Anti-ulcer mechanisms of polyphenols extract of Euphorbia umbellata (Pax) Bruyns (Euphorbiaceae)

Journal of Ethnopharmacology

Volumn 191, Issue , 2016, Pages 29-40

  Minozzo, Bruno Rodrigo ^a   Lemes, Bruna Mikulis ^a   Justo, Aline Da Silva ^a   Lara, Jheniffer Ellen ^a   Petry, Victor Emanuel Kubaski ^a   Fernandes, Daniel ^a   Belló, Caroline ^a   Vellosa, José Carlos Rebuglio ^a   Campagnoli, Eduardo Bauml ^a   Nunes, Otalíbio Castiglione ^b   Kitagawa, Rodrigo Rezende ^b   Avula, Bharathi ^c   Khan, Ikhlas Ahmad ^c   Beltrame, Flávio Luis ^a  

^a STATE UNIVERSITY OF PONTA GROSSA   (Brazil)

^b FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Anti ulcer; Antioxidant; Glutathione; Nitric oxide; Phenolic compounds; Prostaglandins

Indexed keywords

2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); ALCOHOL; ANTIINFECTIVE AGENT; ANTIOXIDANT; ANTIULCER AGENT; CYCLIC GMP; EUPHORBIA UMBELLATA EXTRACT; INDOMETACIN; NITRIC OXIDE; POLYPHENOL DERIVATIVE; PROSTAGLANDIN; RANITIDINE; UNCLASSIFIED DRUG; 2,2'-AZINO-DI-(3-ETHYLBENZOTHIAZOLINE)-6-SULFONIC ACID; BENZOTHIAZOLE DERIVATIVE; ELLAGIC ACID; FLAVONOL DERIVATIVE; GALLIC ACID; METHANOL; PLANT EXTRACT; POLYPHENOL; SOLVENT; SULFONIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; ANTIULCER ACTIVITY; ARTICLE; BARK; CHEMICAL ANALYSIS; CONTROLLED STUDY; EUPHORBIA; EUPHORBIA UMBELLATA; FEMALE; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; RAT; STOMACH; STOMACH LESION; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; ETHNOPHARMACOLOGY; HELICOBACTER PYLORI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; PATHOLOGY; PHYTOTHERAPY; SIGNAL TRANSDUCTION; STOMACH ULCER; WISTAR RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-ULCER AGENTS; ANTIOXIDANTS; BENZOTHIAZOLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELLAGIC ACID; ETHANOL; ETHNOPHARMACOLOGY; EUPHORBIA; FEMALE; FLAVONOLS; GALLIC ACID; HELICOBACTER PYLORI; INDOMETHACIN; METHANOL; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; PLANTS, MEDICINAL; POLYPHENOLS; RATS, WISTAR; SIGNAL TRANSDUCTION; SOLVENTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STOMACH; STOMACH ULCER; SULFONIC ACIDS;

EID: 84975473532     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.06.032     Document Type: Article

References (73)

