Controlled systemic delivery by polymeric implants enhances tissue and plasma curcumin levels compared with oral administration

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 80, Issue 3, 2012, Pages 571-577

  Bansal, Shyam S ^a,b,c   Kausar, Hina ^b   Vadhanam, Manicka V ^b   Ravoori, Srivani ^b   Gupta, Ramesh C ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

Bioavailability; Chemoprevention; Controlled release; Curcumin; Implants; Tissue curcumin levels

Indexed keywords

CURCUMIN; CYTOCHROME; CYTOCHROME P450 1A1; CYTOCHROME P450 3A4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIET; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISCRIMINATION; DRUG EFFICACY; FEMALE; IMPLANT; LIVER; NONHUMAN; RAT;

ABSORBABLE IMPLANTS; ADMINISTRATION, ORAL; ANIMALS; CURCUMIN; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; FEMALE; GLUTATHIONE TRANSFERASE; KINETICS; LIVER; METABOLIC DETOXICATION, PHASE I; METABOLIC DETOXICATION, PHASE II; MICROSOMES, LIVER; POLYMERS; RATS; RATS, INBRED ACI; TISSUE DISTRIBUTION;

EID: 84858149456     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.12.009     Document Type: Article

References (31)

1. B.B. Aggarwal, and K.B. Harikumar Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases Int. J. Biochem. Cell Biol. 41 2009 40 59
2. P. Anand, C. Sundaram, S. Jhurani, A.B. Kunnumakkara, and B.B. Aggarwal Curcumin and cancer: an "old-age" disease with an "age-old" solution Cancer Lett. 267 2008 133 164
3. B.B. Aggarwal, and B. Sung Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets Trends Pharmacol. Sci. 30 2009 85 94
4. J.K. Lin Molecular targets of curcumin Adv. Exp. Med. Biol. 595 2007 227 243
5. S.V. Singh, X. Hu, S.K. Srivastava, M. Singh, H. Xia, J.L. Orchard, and H.A. Zaren Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin Carcinogenesis 19 1998 1357 1360 (Pubitemid 28409831)
6. E. Balogun, M. Hoque, P. Gong, E. Killeen, C.J. Green, R. Foresti, J. Alam, and R. Motterlini Curcumin activates the haemoxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element Biochem. J. 371 2003 887 895 (Pubitemid 36578887)
7. S. Singh, and B.B. Aggarwal Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected] J. Biol. Chem. 270 1995 24995 25000
8. B.B. Aggarwal Apoptosis and nuclear factor-kappa B: a tale of association and dissociation Biochem. Pharmacol. 60 2000 1033 1039
9. S.S. Bansal, M. Goel, F. Aqil, M.V. Vadhanam, R.C. Gupta, Advanced drug-delivery systems of curcumin for cancer chemoprevention, Cancer Prev. Res. (Phila) (2011).
10. J. Shaikh, D.D. Ankola, V. Beniwal, D. Singh, and M.N. Kumar Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer Eur. J. Pharm. Sci. 37 2009 223 230
11. K. Shahani, S.K. Swaminathan, D. Freeman, A. Blum, L. Ma, and J. Panyam Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention Cancer Res. 70 2010 4443 4452
12. H.A. Aziz, K.K. Peh, and Y.T. Tan Solubility of core materials in aqueous polymeric solution effect on microencapsulation of curcumin Drug. Dev. Ind. Pharm. 33 2007 1263 1272 (Pubitemid 350208730)
13. R.L. Thangapazham, A. Puri, S. Tele, R. Blumenthal, and R.K. Maheshwari Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells Int. J. Oncol. 32 2008 1119 1123
