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Volumn 13, Issue 7, 2016, Pages 1029-1046

Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials

Author keywords

Androgen; Erectile Dysfunction; Hypogonadism; Libido; Measure; Steroid

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; ESTRADIOL; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

EID: 84974653290     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1016/j.jsxm.2016.04.068     Document Type: Review
Times cited : (75)

References (144)
  • 1
    • 77954409942 scopus 로고    scopus 로고
    • Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline
    • Bhasin S., Cunningham G.R., Hayes F.J., et al. Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010, 95:2536-2559.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2536-2559
    • Bhasin, S.1    Cunningham, G.R.2    Hayes, F.J.3
  • 2
    • 35948996162 scopus 로고    scopus 로고
    • Prevalence of symptomatic androgen deficiency in men
    • Araujo A.B., Esche G.R., Kupelian V., et al. Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab 2007, 92:4241-4247.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4241-4247
    • Araujo, A.B.1    Esche, G.R.2    Kupelian, V.3
  • 3
    • 63849204029 scopus 로고    scopus 로고
    • The prevalence of and risk factors for androgen deficiency in aging Taiwanese men
    • Liu C.C., Wu W.J., Lee Y.C., et al. The prevalence of and risk factors for androgen deficiency in aging Taiwanese men. J Sex Med 2009, 6:936-946.
    • (2009) J Sex Med , vol.6 , pp. 936-946
    • Liu, C.C.1    Wu, W.J.2    Lee, Y.C.3
  • 4
    • 77954414397 scopus 로고    scopus 로고
    • Identification of late-onset hypogonadism in middle-aged and elderly men
    • Wu F.C., Tajar A., Beynon J.M., et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010, 363:123-135.
    • (2010) N Engl J Med , vol.363 , pp. 123-135
    • Wu, F.C.1    Tajar, A.2    Beynon, J.M.3
  • 5
    • 84879411706 scopus 로고    scopus 로고
    • Risks and benefits of testosterone therapy in older men
    • Spitzer M., Huang G., Basaria S., et al. Risks and benefits of testosterone therapy in older men. Nat Rev Endocrinol 2013, 9:414-424.
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 414-424
    • Spitzer, M.1    Huang, G.2    Basaria, S.3
  • 6
    • 84882281522 scopus 로고    scopus 로고
    • Trends in androgen prescribing in the United States, 2001 to 2011
    • Baillargeon J., Urban R.J., Ottenbacher K.J., et al. Trends in androgen prescribing in the United States, 2001 to 2011. JAMA Intern Med 2013, 173:1465-1466.
    • (2013) JAMA Intern Med , vol.173 , pp. 1465-1466
    • Baillargeon, J.1    Urban, R.J.2    Ottenbacher, K.J.3
  • 7
    • 84886024708 scopus 로고    scopus 로고
    • Global trends in testosterone prescribing, 2000-2011: Expanding the spectrum of prescription drug misuse
    • Handelsman D.J. Global trends in testosterone prescribing, 2000-2011: Expanding the spectrum of prescription drug misuse. Med J Aust 2013, 199:548-551.
    • (2013) Med J Aust , vol.199 , pp. 548-551
    • Handelsman, D.J.1
  • 8
    • 0035143822 scopus 로고    scopus 로고
    • Differential regulation of gonadotropin secretion by testosterone in the human male: Absence of a negative feedback effect of testosterone on follicle-stimulating hormone secretion
    • Hayes F.J., DeCruz S., Seminara S.B., et al. Differential regulation of gonadotropin secretion by testosterone in the human male: Absence of a negative feedback effect of testosterone on follicle-stimulating hormone secretion. J Clin Endocrinol Metab 2001, 86:53-58.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 53-58
    • Hayes, F.J.1    DeCruz, S.2    Seminara, S.B.3
  • 9
    • 0034976485 scopus 로고    scopus 로고
    • Aromatization mediates testosterone's short-term feedback restraint of 24-hour endogenously driven and acute exogenous gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone secretion in young men
    • Schnorr J.A., Bray M.J., Veldhuis J.D. Aromatization mediates testosterone's short-term feedback restraint of 24-hour endogenously driven and acute exogenous gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone secretion in young men. J Clin Endocrinol Metab 2001, 86:2600-2606.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2600-2606
    • Schnorr, J.A.1    Bray, M.J.2    Veldhuis, J.D.3
  • 10
    • 62149115641 scopus 로고    scopus 로고
    • A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: With illustrative examples from male and female populations
    • Mazer N.A. A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: With illustrative examples from male and female populations. Steroids 2009, 74:512-519.
    • (2009) Steroids , vol.74 , pp. 512-519
    • Mazer, N.A.1
  • 11
    • 0030797569 scopus 로고    scopus 로고
    • Effect of testosterone and estradiol in a man with aromatase deficiency
    • Carani C., Qin K., Simoni M., et al. Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 1997, 337:91-95.
    • (1997) N Engl J Med , vol.337 , pp. 91-95
    • Carani, C.1    Qin, K.2    Simoni, M.3
  • 12
    • 0034457552 scopus 로고    scopus 로고
    • Estradiol acts as a germ cell survival factor in the human testis in vitro
    • Pentikainen V., Erkkila K., Suomalainen L., et al. Estradiol acts as a germ cell survival factor in the human testis in vitro. J Clin Endocrinol Metab 2000, 85:2057-2067.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2057-2067
    • Pentikainen, V.1    Erkkila, K.2    Suomalainen, L.3
  • 13
    • 0033567870 scopus 로고    scopus 로고
    • Steroid metabolism and effects in central and peripheral glial cells
    • Melcangi R.C., Magnaghi V., Martini L. Steroid metabolism and effects in central and peripheral glial cells. J Neurobiol 1999, 40:471-483.
    • (1999) J Neurobiol , vol.40 , pp. 471-483
    • Melcangi, R.C.1    Magnaghi, V.2    Martini, L.3
  • 14
    • 0025303307 scopus 로고
    • Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases
    • Andersson S., Russell D.W. Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Proc Natl Acad Sci U S A 1990, 87:3640-3644.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 3640-3644
    • Andersson, S.1    Russell, D.W.2
  • 15
    • 0030982034 scopus 로고    scopus 로고
    • MK-386, an inhibitor of 5alpha-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen
    • Schwartz J.I., Tanaka W.K., Wang D.Z., et al. MK-386, an inhibitor of 5alpha-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen. J Clin Endocrinol Metab 1997, 82:1373-1377.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1373-1377
    • Schwartz, J.I.1    Tanaka, W.K.2    Wang, D.Z.3
  • 16
    • 0027234897 scopus 로고
    • Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression
    • Thigpen A.E., Silver R.I., Guileyardo J.M., et al. Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. J Clin Invest 1993, 92:903-910.
    • (1993) J Clin Invest , vol.92 , pp. 903-910
    • Thigpen, A.E.1    Silver, R.I.2    Guileyardo, J.M.3
  • 17
    • 0036181761 scopus 로고    scopus 로고
    • Expression of the androgen receptor and 5 alpha-reductase type 2 in the developing human fetal penis and urethra
    • Kim K.S., Liu W., Cunha G.R., et al. Expression of the androgen receptor and 5 alpha-reductase type 2 in the developing human fetal penis and urethra. Cell Tissue Res 2002, 307:145-153.
    • (2002) Cell Tissue Res , vol.307 , pp. 145-153
    • Kim, K.S.1    Liu, W.2    Cunha, G.R.3
  • 18
    • 34249856317 scopus 로고    scopus 로고
    • The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men
    • Amory J.K., Wang C., Swerdloff R.S., et al. The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men. J Clin Endocrinol Metab 2007, 92:1659-1665.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1659-1665
    • Amory, J.K.1    Wang, C.2    Swerdloff, R.S.3
  • 19
    • 34249000708 scopus 로고    scopus 로고
    • Testosterone and erectile function: From basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction
    • Traish A.M., Goldstein I., Kim N.N. Testosterone and erectile function: From basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction. Eur Urol 2007, 52:54-70.
