-
1
-
-
84902975772
-
Phototransformable fluorescent proteins: Future challenges
-
Adam, V., Berardozzi, R., Byrdin, M., and Bourgeois, D. (2014). Phototransformable fluorescent proteins: future challenges. Curr. Opin. Chem. Biol. 20, 92-102. doi: 10.1016/j.cbpa.2014.05.016
-
(2014)
Curr. Opin. Chem. Biol.
, vol.20
, pp. 92-102
-
-
Adam, V.1
Berardozzi, R.2
Byrdin, M.3
Bourgeois, D.4
-
2
-
-
0035947372
-
Impairment of the ubiquitinproteasome system by protein aggregation
-
Bence, N. F., Sampat, R. M., and Kopito, R. R. (2001). Impairment of the ubiquitinproteasome system by protein aggregation. Science 292, 1552-1555. doi: 10. 1126/science.292.5521.1552
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
3
-
-
65249181587
-
The ubiquitinproteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington’s disease
-
Bett, J. S., Cook, C., Petrucelli, L., and Bates, G. P. (2009). The ubiquitinproteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington’s disease. PLoS One 4: e5128. doi: 10. 1371/journal.pone.0005128
-
(2009)
PLoS One
, vol.4
, pp. 5128
-
-
Bett, J.S.1
Cook, C.2
Petrucelli, L.3
Bates, G.P.4
-
4
-
-
84898814706
-
Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A
-
Bhat, K. P., Yan, S., Wang, C. E., Li, S., and Li, X. J. (2014). Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A. Proc. Natl. Acad. Sci. U S A 111, 5706-5711. doi: 10.1073/pnas.1402215111
-
(2014)
Proc. Natl. Acad. Sci. U S A
, vol.111
, pp. 5706-5711
-
-
Bhat, K.P.1
Yan, S.2
Wang, C.E.3
Li, S.4
Li, X.J.5
-
5
-
-
34548181882
-
Tracking intracellular protein movements using photoswitchable fluorescent proteins PS-CFP2 and Dendra2
-
Chudakov, D. M., Lukyanov, S., and Lukyanov, K. A. (2007). Tracking intracellular protein movements using photoswitchable fluorescent proteins PS-CFP2 and Dendra2. Nat. Protoc. 2, 2024-2032. doi: 10.1038/nprot.2007.291
-
(2007)
Nat. Protoc.
, vol.2
, pp. 2024-2032
-
-
Chudakov, D.M.1
Lukyanov, S.2
Lukyanov, K.A.3
-
6
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., et al. (1997). Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537-548. doi: 10.1016/s0092-8674(00)80513-9
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
DiFiglia, M.4
Sharp, A.H.5
Ross, C.A.6
-
7
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J. P., et al. (1997). Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990-1993. doi: 10.1126/science.277. 5334.1990
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
DiFiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
-
8
-
-
0033119123
-
Nuclear and neuropil aggregates in Huntington’s disease: Relationship to neuropathology
-
Gutekunst, C. A., Li, S. H., Yi, H., Mulroy, J. S., Kuemmerle, S., Jones, R., et al. (1999). Nuclear and neuropil aggregates in Huntington’s disease: relationship to neuropathology. J. Neurosci. 19, 2522-2534. doi: 10.1093/hmg/8.7.1227
-
(1999)
J. Neurosci.
, vol.19
, pp. 2522-2534
-
-
Gutekunst, C.A.1
Li, S.H.2
Yi, H.3
Mulroy, J.S.4
Kuemmerle, S.5
Jones, R.6
-
9
-
-
84884567375
-
Expanded polyglutamine-containing N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes
-
Juenemann, K., Schipper-Krom, S., Wiemhoefer, A., Kloss, A., Sanz Sanz, A., and Reits, E. A. (2013). Expanded polyglutamine-containing N-terminal huntingtin fragments are entirely degraded by mammalian proteasomes. J. Biol. Chem. 288, 27068-27084. doi: 10.1074/jbc.M113.486076
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 27068-27084
-
-
Juenemann, K.1
Schipper-Krom, S.2
Wiemhoefer, A.3
Kloss, A.4
Sanz Sanz, A.5
Reits, E.A.6
-
10
-
-
1242338856
-
Huntingtin-protein interactions and the pathogenesis of Huntington’s disease
-
Li, S. H., and Li, X. J. (2004). Huntingtin-protein interactions and the pathogenesis of Huntington’s disease. Trends Genet. 20, 146-154. doi: 10.1016/j.tig.2004. 01.008
-
(2004)
Trends Genet.
