Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat

Clinical Science

Volumn 117, Issue 11, 2009, Pages 375-386

  Lubel, John S ^a,b   Herath, Chandana B ^a   Tchongue, Jorge ^c   Grace, Josephine ^a,b   Jia, Zhiyuan ^a   Spencer, Karen ^a   Casley, David ^a   Crowley, Peter ^b   Sievert, William ^c   Burrell, Louise M ^a   Angus, Peter W ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b AUSTIN HOSPITAL   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Angiotensin (1 7); Angiotensin converting enzyme; Cirrhosis; Hepatic fibrosis; Renin angiotensin system

Indexed keywords

ALDOSTERONE; ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; ANGIOTENSIN[1-7]; ANGIOTENSIN[1-7][7 DEXTRO ALANINE]; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; DIPEPTIDYL CARBOXYPEPTIDASE; HYDROXYPROLINE; N ETHYLCARBAMOYL 3 [4 (5 FORMYL 4 METHOXY 2 PHENYL 1 IMIDAZOLYLMETHYL)PHENYL] 5 ISOBUTYL 2 THIOPHENESULFONAMIDE; RENIN; VASCULOTROPIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BLOOD LEVEL; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE MODEL; DRUG TARGETING; HEPATITIS C; HISTOCHEMISTRY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SEQUENCE HOMOLOGY; STELLATE CELL; UPREGULATION;

ACTINS; ADULT; ANGIOTENSIN I; ANGIOTENSIN II; ANIMALS; BILE DUCTS; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; FEMALE; HEPATITIS C, CHRONIC; HUMANS; HYDROXYPROLINE; LIVER; LIVER CIRRHOSIS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RENIN; RENIN-ANGIOTENSIN SYSTEM; RNA, MESSENGER; UP-REGULATION;

EID: 67651192493     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20080647     Document Type: Article

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