    • (2007) Eur Urol , vol.52 , pp. 54-70
    • Traish, A.M.1    Goldstein, I.2    Kim, N.N.3
  • 20
    • 33645962531 scopus 로고    scopus 로고
    • Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence
    • Traish A.M., Guay A.T. Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence. J Sex Med 2006, 3:382-404.
    • (2006) J Sex Med , vol.3 , pp. 382-404
    • Traish, A.M.1    Guay, A.T.2
  • 21
    • 33745253926 scopus 로고    scopus 로고
    • Testosterone undecanoate restores erectile function in a subset of patients with venous leakage: A series of case reports
    • Yassin A.A., Saad F., Traish A. Testosterone undecanoate restores erectile function in a subset of patients with venous leakage: A series of case reports. J Sex Med 2006, 3:727-735.
    • (2006) J Sex Med , vol.3 , pp. 727-735
    • Yassin, A.A.1    Saad, F.2    Traish, A.3
  • 22
    • 33749235692 scopus 로고    scopus 로고
    • Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis
    • Agis-Balboa R.C., Pinna G., Zhubi A., et al. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci U S A 2006, 103:14602-14607.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14602-14607
    • Agis-Balboa, R.C.1    Pinna, G.2    Zhubi, A.3
  • 23
    • 0022483382 scopus 로고
    • Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
    • Majewska M.D., Harrison N.L., Schwartz R.D., et al. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 1986, 232:1004-1007.
    • (1986) Science , vol.232 , pp. 1004-1007
    • Majewska, M.D.1    Harrison, N.L.2    Schwartz, R.D.3
  • 24
    • 84894093087 scopus 로고    scopus 로고
    • Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: A randomized, controlled trial
    • Borst S.E., Yarrow J.F., Conover C.F., et al. Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: A randomized, controlled trial. Am J Physiol Endocrinol Metab 2014, 306:E433-E442.
    • (2014) Am J Physiol Endocrinol Metab , vol.306 , pp. E433-E442
    • Borst, S.E.1    Yarrow, J.F.2    Conover, C.F.3
  • 25
    • 1642578875 scopus 로고    scopus 로고
    • Comparative studies on level of androgens in hair and plasma with premature male-pattern baldness
    • Bang H.J., Yang Y.J., Lho D.S., et al. Comparative studies on level of androgens in hair and plasma with premature male-pattern baldness. J Dermatol Sci 2004, 34:11-16.
    • (2004) J Dermatol Sci , vol.34 , pp. 11-16
    • Bang, H.J.1    Yang, Y.J.2    Lho, D.S.3
  • 26
    • 84862821550 scopus 로고    scopus 로고
    • Effects of oral finasteride on erectile function in a rat model
    • Zhang M.G., Wu W., Zhang C.M., et al. Effects of oral finasteride on erectile function in a rat model. J Sex Med 2012, 9:1328-1336.
    • (2012) J Sex Med , vol.9 , pp. 1328-1336
    • Zhang, M.G.1    Wu, W.2    Zhang, C.M.3
  • 27
    • 80255127536 scopus 로고    scopus 로고
    • The effects of chronic 5-alpha-reductase inhibitor (dutasteride) treatment on rat erectile function
    • Pinsky M.R., Gur S., Tracey A.J., et al. The effects of chronic 5-alpha-reductase inhibitor (dutasteride) treatment on rat erectile function. J Sex Med 2011, 8:3066-3074.
    • (2011) J Sex Med , vol.8 , pp. 3066-3074
    • Pinsky, M.R.1    Gur, S.2    Tracey, A.J.3
  • 28
    • 0016359646 scopus 로고
    • Steroid 5alpha-reductase deficiency in man: An inherited form of male pseudohermaphroditism
    • Imperato-McGinley J., Guerrero L., Gautier T., et al. Steroid 5alpha-reductase deficiency in man: An inherited form of male pseudohermaphroditism. Science 1974, 186:1213-1215.
    • (1974) Science , vol.186 , pp. 1213-1215
    • Imperato-McGinley, J.1    Guerrero, L.2    Gautier, T.3
  • 29
    • 0031550935 scopus 로고    scopus 로고
    • Paternity by intrauterine insemination with sperm from a man with 5alpha-reductase-2 deficiency
    • Katz M.D., Kligman I., Cai L.Q., et al. Paternity by intrauterine insemination with sperm from a man with 5alpha-reductase-2 deficiency. N Engl J Med 1997, 336:994-997.
    • (1997) N Engl J Med , vol.336 , pp. 994-997
    • Katz, M.D.1    Kligman, I.2    Cai, L.Q.3
  • 30
    • 0023915402 scopus 로고
    • Male pseudohermaphroditism due to 5 alpha-reductase deficiency in a Swedish family
    • Ivarsson S.A., Nielsen M.D., Lindberg T. Male pseudohermaphroditism due to 5 alpha-reductase deficiency in a Swedish family. Eur J Pediatr 1988, 147:532-535.
    • (1988) Eur J Pediatr , vol.147 , pp. 532-535
    • Ivarsson, S.A.1    Nielsen, M.D.2    Lindberg, T.3
  • 31
    • 0035140015 scopus 로고    scopus 로고
    • Trinucleotide (CAG) repeat polymorphisms in the androgen receptor gene: Molecular markers of risk for male infertility
    • Mifsud A., Sim C.K., Boettger-Tong H., et al. Trinucleotide (CAG) repeat polymorphisms in the androgen receptor gene: Molecular markers of risk for male infertility. Fertil Steril 2001, 75:275-281.
    • (2001) Fertil Steril , vol.75 , pp. 275-281
    • Mifsud, A.1    Sim, C.K.2    Boettger-Tong, H.3
  • 32
    • 0035724191 scopus 로고    scopus 로고
    • The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males
    • Zitzmann M., Brune M., Kornmann B., et al. The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males. Clin Endocrinol 2001, 55:649-657.
    • (2001) Clin Endocrinol , vol.55 , pp. 649-657
    • Zitzmann, M.1    Brune, M.2    Kornmann, B.3
  • 33
    • 82955201889 scopus 로고    scopus 로고
    • Sex hormone levels, genetic androgen receptor polymorphism, and anxiety in >/=50-year-old males
    • Schneider G., Nienhaus K., Gromoll J., et al. Sex hormone levels, genetic androgen receptor polymorphism, and anxiety in >/=50-year-old males. J Sex Med 2011, 8:3452-3464.
    • (2011) J Sex Med , vol.8 , pp. 3452-3464
    • Schneider, G.1    Nienhaus, K.2    Gromoll, J.3
  • 34
    • 80054949864 scopus 로고    scopus 로고
    • Predictors of pilosebaceous unit responsiveness to testosterone therapy in patients with hypogonadotrophic hypogonadism
    • Dhiman P., Bhansali A., Prasad R., et al. Predictors of pilosebaceous unit responsiveness to testosterone therapy in patients with hypogonadotrophic hypogonadism. Andrologia 2011, 43:422-427.
    • (2011) Andrologia , vol.43 , pp. 422-427
    • Dhiman, P.1    Bhansali, A.2    Prasad, R.3
  • 35
    • 77953576180 scopus 로고    scopus 로고
    • Toward quantifying the usage costs of human immunity: Altered metabolic rates and hormone levels during acute immune activation in men
    • Muehlenbein M.P., Hirschtick J.L., Bonner J.Z., et al. Toward quantifying the usage costs of human immunity: Altered metabolic rates and hormone levels during acute immune activation in men. Am J Hum Biol 2010, 22:546-556.
