pilgaard, L., Moos, T., Duroux, M., A comprehensive overview of exosomes as drug delivery vehicles - endogenous nanocarriers for targeted cancer therapy. Biochim Biophys Acta 1846 (2014), 75–87.
    • (2014) Biochim Biophys Acta , vol.1846 , pp. 75-87
    • Johnsen, K.B.1    Gudbergsson, J.M.2    Skov, M.N.3    Pilgaard, L.4    Moos, T.5    Duroux, M.6
  • 24
    • 84864539550 scopus 로고    scopus 로고
    • Exosomes and the emerging field of exosome-based gene therapy
    • [24] O'Loughlin, A.J., Woffindale, C.A., Wood, M.J., Exosomes and the emerging field of exosome-based gene therapy. Curr Gene Ther 12 (2012), 262–274.
    • (2012) Curr Gene Ther , vol.12 , pp. 262-274
    • O'Loughlin, A.J.1    Woffindale, C.A.2    Wood, M.J.3
  • 25
    • 84906098610 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes as immunotherapies in the fight against cancer
    • [25] Pitt, J.M., Charrier, M., Viaud, S., et al. Dendritic cell-derived exosomes as immunotherapies in the fight against cancer. J Immunol 193 (2014), 1006–1011.
    • (2014) J Immunol , vol.193 , pp. 1006-1011
    • Pitt, J.M.1    Charrier, M.2    Viaud, S.3
  • 26
    • 18144369346 scopus 로고    scopus 로고
    • A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
    • [26] Morse, M.A., Garst, J., Osada, T., et al. A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J Transl Med, 3, 2005, 9.
    • (2005) J Transl Med , vol.3 , pp. 9
    • Morse, M.A.1    Garst, J.2    Osada, T.3
  • 27
    • 18144372419 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial
    • [27] Escudier, B., Dorval, T., Chaput, N., et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J Transl Med, 3, 2005, 10.
    • (2005) J Transl Med , vol.3 , pp. 10
    • Escudier, B.1    Dorval, T.2    Chaput, N.3
  • 28
    • 84862734041 scopus 로고    scopus 로고
    • Exosome removal as a therapeutic adjuvant in cancer
    • [28] Marleau, A.M., Chen, C.S., Joyce, J.A., Tullis, R.H., Exosome removal as a therapeutic adjuvant in cancer. J Transl Med, 10, 2012, 134.
    • (2012) J Transl Med , vol.10 , pp. 134
    • Marleau, A.M.1    Chen, C.S.2    Joyce, J.A.3    Tullis, R.H.4
  • 29
    • 84990304468 scopus 로고    scopus 로고
    • Optimized exosome isolation protocol for cell culture supernatant and human plasma. J Extracell Vesicles. In press.
    • [29] Lobb RJ, Becker M, Wen Wen S, et al. Optimized exosome isolation protocol for cell culture supernatant and human plasma. J Extracell Vesicles. In press. http://dx.doi.org/10.3402/jev.v4.27031.
    • Lobb, R.J.1    Becker, M.2
  • 30
    • 84867126923 scopus 로고    scopus 로고
    • Alternative methods for characterization of extracellular vesicles
    • [30] Momen-Heravi, F., Balaj, L., Alian, S., et al. Alternative methods for characterization of extracellular vesicles. Front Physiol, 3, 2012, 354.
    • (2012) Front Physiol , vol.3 , pp. 354
    • Momen-Heravi, F.1    Balaj, L.2    Alian, S.3
  • 31
    • 84949676674 scopus 로고    scopus 로고
    • Prognostic and predictive miRNA biomarkers in bladder, kidney and prostate cancer: where do we stand in biomarker development? J Cancer Res Clin Oncol. In press.
    • [31] Schubert M, Junker K, Heinzelmann J. Prognostic and predictive miRNA biomarkers in bladder, kidney and prostate cancer: where do we stand in biomarker development? J Cancer Res Clin Oncol. In press. http://dx.doi.org/10.1007/s00432-015-2089-9.
    • Schubert, M.1    Junker, K.2    Heinzelmann, J.3
  • 32
    • 84877756603 scopus 로고    scopus 로고
    • Differential protein profiling of renal cell carcinoma urinary exosomes
    • [32] Raimondo, F., Morosi, L., Corbetta, S., et al. Differential protein profiling of renal cell carcinoma urinary exosomes. Mol Biosyst 9 (2013), 1220–1233.
