Molecular recordings by directed CRISPR spacer acquisition

Science

Volumn 353, Issue 6298, 2016, Pages

  Shipman, Seth L ^a,b,c   Nivala, Jeff ^a,c   Macklis, Jeffrey D ^b   Church, George M ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Harvard University   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CAS1 PROTEIN; CAS2 PROTEIN; CRISPR ASSOCIATED PROTEIN; ESCHERICHIA COLI PROTEIN; NUCLEIC ACID; NUCLEOTIDE; SPACER DNA; SYNTHETIC DNA; UNCLASSIFIED DRUG; CAS2 PROTEIN, E COLI; DEOXYRIBONUCLEASE; ENDONUCLEASE; YGBT PROTEIN, E COLI;

ADAPTATION; CELLS AND CELL COMPONENTS; COLIFORM BACTERIUM; DNA; GENETIC ANALYSIS; GENETIC ENGINEERING; MOLECULAR ANALYSIS;

ARTICLE; BACTERIAL GENOME; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRYSTAL STRUCTURE; DIRECTED MOLECULAR EVOLUTION; DNA INTEGRATION; DNA REPLICATION ORIGIN; DNA SEQUENCE; ELECTROPORATION; ESCHERICHIA COLI; HIGH THROUGHPUT SEQUENCING; INFORMATION PROCESSING; INTRACELLULAR RECORDING; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE MOTIF; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; GENETICS; METABOLISM; PROCEDURES; SYNTHETIC BIOLOGY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DIRECTED MOLECULAR EVOLUTION; ENDODEOXYRIBONUCLEASES; ENDONUCLEASES; ESCHERICHIA COLI PROTEINS; GENOME, BACTERIAL; SYNTHETIC BIOLOGY;

EID: 84975270845     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf1175     Document Type: Article

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