Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist

Journal of Pathology

Volumn 225, Issue 4, 2011, Pages 618-627

  Wösten Van Asperen, Roelie M ^a   Lutter, René ^b   Specht, Patricia A ^c   Moll, Gert N ^d   Van Woensel, Job B ^a   Van Der Loos, Chris M ^b   Van Goor, Harry ^e   Kamilic, Jelena ^e   Florquin, Sandrine ^b   Bos, Albert P ^a  

^a EMMA CHILDREN S HOSPITAL   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d Technology Foundation   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

acute lung injury; angiotensin II; angiotensin (1 7); cytokines

Indexed keywords

ANGIOTENSIN ANTAGONIST; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN RECEPTOR; ANGIOTENSIN[1-7] ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE; LIPOPOLYSACCHARIDE; LOSARTAN; PLACEBO; UNCLASSIFIED DRUG;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; LUNG INJURY; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

ANGIOTENSIN I; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; INTUBATION, INTRATRACHEAL; LIPOPOLYSACCHARIDES; LOSARTAN; LUNG; MACROPHAGES, ALVEOLAR; MALE; PEPTIDE FRAGMENTS; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 81355146424     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2987     Document Type: Article

References (39)

1. Ware LB, Matthay MA,. The acute respiratory distress syndrome. N Engl J Med 2000; 342: 1334-1349.
2. Wheeler AP, Bernard GR,. Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet 2007; 369: 1553-1564.
3. Rubenfeld GD, Herridge MS,. Epidemiology and outcomes of acute lung injury. Chest 2007; 131: 554-562.
4. Phua J, Badia JR, Adhikari NK, et al., Has mortality from acute respiratory distress syndrome decreased over time? A systematic review. Am J Respir Crit Care Med 2009; 179: 220-227.
5. Matute-Bello G, Frevert CW, Martin TR,. Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol 2008; 295: L379-L399.
6. Idell S, Kueppers F, Lippmann M, et al., Angiotensin converting enzyme in bronchoalveolar lavage in ARDS. Chest 1987; 91: 52-56.
7. Jerng JS, Yu CJ, Wang HC, et al., Polymorphism of the angiotensin-converting enzyme gene affects the outcome of acute respiratory distress syndrome. Crit Care Med 2006; 34: 1001-1006.
8. Marshall RP, Webb S, Bellingan GJ, et al., Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Respir Crit Care Med 2002; 166: 646-650.
9. Baudin B,. New aspects on angiotensin-converting enzyme: from gene to disease. Clin Chem Lab Med 2002; 40: 256-265.
10. Suzuki Y, Ruiz-Ortega M, Lorenzo O, et al., Inflammation and angiotensin II. Int J Biochem Cell Biol 2003; 35: 881-900.
11. Wang R, Zagariya A, Ibarra-Sunga O, et al., Angiotensin II induces apoptosis in human and rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 1999; 276: L885-L889.
12. Wösten-van Asperen RM, Lutter R, Haitsma JJ, et al., ACE mediates ventilator-induced lung injury in rats via angiotensin II but not bradykinin. Eur Respir J 2008; 31: 363-371.
13. Li X, Rayford H, Uhal BD,. Essential roles for angiotensin receptor AT1a in bleomycin-induced apoptosis and lung fibrosis in mice. Am J Pathol 2003; 163: 2523-2530.
14. Hagiwara S, Iwasaka H, Matumoto S, et al., Effects of an angiotensin-converting enzyme inhibitor on the inflammatory response in in vivo and in vitro models. Crit Care Med 2009; 37: 626-633.
15. Wösten-van Asperen RM, Lutter R, Specht PA, et al., Ventilator-induced inflammatory response in LPS-exposed rat lung is mediated by angiotensin-converting enzyme. Am J Pathol 2010; 176: 2219-2227.
16. Imai Y, Kuba K, Rao S, et al., Angiotensin-converting enzyme 2 protects from severe acute lung injury. Nature 2005; 436: 112-116.
