Renal tumor-derived exosomes inhibit hepaCAM expression of renal carcinoma cells in a p-AKT-dependent manner

Neoplasma

Volumn 61, Issue 4, 2014, Pages 416-423

  Jiang, X L ^a   Zhang, Y ^a   Tan, B ^a   Luo, C L ^a   Wu, X H ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Exosomes; HepaCAM; p AKT; Renal cancer

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL) PHENYL] 9 PHENYL 1, 2, 4 TRIAZOLO [3, 4 F] [1, 6] NAPHTHYRIDIN 3 (2H) ONE; CELL ADHESION MOLECULE; HEAT SHOCK PROTEIN 70; HEPATIC AND GLIAL CELL ADHESION MOLECULE; INTERCELLULAR ADHESION MOLECULE 1; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; CANCER STAGING; CELL CYCLE; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; EXOSOME; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MTT ASSAY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; WESTERN BLOTTING;

AGED; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, RENAL CELL; CELL CYCLE; CELL PROLIFERATION; EXOSOMES; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; KIDNEY NEOPLASMS; LYMPHATIC METASTASIS; MALE; NEOPLASM GRADING; NEOPLASM STAGING; PHOSPHORYLATION; PROGNOSIS; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 84904385898     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/neo_2014_051     Document Type: Article

References (23)

1. JEMAL A, SIEGEL R, WARD E, HAO Y, XU J, et al. Cancer statistics, 2009. CA Cancer J Clin 2009; 59: 225-249. http://dx.doi.org/10.3322/caac.20006
2. McDermott D.F. Update on the application of interleukin-2 in the treatment of renal cell carcinoma. Clin Cancer Res 2007; 13: 716s-720s. http://dx.doi.org/10.1158/1078-0432.CCR-06-1872
3. CHUNG MOH M, HOON LEE L, SHEN S. Cloning and characterization of hepacam, a novel ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma. J Hepatol 2005; 42: 833-841. http://dx.doi.org/10.1016/j.jhep.2005.01.025
4. MOH MC, ZHANG T, LEE LH, SHEN S. Expression of hepacam is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells. Carcinogenesis 2008; 29: 2298-2305. http://dx.doi.org/10.1093/carcin/bgn226
5. ZHANG QL, LUO CL, WU XH, WANG CY, XU X, et al. Hepacam induces g1 phase arrest and promotes c-myc degradation in human renal cell carcinoma. J Cell Biochem 2011; 112: 2910-2919. http://dx.doi.org/10.1002/jcb.23207
6. CLAYTON A, MITCHELL JP, COURT J, MASON MD, TABI Z. Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res 2007; 67: 7458-7466. http://dx.doi.org/10.1158/0008-5472.CAN-06-3456
7. VALENTI R, HUBER V, FILIPAZZI P, PILLA L, SOVENA G, et al. Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on t lymphocytes. Cancer Res 2006; 66: 9290-9298. http://dx.doi.org/10.1158/0008-5472.CAN-06-1819
8. KIM JW, WIECKOWSKI E, TAYLOR DD, REICHERT TE, WATKINS S, et al. Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated t lymphocytes. Clin Cancer Res 2005;11:1010-1020.
9. TAYLOR DD, GERCEL-TAYLOR C, LYONS KS, STANSON J, WHITESIDE TL. T-cell apoptosis and suppression of t-cell receptor/cd3-zeta by fas ligand-containing membrane vesicles shed from ovarian tumors. Clin Cancer Res 2003; 9: 5113-5119.
10. QU JL, QU XJ, ZHAO MF, TENG YE, ZHANG Y, et al. Gastric cancer exosomes promote tumor cell proliferation through pi3k/akt and mapk/erk activation. Dig Liver Dis 2009; 41: 875-880.http://dx.doi.org/10.1016/j.dld.2009.04.006
11. DATTA SR, BRUNET A, GREENBERG ME. Cellular survival: A play in three akts. Genes Dev 1999;13: 2905-2927. http://dx.doi.org/10.1101/gad.13.22.2905
12. XUN C, LUO C, WU X, ZHANG Q, YAN L, et al. Expression of hepacam and its effect on proliferation of tumor cells in renal cell carcinoma. Urology 2010; 75: 828-834. http://dx.doi.org/10.1016/j.urology.2009.11.024
13. HE Y, WU X, LUO C, WANG L, LIN J. Functional significance of the hepacam gene in bladder cancer. BMC cancer 2010; 10: 83. http://dx.doi.org/10.1186/1471-2407-10-83
14. ZHANG Y, LUO CL, HE BC, ZHANG JM, CHENG G, et al. Exosomes derived from il-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: A novel vaccine for renal cell carcinoma. Int J Oncol 2010; 36: 133-140.
15. ABDELNOUR BERCHTOLD E, CERANTOLA Y, ROULIN D, DORMOND-MEUWLY A, DEMARTINES N, et al. Ra-pamycin-mediated foxo1 inactivation reduces the anticancer efficacy of rapamycin. Anticancer Res 2010; 30: 799-804.
16. LEE HJ, SEO HS, KIM GJ, JEON CY, PARK JH, et al. Houttuy-nia cordata thunb inhibits the production of proinflammatory cytokines through inhibition of the nfkappab signaling path-way in hmc1 human mast cells. Molecular medicine reports 2013; 8: 731-736.
17. PAN C, WU X, LUO C, YANG S, PU J, et al. Exon 2 methylation inhibits hepacam expression in transitional cell carcinoma of the bladder. Urol Int 2010; 85: 347-354. http://dx.doi.org/10.1159/000318889
18. DOWNWARD J. Pi 3-kinase, akt and cell survival. Semin Cell Dev Biol 2004; 15: 177-182. http://dx.doi.org/10.1016/j.semcdb.2004.01.002
19. DAVID O, JETT J, LEBEAU H, DY G, HUGHES J, et al. Phospho-akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvan-tage. Clin Cancer Res 2004; 10: 6865-6871. http://dx.doi.org/10.1158/1078-0432.CCR-04-0174
20. HAGER M, HAUFE H, KEMMERLING R, HITZL W, MIKUZ G, et al. Increased activated akt expression in renal cell carcinomas and prognosis. J Cell Mol Med 2009; 13: 2181-2188. http://dx.doi.org/10.1111/j.1582-4934.2008.00488.x
21. BINION DG, HEIDEMANN J, LI MS, NELSON VM, OTTERSON MF, et al. Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by pi 3-kinase/akt/mapk/nf-kappab: In-hibitory role of curcumin. Am J Physiol Gastrointest Liver Physiol 2009; 297: G259-268. http://dx.doi.org/10.1152/ajpgi.00087.2009
22. OH JH, KWON TK. Withaferin a inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules by inactivation of akt and nf-kappab in human pulmonary epithelial cells. Int Immunopharmacol 2009; 9: 614-619. http://dx.doi.org/10.1016/j.intimp.2009.02.002
23. HOWARD S, BERDINI V, BOULSTRIDGE JA, CARR MG, CROSS DM, et al. Fragment-based discovery of the pyra-zol-4-yl urea (at9283), a multitargeted kinase inhibitor with potent aurora kinase activity. J Med Chem 2009; 52: 379-388. http://dx.doi.org/10.1021/jm800984v