Conophylline protects cells in cellular models of neurodegenerative diseases by inducing Mammalian target of rapamycin (mTOR)-independent autophagy

Journal of Biological Chemistry

Volumn 290, Issue 10, 2015, Pages 6168-6178

  Sasazawa, Yukiko ^a   Sato, Natsumi ^a   Umezawa, Kazuo ^b   Simizu, Siro ^a  

^a KEIO UNIVERSITY   (Japan)

^b AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CELL DEATH; MAMMALS; MOBILE SECURITY;

1-METHYL-4-PHENYLPYRIDINIUM; CELLULAR RESPONSE; HUNTINGTON DISEASE; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); MUTANT HUNTINGTIN; NEURODEGENERATIVE DISORDERS; PROTEIN AGGREGATION; THERAPEUTIC DRUGS;

NEURODEGENERATIVE DISEASES;

CONOPHYLLINE; MAMMALIAN TARGET OF RAPAMYCIN; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; HTT PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; NERVE PROTEIN; PROTECTIVE AGENT; TARGET OF RAPAMYCIN KINASE; VINCA ALKALOID;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL MATURATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; NEUROPROTECTION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DRUG EFFECTS; GENETICS; HUNTINGTON DISEASE; METABOLISM; PATHOLOGY; PROTEIN AGGREGATION, PATHOLOGICAL;

MAMMALIA; VINCA;

ANIMALS; AUTOPHAGY; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; HUNTINGTON DISEASE; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PROTECTIVE AGENTS; PROTEIN AGGREGATION, PATHOLOGICAL; TOR SERINE-THREONINE KINASES; VINCA ALKALOIDS;

EID: 84925004049     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.606293     Document Type: Article

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