17. Donoghue M, Hsieh F, Baronas E, et al., A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 2000; 87: E1-E9.
18. Tipnis SR, Hooper NM, Hyde R, et al., A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 2000; 275: 33238-33243.
19. Gallagher PE, Ferrario CM, Tallant EA,. Regulation of ACE2 in cardiac myocytes and fibroblasts. Am J Physiol Heart Circ Physiol 2008; 295: H2373-H2379.
20. Su Z, Zimpelmann J, Burns KD,. Angiotensin-(1-7) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells. Kidney Int 2006; 69: 2212-2218.
21. Jerng JS, Hsu YC, Wu HD, et al., Role of the renin-angiotensin system in ventilator-induced lung injury: an in vivo study in a rat model. Thorax 2007; 62: 527-535.
22. Vickers C, Hales P, Kaushik V, et al., Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase (ACE-2). J Biol Chem 2002; 277: 14838-14843.
23. Wysocki J, Ye M, Soler MJ, et al., ACE and ACE2 activity in diabetic mice. Diabetes 2006; 55: 2132-2139.
24. Bligh EG, Dyer WJ,. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37: 911-917.
25. Kluskens LD, Nelemans SA, Rink R, et al., Angiotensin-(1-7) with thioether bridge: an angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog. J Pharmacol Exp Ther 2009; 328: 849-854.
26. Becker LK, Etelvino GM, Santos RA, et al., Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain. Am J Physiol Heart Circ Physiol 2007; 293: H1416-H1424.
27. van der Loos CM,. Multiple immunoenzyme staining: methods and visualizations for the observation with spectral imaging. J Histochem Cytochem 2008; 56: 313-328.
28. van der Loos CM,. Chromogens in multiple immunohistochemical staining used for visual assessment and spectral imaging: the colourful future. J Histotechnol 2010; 33: 31-40.
29. van der Loos CM, Teeling P,. A general applicable sequential alkaline phosphatase immunohistochemical double staining. J Histotechnol 2008; 31: 119-127.
30. Allred AJ, Diz DI, Ferrario CM, et al., Pathways for angiotensin-(1-7) metabolism in pulmonary and renal tissue. Am J Physiol Renal Physiol 2000; 279: F841-F850.
31. Thorley AJ, Ford PA, Giembycz MA, et al., Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages. J Immunol 2007; 178: 436-473.
32. Grobe JL, Mecca AP, Lingis M, et al., Prevention of angiotensin II-induced cardiac remodelling by angiotensin-(1-7). Am J Physiol Heart Circ Physiol 2007; 292: H736-H742.
33. Mercure C, Yogi A, Callera GE, et al., Angiotensin (1-7) blunts hypertensive cardiac remodelling by a direct effect on the heart. Circ Res 2008; 103: 1319-1326.
34. Pereira RM, Dos Santos RA, Teixeira MM, et al., The renin-angiotensin system in a rat model of hepatic fibrosis: evidence for a protective role of angiotensin-(1-7). J Hepatol 2007; 46: 674-681.
35. Li X, Molina-Molina M, Abdul-Hafez A, et al., Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2008; 295: L178-L185.
36. Wang R, Zagariya A, Ang E, et al., Fas-induced apoptosis of alveolar epithelial cells requires Ang II generation and receptor interaction. Am J Physiol Lung Cell Mol Physiol 1999; 277: L1245-L1250.
37. Li X, Molina-Molina M, Abdul-Hafez A, et al., Extravascular sources of lung angiotesin peptide synthesis in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Phsyiol 2006; 291: L887-L895.
38. Renzoni EA, Abraham DJ, Howat S, et al., Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts. Respir Res 2004; 5: 24.
39. Uhal BD, Kim JK, Li X, et al., Angiotensin-TGF-β1 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myofibroblasts and macrophages. Curr Pharm Des 2007; 13: 1247-1256.