    • (2013) Mol Biosyst , vol.9 , pp. 1220-1233
    • Raimondo, F.1    Morosi, L.2    Corbetta, S.3
  • 33
    • 84858992443 scopus 로고    scopus 로고
    • A hyphenated microLC-Q-TOF-MS platform for exosomal lipidomics investigations: application to RCC urinary exosomes
    • [33] Del Boccio, P., Raimondo, F., Pieragostino, D., et al. A hyphenated microLC-Q-TOF-MS platform for exosomal lipidomics investigations: application to RCC urinary exosomes. Electrophoresis 33 (2012), 689–696.
    • (2012) Electrophoresis , vol.33 , pp. 689-696
    • Del Boccio, P.1    Raimondo, F.2    Pieragostino, D.3
  • 34
    • 84862123012 scopus 로고    scopus 로고
    • Biology of metastatic renal cell carcinoma
    • [34] Milella, M., Felici, A., Biology of metastatic renal cell carcinoma. J Cancer 2 (2011), 369–373.
    • (2011) J Cancer , vol.2 , pp. 369-373
    • Milella, M.1    Felici, A.2
  • 35
    • 84878911644 scopus 로고    scopus 로고
    • The 786-0 renal cancer cell-derived exosomes promote angiogenesis by downregulating the expression of hepatocyte cell adhesion molecule
    • [35] Zhang, L., Wu, X., Luo, C., et al. The 786-0 renal cancer cell-derived exosomes promote angiogenesis by downregulating the expression of hepatocyte cell adhesion molecule. Mol Med Rep 8 (2013), 272–276.
    • (2013) Mol Med Rep , vol.8 , pp. 272-276
    • Zhang, L.1    Wu, X.2    Luo, C.3
  • 36
    • 74549132676 scopus 로고    scopus 로고
    • Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: a novel vaccine for renal cell carcinoma
    • [36] Zhang, Y., Luo, C.L., He, B.C., Zhang, J.M., Cheng, G., Wu, X.H., Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: a novel vaccine for renal cell carcinoma. Int J Oncol 36 (2010), 133–140.
    • (2010) Int J Oncol , vol.36 , pp. 133-140
    • Zhang, Y.1    Luo, C.L.2    He, B.C.3    Zhang, J.M.4    Cheng, G.5    Wu, X.H.6
  • 37
    • 84918815052 scopus 로고    scopus 로고
    • Improved vaccine efficacy of tumor exosome compared to tumor lysate loaded dendritic cells in mice
    • [37] Gu, X., Erb, U., Buchler, M.W., Zoller, M., Improved vaccine efficacy of tumor exosome compared to tumor lysate loaded dendritic cells in mice. Int J Cancer 136 (2015), E74–E84.
    • (2015) Int J Cancer , vol.136 , pp. E74-E84
    • Gu, X.1    Erb, U.2    Buchler, M.W.3    Zoller, M.4
  • 38
    • 84921395983 scopus 로고    scopus 로고
    • Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3
    • [38] Diao, J., Yang, X., Song, X., et al. Exosomal Hsp70 mediates immunosuppressive activity of the myeloid-derived suppressor cells via phosphorylation of Stat3. Med Oncol, 32, 2015, 453.
    • (2015) Med Oncol , vol.32 , pp. 453
    • Diao, J.1    Yang, X.2    Song, X.3
  • 39
    • 84904385898 scopus 로고    scopus 로고
    • Renal tumor-derived exosomes inhibit hepaCAM expression of renal carcinoma cells in a p-AKT-dependent manner
    • [39] Jiang, X.L., Zhang, Y., Tan, B., Luo, C.L., Wu, X.H., Renal tumor-derived exosomes inhibit hepaCAM expression of renal carcinoma cells in a p-AKT-dependent manner. Neoplasma 61 (2014), 416–423.
    • (2014) Neoplasma , vol.61 , pp. 416-423
    • Jiang, X.L.1    Zhang, Y.2    Tan, B.3    Luo, C.L.4    Wu, X.H.5
  • 40
    • 54049126940 scopus 로고    scopus 로고
    • Identification of a tumor-initiating stem cell population in human renal carcinomas
    • [40] Bussolati, B., Bruno, S., Grange, C., Ferrando, U., Camussi, G., Identification of a tumor-initiating stem cell population in human renal carcinomas. FASEB J 22 (2008), 3696–3705.