    • (2010) Am J Hum Biol , vol.22 , pp. 546-556
    • Muehlenbein, M.P.1    Hirschtick, J.L.2    Bonner, J.Z.3
  • 36
    • 33846961810 scopus 로고    scopus 로고
    • The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men
    • Travison T.G., Araujo A.B., Kupelian V., et al. The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. J Clin Endocrinol Metab 2007, 92:549-555.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 549-555
    • Travison, T.G.1    Araujo, A.B.2    Kupelian, V.3
  • 37
    • 84868611284 scopus 로고    scopus 로고
    • Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men
    • Yeap B.B., Alfonso H., Chubb S.A., et al. Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men. J Clin Endocrinol Metab 2012, 97:4030-4039.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 4030-4039
    • Yeap, B.B.1    Alfonso, H.2    Chubb, S.A.3
  • 38
    • 80051560339 scopus 로고    scopus 로고
    • Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts
    • Bhasin S., Pencina M., Jasuja G.K., et al. Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts. J Clin Endocrinol Metab 2011, 96:2430-2439.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2430-2439
    • Bhasin, S.1    Pencina, M.2    Jasuja, G.K.3
  • 39
    • 0036170745 scopus 로고    scopus 로고
    • Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study
    • Feldman H.A., Longcope C., Derby C.A., et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 2002, 87:589-598.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 589-598
    • Feldman, H.A.1    Longcope, C.2    Derby, C.A.3
  • 40
    • 0032522860 scopus 로고    scopus 로고
    • Sex hormones and age: A cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men
    • Ferrini R.L., Barrett-Connor E. Sex hormones and age: A cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men. Am J Epidemiol 1998, 147:750-754.
    • (1998) Am J Epidemiol , vol.147 , pp. 750-754
    • Ferrini, R.L.1    Barrett-Connor, E.2
  • 41
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging
    • Harman S.M., Metter E.J., Tobin J.D., et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001, 86:724-731.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3
  • 42
    • 84881522951 scopus 로고    scopus 로고
    • Longitudinal changes in testosterone over five years in community-dwelling men
    • Shi Z., Araujo A.B., Martin S., et al. Longitudinal changes in testosterone over five years in community-dwelling men. J Clin Endocrinol Metab 2013, 98:3289-3297.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 3289-3297
    • Shi, Z.1    Araujo, A.B.2    Martin, S.3
  • 43
    • 84867249434 scopus 로고    scopus 로고
    • Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: The healthy man study
    • Sartorius G., Spasevska S., Idan A., et al. Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: The healthy man study. Clin Endocrinol 2012, 77:755-763.
    • (2012) Clin Endocrinol , vol.77 , pp. 755-763
    • Sartorius, G.1    Spasevska, S.2    Idan, A.3
  • 44
    • 1442327856 scopus 로고    scopus 로고
    • Measurement of total serum testosterone in adult men: Comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry
    • Wang C., Catlin D.H., Demers L.M., et al. Measurement of total serum testosterone in adult men: Comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab 2004, 89:534-543.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 534-543
    • Wang, C.1    Catlin, D.H.2    Demers, L.M.3
  • 45
    • 62149150656 scopus 로고    scopus 로고
    • Interlaboratory comparison study of serum total testosterone [corrected] measurements performed by mass spectrometry methods
    • Vesper H.W., Bhasin S., Wang C., et al. Interlaboratory comparison study of serum total testosterone [corrected] measurements performed by mass spectrometry methods. Steroids 2009, 74:498-503.
    • (2009) Steroids , vol.74 , pp. 498-503
    • Vesper, H.W.1    Bhasin, S.2    Wang, C.3
  • 46
    • 0001919768 scopus 로고    scopus 로고
    • Utilization of commercial laboratory results in management of hyperandrogenism in women
    • Steinberger E., Ayala C., Hsi B., et al. Utilization of commercial laboratory results in management of hyperandrogenism in women. Endocr Pract 1998, 4:1-10.
    • (1998) Endocr Pract , vol.4 , pp. 1-10
    • Steinberger, E.1    Ayala, C.2    Hsi, B.3
  • 47
    • 64549120309 scopus 로고    scopus 로고
    • Predictive accuracy and sources of variability in calculated free testosterone estimates
    • Sartorius G., Ly L.P., Sikaris K., et al. Predictive accuracy and sources of variability in calculated free testosterone estimates. Ann Clin Biochem 2009, 46:137-143.
    • (2009) Ann Clin Biochem , vol.46 , pp. 137-143
    • Sartorius, G.1    Ly, L.P.2    Sikaris, K.3
  • 48
    • 62349139045 scopus 로고    scopus 로고
    • The effect of diurnal variation on clinical measurement of serum testosterone and other sex hormone levels in men
    • Brambilla D.J., Matsumoto A.M., Araujo A.B., et al. The effect of diurnal variation on clinical measurement of serum testosterone and other sex hormone levels in men. J Clin Endocrinol Metab 2009, 94:907-913.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 907-913
    • Brambilla, D.J.1    Matsumoto, A.M.2    Araujo, A.B.3
  • 49
    • 84883857592 scopus 로고    scopus 로고
    • Genetic and environmental influences of daily and intra-individual variation in testosterone levels in middle-aged men
    • Panizzon M.S., Hauger R., Jacobson K.C., et al. Genetic and environmental influences of daily and intra-individual variation in testosterone levels in middle-aged men. Psychoneuroendocrinology 2013, 38:2163-2172.
    • (2013) Psychoneuroendocrinology , vol.38 , pp. 2163-2172
    • Panizzon, M.S.1    Hauger, R.2    Jacobson, K.C.3
  • 50
    • 45349099672 scopus 로고    scopus 로고
    • Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblings
    • Bogaert V., Taes Y., Konings P., et al. Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblings. Clin Endocrinol 2008, 69:129-135.
    • (2008) Clin Endocrinol , vol.69 , pp. 129-135
    • Bogaert, V.1    Taes, Y.2    Konings, P.3
  • 51
    • 34547816654 scopus 로고    scopus 로고
    • Heritability of reproductive hormones in adult male twins
    • Kuijper E.A., Lambalk C.B., Boomsma D.I., et al. Heritability of reproductive hormones in adult male twins. Hum Reprod 2007, 22:2153-2159.
    • (2007) Hum Reprod , vol.22 , pp. 2153-2159
    • Kuijper, E.A.1    Lambalk, C.B.2    Boomsma, D.I.3
  • 52
    • 21244468349 scopus 로고    scopus 로고
    • Heritability of plasma sex hormones and hormone binding globulin in adult male twins
    • Ring H.Z., Lessov C.N., Reed T., et al. Heritability of plasma sex hormones and hormone binding globulin in adult male twins. J Clin Endocrinol Metab 2005, 90:3653-3658.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3653-3658
    • Ring, H.Z.1    Lessov, C.N.2    Reed, T.3
  • 53
    • 77957785833 scopus 로고    scopus 로고
    • Evidence for geographical and racial variation in serum sex steroid levels in older men
    • Orwoll E.S., Nielson C.M., Labrie F., et al. Evidence for geographical and racial variation in serum sex steroid levels in older men. J Clin Endocrinol Metab 2010, 95:E151-E160.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. E151-E160
    • Orwoll, E.S.1    Nielson, C.M.2    Labrie, F.3
  • 54
    • 36249031484 scopus 로고    scopus 로고
    • Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men
    • Brambilla D.J., O'Donnell A.B., Matsumoto A.M., et al. Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men. Clin Endocrinol 2007, 67:853-862.
    • (2007) Clin Endocrinol , vol.67 , pp. 853-862
    • Brambilla, D.J.1    O'Donnell, A.B.2    Matsumoto, A.M.3
  • 55
    • 0036257524 scopus 로고    scopus 로고
    • Evaluation of assays available to measure free testosterone
    • Morley J.E., Patrick P., Perry H.M. Evaluation of assays available to measure free testosterone. Metabolism 2002, 51:554-559.
    • (2002) Metabolism , vol.51 , pp. 554-559
    • Morley, J.E.1    Patrick, P.2    Perry, H.M.3
  • 56
    • 84878715496 scopus 로고    scopus 로고
    • Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: A systematic review and meta-analysis
    • Corona G., Rastrelli G., Monami M., et al. Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: A systematic review and meta-analysis. Eur J Endocrinol 2013, 168:829-843.
