메뉴 건너뛰기




Volumn 197, Issue 1, 2016, Pages 278-287

Phosphoinositide 3-kinase d regulates dectin-2 signaling and the generation of Th2 and Th17 immunity

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DECTIN 2; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; PEPTIDOLEUKOTRIENE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PROTEIN KINASE C DELTA; PROTEIN KINASE SYK; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DECTIN-2, MOUSE; LECTIN; PIK3CD PROTEIN, MOUSE;

EID: 84975215491     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1502485     Document Type: Article
Times cited : (14)

References (57)
  • 1
    • 84859405717 scopus 로고    scopus 로고
    • Signaling by myeloid C-type lectin receptors in immunity and homeostasis
    • Sancho, D., and C. Reis e Sousa. 2012. Signaling by myeloid C-type lectin receptors in immunity and homeostasis. Annu. Rev. Immunol. 30: 491-529.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 491-529
    • Sancho, D.1    Reis Sousa, E.C.2
  • 2
    • 77953289487 scopus 로고    scopus 로고
    • Dectin-2 recognition of a-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans
    • Saijo, S., S. Ikeda, K. Yamabe, S. Kakuta, H. Ishigame, A. Akitsu, N. Fujikado, T. Kusaka, S. Kubo, S. H. Chung, et al. 2010. Dectin-2 recognition of a-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 32: 681-691.
    • (2010) Immunity , vol.32 , pp. 681-691
    • Saijo, S.1    Ikeda, S.2    Yamabe, K.3    Kakuta, S.4    Ishigame, H.5    Akitsu, A.6    Fujikado, N.7    Kusaka, T.8    Kubo, S.9    Chung, S.H.10
  • 4
    • 84929946842 scopus 로고    scopus 로고
    • Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses
    • Deng, Z., S. Ma, H. Zhou, A. Zang, Y. Fang, T. Li, H. Shi, M. Liu, M. Du, P. R. Taylor, et al. 2015. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat. Immunol. 16: 642-652.
    • (2015) Nat. Immunol. , vol.16 , pp. 642-652
    • Deng, Z.1    Ma, S.2    Zhou, H.3    Zang, A.4    Fang, Y.5    Li, T.6    Shi, H.7    Liu, M.8    Du, M.9    Taylor, P.R.10
  • 7
    • 77956218105 scopus 로고    scopus 로고
    • CARD9 mediates Dectin-2-induced IkBa kinase ubiquitination leading to activation of NF-kB in response to stimulation by the hyphal form of Candida albicans
    • Bi, L., S. Gojestani, W. Wu, Y. M. Hsu, J. Zhu, K. Ariizumi, and X. Lin. 2010. CARD9 mediates Dectin-2-induced IkBa kinase ubiquitination leading to activation of NF-kB in response to stimulation by the hyphal form of Candida albicans. J. Biol. Chem. 285: 25969-25977.
    • (2010) J. Biol. Chem. , vol.285 , pp. 25969-25977
    • Bi, L.1    Gojestani, S.2    Wu, W.3    Hsu, Y.M.4    Zhu, J.5    Ariizumi, K.6    Lin, X.7
  • 9
    • 0029098680 scopus 로고
    • Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages
    • Brock, T. G., R. W. McNish, and M. Peters-Golden. 1995. Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. J. Biol. Chem. 270: 21652-21658.
    • (1995) J. Biol. Chem. , vol.270 , pp. 21652-21658
    • Brock, T.G.1    McNish, R.W.2    Peters-Golden, M.3
  • 10
    • 0025810578 scopus 로고
    • A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP
    • Clark, J. D., L. L. Lin, R. W. Kriz, C. S. Ramesha, L. A. Sultzman, A. Y. Lin, N. Milona, and J. L. Knopf. 1991. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP. Cell 65: 1043-1051.
    • (1991) Cell , vol.65 , pp. 1043-1051
    • Clark, J.D.1    Lin, L.L.2    Kriz, R.W.3    Ramesha, C.S.4    Sultzman, L.A.5    Lin, A.Y.6    Milona, N.7    Knopf, J.L.8
  • 11
    • 0027958828 scopus 로고
    • Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4
    • Lam, B. K., J. F. Penrose, G. J. Freeman, and K. F. Austen. 1994. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc. Natl. Acad. Sci. USA 91: 7663-7667.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7663-7667
    • Lam, B.K.1    Penrose, J.F.2    Freeman, G.J.3    Austen, K.F.4
  • 12
    • 60549110301 scopus 로고    scopus 로고
    • Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells
    • Barrett, N. A., A. Maekawa, O. M. Rahman, K. F. Austen, and Y. Kanaoka. 2009. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J. Immunol. 182: 1119-1128.