1. H. Aebi Catalase in vitro Methods Enzymol. 105 1984 121 126
2. M. Amin, F. Anwar, F. Naz, T. Mehmood, and N. Saari Anti-Helicobacter pylori and urease inhibition activities of some traditional medicinal plants Molecules 18 2013 2135 2139
3. A.S. Awaad, N.A. Al-Jaber, J.E. Moses, R.M. El-Meligy, and M.R. Zain Antiulcerogenic activities of the extracts and isolated flavonoids of Euphorbia cuneata Vahl Phytother. Res. 27 2013 126 130
4. R. Begum, B. Aslam, I. Javed, T. Khaliq, F. Muhammad, and A. Raza Gastroprotective and antioxidant effect of Euphorbia prostrata against indomethacin induced gastric ulcers in healthy adult male albino rabbits Int. Res. J. Pharm. 5 2014 846 850
5. A.M.S.S. Beserra, P.I. Calegari, M.C. Souza, R.A.N. Santos, J.C.S. Lima, R.M. Silva, S.O. Balogun, and D.T.O. Martins Gastroprotective and ulcer-healing mechanisms of ellagic acid in experimental rats J. Agric. Food Chem. 59 2011 6957 6965
6. R. Borges, M.V.M. Nascimento, A.A.V. Carvalho, M.C. Valadares, J.R. Paula, E.A. Costa, and L.C. Cunha Antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum Pax. (Euphorbiaceae) leaves and its fractions Evid. Based Complement. Altern. 2013 2013 1 9
7. G.F.R. Caldas, A.R.S. Oliveira, A.V. Araújo, S.S.L. Lafayette, G.S. Albuquerque, J.C. Silva-Neto, J.H. Costa-Silva, F. Ferreira, J.G.M. Costa, and A.G. Wanderley Gastroprotective mechanisms of the monoterpene 1,8-cineole (eucalyptol) PLoS One 10 2015 1 17
8. C. Carrasco-Pozo, H. Speisky, O. Brunser, E. Pastene, and M. Gotteland Apple peel polyphenols protect against gastrointestinal mucosa alterations induced by indomethacin in rats J. Agri. Food Chem. 59 2011 6459 6466
9. F.K.L. Chan, and W.K. Leung Peptic-ulcer disease Lancet 360 2002 933 941
10. Clinical and Laboratory Standards Institute (CLSI) Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically 2003 CLSI Wayne, PA [document M07- A6]
11. K.W. Cordeiro, L.A. Pinto, A.S.N. Formagio, S.F. Andrade, C.A.L. Kassuya, and K.C. Freitas Antiulcerogenic effect of Croton urucurana Baillon bark J. Ethnopharmacol. 143 2012 331 337
12. V.D. Corleto, S. Festa, E. Di Giulio, and B. Annibale Proton pump inhibitor therapy and potential long-term harm Curr. Opin. Endocrinol. Diabetes Obes. 21 2014 3 8
13. L.L.G. Costa, V.C. David, R.M.C. Pinto, B.R. Minozzo, V.A. Kozlowski Junior, L.A. Campos, R.Z. Silva, and F.L. Beltrame Anti-ulcer activity of Synadenium grantii latex Bras. J. Farmacogn. 22 2012 1070 1078
14. M. Costa, V.F. Ximenes, and L.M. Fonseca Hypochlorous acid inhibition by acetoacetate: implications on neutrophil functions Biol. Pharm. Bull. 27 2004 1183 1187
15. S. DalBó, S. Goulart, H. Horst, M.G. Pizzolatti, and R.M. Ribeiro-do-Valle Activation of endothelial nitric oxide synthase by proanthocyanidin-rich fraction from Croton celtidifolius (Euphorbiaceae): involvement of extracellular calcium influx in rat thoracic aorta J. Pharmacol. Sci. 107 2008 181 189
16. C.T. Dillon, T.W. Hambley, B.J. Kennedy, P.A. Lay, Q. Zhou, N.M. Davies, J.R. Biffin, and H.L. Regtop Gastrointestinal toxicity, antiinflammatory activity, and superoxide dismutase activity of copper and zinc complexes of the antiinflammatory drug indomethacin Chem. Res. Toxicol. 16 2003 28 37
17. G.L. Ellman Tissue sulphydryl groups Arch. Biochem. Biophys. 589 1959 70 77
18. M.H. Farzaei, M. Abdollahi, and R. Rahimi Role of dietary polyphenols in the management of peptic ulcer World J. Gastroenterol. 21 2015 6499 6517