    • (2013) Eur J Endocrinol , vol.168 , pp. 829-843
    • Corona, G.1    Rastrelli, G.2    Monami, M.3
  • 57
    • 84879836715 scopus 로고    scopus 로고
    • Comparing effects of low- and high-volume moderate-intensity exercise on sexual function and testosterone in obese men
    • Khoo J., Tian H.H., Tan B., et al. Comparing effects of low- and high-volume moderate-intensity exercise on sexual function and testosterone in obese men. J Sex Med 2013, 10:1823-1832.
    • (2013) J Sex Med , vol.10 , pp. 1823-1832
    • Khoo, J.1    Tian, H.H.2    Tan, B.3
  • 58
    • 77449091684 scopus 로고    scopus 로고
    • Salivary hormonal responses to different water-based exercise protocols in young and elderly men
    • Cadore E.L., Lhullier F.L., Alberton C.L., et al. Salivary hormonal responses to different water-based exercise protocols in young and elderly men. J Strength Cond Res 2009, 23:2695-2701.
    • (2009) J Strength Cond Res , vol.23 , pp. 2695-2701
    • Cadore, E.L.1    Lhullier, F.L.2    Alberton, C.L.3
  • 59
    • 8144222233 scopus 로고    scopus 로고
    • Acute hormonal responses to heavy resistance exercise in strength athletes versus nonathletes
    • Ahtiainen J.P., Pakarinen A., Kraemer W.J., et al. Acute hormonal responses to heavy resistance exercise in strength athletes versus nonathletes. Can J Appl Physiol 2004, 29:527-543.
    • (2004) Can J Appl Physiol , vol.29 , pp. 527-543
    • Ahtiainen, J.P.1    Pakarinen, A.2    Kraemer, W.J.3
  • 60
    • 59649107776 scopus 로고    scopus 로고
    • Hormonal responses to resistance exercise in long-term trained and untrained middle-aged men
    • Cadore E.L., Lhullier F.L., Brentano M.A., et al. Hormonal responses to resistance exercise in long-term trained and untrained middle-aged men. J Strength Cond Res 2008, 22:1617-1624.
    • (2008) J Strength Cond Res , vol.22 , pp. 1617-1624
    • Cadore, E.L.1    Lhullier, F.L.2    Brentano, M.A.3
  • 61
    • 0041524095 scopus 로고    scopus 로고
    • The associations of age, lifestyle factors and chronic disease with testosterone in men: The Tromso Study
    • Svartberg J., Midtby M., Bonaa K.H., et al. The associations of age, lifestyle factors and chronic disease with testosterone in men: The Tromso Study. Eur J Endocrinol 2003, 149:145-152.
    • (2003) Eur J Endocrinol , vol.149 , pp. 145-152
    • Svartberg, J.1    Midtby, M.2    Bonaa, K.H.3
  • 62
    • 30344448551 scopus 로고    scopus 로고
    • Relationship between testosterone serum levels and lifestyle in aging men
    • Ponholzer A., Plas E., Schatzl G., et al. Relationship between testosterone serum levels and lifestyle in aging men. Aging Male 2005, 8:190-193.
    • (2005) Aging Male , vol.8 , pp. 190-193
    • Ponholzer, A.1    Plas, E.2    Schatzl, G.3
  • 63
    • 0028091876 scopus 로고
    • The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men
    • Field A.E., Colditz G.A., Willett W.C., et al. The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men. J Clin Endocrinol Metab 1994, 79:1310-1316.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1310-1316
    • Field, A.E.1    Colditz, G.A.2    Willett, W.C.3
  • 64
    • 84889644088 scopus 로고    scopus 로고
    • Association of cigarette smoking with reproductive hormone levels and semen quality in healthy adult men in Taiwan
    • Jeng H.A., Chen Y.L., Kantaria K.N. Association of cigarette smoking with reproductive hormone levels and semen quality in healthy adult men in Taiwan. J Environ Sci Health A Tox Hazard Subst Environ Eng 2014, 49:262-268.
    • (2014) J Environ Sci Health A Tox Hazard Subst Environ Eng , vol.49 , pp. 262-268
    • Jeng, H.A.1    Chen, Y.L.2    Kantaria, K.N.3
  • 65
    • 66649105186 scopus 로고    scopus 로고
    • Evaluation of the effects of cigarette smoking on testosterone levels in adult men
    • Halmenschlager G., Rossetto S., Lara G.M., et al. Evaluation of the effects of cigarette smoking on testosterone levels in adult men. J Sex Med 2009, 6:1763-1772.
    • (2009) J Sex Med , vol.6 , pp. 1763-1772
    • Halmenschlager, G.1    Rossetto, S.2    Lara, G.M.3
  • 66
    • 0032498813 scopus 로고    scopus 로고
    • Annual rhythmic variations of follitropin, lutropin, testosterone and sex-hormone-binding globulin in men
    • Valero-Politi J., Fuentes-Arderiu X. Annual rhythmic variations of follitropin, lutropin, testosterone and sex-hormone-binding globulin in men. Clin Chim Acta 1998, 271:57-71.
    • (1998) Clin Chim Acta , vol.271 , pp. 57-71
    • Valero-Politi, J.1    Fuentes-Arderiu, X.2
  • 67
    • 34250727149 scopus 로고    scopus 로고
    • Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: A longitudinal study
    • Ruhayel Y., Malm G., Haugen T.B., et al. Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: A longitudinal study. Clin Endocrinol 2007, 67:85-92.
    • (2007) Clin Endocrinol , vol.67 , pp. 85-92
    • Ruhayel, Y.1    Malm, G.2    Haugen, T.B.3
  • 68
    • 0021706324 scopus 로고
    • Circadian and circannual rhythms of hormonal variables in elderly men and women
    • Nicolau G.Y., Lakatua D., Sackett-Lundeen L., et al. Circadian and circannual rhythms of hormonal variables in elderly men and women. Chronobiol Int 1984, 1:301-319.
    • (1984) Chronobiol Int , vol.1 , pp. 301-319
    • Nicolau, G.Y.1    Lakatua, D.2    Sackett-Lundeen, L.3
  • 69
    • 35948976533 scopus 로고    scopus 로고
    • Lack of seasonal variation in serum sex hormone levels in middle-aged to older men in the Boston area
    • Brambilla D.J., O'Donnell A.B., Matsumoto A.M., et al. Lack of seasonal variation in serum sex hormone levels in middle-aged to older men in the Boston area. J Clin Endocrinol Metab 2007, 92:4224-4229.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4224-4229
    • Brambilla, D.J.1    O'Donnell, A.B.2    Matsumoto, A.M.3
  • 70
    • 0021880169 scopus 로고
    • Circannual concentrations of melatonin, gonadotrophins, prolactin and gonadal steroids in males in a geographical area with a large annual variation in daylight
    • Martikainen H., Tapanainen J., Vakkuri O., et al. Circannual concentrations of melatonin, gonadotrophins, prolactin and gonadal steroids in males in a geographical area with a large annual variation in daylight. Acta Endocrinol 1985, 109:446-450.
    • (1985) Acta Endocrinol , vol.109 , pp. 446-450
    • Martikainen, H.1    Tapanainen, J.2    Vakkuri, O.3
  • 71
    • 0024419106 scopus 로고
    • Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men
    • Plymate S.R., Tenover J.S., Bremner W.J. Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men. J Androl 1989, 10:366-371.
    • (1989) J Androl , vol.10 , pp. 366-371
    • Plymate, S.R.1    Tenover, J.S.2    Bremner, W.J.3
  • 72
    • 0020635522 scopus 로고
    • Loss of circadian rhythmicity in blood testosterone levels with aging in normal men
    • Bremner W.J., Vitiello M.V., Prinz P.N. Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 1983, 56:1278-1281.