    • (2008) FASEB J , vol.22 , pp. 3696-3705
    • Bussolati, B.1    Bruno, S.2    Grange, C.3    Ferrando, U.4    Camussi, G.5
  • 41
    • 79960960417 scopus 로고    scopus 로고
    • Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche
    • [41] Grange, C., Tapparo, M., Collino, F., et al. Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Cancer Res 71 (2011), 5346–5356.
    • (2011) Cancer Res , vol.71 , pp. 5346-5356
    • Grange, C.1    Tapparo, M.2    Collino, F.3
  • 42
    • 84928381096 scopus 로고    scopus 로고
    • Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells
    • [42] Lindoso, R.S., Collino, F., Camussi, G., Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells. Oncotarget 6 (2015), 7959–7969.
    • (2015) Oncotarget , vol.6 , pp. 7959-7969
    • Lindoso, R.S.1    Collino, F.2    Camussi, G.3
  • 43
    • 84900384847 scopus 로고    scopus 로고
    • Microvesicles derived from human Wharton's jelly mesenchymal stem cells promote human renal cancer cell growth and aggressiveness through induction of hepatocyte growth factor
    • [43] Du, T., Ju, G., Wu, S., et al. Microvesicles derived from human Wharton's jelly mesenchymal stem cells promote human renal cancer cell growth and aggressiveness through induction of hepatocyte growth factor. PLoS One, 9, 2014, e96836.
    • (2014) PLoS One , vol.9 , pp. e96836
    • Du, T.1    Ju, G.2    Wu, S.3
  • 44
    • 84870936601 scopus 로고    scopus 로고
    • Comparative and targeted proteomic analyses of urinary microparticles from bladder cancer and hernia patients
    • [44] Chen, C.L., Lai, Y.F., Tang, P., et al. Comparative and targeted proteomic analyses of urinary microparticles from bladder cancer and hernia patients. J Proteome Res 11 (2012), 5611–5629.
    • (2012) J Proteome Res , vol.11 , pp. 5611-5629
    • Chen, C.L.1    Lai, Y.F.2    Tang, P.3
  • 45
    • 77953161017 scopus 로고    scopus 로고
    • Proteomics analysis of bladder cancer exosomes
    • [45] Welton, J.L., Khanna, S., Giles, P.J., et al. Proteomics analysis of bladder cancer exosomes. Mol Cell Proteomics 9 (2010), 1324–1338.
    • (2010) Mol Cell Proteomics , vol.9 , pp. 1324-1338
    • Welton, J.L.1    Khanna, S.2    Giles, P.J.3
  • 46
    • 84895744810 scopus 로고    scopus 로고
    • Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors
    • [46] Jeppesen, D.K., Nawrocki, A., Jensen, S.G., et al. Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors. Proteomics 14 (2014), 699–712.
    • (2014) Proteomics , vol.14 , pp. 699-712
    • Jeppesen, D.K.1    Nawrocki, A.2    Jensen, S.G.3
  • 47
    • 84959887679 scopus 로고    scopus 로고
    • MicroRNA expression profiling in bladder cancer: the challenge of next generation sequencing in tissues and biofluids
    • [47] Matullo, G., Naccarati, A., Pardini, B., MicroRNA expression profiling in bladder cancer: the challenge of next generation sequencing in tissues and biofluids. Int J Cancer 138 (2016), 2334–2345.
    • (2016) Int J Cancer , vol.138 , pp. 2334-2345
    • Matullo, G.1    Naccarati, A.2    Pardini, B.3
  • 48
    • 84947440462 scopus 로고    scopus 로고
    • MicroRNA molecular profiling from matched tumor and bio-fluids in bladder cancer
    • [48] Armstrong, D.A., Green, B.B., Seigne, J.D., Schned, A.R., Marsit, C.J., MicroRNA molecular profiling from matched tumor and bio-fluids in bladder cancer. Mol Cancer, 14, 2015, 194.
