Endosomal acidic pH-induced conformational changes of a cytosol-penetrating antibody mediate endosomal escape

Journal of Controlled Release

Volumn 235, Issue , 2016, Pages 165-175

  Kim, Ji Sun ^a   Choi, Dong Ki ^a   Shin, Ju Yeon ^a   Shin, Seung Min ^a   Park, Seong Wook ^a   Cho, Hyun Soo ^b   Kim, Yong Sung ^a  

^a Ajou University   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Antibody intracellular trafficking; Cytosol penetrating antibody; Endosomal escape; Membrane pore formation; pH dependent conformational change

Indexed keywords

CELL MEMBRANES; CELLS; CYTOLOGY; MOLECULAR BIOLOGY; PROTEINS;

CONFORMATIONAL CHANGE; CYTOSOLS; ENDOSOMAL ESCAPES; INTRACELLULAR TRAFFICKING; MEMBRANE PORES;

ANTIBODIES;

ADALIMUMAB; ANTIBODY; CELL SURFACE RECEPTOR; CYTOSOL PENETRATING ANTIBODY TMAB4; HEPARANASE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; PROTEOHEPARAN SULFATE; UNCLASSIFIED DRUG; BETA GLUCURONIDASE; TUBULIN;

ACIDIFICATION; ACIDITY; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOSOL; DISSOCIATION; DRUG RELEASE; ENDOCYTOSIS; ENDOSOME; HELA CELL LINE; INTERNALIZATION; MEMBRANE FORMATION; MEMBRANE STABILIZATION; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PH; PROTEIN CONFORMATION;

ANIMALS; CHO CELLS; CRICETULUS; CYTOSOL; ENDOSOMES; GLUCURONIDASE; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; PROTEIN CONFORMATION; TUBULIN;

EID: 84974715611     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.05.066     Document Type: Article

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