Angiotensin-(1-7) improves oxygenation, while reducing cellular infiltrate and fibrosis in experimental Acute Respiratory Distress Syndrome

Intensive Care Medicine Experimental

Volumn 3, Issue 1, 2015, Pages 1-17

  Zambelli, Vanessa ^a   Bellani, Giacomo ^a,b   Borsa, Roberto ^a   Pozzi, Federico ^a   Grassi, Alice ^a   Scanziani, Margherita ^a   Castiglioni, Vittoria ^c   Masson, Serge ^d   Decio, Alessandra ^d   Laffey, John G ^e,f   Latini, Roberto ^d   Pesenti, Antonio ^a,b  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

^c Mouse and Animal Pathology Lab   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e ST MICHAEL'S HOSPITAL   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

Angiotensin (1 7); ARDS; Renin angiotensin system

Indexed keywords

ANGIOTENSIN[1-7]; COLLAGEN;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL GAS; ARTICLE; BLOOD GAS ANALYSIS; BLOOD OXYGEN TENSION; CELL INFILTRATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; HISTOLOGY; HISTOPATHOLOGY; LEUKOCYTE COUNT; LUNG FIBROSIS; LUNG INJURY; LUNG LAVAGE; MALE; NONHUMAN; OXYGEN SATURATION; PNEUMONIA; PRIORITY JOURNAL; RAT;

EID: 84975464977     PISSN: None     EISSN: 2197425X     Source Type: Journal    
DOI: 10.1186/s40635-015-0044-3     Document Type: Article

References (44)