    • (2015) Mol Cancer , vol.14 , pp. 194
    • Armstrong, D.A.1    Green, B.B.2    Seigne, J.D.3    Schned, A.R.4    Marsit, C.J.5
  • 49
    • 84958214273 scopus 로고    scopus 로고
    • Expression of the long non-coding RNA HOTAIR correlates with disease progression in bladder cancer and is contained in bladder cancer patient urinary exosomes
    • [49] Berrondo, C., Flax, J., Kucherov, V., et al. Expression of the long non-coding RNA HOTAIR correlates with disease progression in bladder cancer and is contained in bladder cancer patient urinary exosomes. PLoS One, 11, 2016, e0147236.
    • (2016) PLoS One , vol.11 , pp. e0147236
    • Berrondo, C.1    Flax, J.2    Kucherov, V.3
  • 50
    • 84904253489 scopus 로고    scopus 로고
    • Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression
    • [50] Beckham, C.J., Olsen, J., Yin, P.N., et al. Bladder cancer exosomes contain EDIL-3/Del1 and facilitate cancer progression. J Urol 192 (2014), 583–592.
    • (2014) J Urol , vol.192 , pp. 583-592
    • Beckham, C.J.1    Olsen, J.2    Yin, P.N.3
  • 51
    • 79952115930 scopus 로고    scopus 로고
    • Exosomes derived form bladder transitional cell carcinoma cells induce CTL cytotoxicity in vitro [in Chinese]
    • [51] Zhang, J.M., Wu, X.H., Zhang, Y., Xia, Y.G., Luo, C.L., Exosomes derived form bladder transitional cell carcinoma cells induce CTL cytotoxicity in vitro [in Chinese]. Zhonghua Zhong Liu Za Zhi 31 (2009), 738–741.
    • (2009) Zhonghua Zhong Liu Za Zhi , vol.31 , pp. 738-741
    • Zhang, J.M.1    Wu, X.H.2    Zhang, Y.3    Xia, Y.G.4    Luo, C.L.5
  • 52
    • 84883412245 scopus 로고    scopus 로고
    • Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro
    • [52] Yang, L., Wu, X.H., Wang, D., Luo, C.L., Chen, L.X., Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro. Mol Med Rep 8 (2013), 1272–1278.
    • (2013) Mol Med Rep , vol.8 , pp. 1272-1278
    • Yang, L.1    Wu, X.H.2    Wang, D.3    Luo, C.L.4    Chen, L.X.5
  • 53
    • 84991017501 scopus 로고    scopus 로고
    • Urothelial cells undergo epithelial-to-mesenchymal transition after exposure to muscle invasive bladder cancer exosomes
    • [53] Franzen, C.A., Blackwell, R.H., Todorovic, V., et al. Urothelial cells undergo epithelial-to-mesenchymal transition after exposure to muscle invasive bladder cancer exosomes. Oncogenesis, 4, 2015, e163.
    • (2015) Oncogenesis , vol.4 , pp. e163
    • Franzen, C.A.1    Blackwell, R.H.2    Todorovic, V.3
  • 54
    • 84908139770 scopus 로고    scopus 로고
    • Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties
    • [54] Ostenfeld, M.S., Jeppesen, D.K., Laurberg, J.R., et al. Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties. Cancer Res 74 (2014), 5758–5771.
    • (2014) Cancer Res , vol.74 , pp. 5758-5771
    • Ostenfeld, M.S.1    Jeppesen, D.K.2    Laurberg, J.R.3
  • 55
    • 84929649283 scopus 로고    scopus 로고
    • Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles
    • [55] Minciacchi, V.R., You, S., Spinelli, C., et al. Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles. Oncotarget 6 (2015), 11327–11341.
    • (2015) Oncotarget , vol.6 , pp. 11327-11341
    • Minciacchi, V.R.1    You, S.2    Spinelli, C.3
  • 56
    • 84940467558 scopus 로고    scopus 로고
    • Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel
    • [56] Kharaziha, P., Chioureas, D., Rutishauser, D., et al. Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. Oncotarget 6 (2015), 21740–21754.
    • (2015) Oncotarget , vol.6 , pp. 21740-21754
    • Kharaziha, P.1    Chioureas, D.2    Rutishauser, D.3
  • 57
    • 84894235330 scopus 로고    scopus 로고
    • Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer
    • [57] Duijvesz, D., Burnum-Johnson, K.E., Gritsenko, M.A., et al. Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer. PLoS One, 8, 2013, e82589.