    • (2009) J. Immunol. , vol.182 , pp. 1119-1128
    • Barrett, N.A.1    Maekawa, A.2    Rahman, O.M.3    Austen, K.F.4    Kanaoka, Y.5
  • 19
    • 85027938991 scopus 로고    scopus 로고
    • Signaling through FcRg-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses
    • Tjota, M. Y., C. L. Hrusch, K. M. Blaine, J. W. Williams, N. A. Barrett, and A. I. Sperling. 2014. Signaling through FcRg-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses. J. Allergy Clin. Immunol. 134: 706-713.e8.
    • (2014) J. Allergy Clin. Immunol. , vol.134 , pp. 706e8-713e8
    • Tjota, M.Y.1    Hrusch, C.L.2    Blaine, K.M.3    Williams, J.W.4    Barrett, N.A.5    Sperling, A.I.6
  • 20
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley, L. C. 2002. The phosphoinositide 3-kinase pathway. Science 296: 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 24
    • 71849094777 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells
    • Kuehn, H. S., E. J. Swindle, M. S. Kim, M. A. Beaven, D. D. Metcalfe, and A. M. Gilfillan. 2008. The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells. J. Immunol. 181: 7706-7712.
    • (2008) J. Immunol. , vol.181 , pp. 7706-7712
    • Kuehn, H.S.1    Swindle, E.J.2    Kim, M.S.3    Beaven, M.A.4    Metcalfe, D.D.5    Gilfillan, A.M.6
  • 25
    • 0035933888 scopus 로고    scopus 로고
    • Attenuated zymosan-induced peritoneal vascular permeability and IgEdependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase
    • Kanaoka, Y., A. Maekawa, J. F. Penrose, K. F. Austen, and B. K. Lam. 2001. Attenuated zymosan-induced peritoneal vascular permeability and IgEdependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase. J. Biol. Chem. 276: 22608-22613.
    • (2001) J. Biol. Chem. , vol.276 , pp. 22608-22613
    • Kanaoka, Y.1    Maekawa, A.2    Penrose, J.F.3    Austen, K.F.4    Lam, B.K.5
  • 26
    • 33846469538 scopus 로고    scopus 로고
    • The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
    • Hsu, Y. M., Y. Zhang, Y. You, D. Wang, H. Li, O. Duramad, X. F. Qin, C. Dong, and X. Lin. 2007. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat. Immunol. 8: 198-205.
    • (2007) Nat. Immunol. , vol.8 , pp. 198-205
    • Hsu, Y.M.1    Zhang, Y.2    You, Y.3    Wang, D.4    Li, H.5    Duramad, O.6    Qin, X.F.7    Dong, C.8    Lin, X.9
  • 27
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz, M. B., N. Kukutsch, A. L. Ogilvie, S. Rössner, F. Koch, N. Romani, and G. Schuler. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223: 77-92.
    • (1999) J. Immunol. Methods , vol.223 , pp. 77-92
    • Lutz, M.B.1    Kukutsch, N.2    Ogilvie, A.L.3    Rössner, S.4    Koch, F.5    Romani, N.6    Schuler, G.7
  • 28
    • 84867907479 scopus 로고    scopus 로고
    • Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation
    • Barrett, N. A., J. M. Fernandez, A. Maekawa, W. Xing, L. Li, M. W. Parsons, K. F. Austen, and Y. Kanaoka. 2012. Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation. J. Immunol. 189: 4556-4565.
    • (2012) J. Immunol. , vol.189 , pp. 4556-4565
    • Barrett, N.A.1    Fernandez, J.M.2    Maekawa, A.3    Xing, W.4    Li, L.5    Parsons, M.W.6    Austen, K.F.7    Kanaoka, Y.8
  • 29
    • 33645827963 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase d attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
    • Lee, K. S., H. K. Lee, J. S. Hayflick, Y. C. Lee, and K. D. Puri. 2006. Inhibition of phosphoinositide 3-kinase d attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J. 20: 455-465.
    • (2006) FASEB J. , vol.20 , pp. 455-465
    • Lee, K.S.1    Lee, H.K.2    Hayflick, J.S.3    Lee, Y.C.4    Puri, K.D.5
  • 31
    • 0141532180 scopus 로고    scopus 로고
    • Class i phosphoinositide 3-kinase p110b is required for apoptotic cell and Fcg receptor-mediated phagocytosis by macrophages
    • Leverrier, Y., K. Okkenhaug, C. Sawyer, A. Bilancio, B. Vanhaesebroeck, and A. J. Ridley. 2003. Class I phosphoinositide 3-kinase p110b is required for apoptotic cell and Fcg receptor-mediated phagocytosis by macrophages. J. Biol. Chem. 278: 38437-38442.