, vol.20
, pp. 146-154
-
-
Li, S.H.1
Li, X.J.2
-
11
-
-
0035503511
-
Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington’s disease mice
-
Li, H., Li, S. H., Yu, Z. X., Shelbourne, P. F., and Li, X. J. (2001). Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington’s disease mice. J. Neurosci. 21, 8473-8481.
-
(2001)
J. Neurosci.
, vol.21
, pp. 8473-8481
-
-
Li, H.1
Li, S.H.2
Yu, Z.X.3
Shelbourne, P.F.4
Li, X.J.5
-
12
-
-
0035862896
-
Neurological abnormalities in a knock-in mouse model of Huntington’s disease
-
Lin, C. H., Tallaksen-Greene, S., Chien, W. M., Cearley, J. A., Jackson, W. S., Crouse, A. B., et al. (2001). Neurological abnormalities in a knock-in mouse model of Huntington’s disease. Hum. Mol. Genet. 10, 137-144. doi: 10. 1093/hmg/10.2.137
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 137-144
-
-
Lin, C.H.1
Tallaksen-Greene, S.2
Chien, W.M.3
Cearley, J.A.4
Jackson, W.S.5
Crouse, A.B.6
-
13
-
-
77951665859
-
Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease
-
Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., et al. (2010). Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease. Nat. Neurosci. 13, 567-576. doi: 10.1038/nn.2528
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 567-576
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Wong, E.3
Tang, G.4
Koga, H.5
Kaushik, S.6
-
14
-
-
2342485108
-
Proteasome degrades soluble expanded polyglutamine completely and efficiently
-
Michalik, A., and Van Broeckhoven, C. (2004). Proteasome degrades soluble expanded polyglutamine completely and efficiently. Neurobiol. Dis. 16, 202-211. doi: 10.1016/j.nbd.2003.12.020
-
(2004)
Neurobiol. Dis.
, vol.16
, pp. 202-211
-
-
Michalik, A.1
Van Broeckhoven, C.2
-
15
-
-
79551554590
-
The importance of integrating basic and clinical research toward the development of new therapies for Huntington’s disease
-
Munoz-Sanjuan, I., and Bates, G. P. (2011). The importance of integrating basic and clinical research toward the development of new therapies for Huntington’s disease. J. Clin. Invest. 121, 476-483. doi: 10.1172/JCI45364
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 476-483
-
-
Munoz-Sanjuan, I.1
Bates, G.P.2
-
16
-
-
40849147435
-
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking
-
Orr, A. L., Li, S., Wang, C. E., Li, H., Wang, J., Rong, J., et al. (2008). N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. J. Neurosci. 28, 2783-2792. doi: 10.1523/JNEUROSCI.0106-08.2008
-
(2008)
J. Neurosci.
, vol.28
, pp. 2783-2792
-
-
Orr, A.L.1
Li, S.2
Wang, C.E.3
Li, H.4
Wang, J.5
Rong, J.6
-
17
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
Pandey, U. B., Nie, Z., Batlevi, Y., McCray, B. A., Ritson, G. P., Nedelsky, N. B., et al. (2007). HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863. doi: 10. 1038/nature05853
-
(2007)
Nature
, vol.447
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
McCray, B.A.4
Ritson, G.P.5
Nedelsky, N.B.6
-
18
-
-
0348013126
-
Autophagy regulates the processing of amino terminal huntingtin fragments
-
Qin, Z. H., Wang, Y., Kegel, K. B., Kazantsev, A., Apostol, B. L., Thompson, L. M., et al. (2003). Autophagy regulates the processing of amino terminal huntingtin fragments. Hum. Mol. Genet. 12, 3231-3244. doi: 10.1093/hmg/ddg346
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 3231-3244
-
-
Qin, Z.H.1
Wang, Y.2
Kegel, K.B.3
Kazantsev, A.4
Apostol, B.L.5
Thompson, L.M.6
-
19
-
-
2642586352
-
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington’s disease
-
Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., et al. (2004). Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington’s disease. Nat. Genet. 36, 585-595. doi: 10.1038/ng1362
-
(2004)
Nat. Genet.