19. FDA News Release, 2012. FDA approves first anti-diarrheal drug for HIV/AIDS patients. U.S. Food and Drug Administration. Available at: (http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm333701.htm).
20. G. Gadamsetty, S. Maru, A. Tyagi, and S.N. Chakravarthula Anti-inflammatory, cytotoxic and antioxidant effects of methanolic extracts of Drypetes sepiaria (Euphorbiaceae) Afr. J. Tradit. Complement. Altern. Med. 12 2013 274 282
21. E.M. Galati, M.R. Mondello, D. Giuffrida, G. Dugo, N. Miceli, S. Pergolizzi, and M.F. Taviano Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) Mill. fruit juice: antioxidant and antiulcerogenic activity J. Agric. Food Chem. 51 2003 4903 4908
22. M.B. Grisham, M.M. Jefferson, and E.L. Thomas Chlorination of endogenous amines by isolated neutrophil. Ammonia-dependent bactericidal, cytotoxic, and cytolytic activities of the chloramines J. Biol. Chem. 259 1984 10404 10413
23. M. Guslandi Effects of ethanol on the gastric mucosa Dig. Dis. Sci. 5 1987 21 32
24. Y. Hamauzu, T. Inno, C. Kume, M. Iriem, and K. Hiramatsu Antioxidant and antiulcerative properties of phenolic from Chinese quince, quince, and apple fruits J. Agric. Food Chem. 54 2006 765 772
25. I.U. Haq, N. Ullah, G. Bibi, S. Kanwal, M.S. Ahmad, and B. Mirza Antioxidant and cytotoxic activities and phytochemical analysis of Euphorbia wallichii root extract and its fractions Iran. J. Pharm. Res. 11 2012 241 249
26. L. Hayden, G. Thomas, and G.B. West Inhibitors of gastric lesions in the rat J. Pharm. Pharmacol. 30 1978 244 246
27. L. Jakobek Interactions of polyphenols with carbohydrates, lipids and proteins Food Chem. 175 2015 556 567
28. F.E.B. Júnior, D.R. Oliveira, A.A. Boligon, M.L. Athayde, J.P. Kamdem, G.E. Macedo, G.F. Silva, I.R.A. Menezes, J.G.M. Costa, H.D.M. Coutinho, M.R. Kerntopf, and T. Posser Protective effects of Croton campestris A. St-Hill in different ulcer models in rodent: evidence for the involvement of nitric oxide and prostaglandins J. Ethnopharmacol. 153 2014 469 477
29. S. Kato, M. Umeda, M. Takeeda, K. Kanatsu, and K. Takeuchi Effect of taurine on ulcerogenic response and impaired ulcer healing induced by monochloramine in rat stomachs Aliment. Pharmacol. Ther. 16 2002 35 43
30. S. Khennouf, H. Benabdallah, K. Gharzouli, S. Amira, H. Ito, T. Kim, T. Yoshida, and A. Gharzouli Effect of tannins from Quercus suber and Quercus coccifera leaves on ethanol-induced gastric lesions in mice J. Agric. Food Chem. 51 2003 1469 1473
31. M.M. Khattab, M.Z. Gad, and D. Abdallah Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion Pharmacol. Res. 43 2001 463 467
32. A.D. Kinghorn Major skin-irritant principle from Synadenium grantii J. Pharm. Sci. 69 1980 1446 1447
33. R.R. Kitagawa, C. Bonacorsi, L.M. Fonseca, W. Vilegas, and M.S.G. Raddi Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes Bras. J. Farmacogn. 22 2012 53 59
34. F. Klamt, and E. Schacter Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human b lymphoma cells through mitochondrial damage J. Biol. Chem. 280 2005 21346 21352
35. L.C. Klein-Júnior, J.R. Santin, R. Niero, S.F. Andrade, and V. Cechinel-Filho The therapeutic lead potencial of metabolites obtained from natural sources for the treatment of peptic ulcer Phytochem. Rev. 11 2012 567 616
36. I. Kobayashi, K. Murakami, M. Kato, S. Kato, T. Azuma, S. Takahashi, N. Uemura, T. Katsuyama, Y. Fukuda, K. Haruma, M. Nasu, and T. Fujioka Changing antimicrobial susceptibility epidemiology of Helicobacter pylori strains in Japan between 2002 and 2005 J. Clin. Microbiol. 45 2007 4006 4010
