A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells

mAbs

Volumn 6, Issue 6, 2014, Pages 1402-1414

  Choi, Dong Ki ^a   Bae, Jeomil ^a   Shin, Seung Min ^a   Shin, Ju Yeon ^a   Kim, Sunghoon ^b   Kim, Yong Sung ^a  

^a Ajou University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Cell penetrating antibody; Cellular internalization; Cytosolic protein targeting; Endosomal release; IgG antibody; Intracellular trafficking; Next generation antibody

Indexed keywords

ADALIMUMAB; BEVACIZUMAB; CLATHRIN; CYTOSOL PENETRATING ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; PROTEOGLYCAN; UNCLASSIFIED DRUG; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN VARIABLE REGION;

ARTICLE; CELL NUCLEUS; CELL SURFACE; CELLS; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; CYTOTOXICITY; DRUG BINDING; DRUG DESIGN; DRUG PENETRATION; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENDOSOME; FEMALE; GOLGI COMPLEX; HEAVY CHAIN; HELA CELL LINE; HUMAN; HUMAN CELL; INTERNALIZATION; INTRACELLULAR SPACE; LIGHT CHAIN; LIVING CELL; LYSOSOME; AMINO ACID SEQUENCE; ANIMAL; CELL SURVIVAL; CHO CELL LINE; CONFOCAL MICROSCOPY; CRICETULUS; GENETICS; HAMSTER; HT 29 CELL LINE; IMMUNOGLOBULIN VARIABLE REGION; K562 CELL LINE; MCF 7 CELL LINE; METABOLISM; MOLECULAR GENETICS; PROCEDURES; PROTEIN ENGINEERING; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; TIME LAPSE IMAGING; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; CYTOSOL; ENDOCYTOSIS; HELA CELLS; HT29 CELLS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; K562 CELLS; MCF-7 CELLS; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY, AMINO ACID; TIME-LAPSE IMAGING;

EID: 84920759239     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.36389     Document Type: Article

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