Lung cancer inhibitory activity of dietary berries and berry polyphenolics

Journal of Berry Research

Volumn 6, Issue 2, 2016, Pages 105-114

  Aqil, Farrukh ^a,b   Jeyabalan, Jeyaprakash ^b   Kausar, Hina ^b   Munagala, Radha ^a,b   Singh, Inder Pal ^c   Gupta, Ramesh ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

anthocyanidins; anthocyanins; Berries; lung cancer; tumor xenograft

Indexed keywords

EID: 84975270437     PISSN: 18785093     EISSN: 18785123     Source Type: Journal    
DOI: 10.3233/JBR-160120     Document Type: Article

References (31)

1. American Cancer Society, Cancer Facts and Figures American Cancer society, Atlanta.: 2015
2. Saisho S, Yasuda K, Maeda A, Yukawa T, Okita R, Hirami Y, et al. Post-recurrence survival of patients with non-small-cell lung cancer after curative resection with or without induction/adjuvant chemotherapy. Interact Cardiov Th. 2013; 16(2): 166-72
3. Harris GK, Gupta A, Nines RG, Kresty LA, Habib SG, Frankel WL, et al. Effects of lyophilized black raspberries on azoxymethaneinduced colon cancer and 8-hydroxy-2?-deoxyguanosine levels in the Fischer 344 rat. Nutr Cancer. 2001; 40(2): 125-33
4. Stoner GD, Wang LS, Seguin C, Rocha C, Stoner K, Chiu S, et al. Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. Pharm Res. 2010; 27(6): 1138-45
5. Wang LS, Hecht SS, Carmella SG, Yu N, Larue B, Henry C, et al. Anthocyanins in black raspberries prevent esophageal tumors in rats. Cancer prevention research. 2009; 2(1): 84-93
6. Wang LS, Hecht S, Carmella S, Seguin C, Rocha C, Yu N, et al. Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus. Journal of agricultural and food chemistry. 2010; 58(7): 3992-5
7. Aiyer HS, Srinivasan C, Gupta RC. Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats. Nutr Cancer. 2008; 60(2): 227-34
8. Aiyer HS, Gupta RC. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Cancer Prevention Research. 2010; 3(6): 727-37
9. Srivani Ravoori HK, Farrukh Aqil and Ramesh C. Gupta. editor Distinct molecular targets of blueberry and black raspberry in breast cancer prevention. American Association of Cancer Research. 2010; Washington DC
10. Aqil F, Vadhanam MV, Jeyabalan J, Cai J, Singh IP, Gupta RC. Detection of anthocyanins/anthocyanidins in animal tissues. J Agric Food Chem. 2014; 62(18): 3912-8
11. Jeyabalan J, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC. Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer. J Agric Food Chem. 2014; 62(18): 3963-71
12. Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009; 2(5): 270-8
13. Aqil F, Munagala R, Jeyabalan J, Joshi T, Singh IP, Gupta RC. The Indian Blackberry (Jamun), Antioxidant Capacity, and Cancer Protection. In: Preedy V, editor. Cancer: Oxidative Stress and Dietary Antioxidants. Amsterdam. 2015
14. Kausar H, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, et al. Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Letters. 2012; 325(1): 54-62
15. Aqil F, Gupta A, Munagala R, Jeyabalan J, Kausar H, Sharma RJ, et al. Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L. (Jamun, the Indian Blackberry). Nutrition and Cancer. 2012; 64(3): 428-38
16. Jeyabalan J, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC. Chemopreventive and Therapeutic Activity of Dietary Blueberry against Estrogen-Mediated Breast Cancer. J Agr Food Chem. 2014; 62(18): 3963-71
17. Aiyer HS, Vadhanam MV, Stoyanova R, Caprio GD, Clapper ML, Gupta RC. Dietary berries and ellagic acid prevent oxidative DNA damage and modulate expression of DNA repair genes. Int J Mol Sci. 2008; 9(3): 327-41
18. Li L, Adams LS, Chen S, Killian C, Ahmed A, Seeram NP. Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-Tumorigenic breast cells. J Agric Food Chem. 2009; 57(3): 826-31
19. Munagala R, Kausar H, Munjal C, Gupta RC. Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells. Carcinogenesis. 2011; 32(11): 1697-705
20. Ravoori S, Vadhanam MV, Aqil F, Gupta RC. Inhibition of Estrogen-Mediated Mammary Tumorigenesis by Blueberry and Black Raspberry. J Agr Food Chem. 2012; 60(22): 5547-55
21. Bansal SS, Kausar H, Vadhanam MV, Ravoori S, Gupta RC. Controlled systemic delivery by polymeric implants enhances tissue and plasma curcumin levels compared with oral administration. Eur J Pharm Biopharm. 2012; 80(3): 571-7
22. Tian QG, Giusti MM, Stoner GD, Schwartz SJ. Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. J Agr Food Chem. 2006; 54(4): 1467-72
23. Stoner GD, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, et al. Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. J Clin Pharmacol. 2005; 45(10): 1153-64
24. Ghavami G, Kazemali MR, Sardari S. Informatics of drug synergism in naturally occurring anticancer agents. Recent Patents on Anti-Cancer Drug Discovery. 2011; 6(1): 26-44
25. AlQathama A, Prieto JM. Natural products with therapeutic potential in melanoma metastasis. Natural Product Reports. 2015; 32(8): 1170-82
26. Hou DX, Tong X, Terahara N, Luo D, Fujii M. Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys. 2005; 440(1): 101-9
27. Feng R, Ni HM, Wang SY, Tourkova IL, Shurin MR, Harada H, et al. Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. The Journal of Biological Chemistry. 2007; 282(18): 13468-76
28. Yuan B, Okusumi S, Yoshino Y, Moriyama C, Tanaka S, Hirano T, et al. Delphinidin induces cytotoxicity and potentiates cytocidal effect in combination with arsenite in an acute promyelocytic leukemia NB4 cell line. Oncology Reports. 2015; 34(1): 431-8
29. Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nature reviews Drug Discovery. 2009; 8(7): 579-91
30. Zhang XY, Bai DC, Wu YJ, Li WG, Liu NF. Proanthocyanidin from grape seeds enhances anti-Tumor effect of doxorubicin both in vitro and in vivo. Pharmazie. 2005; 60(7): 533-8
31. Zhang XY, Li WG, Wu YJ, Bai DC, Liu NF. Proanthocyanidin from grape seeds enhances doxorubicin-induced antitumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells. Can J Physiol Pharm. 2005; 83(3): 309-18