37. P. Malfertheiner, F.K.L. Chan, and K.E.L. McColl Peptic ulcer disease Lancet 374 2009 1449 1461
38. H. Matsuda, Y. Li, and M. Yoshikawa Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats Life Sci. 65 1999 27 32
39. T. Matsuhashi, M. Otaka, M. Odashima, M. Jin, K. Komatsu, I. Wada, Y. Horikawa, R. Ohba, J. Oyake, N. Hatakeyama, and S. Watanabe Protective effect of a novel rice extract against ethanol-induced gastric mucosal injury in rat Dig. Dis. Sci. 52 2007 434 441
40. L.V. Modolo, A.X. Souza, L.P. Horta, D.P. Araujo, and A. Fátima An overview on the potential of natural products as urease inhibitors: a review J. Adv. Res. 6 2015 35 44
41. M.H. Moghadasian, and D.V. Godin Ethanol-induced gastrointestinal damage: influence of endogenous antioxidant components and gender Dig. Dis. Sci. 41 1996 791 797
42. A.C.M. Munhoz, B.R. Minozzo, L.S. Cruz, T.L. Oliveira, W.M. Machado, A.V. Pererira, D. Fernandes, F.A. Manente, J.C.R. Vellosa, A. Nepel, A. Barison, and F.L. Beltrame Chemical and pharmacological investigation of the stem bark of Synadenium grantii Planta Med. 80 2014 458 464
43. B. Munro, Q.V. Vuong, A.C. Chalmers, C.D. Goldsmith, M.C. Bowyer, and C.J. Scarllet Phytochemical, antioxidant and anti-cancer properties of Euphorbia tirucalli methanolic and aqueous extracts Antioxidants 4 2015 647 661
44. D.J. Newman, and G.M. Cragg Natural products as sources of new drugs over the 30 years from 1981 to 2010 J. Nat. Prod. 75 2012 311 335
45. I.A.L. Nogueira, A.B.B. Leão, M.S. Vieira, P.L. Benfica, L.C. Cunha, and M.C. Valadares Antitumoral and antiangiogenic activity of Synadenium umbellatum Pax J. Ethnopharmacol. 120 2012 474 478
46. P.I. Ohlson, and K.G. Paul The molar absorptivity of horseradish peroxidase Acta Chem. Scan. B 31 1976 373 375
47. B.I. Okeleye, P.O. Bessong, and R.N. Ndip Preliminary phytochemical screening and in vitro anti-Helicobacter pylori activity of extracts of the stem bark of Bridelia micrantha (Hochst., Baill., Euphorbiaceae) Molecules 16 2011 6193 6205
48. E. Pastene, M. Troncoso, G. Figueroa, J. Alarcón, and H. Speisky Association between polymerization degree of apple peel polyphenols and inhibition of Helicobacter pylori urease J. Agric. Food Chem. 57 2009 416 424
49. N. Pellegrini, R. Ke, M. Yang, and C. Rice-Evans Screening of dietary carotenoids and carotenoid-rich fruit extracts for antioxidant activities applying 2,2′-Azinobis(3-ethylenebenzothiazoline-6-sulfonic acid) radical cation decolorization assay Method. Enzymol. 299 1998 379 389
50. +ATPase and gastric mucosa carbonic anhydrase enzyme in humans (in vitro and in vivo experiments) J. Pharmacol. Exp. Ther. 290 1999 530 534
51. K. Rathnakumar, R. Verma, S. Jaikumar, and S. Sengottuvelu Antiulcer activity of Euphorbia hirta against experimentally induced ulcer in rats Int. J. Pharm. Biol. Chem. Sci. 3 2013 16 20
52. B. Reyes-Trejo, M.E. Sáncehz-Mendoza, A.A. Becerra-García, E. Cedillo-Portugal, C. Catillo-Henkel, and J. Arrieta Bioassay-guided isolation of an anti-ulcer diterpenoid from Croton reflexifolius: role of nitric-oxide, prostaglandins and sulfhydryls J. Pharm. Pharmacol. 60 2008 931 936
53. J. Robak, and R.J. Gryglewski Flavonoids are scavengers of superoxide anions Biochem. Pharmacol. 37 1988 837 841
54. A.L. Rozza, T.M. Moraes, H. Kushima, D.S. Nunes, C.A. Hiruma-Lima, and C.H. Pellizzon Involvement of glutathione, sulfhydryl compounds, nitric oxide, vasoactive intestinal peptide, and heat-shock protein-70 in the gastroprotective mechanism of Croton cajucara Benth. (Euphorbiaceae) essential oil J. Med. Food 14 2011 1011 1017