    • (2003) J. Biol. Chem. , vol.278 , pp. 38437-38442
    • Leverrier, Y.1    Okkenhaug, K.2    Sawyer, C.3    Bilancio, A.4    Vanhaesebroeck, B.5    Ridley, A.J.6
  • 35
    • 0027169534 scopus 로고
    • CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
    • Tuveson, D. A., R. H. Carter, S. P. Soltoff, and D. T. Fearon. 1993. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 260: 986-989.
    • (1993) Science , vol.260 , pp. 986-989
    • Tuveson, D.A.1    Carter, R.H.2    Soltoff, S.P.3    Fearon, D.T.4
  • 36
    • 0034507903 scopus 로고    scopus 로고
    • BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
    • Okada, T., A. Maeda, A. Iwamatsu, K. Gotoh, and T. Kurosaki. 2000. BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 13: 817-827.
    • (2000) Immunity , vol.13 , pp. 817-827
    • Okada, T.1    Maeda, A.2    Iwamatsu, A.3    Gotoh, K.4    Kurosaki, T.5
  • 37
    • 0032479864 scopus 로고    scopus 로고
    • T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-z complex, recruits intracellular signaling proteins to the plasma membrane
    • Bruyns, E., A. Marie-Cardine, H. Kirchgessner, K. Sagolla, A. Shevchenko, M. Mann, F. Autschbach, A. Bensussan, S. Meuer, and B. Schraven. 1998. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-z complex, recruits intracellular signaling proteins to the plasma membrane. J. Exp. Med. 188: 561-575.
    • (1998) J. Exp. Med. , vol.188 , pp. 561-575
    • Bruyns, E.1    Marie-Cardine, A.2    Kirchgessner, H.3    Sagolla, K.4    Shevchenko, A.5    Mann, M.6    Autschbach, F.7    Bensussan, A.8    Meuer, S.9    Schraven, B.10
  • 38
    • 4544323522 scopus 로고    scopus 로고
    • Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase
    • Shim, E. K., C. S. Moon, G. Y. Lee, Y. J. Ha, S. K. Chae, and J. R. Lee. 2004. Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase. FEBS Lett. 575: 35-40.
    • (2004) FEBS Lett. , vol.575 , pp. 35-40
    • Shim, E.K.1    Moon, C.S.2    Lee, G.Y.3    Ha, Y.J.4    Chae, S.K.5    Lee, J.R.6
  • 39
    • 79952772660 scopus 로고    scopus 로고
    • Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells
    • Shim, E. K., S. H. Jung, and J. R. Lee. 2011. Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells. J. Immunol. 186: 2926-2935.
    • (2011) J. Immunol. , vol.186 , pp. 2926-2935
    • Shim, E.K.1    Jung, S.H.2    Lee, J.R.3
  • 40
    • 84882714745 scopus 로고    scopus 로고
    • C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection
    • Zhu, L. L., X. Q. Zhao, C. Jiang, Y. You, X. P. Chen, Y. Y. Jiang, X. M. Jia, and X. Lin. 2013. C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity 39: 324-334.
    • (2013) Immunity , vol.39 , pp. 324-334
    • Zhu, L.L.1    Zhao, X.Q.2    Jiang, C.3    You, Y.4    Chen, X.P.5    Jiang, Y.Y.6    Jia, X.M.7    Lin, X.8
  • 41
    • 84878489056 scopus 로고    scopus 로고
    • LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-g production by repressing b-catenin activation in dendritic cells
    • Orr, S. J., A. R. Burg, T. Chan, L. Quigley, G. W. Jones, J. W. Ford, D. Hodge, C. Razzook, J. Sarhan, Y. L. Jones, et al. 2013. LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-g production by repressing b-catenin activation in dendritic cells. PLoS Pathog. 9: e1003357.
    • (2013) PLoS Pathog. , vol.9 , pp. e1003357
    • Orr, S.J.1    Burg, A.R.2    Chan, T.3    Quigley, L.4    Jones, G.W.5    Ford, J.W.6    Hodge, D.7    Razzook, C.8    Sarhan, J.9    Jones, Y.L.10
  • 42
    • 34547928769 scopus 로고    scopus 로고
    • TLR-4 and sustained calcium agonists synergistically produce eicosanoids independent of protein synthesis in RAW264. 7 cells
    • Buczynski, M. W., D. L. Stephens, R. C. Bowers-Gentry, A. Grkovich, R. A. Deems, and E. A. Dennis. 2007. TLR-4 and sustained calcium agonists synergistically produce eicosanoids independent of protein synthesis in RAW264.7 cells. J. Biol. Chem. 282: 22834-22847.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22834-22847
    • Buczynski, M.W.1    Stephens, D.L.2    Bowers-Gentry, R.C.3    Grkovich, A.4    Deems, R.A.5    Dennis, E.A.6
  • 43
    • 0033959733 scopus 로고    scopus 로고
    • BLNK: Connecting Syk and Btk to calcium signals
    • Kurosaki, T., and S. Tsukada. 2000. BLNK: connecting Syk and Btk to calcium signals. Immunity 12: 1-5.