    • (1983) J Clin Endocrinol Metab , vol.56 , pp. 1278-1281
    • Bremner, W.J.1    Vitiello, M.V.2    Prinz, P.N.3
  • 73
    • 34547632140 scopus 로고    scopus 로고
    • The association of time of day and serum testosterone concentration in a large screening population
    • Crawford E.D., Barqawi A.B., O'Donnell C., et al. The association of time of day and serum testosterone concentration in a large screening population. BJU Int 2007, 100:509-513.
    • (2007) BJU Int , vol.100 , pp. 509-513
    • Crawford, E.D.1    Barqawi, A.B.2    O'Donnell, C.3
  • 74
    • 0037793319 scopus 로고    scopus 로고
    • Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle-aged men compared with those in young men
    • Diver M.J., Imtiaz K.E., Ahmad A.M., et al. Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle-aged men compared with those in young men. Clin Endocrinol 2003, 58:710-717.
    • (2003) Clin Endocrinol , vol.58 , pp. 710-717
    • Diver, M.J.1    Imtiaz, K.E.2    Ahmad, A.M.3
  • 75
    • 23844534740 scopus 로고    scopus 로고
    • Effects of acutely displaced sleep on testosterone
    • Axelsson J., Ingre M., Akerstedt T., et al. Effects of acutely displaced sleep on testosterone. J Clin Endocrinol Metab 2005, 90:4530-4535.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4530-4535
    • Axelsson, J.1    Ingre, M.2    Akerstedt, T.3
  • 76
    • 34447117600 scopus 로고    scopus 로고
    • Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans
    • Rohrmann S., Nelson W.G., Rifai N., et al. Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans. J Clin Endocrinol Metab 2007, 92:2519-2525.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2519-2525
    • Rohrmann, S.1    Nelson, W.G.2    Rifai, N.3
  • 77
    • 33751504330 scopus 로고    scopus 로고
    • Serum androgen levels in black, Hispanic, and white men
    • Litman H.J., Bhasin S., Link C.L., et al. Serum androgen levels in black, Hispanic, and white men. J Clin Endocrinol Metab 2006, 91:4326-4334.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4326-4334
    • Litman, H.J.1    Bhasin, S.2    Link, C.L.3
  • 78
    • 0028846963 scopus 로고
    • Serum androgens and sex hormone-binding globulins in relation to lifestyle factors in older African-American, white, and Asian men in the United States and Canada
    • Wu A.H., Whittemore A.S., Kolonel L.N., et al. Serum androgens and sex hormone-binding globulins in relation to lifestyle factors in older African-American, white, and Asian men in the United States and Canada. Cancer Epidemiol Biomarkers Prev 1995, 4:735-741.
    • (1995) Cancer Epidemiol Biomarkers Prev , vol.4 , pp. 735-741
    • Wu, A.H.1    Whittemore, A.S.2    Kolonel, L.N.3
  • 79
    • 0031838607 scopus 로고    scopus 로고
    • The heritability of testosterone: A study of Dutch adolescent twins and their parents
    • Harris J.A., Vernon P.A., Boomsma D.I. The heritability of testosterone: A study of Dutch adolescent twins and their parents. Behav Genet 1998, 28:165-171.
    • (1998) Behav Genet , vol.28 , pp. 165-171
    • Harris, J.A.1    Vernon, P.A.2    Boomsma, D.I.3
  • 80
    • 33750114738 scopus 로고    scopus 로고
    • Heritability of testosterone levels in 12-year-old twins and its relation to pubertal development
    • Hoekstra R.A., Bartels M., Boomsma D.I. Heritability of testosterone levels in 12-year-old twins and its relation to pubertal development. Twin Res Hum Genet 2006, 9:558-565.
    • (2006) Twin Res Hum Genet , vol.9 , pp. 558-565
    • Hoekstra, R.A.1    Bartels, M.2    Boomsma, D.I.3
  • 81
    • 0021948623 scopus 로고
    • Familial factors affecting prostatic cancer risk and plasma sex-steroid levels
    • Meikle A.W., Smith J.A., West D.W. Familial factors affecting prostatic cancer risk and plasma sex-steroid levels. Prostate 1985, 6:121-128.
    • (1985) Prostate , vol.6 , pp. 121-128
    • Meikle, A.W.1    Smith, J.A.2    West, D.W.3
  • 82
    • 0031680573 scopus 로고    scopus 로고
    • Biological day-to-day variation and daytime changes of testosterone, follitropin, lutropin and oestradiol-17beta in healthy men
    • Ahokoski O., Virtanen A., Huupponen R., et al. Biological day-to-day variation and daytime changes of testosterone, follitropin, lutropin and oestradiol-17beta in healthy men. Clin Chem Lab Med 1998, 36:485-491.
    • (1998) Clin Chem Lab Med , vol.36 , pp. 485-491
    • Ahokoski, O.1    Virtanen, A.2    Huupponen, R.3
  • 83
    • 0027179155 scopus 로고
    • Within- and between-subject biological variations of follitropin, lutropin, testosterone, and sex-hormone-binding globulin in men
    • Valero-Politi J., Fuentes-Arderiu X. Within- and between-subject biological variations of follitropin, lutropin, testosterone, and sex-hormone-binding globulin in men. Clin Chem 1993, 39:1723-1725.
    • (1993) Clin Chem , vol.39 , pp. 1723-1725
    • Valero-Politi, J.1    Fuentes-Arderiu, X.2
  • 84
    • 0033757537 scopus 로고    scopus 로고
    • Decreased androgen levels in massively obese men may be associated with impaired function of the gonadostat
    • Lima N., Cavaliere H., Knobel M., et al. Decreased androgen levels in massively obese men may be associated with impaired function of the gonadostat. Int J Obes Relat Metab Disord 2000, 24:1433-1437.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 1433-1437
    • Lima, N.1    Cavaliere, H.2    Knobel, M.3
  • 85
    • 65249111136 scopus 로고    scopus 로고
    • Effect of Roux-en-Y gastric bypass surgery on the sex steroids and quality of life in obese men
    • Hammoud A., Gibson M., Hunt S.C., et al. Effect of Roux-en-Y gastric bypass surgery on the sex steroids and quality of life in obese men. J Clin Endocrinol Metab 2009, 94:1329-1332.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 1329-1332
    • Hammoud, A.1    Gibson, M.2    Hunt, S.C.3
  • 86
    • 0021874135 scopus 로고
    • Plasma free testosterone-is an index sufficient?
    • Nanjee M.N., Wheeler M.J. Plasma free testosterone-is an index sufficient?. Ann Clin Biochem 1985, 22:387-390.
    • (1985) Ann Clin Biochem , vol.22 , pp. 387-390
    • Nanjee, M.N.1    Wheeler, M.J.2
  • 87
    • 0020417830 scopus 로고
    • Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature
    • Sodergard R., Backstrom T., Shanbhag V., et al. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem 1982, 16:801-810.
    • (1982) J Steroid Biochem , vol.16 , pp. 801-810
    • Sodergard, R.1    Backstrom, T.2    Shanbhag, V.3
  • 88
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • Vermeulen A., Verdonck L., Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999, 84:3666-3672.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3666-3672
    • Vermeulen, A.1    Verdonck, L.2    Kaufman, J.M.3
  • 89
    • 15944403154 scopus 로고    scopus 로고
    • Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays
    • Ly L.P., Handelsman D.J. Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays. Eur J Endocrinol 2005, 152:471-478.
    • (2005) Eur J Endocrinol , vol.152 , pp. 471-478
    • Ly, L.P.1    Handelsman, D.J.2
  • 90
    • 84856432103 scopus 로고    scopus 로고
    • The coming of age of liquid chromatography coupled to tandem mass spectrometry in the endocrinology laboratory
    • Carvalho V.M. The coming of age of liquid chromatography coupled to tandem mass spectrometry in the endocrinology laboratory. J Chromatogr B 2012, 883-884:50-58.