    • (2013) PLoS One , vol.8 , pp. e82589
    • Duijvesz, D.1    Burnum-Johnson, K.E.2    Gritsenko, M.A.3
  • 58
    • 84927573946 scopus 로고    scopus 로고
    • The emerging role of extracellular vesicles as biomarkers for urogenital cancers
    • [58] Nawaz, M., Camussi, G., Valadi, H., et al. The emerging role of extracellular vesicles as biomarkers for urogenital cancers. Nat Rev Urol 11 (2014), 688–701.
    • (2014) Nat Rev Urol , vol.11 , pp. 688-701
    • Nawaz, M.1    Camussi, G.2    Valadi, H.3
  • 59
    • 79957673695 scopus 로고    scopus 로고
    • Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer
    • [59] Tavoosidana, G., Ronquist, G., Darmanis, S., et al. Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer. Proc Natl Acad Sci U S A 108 (2011), 8809–8814.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 8809-8814
    • Tavoosidana, G.1    Ronquist, G.2    Darmanis, S.3
  • 60
    • 84943662969 scopus 로고    scopus 로고
    • Immuno-based detection of extracellular vesicles in urine as diagnostic marker for prostate cancer
    • [60] Duijvesz, D., Versluis, C.Y., van der Fels, C.A., et al. Immuno-based detection of extracellular vesicles in urine as diagnostic marker for prostate cancer. Int J Cancer 137 (2015), 2869–2878.
    • (2015) Int J Cancer , vol.137 , pp. 2869-2878
    • Duijvesz, D.1    Versluis, C.Y.2    van der Fels, C.A.3
  • 61
    • 84898440450 scopus 로고    scopus 로고
    • Prostate cancer biomarker profiles in urinary sediments and exosomes
    • [61] Dijkstra, S., Birker, I.L., Smit, F.P., et al. Prostate cancer biomarker profiles in urinary sediments and exosomes. J Urol 191 (2014), 1132–1138.
    • (2014) J Urol , vol.191 , pp. 1132-1138
    • Dijkstra, S.1    Birker, I.L.2    Smit, F.P.3
  • 62
    • 84947034977 scopus 로고    scopus 로고
    • A molecular signature of PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result
    • [62] Donovan, M.J., Noerholm, M., Bentink, S., et al. A molecular signature of PCA3 and ERG exosomal RNA from non-DRE urine is predictive of initial prostate biopsy result. Prostate Cancer Prostatic Dis 18 (2015), 370–375.
    • (2015) Prostate Cancer Prostatic Dis , vol.18 , pp. 370-375
    • Donovan, M.J.1    Noerholm, M.2    Bentink, S.3
  • 63
    • 84924372715 scopus 로고    scopus 로고
    • Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer
    • [63] Huang, X., Yuan, T., Liang, M., et al. Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer. Eur Urol 67 (2015), 33–41.
    • (2015) Eur Urol , vol.67 , pp. 33-41
    • Huang, X.1    Yuan, T.2    Liang, M.3
  • 65
    • 84856812332 scopus 로고    scopus 로고
    • Changes in circulating microRNA levels associated with prostate cancer
    • [65] Bryant, R.J., Pawlowski, T., Catto, J.W., et al. Changes in circulating microRNA levels associated with prostate cancer. Br J Cancer 106 (2012), 768–774.
    • (2012) Br J Cancer , vol.106 , pp. 768-774
    • Bryant, R.J.1    Pawlowski, T.2    Catto, J.W.3
  • 66
    • 84906334565 scopus 로고    scopus 로고
    • Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: apoptotic bodies, microvesicles, and exosomes
    • [66] Lazaro-Ibanez, E., Sanz-Garcia, A., Visakorpi, T., et al. Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: apoptotic bodies, microvesicles, and exosomes. Prostate 74 (2014), 1379–1390.
    • (2014) Prostate , vol.74 , pp. 1379-1390
    • Lazaro-Ibanez, E.1    Sanz-Garcia, A.2    Visakorpi, T.3
  • 67
    • 84993261360 scopus 로고    scopus 로고
    • van Moorselaar RJ, Jimenez CR. Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. J Extracell Vesicles. In press.
    • [67] Bijnsdorp IV, Geldof AA, Lavaei M, Piersma SR, van Moorselaar RJ, Jimenez CR. Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. J Extracell Vesicles. In press. http://dx.doi.org/10.3402/jev.v2i0.22097.