14. J. Cuomo, G. Appendino, A.S. Dern, E. Schneider, T.P. McKinnon, M.J. Brown, S. Togni, and B.M. Dixon Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation J. Nat. Prod. 74 2011 664 669
15. S.S. Bansal, M.V. Vadhanam, and R.C. Gupta Development and in vitro-in vivo evaluation of polymeric implants for continuous systemic delivery of curcumin Pharm. Res. 28 2011 1121 1130
16. S.S. Bansal, H. Kausar, F. Aqil, J. Jeyabalan, M.V. Vadhanam, R.C. Gupta, S. Ravoori, Curcumin implants for continuous systemic delivery: safety and biocompatibility, Drug Deliv Trans Res (in press).
17. S. Ravoori, M.V. Vadhanam, S. Sahoo, C. Srinivasan, and R.C. Gupta Mammary tumor induction in ACI rats exposed to low levels of 17beta-estradiol Int. J. Oncol. 31 2007 113 120
18. P.K. Smith, R.I. Krohn, G.T. Hermanson, A.K. Mallia, F.H. Gartner, M.D. Provenzano, E.K. Fujimoto, N.M. Goeke, B.J. Olson, and D.C. Klenk Measurement of protein using bicinchoninic acid Anal. Biochem. 150 1985 76 85 (Pubitemid 16258399)
19. Y. Lemmouchi, E. Schacht, and C. Lootens In vitro release of trypanocidal drugs from biodegradable implants based on poly([var epsilon]-caprolactone) and poly(-lactide) J. Control. Release 55 1998 79 85 (Pubitemid 28477566)
20. D. Suresh, and K. Srinivasan Tissue distribution and elimination of capsaicin, piperine and curcumin following oral intake in rats Indian J. Med. Res. 131 2010 682 691
21. P. Anand, A.B. Kunnumakkara, R.A. Newman, and B.B. Aggarwal Bioavailability of curcumin: problems and promises Mol. Pharm. 4 2007 807 818
22. C.R. Ireson, D.J. Jones, S. Orr, M.W. Coughtrie, D.J. Boocock, M.L. Williams, P.B. Farmer, W.P. Steward, and A.J. Gescher Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine Cancer Epidemiol. Biomar. Prev. 11 2002 105 111 (Pubitemid 34118319)
23. B. Wahlang, Y.B. Pawar, and A.K. Bansal Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model Eur. J. Pharm. Biopharm. 77 2011 275 282
24. H.P. Ciolino, P.J. Daschner, T.T. Wang, and G.C. Yeh Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells Biochem. Pharmacol. 56 1998 197 206 (Pubitemid 28479827)
25. V.K. Goud, K. Polasa, and K. Krishnaswamy Effect of turmeric on xenobiotic metabolising enzymes Plant Foods Hum. Nutr. 44 1993 87 92
26. D.Y. Liu, M. Yang, H.J. Zhu, Y.F. Zheng, and X.Q. Zhu [Human pregnane × receptor-mediated transcriptional regulation of cytochrome P450 3A4 by some phytochemicals] Zhejiang Da Xue Xue Bao Yi Xue Ban 35 2006 8 13
27. C. Zhang, A. Browne, D. Child, and R.E. Tanzi Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein J. Biol. Chem. 285 2010 28472 28480
28. J. Weissenberger, M. Priester, C. Bernreuther, S. Rakel, M. Glatzel, V. Seifert, and D. Kogel Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway Clin. Cancer Res. 16 2010 5781 5795
29. T.R. Buggins, P.A. Dickinson, and G. Taylor The effects of pharmaceutical excipients on drug disposition Adv. Drug Deliv. Rev. 59 2007 1482 1503 (Pubitemid 350122775)
30. P.H. Jellinck, P.G. Forkert, D.S. Riddick, A.B. Okey, J.J. Michnovicz, and H.L. Bradlow Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation Biochem. Pharmacol. 45 1993 1129 1136 (Pubitemid 23079991)
31. H.H. Tonnesen Solubility, chemical and photochemical stability of curcumin in surfactant solutions. Studies of curcumin and curcuminoids, XXVIII Pharmazie 57 2002 820 824 (Pubitemid 36014615)