1. Frank AJ, Thompson BT (2010) Pharmacological treatments for acute respiratory distress syndrome. Curr Opin Crit Care 16:62–68
2. Dreyfuss D, Saumon G (1998) Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 157:294–323
3. Suzuki Y, Ruiz-Ortega M, Lorenzo O, Reperez M, Esteban V, Egido J (2003) Inflammation and angiotensin II. Int J Biochem Cell Biol 35:881–900
4. Marshall RP, Gohlke P, Chambers RC, Howell DC, Bottoms SE, Unger T, McAnulty RJ, Laurent GJ (2004) Angiotensin II and the fibroproliferative response to acute lung injury. Am J Physiol Lung Cell Mol Physiol 286:L156–L164
5. Simoes e Silva AC, Silveira KD, Ferreira AJ, Teixeira MM. ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis (2013) Br J Pharmacol 169:477-492
6. Marshall RP, Webb S, Bellingan GJ, Montgomery HE, Chaudhari B, McAnulty RJ, Humphries SE, Hill MR, Laurent GJ (2002) Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Resp Crit Care Med 166:646–650
7. Cambien F, Alhenc-Gelas F, Herberth B, Andre JL, Rakotovao R, Gonzales MF, Allegrini J, Bloch C (1988) Familial resemblance of plasma angiotensin-converting enzyme level: the Nancy Study. Am J Hum Genet 43:774–780
8. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F (1990) An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86:1343–1346
9. Jerng JS, Yu CJ, Wang HC, Chen KY, Cheng SL, Yang PC (2006) Polymorphism of the angiotensin-converting enzyme gene affects the outcome of acute respiratory distress syndrome. Crit Care Med 34:1001–1006
10. Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P (2002) Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem 277:14838–14843
11. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S (2000) A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 87:E1–E9
12. Bader M (2013) ACE2, angiotensin-(1-7), and Mas: the other side of the coin. Pflugers Arch 465:79–85
13. Zambelli V, Grassi A, Bellani G (2012) Role of the Renin-Angiotensin System in ARDS. In: Vincent JL (ed) Yearbook of intensive care and emergency medicine. Springer, Berlin
14. Benter IF, Diz DI, Ferrario CM (1993) Cardiovascular actions of angiotensin(1-7). Peptides 14:679–684
15. Tallant EA, Diz DI, Ferrario CM (1999) State-of-the-Art lecture. Antiproliferative actions of angiotensin-(1-7) in vascular smooth muscle. Hypertension 34:950–957
16. Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ (2007) Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). Am J Physiol Heart Circ Physiol 292:H736–H742
17. da Silveira KD, Coelho FM, Vieira AT, Sachs D, Barroso LC, Costa VV, Bretas TL, Bader M, de Sousa LP, da Silva TA, dos Santos RA, Simões e Silva AC, Teixeira MM (2010) Anti-inflammatory effects of the activation of the angiotensin-(1-7) receptor, MAS, in experimental models of arthritis. J Immunol 185:5569–5576
18. Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, Crackower MA, Fukamizu A, Hui CC, Hein L, Uhlig S, Slutsky AS, Jiang C, Penninger JM (2005) Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature 436:112–116
19. Passos-Silva DG, Verano-Braga T, Santos RA (2013) Angiotensin-(1-7): beyond the cardio-renal actions. Clin Sci (Lond) 124:443–456
20. Shah A, Oh YB, Lee SH, Lim JM, Kim SH (2012) Angiotensin-(1-7) attenuates hypertension in exercise-trained renal hypertensive rats. Am J Physiol Heart Circ Physiol 302:H2372–H2380
21. Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM (2007) Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res 75:29–39
22. Lubel JS, Herath CB, Tchongue J, Grace J, Jia Z, Spencer K, Casley D, Crowley P, Sievert W, Burrell LM, Angus PW (2009) Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat. Clin Sci (Lond) 117:375–386
23. Shenoy V, Ferreira AJ, Qi Y, Fraga-Silva RA, Díez-Freire C, Dooies A, Jun JY, Sriramula S, Mariappan N, Pourang D, Venugopal CS, Francis J, Reudelhuber T, Santos RA, Patel JM, Raizada MK, Katovich MJ (2010) The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension. Am J Respir Crit Care Med 182:1065–1072
24. Klein N, Gembardt F, Supé S, Kaestle SM, Nickles H, Erfinanda L, Lei X, Yin J, Wang L, Mertens M, Szaszi K, Walther T, Kuebler WM (2013) Angiotensin-(1-7) protects from experimental acute lung injury. Crit Care Med 41:e334–e343
25. Cabrera-Benitez NE, Laffey JG, Parotto M, Spieth PM, Villar J, Zhang H, Slutsky AS (2014) Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome. Anesthesiology [Epub ahead of print]
26. Amigoni M, Bellani G, Scanziani M, Masson S, Bertoli E, Radaelli E, Patroniti N, Di Lelio A, Pesenti A, Latini R (2008) Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization. Anesthesiology 108:1037–1046
27. Amigoni M, Bellani G, Zambelli V, Scanziani M, Farina F, Fagnani L, Latini R, Fumagalli R, Pesenti A (2013) Unilateral acid aspiration augments the effects of ventilator lung injury also in the controlateral lung. Anesthesiology 119:642–651
28. Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM, Acute Lung Injury in Animals Study Group (2011) An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol 44:725–738
29. Kuiper JW, Plötz FB, Groeneveld AJ, Haitsma JJ, Jothy S, Vaschetto R, Zhang H, Slutsky AS (2011) High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study. BMC Anesthesiol 11:26
30. Silva DM, Vianna HR, Cortes SF, Campagnole-Santos MJ, Santos RA, Lemos VS (2007) Evidence for a new angiotensin-(1-7) receptor subtype in the aorta of Sprague-Dawley rats. Peptides 28:702–707
31. Rodgers KE, Oliver J, diZerega GS (2006) Phase I/II dose escalation study of angiotensin 1-7 [A(1-7)] administered before and after chemotherapy in patients with newly diagnosed breast cancer. Cancer Chemoter Pharmacol 57:559–568
32. Barroso LC, Silveira KD, Lima CX, Borges V, Bader M, Rachid M, Santos RA, Souza DG, Simões E, Silva AC, Teixeira MM (2012) Renoprotective effects of AVE0991, a nonpeptide Mas receptor agonist, in experimental acute renal injury. Int J Hypertens 2012:808726
33. Arndt PG, Young SK, Poch KR, Nick JA, Falk S, Schrier RW, Worthen GS (2006) Systemic inhibition of the angiotensin-converting enzyme limits lipopolysaccharide-induced lung neutrophil recruitment through both bradykinin and angiotensin II-regulated pathways. J Immunol 177:7233–7241
34. Sampaio WO, Souza dos Santos RA, Faria-Silva R, da Mata Machado LT, Schiffrin EL, Touyz RM (2007) Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension 49:185–192
35. Peiró C, Vallejo S, Gembardt F, Azcutia V, Heringer-Walther S, Rodríguez-Mañas L, Schultheiss HP, Sánchez-Ferrer CF, Walther T (2007) Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function. J Hypertens 25:2421–2425
36. Roman A, Legallo R, McGahren ED (2004) Blocking of endogenous nitric oxide increases white blood cell accumulation in rat lung. J Pediatr Surg 39:48–52
37. Dilauro M, Burns KD (2009) Angiotensin-(1-7) and its effects in the kidney. ScientificWorldJournal 9:522–535
38. Chen Q, Yang Y, Huang Y, Pan C, Liu L, Qiu H (2013) Angiotensin-(1-7) attenuates lung fibrosis by way of Mas receptor in acute lung injury. J Surg Res 185:740–747
39. Meng Y, Yu CH, Li W, Luo W, Huang S, Wu PS, Cai SX, Li X (2014) Angiotensin-converting enzyme 2/Angiotensin-(1-7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-kB pathway. Am J Respir Cell Mol Biol 50:723–736
40. Zambelli V, Di Grigoli G, Scanziani M, Valtorta S, Amigoni M, Belloli S, Messa C, Pesenti A, Fazio F, Bellani G, Moresco RM (2012) Time course of metabolic activity and cellular infiltration in a murine model of acid-induced lung injury. Intensive Care Med 38:694–701
41. Jones HA, Schofield J, Krausz T, Boobis A, Haslett C (1998) Pulmonary fibrosis correlates with duration of tissue neutrophil activation. Am J Respir Crit Care Med 158:620–628
42. Shen L, Mo H, Cai L, Kong T, Zheng W, Ye J, Qi J, Xiao Z (2009) Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases. Shock 31:500–506
43. Raiden S, Nahmod K, Nahmod V, Semeniuk G, Pereira Y, Alvarez C, Giordano M, Geffner JR (2002) Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome. J Pharmacol Exp Ther 303:45–51
44. Wösten-van Asperen RM, Lutter R, Specht PA, Moll GN, van Woensel JB, van der Loos CM, van Goor H, Kamilic J, Florquin S, Bos AP (2011) Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1–7) or an angiotensin II receptor antagonist. J Pathol 225:618–627