, vol.36
, pp. 585-595
-
-
Ravikumar, B.1
Vacher, C.2
Berger, Z.3
Davies, J.E.4
Luo, S.5
Oroz, L.G.6
-
20
-
-
84855165944
-
Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria and selective synaptic degeneration in Huntington’s disease
-
Reddy, P. H., and Shirendeb, U. P. (2012). Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria and selective synaptic degeneration in Huntington’s disease. Biochim. Biophys. Acta 1822, 101-110. doi: 10.1016/j.bbadis.2011.10.016
-
(2012)
Biochim. Biophys. Acta
, vol.1822
, pp. 101-110
-
-
Reddy, P.H.1
Shirendeb, U.P.2
-
21
-
-
0001589776
-
Differential loss of striatal projection neurons in Huntington’s disease
-
Reiner, A., Albin, R. L., Anderson, K. D., D’Amato, C. J., Penney, J. B., and Young, A. B. (1988). Differential loss of striatal projection neurons in Huntington’s disease. Proc. Natl. Acad. Sci. U S A 85, 5733-5737. doi: 10.1073/pnas.85.15. 5733
-
(1988)
Proc. Natl. Acad. Sci. U S A
, vol.85
, pp. 5733-5737
-
-
Reiner, A.1
Albin, R.L.2
Anderson, K.D.3
D’Amato, C.J.4
Penney, J.B.5
Young, A.B.6
-
22
-
-
0029586383
-
Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington’s disease patients
-
Richfield, E. K., Maguire-Zeiss, K. A., Vonkeman, H. E., and Voorn, P. (1995). Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington’s disease patients. Ann. Neurol. 38, 852-861. doi: 10. 1002/ana.410380605
-
(1995)
Ann. Neurol.
, vol.38
, pp. 852-861
-
-
Richfield, E.K.1
Maguire-Zeiss, K.A.2
Vonkeman, H.E.3
Voorn, P.4
-
23
-
-
84898017417
-
Huntington disease: Natural history, biomarkers and prospects for therapeutics
-
Ross, C. A., Aylward, E. H., Wild, E. J., Langbehn, D. R., Long, J. D., Warner, J. H., et al. (2014). Huntington disease: natural history, biomarkers and prospects for therapeutics. Nat. Rev. Neurol. 10, 204-216. doi: 10.1038/nrneurol.2014.24
-
(2014)
Nat. Rev. Neurol.
, vol.10
, pp. 204-216
-
-
Ross, C.A.1
Aylward, E.H.2
Wild, E.J.3
Langbehn, D.R.4
Long, J.D.5
Warner, J.H.6
-
24
-
-
84925004049
-
Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy
-
Sasazawa, Y., Sato, N., Umezawa, K., and Simizu, S. (2015). Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy. J. Biol. Chem. 290, 6168-6178. doi: 10.1074/jbc.m114.606293
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 6168-6178
-
-
Sasazawa, Y.1
Sato, N.2
Umezawa, K.3
Simizu, S.4
-
25
-
-
0033054555
-
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
-
Schilling, G., Becher, M. W., Sharp, A. H., Jinnah, H. A., Duan, K., Kotzuk, J. A., et al. (1999). Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum. Mol. Genet. 8, 397-407. doi: 10.1093/hmg/8.3.397
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 397-407
-
-
Schilling, G.1
Becher, M.W.2
Sharp, A.H.3
Jinnah, H.A.4
Duan, K.5
Kotzuk, J.A.6
-
26
-
-
70350339406
-
Targeting proteins for degradation
-
Schrader, E. K., Harstad, K. G., and Matouschek, A. (2009). Targeting proteins for degradation. Nat. Chem. Biol. 5, 815-822. doi: 10.1038/nchembio.250
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 815-822
-
-
Schrader, E.K.1
Harstad, K.G.2
Matouschek, A.3
-
27
-
-
84863833900
-
Network organization of the huntingtin proteomic interactome in mammalian brain
-
