A Central Cysteine Residue Is Essential for the Thermal Stability and Function of SUMO-1 Protein and SUMO-1 Peptide-Protein Conjugates

Bioconjugate Chemistry

Volumn 27, Issue 6, 2016, Pages 1540-1546

  Drobecq, Hervé ^a   Boll, Emmanuelle ^a   Sénéchal, Magalie ^a   Desmet, Rémi ^a   Saliou, Jean Michel ^a   Lacapère, Jean Jacques ^b   Mougel, Alexandra ^a   Vicogne, Jérôme ^a   Melnyk, Oleg ^a  

^a UNIV LILLE   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; CHEMICAL STABILITY; MACHINERY; PEPTIDES; THERMODYNAMIC STABILITY;

CELLULAR MACHINERY; CYSTEINE RESIDUES; PEPTIDE PROTEINS; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN CONJUGATES; PROTEIN INTERACTION; SMALL UBIQUITIN-LIKE MODIFIERS; SUMOYLATION; TARGETED PROTEINS; WILD TYPES;

ENZYMES;

ALANINE; CYSTEINE; PROTEIN P53; SUMO 1 PROTEIN; PEPTIDE FRAGMENT;

ARTICLE; CIRCULAR DICHROISM; COMPARATIVE STUDY; CONJUGATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; PEPTIDE PROTEIN CONJUGATE; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEPLETION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TARGETING; SUMOYLATION; THERMOSTABILITY; WILD TYPE; AMINO ACID SEQUENCE; CHEMISTRY; CONSERVED SEQUENCE; METABOLISM; MOLECULAR MODEL; PROTEIN DOMAIN; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION; TEMPERATURE;

AMINO ACID SEQUENCE; CONSERVED SEQUENCE; CYSTEINE; HUMANS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN DOMAINS; PROTEIN STABILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUMO-1 PROTEIN; TEMPERATURE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84975122321     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/acs.bioconjchem.6b00211     Document Type: Article

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