    • (2012) J Chromatogr B , pp. 50-58
    • Carvalho, V.M.1
  • 91
    • 33846991956 scopus 로고    scopus 로고
    • Position statement: Utility, limitations, and pitfalls in measuring testosterone: An Endocrine Society position statement
    • Rosner W., Auchus R.J., Azziz R., et al. Position statement: Utility, limitations, and pitfalls in measuring testosterone: An Endocrine Society position statement. J Clin Endocrinol Metab 2007, 92:405-413.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 405-413
    • Rosner, W.1    Auchus, R.J.2    Azziz, R.3
  • 92
    • 36049021839 scopus 로고    scopus 로고
    • Laboratory testing of gonadal steroids in children
    • Albrecht L., Styne D. Laboratory testing of gonadal steroids in children. Pediatr Endocrinol Rev 2007, 5(Suppl. 1):599-607.
    • (2007) Pediatr Endocrinol Rev , vol.5 , pp. 599-607
    • Albrecht, L.1    Styne, D.2
  • 93
    • 33749572914 scopus 로고    scopus 로고
    • Androgen therapy in women: An Endocrine Society clinical practice guideline
    • Wierman M.E., Basson R., Davis S.R., et al. Androgen therapy in women: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2006, 91:3697-3710.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3697-3710
    • Wierman, M.E.1    Basson, R.2    Davis, S.R.3
  • 95
    • 77955428229 scopus 로고    scopus 로고
    • Standardization of testosterone measurements in humans
    • Vesper H.W., Botelho J.C. Standardization of testosterone measurements in humans. J Steroid Biochem Mol Biol 2010, 121:513-519.
    • (2010) J Steroid Biochem Mol Biol , vol.121 , pp. 513-519
    • Vesper, H.W.1    Botelho, J.C.2
  • 96
    • 84974614033 scopus 로고    scopus 로고
    • Accessed May 12
    • Control CfD. Accessed May 12, 2016. http://www.cdc.gov/labstandards/hs.html.
    • (2016) Control CfD
  • 97
    • 56749163628 scopus 로고    scopus 로고
    • Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations
    • Wang C., Nieschlag E., Swerdloff R., et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol 2008, 159:507-514.
    • (2008) Eur J Endocrinol , vol.159 , pp. 507-514
    • Wang, C.1    Nieschlag, E.2    Swerdloff, R.3
  • 98
    • 54149084920 scopus 로고    scopus 로고
    • The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders
    • Bhasin S., Zhang A., Coviello A., et al. The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders. Steroids 2008, 73:1311-1317.
    • (2008) Steroids , vol.73 , pp. 1311-1317
    • Bhasin, S.1    Zhang, A.2    Coviello, A.3
  • 99
    • 0019759637 scopus 로고
    • Transport of steroid hormones: Binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma
    • Dunn J.F., Nisula B.C., Rodbard D. Transport of steroid hormones: Binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 1981, 53:58-68.
    • (1981) J Clin Endocrinol Metab , vol.53 , pp. 58-68
    • Dunn, J.F.1    Nisula, B.C.2    Rodbard, D.3
  • 100
    • 84860741362 scopus 로고    scopus 로고
    • Evolving utility of sex hormone-binding globulin measurements in clinical medicine
    • Hammond G.L., Wu T.S., Simard M. Evolving utility of sex hormone-binding globulin measurements in clinical medicine. Curr Opin Endocrinol Diabetes Obes 2012, 19:183-189.
    • (2012) Curr Opin Endocrinol Diabetes Obes , vol.19 , pp. 183-189
    • Hammond, G.L.1    Wu, T.S.2    Simard, M.3
  • 101
    • 0033678650 scopus 로고    scopus 로고
    • Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men
    • van den Beld A.W., de Jong F.H., Grobbee D.E., et al. Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 2000, 85:3276-3282.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3276-3282
    • van den Beld, A.W.1    de Jong, F.H.2    Grobbee, D.E.3
  • 102
    • 40349091513 scopus 로고    scopus 로고
    • Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men
    • Almeida O.P., Yeap B.B., Hankey G.J., et al. Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch Gen Psychiatry 2008, 65:283-289.
    • (2008) Arch Gen Psychiatry , vol.65 , pp. 283-289
    • Almeida, O.P.1    Yeap, B.B.2    Hankey, G.J.3
  • 103
    • 79952048597 scopus 로고    scopus 로고
    • Testosterone, sex hormone-binding globulin and the metabolic syndrome: A systematic review and meta-analysis of observational studies
    • Brand J.S., van der Tweel I., Grobbee D.E., et al. Testosterone, sex hormone-binding globulin and the metabolic syndrome: A systematic review and meta-analysis of observational studies. Int J Epidemiol 2011, 40:189-207.
    • (2011) Int J Epidemiol , vol.40 , pp. 189-207
    • Brand, J.S.1    van der Tweel, I.2    Grobbee, D.E.3
  • 104
    • 84864619335 scopus 로고    scopus 로고
    • A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation
    • Coviello A.D., Haring R., Wellons M., et al. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genet 2012, 8:e1002805.
    • (2012) PLoS Genet , vol.8 , pp. e1002805
    • Coviello, A.D.1    Haring, R.2    Wellons, M.3
  • 105
    • 58549104538 scopus 로고    scopus 로고
    • Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men
    • Vanbillemont G., Bogaert V., De Bacquer D., et al. Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men. Clin Endocrinol 2009, 70:303-310.
    • (2009) Clin Endocrinol , vol.70 , pp. 303-310
    • Vanbillemont, G.1    Bogaert, V.2    De Bacquer, D.3
  • 106
    • 24144439116 scopus 로고    scopus 로고
    • Role of endocytosis in cellular uptake of sex steroids
    • Hammes A., Andreassen T.K., Spoelgen R., et al. Role of endocytosis in cellular uptake of sex steroids. Cell 2005, 122:751-762.
    • (2005) Cell , vol.122 , pp. 751-762
    • Hammes, A.1    Andreassen, T.K.2    Spoelgen, R.3
  • 107
    • 4444233038 scopus 로고    scopus 로고
    • A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men
    • Morris P.D., Malkin C.J., Channer K.S., et al. A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men. Eur J Endocrinol 2004, 151:241-249.
    • (2004) Eur J Endocrinol , vol.151 , pp. 241-249
    • Morris, P.D.1    Malkin, C.J.2    Channer, K.S.3
  • 108
    • 84908568336 scopus 로고    scopus 로고
    • A multi-step, dynamic allosteric model of testosterone's binding to sex hormone binding globulin
    • Zakharov M.N., Bhasin S., Travison T.G., et al. A multi-step, dynamic allosteric model of testosterone's binding to sex hormone binding globulin. Mol Cell Endocrinol 2015, 399:190-200.
    • (2015) Mol Cell Endocrinol , vol.399 , pp. 190-200
    • Zakharov, M.N.1    Bhasin, S.2    Travison, T.G.3
  • 109
  • 110
    • 0033821819 scopus 로고    scopus 로고
    • Validation of a screening questionnaire for androgen deficiency in aging males
    • Morley J.E., Charlton E., Patrick P., et al. Validation of a screening questionnaire for androgen deficiency in aging males. Metabolism 2000, 49:1239-1242.
    • (2000) Metabolism , vol.49 , pp. 1239-1242
    • Morley, J.E.1    Charlton, E.2    Patrick, P.3
  • 111
    • 0034492440 scopus 로고    scopus 로고
    • Construction and field validation of a self-administered screener for testosterone deficiency (hypogonadism) in ageing men
    • Smith K.W., Feldman H.A., McKinlay J.B. Construction and field validation of a self-administered screener for testosterone deficiency (hypogonadism) in ageing men. Clin Endocrinol 2000, 53:703-711.