Shirasaki, D. I., Greiner, E. R., Al-Ramahi, I., Gray, M., Boontheung, P., Geschwind, D. H., et al. (2012). Network organization of the huntingtin proteomic interactome in mammalian brain. Neuron 75, 41-57. doi: 10.1016/j. neuron.2012.05.024
-
(2012)
Neuron
, vol.75
, pp. 41-57
-
-
Shirasaki, D.I.1
Greiner, E.R.2
Al-Ramahi, I.3
Gray, M.4
Boontheung, P.5
Geschwind, D.H.6
-
28
-
-
38349114036
-
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases
-
Tan, J. M., Wong, E. S., Kirkpatrick, D. S., Pletnikova, O., Ko, H. S., Tay, S. P., et al. (2008). Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum. Mol. Genet. 17, 431-439. doi: 10.1093/hmg/ddm320
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 431-439
-
-
Tan, J.M.1
Wong, E.S.2
Kirkpatrick, D.S.3
Pletnikova, O.4
Ko, H.S.5
Tay, S.P.6
-
29
-
-
84883204078
-
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
-
Tsvetkov, A. S., Arrasate, M., Barmada, S., Ando, D. M., Sharma, P., Shaby, B. A., et al. (2013). Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration. Nat. Chem. Biol. 9, 586-592. doi: 10.1038/nchembio.1308
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 586-592
-
-
Tsvetkov, A.S.1
Arrasate, M.2
Barmada, S.3
Ando, D.M.4
Sharma, P.5
Shaby, B.A.6
-
30
-
-
1842766144
-
Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins
-
Venkatraman, P., Wetzel, R., Tanaka, M., Nukina, N., and Goldberg, A. L. (2004). Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol. Cell 14, 95-104. doi: 10.1016/s1097-2765(04)00151-0
-
(2004)
Mol. Cell
, vol.14
, pp. 95-104
-
-
Venkatraman, P.1
Wetzel, R.2
Tanaka, M.3
Nukina, N.4
Goldberg, A.L.5
-
32
-
-
41549129945
-
Impaired ubiquitin-proteasome system activity in the synapses of Huntington’s disease mice
-
Wang, J., Wang, C. E., Orr, A., Tydlacka, S., Li, S. H., and Li, X. J. (2008a). Impaired ubiquitin-proteasome system activity in the synapses of Huntington’s disease mice. J. Cell Biol. 180, 1177-1189. doi: 10.1083/jcb.200709080
-
(2008)
J. Cell Biol.
, vol.180
, pp. 1177-1189
-
-
Wang, J.1
Wang, C.E.2
Orr, A.3
Tydlacka, S.4
Li, S.H.5
Li, X.J.6
-
33
-
-
44649113841
-
Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin
-
Wang, C. E., Zhou, H., McGuire, J. R., Cerullo, V., Lee, B., Li, S. H., et al. (2008b). Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin. J. Cell Biol. 181, 803-816. doi: 10.1083/jcb.200710158
-
(2008)
J. Cell Biol.
, vol.181
, pp. 803-816
-
-
Wang, C.E.1
Zhou, H.2
McGuire, J.R.3
Cerullo, V.4
Lee, B.5
Li, S.H.6
-
34
-
-
0034163497
-
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knockin mice
-
Wheeler, V. C., White, J. K., Gutekunst, C. A., Vrbanac, V., Weaver, M., Li, X. J., et al. (2000). Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knockin mice. Hum. Mol. Genet. 9, 503-513. doi: 10.1093/hmg/9.4.503
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 503-513
-
-
Wheeler, V.C.1
White, J.K.2
Gutekunst, C.A.3
Vrbanac, V.4
Weaver, M.5
Li, X.J.6
-
35
-
-
84892755229
-
The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation
-
Wong, Y. C., and Holzbaur, E. L. (2014). The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation. J. Neurosci. 34, 1293-1305. doi: 10.1523/JNEUROSCI.1870-13.2014
-
(2014)
J. Neurosci.
, vol.34
, pp. 1293-1305
-
-
Wong, Y.C.1
Holzbaur, E.L.2
|