Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo

Journal of the American Chemical Society

Volumn 137, Issue 44, 2015, Pages 14084-14093

  Li, Margie ^a   Tao, Yong ^b   Shu, Yilai ^b,c,d   LaRochelle, Jonathan R ^e   Steinauer, Angela ^e   Thompson, David ^a   Schepartz, Alanna ^e   Chen, Zheng Yi ^b   Liu, David R ^a,f  

^a HARVARD UNIVERSITY   (United States)

^b MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^c FUDAN UNIVERSITY   (China)

^d BEIJING HOSPITAL   (China)

^e YALE UNIVERSITY   (United States)

^f HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; CELLS; CYTOLOGY; MAMMALS; NUCLEIC ACIDS; PEPTIDES;

CYTOPLASMIC DELIVERY; CYTOSOLIC PROTEINS; MAMMALIAN CELL TOXICITY; MICROBIAL MEMBRANES; PEPTIDE SEQUENCES; PROTEIN CONJUGATIONS; STRUCTURE-FUNCTION STUDIES; THERAPEUTIC POTENTIALS;

PROTEINS;

AUREIN 1.2; CHLOROQUINE; CRE RECOMBINASE; HYBRID PROTEIN; NUCLEIC ACID; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; AUREIN 1.2 PEPTIDE; GREEN FLUORESCENT PROTEIN; INTEGRASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASSAY; CELL CULTURE; CONJUGATION; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; CYTOSOLIC FRACTION; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; ENDOSOME; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INNER EAR; INNER HAIR CELL; MAMMAL CELL; MEMBRANE DAMAGE; MOUSE; NONHUMAN; OUTER HAIR CELL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN FOLDING; PROTEIN TRANSPORT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; CYTOLOGY; METABOLISM;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELLS, CULTURED; CYTOPLASM; DRUG DELIVERY SYSTEMS; EAR, INNER; ENDOSOMES; GREEN FLUORESCENT PROTEINS; INTEGRASES; MICE;

EID: 84947438185     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b05694     Document Type: Article

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