    • (2000) Immunity , vol.12 , pp. 1-5
    • Kurosaki, T.1    Tsukada, S.2
  • 44
    • 7944227491 scopus 로고    scopus 로고
    • Protein kinase Cd functions downstream of Ca2+ mobilization in FcϵRI signaling to degranulation in mast cells
    • Cho, S. H., C. H. Woo, S. B. Yoon, and J. H. Kim. 2004. Protein kinase Cd functions downstream of Ca2+ mobilization in FcϵRI signaling to degranulation in mast cells. J. Allergy Clin. Immunol. 114: 1085-1092.
    • (2004) J. Allergy Clin. Immunol. , vol.114 , pp. 1085-1092
    • Cho, S.H.1    Woo, C.H.2    Yoon, S.B.3    Kim, J.H.4
  • 45
    • 65449131255 scopus 로고    scopus 로고
    • Phospholipase Cg2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells
    • Xu, S., J. Huo, K. G. Lee, T. Kurosaki, and K. P. Lam. 2009. Phospholipase Cg2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells. J. Biol. Chem. 284: 7038-7046.
    • (2009) J. Biol. Chem. , vol.284 , pp. 7038-7046
    • Xu, S.1    Huo, J.2    Lee, K.G.3    Kurosaki, T.4    Lam, K.P.5
  • 46
    • 83755168978 scopus 로고    scopus 로고
    • Phospholipase Cg2 (PLCg2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses
    • Gorjestani, S., M. Yu, B. Tang, D. Zhang, D. Wang, and X. Lin. 2011. Phospholipase Cg2 (PLCg2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. J. Biol. Chem. 286: 43651-43659.
    • (2011) J. Biol. Chem. , vol.286 , pp. 43651-43659
    • Gorjestani, S.1    Yu, M.2    Tang, B.3    Zhang, D.4    Wang, D.5    Lin, X.6
  • 48
    • 84922705819 scopus 로고    scopus 로고
    • Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33
    • Verma, A., D. N. Kroetz, J. L. Tweedle, and G. S. Deepe, Jr. 2015. Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. Mucosal Immunol. 8: 380-389.
    • (2015) Mucosal Immunol. , vol.8 , pp. 380-389
    • Verma, A.1    Kroetz, D.N.2    Tweedle, J.L.3    Deepe, G.S.4
  • 52
    • 79960924748 scopus 로고    scopus 로고
    • TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium
    • Zhang, L., R. Lu, G. Zhao, S. C. Pflugfelder, and D. Q. Li. 2011. TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium. Int. J. Biochem. Cell Biol. 43: 1383-1391.
    • (2011) Int. J. Biochem. Cell Biol. , vol.43 , pp. 1383-1391
    • Zhang, L.1    Lu, R.2    Zhao, G.3    Pflugfelder, S.C.4    Li, D.Q.5
  • 53
    • 84871823380 scopus 로고    scopus 로고
    • Simultaneous quantitation of IC87114, roflumilast and its active metabolite roflumilast N-oxide in plasma by LC-MS/MS: Application for a pharmacokinetic study
    • Thappali, S. R., K. V. Varanasi, S. Veeraraghavan, S. K. Vakkalanka, and K. Mukkanti. 2012. Simultaneous quantitation of IC87114, roflumilast and its active metabolite roflumilast N-oxide in plasma by LC-MS/MS: application for a pharmacokinetic study. J. Mass Spectrom. 47: 1612-1619.
    • (2012) J. Mass Spectrom. , vol.47 , pp. 1612-1619
    • Thappali, S.R.1    Varanasi, K.V.2    Veeraraghavan, S.3    Vakkalanka, S.K.4    Mukkanti, K.5
  • 57
    • 84896765296 scopus 로고    scopus 로고
    • Idelalisib - A PI3Kd inhibitor for B-cell cancers
    • Fruman, D. A., and L. C. Cantley. 2014. Idelalisib-a PI3Kd inhibitor for B-cell cancers. N. Engl. J. Med. 370: 1061-1062.
    • (2014) N. Engl. J. Med. , vol.370 , pp. 1061-1062
    • Fruman, D.A.1    Cantley, L.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.