    • (2000) Clin Endocrinol , vol.53 , pp. 703-711
    • Smith, K.W.1    Feldman, H.A.2    McKinlay, J.B.3
  • 112
    • 70049092347 scopus 로고    scopus 로고
    • Hypogonadism-related symptoms: Development and evaluation of an empirically derived self-rating instrument (HRS 'Hypogonadism Related Symptom Scale')
    • Wiltink J., Beutel M.E., Brahler E., et al. Hypogonadism-related symptoms: Development and evaluation of an empirically derived self-rating instrument (HRS 'Hypogonadism Related Symptom Scale'). Andrologia 2009, 41:297-304.
    • (2009) Andrologia , vol.41 , pp. 297-304
    • Wiltink, J.1    Beutel, M.E.2    Brahler, E.3
  • 113
    • 4243153928 scopus 로고    scopus 로고
    • Preliminary development of a new individualised questionnaire measuring quality of life in older men with age-related hormonal decline: The A-RHDQoL
    • McMillan C.V., Bradley C., Giannoulis M., et al. Preliminary development of a new individualised questionnaire measuring quality of life in older men with age-related hormonal decline: The A-RHDQoL. Health Qual Life Outcomes 2003, 1:51.
    • (2003) Health Qual Life Outcomes , vol.1 , pp. 51
    • McMillan, C.V.1    Bradley, C.2    Giannoulis, M.3
  • 114
    • 33745279085 scopus 로고    scopus 로고
    • ANDROTEST: A structured interview for the screening of hypogonadism in patients with sexual dysfunction
    • Corona G., Mannucci E., Petrone L., et al. ANDROTEST: A structured interview for the screening of hypogonadism in patients with sexual dysfunction. J Sex Med 2006, 3:706-715.
    • (2006) J Sex Med , vol.3 , pp. 706-715
    • Corona, G.1    Mannucci, E.2    Petrone, L.3
  • 115
    • 33644615112 scopus 로고    scopus 로고
    • Comparison of screening questionnaires for the diagnosis of hypogonadism
    • Morley J.E., Perry H.M., Kevorkian R.T., et al. Comparison of screening questionnaires for the diagnosis of hypogonadism. Maturitas 2006, 53:424-429.
    • (2006) Maturitas , vol.53 , pp. 424-429
    • Morley, J.E.1    Perry, H.M.2    Kevorkian, R.T.3
  • 116
    • 68149160557 scopus 로고    scopus 로고
    • Is the Androgen Deficiency of Aging Men (ADAM) questionnaire useful for the screening of partial androgenic deficiency of aging men?
    • Blumel J.E., Chedraui P., Gili S.A., et al. Is the Androgen Deficiency of Aging Men (ADAM) questionnaire useful for the screening of partial androgenic deficiency of aging men?. Maturitas 2009, 63:365-368.
    • (2009) Maturitas , vol.63 , pp. 365-368
    • Blumel, J.E.1    Chedraui, P.2    Gili, S.A.3
  • 117
    • 4744352683 scopus 로고    scopus 로고
    • Interest of the Androgen Deficiency in Aging Males (ADAM) questionnaire for the identification of hypogonadism in elderly community-dwelling male volunteers
    • Tancredi A., Reginster J.Y., Schleich F., et al. Interest of the Androgen Deficiency in Aging Males (ADAM) questionnaire for the identification of hypogonadism in elderly community-dwelling male volunteers. Eur J Endocrinol 2004, 151:355-360.
    • (2004) Eur J Endocrinol , vol.151 , pp. 355-360
    • Tancredi, A.1    Reginster, J.Y.2    Schleich, F.3
  • 118
    • 36049020269 scopus 로고    scopus 로고
    • Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in an elderly Swedish population
    • Spetz A.C., Palmefors L., Skobe R.S., et al. Testosterone correlated to symptoms of partial androgen deficiency in aging men (PADAM) in an elderly Swedish population. Menopause 2007, 14:999-1005.
    • (2007) Menopause , vol.14 , pp. 999-1005
    • Spetz, A.C.1    Palmefors, L.2    Skobe, R.S.3
  • 119
    • 79952416649 scopus 로고    scopus 로고
    • Low testosterone concentrations and the symptoms of testosterone deficiency according to the Androgen Deficiency in Ageing Males (ADAM) and Ageing Males' Symptoms rating scale (AMS) questionnaires
    • Emmelot-Vonk M.H., Verhaar H.J., Nakhai-Pour H.R., et al. Low testosterone concentrations and the symptoms of testosterone deficiency according to the Androgen Deficiency in Ageing Males (ADAM) and Ageing Males' Symptoms rating scale (AMS) questionnaires. Clin Endocrinol 2011, 74:488-494.
    • (2011) Clin Endocrinol , vol.74 , pp. 488-494
    • Emmelot-Vonk, M.H.1    Verhaar, H.J.2    Nakhai-Pour, H.R.3
  • 120
    • 4744338326 scopus 로고    scopus 로고
    • Can results of the Aging Males' Symptoms (AMS) scale predict those of screening scales for androgen deficiency?
    • Heinemann L.A., Saad F., Heinemann K., et al. Can results of the Aging Males' Symptoms (AMS) scale predict those of screening scales for androgen deficiency?. Aging Male 2004, 7:211-218.
    • (2004) Aging Male , vol.7 , pp. 211-218
    • Heinemann, L.A.1    Saad, F.2    Heinemann, K.3
  • 121
    • 84863495003 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial on the effect of long-acting testosterone treatment as assessed by the Aging Male Symptoms scale
    • Ho C.C., Tong S.F., Low W.Y., et al. A randomized, double-blind, placebo-controlled trial on the effect of long-acting testosterone treatment as assessed by the Aging Male Symptoms scale. BJU Int 2012, 110:260-265.
    • (2012) BJU Int , vol.110 , pp. 260-265
    • Ho, C.C.1    Tong, S.F.2    Low, W.Y.3
  • 123
    • 84861969972 scopus 로고    scopus 로고
    • Testosterone treatment and mortality in men with low testosterone levels
    • Shores M.M., Smith N.L., Forsberg C.W., et al. Testosterone treatment and mortality in men with low testosterone levels. J Clin Endocrinol Metab 2012, 97:2050-2058.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2050-2058
    • Shores, M.M.1    Smith, N.L.2    Forsberg, C.W.3
  • 124
    • 77954394453 scopus 로고    scopus 로고
    • Clinical review 1: Adverse effects of testosterone therapy in adult men: A systematic review and meta-analysis
    • Fernandez-Balsells M.M., Murad M.H., Lane M., et al. Clinical review 1: Adverse effects of testosterone therapy in adult men: A systematic review and meta-analysis. J Clin Endocrinol Metab 2010, 95:2560-2575.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2560-2575
    • Fernandez-Balsells, M.M.1    Murad, M.H.2    Lane, M.3
  • 125
    • 29044435583 scopus 로고    scopus 로고
    • Effect of aromatase inhibition on bone metabolism in elderly hypogonadal men
    • Leder B.Z., Finkelstein J.S. Effect of aromatase inhibition on bone metabolism in elderly hypogonadal men. Osteoporos Int 2005, 16:1487-1494.
    • (2005) Osteoporos Int , vol.16 , pp. 1487-1494
    • Leder, B.Z.1    Finkelstein, J.S.2
  • 126
    • 73249124203 scopus 로고    scopus 로고
    • Effects of aromatase inhibition on bone mineral density and bone turnover in older men with low testosterone levels
    • Burnett-Bowie S.A., McKay E.A., Lee H., et al. Effects of aromatase inhibition on bone mineral density and bone turnover in older men with low testosterone levels. J Clin Endocrinol Metab 2009, 94:4785-4792.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4785-4792
    • Burnett-Bowie, S.A.1    McKay, E.A.2    Lee, H.3
  • 127
    • 84860860432 scopus 로고    scopus 로고
    • Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism and metabolic syndrome: Results from a 36 months controlled study
    • Aversa A., Bruzziches R., Francomano D., et al. Effects of long-acting testosterone undecanoate on bone mineral density in middle-aged men with late-onset hypogonadism and metabolic syndrome: Results from a 36 months controlled study. Aging Male 2012, 15:96-102.