55. T. Sangma, S. Jain, and P. Mediratta Effect of ovarian sex hormones on non-steroidal anti-inflammatory drug-induced gastric lesions in female rats Indian J. Pharmacol. 46 2014 113 116
56. J. Sedlak, and R.H. Lindsay Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal. Biochem. 25 1968 192 205
57. V. Sharma, P. Janmeda, R. Paliwal, and S. Sharma Antihepatotoxic activity of Euphorbia neriifolia extract against N-nitrosodiethylamine-induced hepatocarcinogenesis in mice J. Chin. Integr. Med. 10 2012 1303 1309
58. K. Shetty, and R.G. Labbe Food-borne pathogens, health and role of dietary phytochemicals Asia Pac. J. Clin. Nutr. 7 1998 270 276
59. A.T. Shimoyama, J.R. Santin, I.D. Machado, A.M.O. Silva, I.L.P. Melo, J. Mancini-Filho, and S.H.P. Farsky Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer Naunyn-Schmiede.'s. Arch. Pharm. 386 2013 5 14
60. +-ATPase and Helicobacter pylori growth by phenolic antioxidants of Curcuma amada J. Agri. Food Chem. 55 2007 7377 7386
61. L.P. Silva, C.D. Angelis, F. Bonamin, H. Kushima, F.J. Mininel, L.C. Santos, F.K. Dellela, S.L. Felisbino, W. Vilegas, L.R.M. Rocha, M.A.S. Ramos, T.M. Bauab, W. Toma, and C.A. Hiruma-Lima Terminalia catappa L.: a medicinal plant from the Caribbean pharmacopeia with anti-Helicobater pylori and antiulcer action in experimental rodent models J. Ethnopharmacol. 159 2015 285 295
62. J.R. Soares, T.C. Dinis, A.P. Cunha, and L.M. Almeida Antioxidant activities of some extracts of Thymuszygis Free Radic. Res. 26 1997 469 478
63. G. Sreenika, K.N. Sravanthi, B.V.S. Lakshmi, P. Thulja, and M. Sudhakar Antioxidant and antitumor activity of Euphorbia milli flower extract against in vivo breast cancer and colon cancer in mice World J. Pharm. Pharma. Sci. 4 2015 912 934
64. S. Szabo, and A. Brown Prevention of ethanol-induced vascular injury and gastric mucosal lesions by sucralfate and its components: possible role of endogenous sulfhydryls Proc. Soc. Exp. Biol. Med. 4 1987 493 497
65. S. Szabo, J.S. Trier, and P.W. Frankel Sulfhydryl compounds may mediate gastric cytoprotection Science 9 1981 200 202
66. S.M. Tabei, S. Fakher, M. Djalali, M.H. Javanbakht, M. Zarei, H. Derakhshanian, M.R. Sadeghi, E. Mostafavi, and F. Kargar Effect of vitamins A, E, C and omega-3 fatty acids supplementation on the level of catalase and superoxide dismutase activities in streptozotocin-induced diabetic rats BratislLekListy 116 2015 115 118
67. T. Tanaka, M. Kawase, and S. Tani Urease inhibitory activity of simple α, β-unsaturated ketones Life Sci. 73 2003 2985 2990
68. 2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells Investig. Ophthalmol. Vis. Sci. 36 1995 1271 1279
69. S.M.L. Vasconcelos, M.O.F. Goulart, J.B.F. Moura, V. Manfredini, M.S. Benfato, and L.T. Kubota Reactive oxygen and nitrogen species, antioxidants and markers of oxidative damage in human blood: main analytical methods for their determination Quim. Nova. 30 2007 1323 1338
70. J.L. Wallace Prostaglandins, NSAIDs, and gastric mucosal protection: why does not the stomach digest itself? Physiol. Rev. 88 2008 1547 1565
71. D.L. Weeks, and G. Sachs Sites of pH regulation of the urea channel of Helicobacter pylori Molec. Microbiol. 40 2001 1249 1259
72. World Health Organization (WHO), 2011. The World Traditional Medicines Situation, in Traditional medicines: Global Situation, Issues and Challenges, Geneva. 3, pp. 1-14
73. Y. Yuan, I.T. Padol, and R.H. Hunt Peptic ulcer disease today Nat. Clin. Pract. Gastroenterol. 3 2006 80 90