    • Bijnsdorp, I.V.1    Geldof, A.A.2    Lavaei, M.3    Piersma, S.R.4
  • 68
    • 84925446437 scopus 로고    scopus 로고
    • Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes
    • [68] Webber, J.P., Spary, L.K., Sanders, A.J., et al. Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene 34 (2015), 290–302.
    • (2015) Oncogene , vol.34 , pp. 290-302
    • Webber, J.P.1    Spary, L.K.2    Sanders, A.J.3
  • 69
    • 84870911785 scopus 로고    scopus 로고
    • Docetaxel-resistance in prostate cancer: evaluating associated phenotypic changes and potential for resistance transfer via exosomes
    • [69] Corcoran, C., Rani, S., O'Brien, K., et al. Docetaxel-resistance in prostate cancer: evaluating associated phenotypic changes and potential for resistance transfer via exosomes. PLoS One, 7, 2012, e50999.
    • (2012) PLoS One , vol.7 , pp. e50999
    • Corcoran, C.1    Rani, S.2    O'Brien, K.3
  • 70
    • 59149083102 scopus 로고    scopus 로고
    • Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis
    • [70] Castellana, D., Zobairi, F., Martinez, M.C., et al. Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis. Cancer Res 69 (2009), 785–793.
    • (2009) Cancer Res , vol.69 , pp. 785-793
    • Castellana, D.1    Zobairi, F.2    Martinez, M.C.3
  • 71
    • 84871343406 scopus 로고    scopus 로고
    • Microvesicles released from hormone-refractory prostate cancer cells facilitate mouse pre-osteoblast differentiation
    • [71] Itoh, T., Ito, Y., Ohtsuki, Y., et al. Microvesicles released from hormone-refractory prostate cancer cells facilitate mouse pre-osteoblast differentiation. J Mol Histol 43 (2012), 509–515.
    • (2012) J Mol Histol , vol.43 , pp. 509-515
    • Itoh, T.1    Ito, Y.2    Ohtsuki, Y.3
  • 72
    • 84931033158 scopus 로고    scopus 로고
    • Prostate tumor-derived exosomes down-regulate NKG2D expression on natural killer cells and CD8+ T cells: mechanism of immune evasion
    • [72] Lundholm, M., Schroder, M., Nagaeva, O., et al. Prostate tumor-derived exosomes down-regulate NKG2D expression on natural killer cells and CD8+ T cells: mechanism of immune evasion. PLoS One, 9, 2014, e108925.
    • (2014) PLoS One , vol.9 , pp. e108925
    • Lundholm, M.1    Schroder, M.2    Nagaeva, O.3
  • 73
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2
    • [73] Clayton, A., Mitchell, J.P., Court, J., Mason, M.D., Tabi, Z., Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res 67 (2007), 7458–7466.
    • (2007) Cancer Res , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 74
    • 79960959598 scopus 로고    scopus 로고
    • Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy
    • [74] Rountree, R.B., Mandl, S.J., Nachtwey, J.M., et al. Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy. Cancer Res 71 (2011), 5235–5244.
    • (2011) Cancer Res , vol.71 , pp. 5235-5244
    • Rountree, R.B.1    Mandl, S.J.2    Nachtwey, J.M.3
  • 75
    • 79952115112 scopus 로고    scopus 로고
    • The application of exosomes as a nanoscale cancer vaccine
    • [75] Tan, A., De La Pena, H., Seifalian, A.M., The application of exosomes as a nanoscale cancer vaccine. Int J Nanomedicine 5 (2010), 889–900.
    • (2010) Int J Nanomedicine , vol.5 , pp. 889-900
    • Tan, A.1    De La Pena, H.2    Seifalian, A.M.3
  • 76
    • 84940467327 scopus 로고    scopus 로고
    • Serum exosomal P-glycoprotein is a potential marker to diagnose docetaxel resistance and select a taxoid for patients with prostate cancer
    • 385 e15–20
    • [76] Kato, T., Mizutani, K., Kameyama, K., et al. Serum exosomal P-glycoprotein is a potential marker to diagnose docetaxel resistance and select a taxoid for patients with prostate cancer. Urol Oncol, 33, 2015 385 e15–20.
    • (2015) Urol Oncol , vol.33
    • Kato, T.1    Mizutani, K.2    Kameyama, K.3


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