    • (2012) Aging Male , vol.15 , pp. 96-102
    • Aversa, A.1    Bruzziches, R.2    Francomano, D.3
  • 128
    • 0026386856 scopus 로고
    • The effects of normal aging on the response of the pituitary-gonadal axis to chronic clomiphene administration in men
    • Tenover J.S., Bremner W.J. The effects of normal aging on the response of the pituitary-gonadal axis to chronic clomiphene administration in men. J Androl 1991, 12:258-263.
    • (1991) J Androl , vol.12 , pp. 258-263
    • Tenover, J.S.1    Bremner, W.J.2
  • 129
    • 84887056433 scopus 로고    scopus 로고
    • Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels
    • Vigen R., O'Donnell C.I., Baron A.E., et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA 2013, 310:1829-1836.
    • (2013) JAMA , vol.310 , pp. 1829-1836
    • Vigen, R.1    O'Donnell, C.I.2    Baron, A.E.3
  • 130
    • 84883699325 scopus 로고    scopus 로고
    • Gonadal steroids and body composition, strength, and sexual function in men
    • Finkelstein J.S., Lee H., Burnett-Bowie S.A., et al. Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med 2013, 369:1011-1022.
    • (2013) N Engl J Med , vol.369 , pp. 1011-1022
    • Finkelstein, J.S.1    Lee, H.2    Burnett-Bowie, S.A.3
  • 131
    • 0033304542 scopus 로고    scopus 로고
    • Effect of testosterone treatment on bone mineral density in men over 65 years of age
    • Snyder P.J., Peachey H., Hannoush P., et al. Effect of testosterone treatment on bone mineral density in men over 65 years of age. J Clin Endocrinol Metab 1999, 84:1966-1972.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1966-1972
    • Snyder, P.J.1    Peachey, H.2    Hannoush, P.3
  • 132
    • 84902074891 scopus 로고    scopus 로고
    • Testosterone supplementation and sexual function: A meta-analysis study
    • Corona G., Isidori A.M., Buvat J., et al. Testosterone supplementation and sexual function: A meta-analysis study. J Sex Med 2014, 11:1577-1592.
    • (2014) J Sex Med , vol.11 , pp. 1577-1592
    • Corona, G.1    Isidori, A.M.2    Buvat, J.3
  • 133
    • 84978079951 scopus 로고    scopus 로고
    • Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone.
    • E-pub ahead of print.
    • Antonio L, Wu FC, O'Neill TW, et al. Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone. J Clin Endocrinol Metab. E-pub ahead of print. doi:10.1210/jc.2015-4106.
    • J Clin Endocrinol Metab
    • Antonio, L.1    Wu, F.C.2    O'Neill, T.W.3
  • 134
    • 68949192561 scopus 로고    scopus 로고
    • Testosterone and depression: Systematic review and meta-analysis
    • Zarrouf F.A., Artz S., Griffith J., et al. Testosterone and depression: Systematic review and meta-analysis. J Psychiatr Pract 2009, 15:289-305.
    • (2009) J Psychiatr Pract , vol.15 , pp. 289-305
    • Zarrouf, F.A.1    Artz, S.2    Griffith, J.3
  • 135
    • 84868206038 scopus 로고    scopus 로고
    • Clomiphene citrate is safe and effective for long-term management of hypogonadism
    • Moskovic D.J., Katz D.J., Akhavan A., et al. Clomiphene citrate is safe and effective for long-term management of hypogonadism. BJU Int 2012, 110:1524-1528.
    • (2012) BJU Int , vol.110 , pp. 1524-1528
    • Moskovic, D.J.1    Katz, D.J.2    Akhavan, A.3
  • 136
    • 75149116750 scopus 로고    scopus 로고
    • Trough serum testosterone predicts the development of polycythemia in hypogonadal men treated for up to 21 years with subcutaneous testosterone pellets
    • Ip F.F., di Pierro I., Brown R., et al. Trough serum testosterone predicts the development of polycythemia in hypogonadal men treated for up to 21 years with subcutaneous testosterone pellets. Eur J Endocrinol 2010, 162:385-390.
    • (2010) Eur J Endocrinol , vol.162 , pp. 385-390
    • Ip, F.F.1    di Pierro, I.2    Brown, R.3
  • 137
    • 84155170966 scopus 로고    scopus 로고
    • Testosterone replacement therapy and polycythemia in HIV-infected patients
    • Vorkas C.K., Vaamonde C.M., Glesby M.J. Testosterone replacement therapy and polycythemia in HIV-infected patients. AIDS 2012, 26:243-245.
    • (2012) AIDS , vol.26 , pp. 243-245
    • Vorkas, C.K.1    Vaamonde, C.M.2    Glesby, M.J.3
  • 138
    • 79960452984 scopus 로고    scopus 로고
    • Efficacy and safety study of 1.62% testosterone gel for the treatment of hypogonadal men
    • Kaufman J.M., Miller M.G., Garwin J.L., et al. Efficacy and safety study of 1.62% testosterone gel for the treatment of hypogonadal men. J Sex Med 2011, 8:2079-2089.
    • (2011) J Sex Med , vol.8 , pp. 2079-2089
    • Kaufman, J.M.1    Miller, M.G.2    Garwin, J.L.3
  • 139
    • 16344390576 scopus 로고    scopus 로고
    • Comparison of the steady-state pharmacokinetics, metabolism, and variability of a transdermal testosterone patch versus a transdermal testosterone gel in hypogonadal men
    • Mazer N., Bell D., Wu J., et al. Comparison of the steady-state pharmacokinetics, metabolism, and variability of a transdermal testosterone patch versus a transdermal testosterone gel in hypogonadal men. J Sex Med 2005, 2:213-226.
    • (2005) J Sex Med , vol.2 , pp. 213-226
    • Mazer, N.1    Bell, D.2    Wu, J.3
  • 140
    • 0032527547 scopus 로고    scopus 로고
    • Methodology and reports of systematic reviews and meta-analyses: A comparison of Cochrane reviews with articles published in paper-based journals
    • Jadad A.R., Cook D.J., Jones A., et al. Methodology and reports of systematic reviews and meta-analyses: A comparison of Cochrane reviews with articles published in paper-based journals. JAMA 1998, 280:278-280.
    • (1998) JAMA , vol.280 , pp. 278-280
    • Jadad, A.R.1    Cook, D.J.2    Jones, A.3
  • 141
    • 80053322723 scopus 로고    scopus 로고
    • Minimal clinically important differences in the erectile function domain of the International Index of Erectile Function scale
    • Rosen R.C., Allen K.R., Ni X., et al. Minimal clinically important differences in the erectile function domain of the International Index of Erectile Function scale. Eur Urol 2011, 60:1010-1016.
    • (2011) Eur Urol , vol.60 , pp. 1010-1016
    • Rosen, R.C.1    Allen, K.R.2    Ni, X.3
  • 142
    • 29144469309 scopus 로고    scopus 로고
    • Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials
    • Calof O.M., Singh A.B., Lee M.L., et al. Adverse events associated with testosterone replacement in middle-aged and older men: A meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci 2005, 60:1451-1457.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 1451-1457
    • Calof, O.M.1    Singh, A.B.2    Lee, M.L.3
  • 143
    • 84880923151 scopus 로고    scopus 로고
    • Use of testosterone replacement therapy in the United States and its effect on subsequent prostate cancer outcomes
    • Kaplan A.L., Hu J.C. Use of testosterone replacement therapy in the United States and its effect on subsequent prostate cancer outcomes. Urology 2013, 82:321-326.
    • (2013) Urology , vol.82 , pp. 321-326
    • Kaplan, A.L.1    Hu, J.C.2
  • 144
    • 84880036090 scopus 로고    scopus 로고
    • Testosterone replacement therapy in patients with prostate cancer after radical prostatectomy
    • Pastuszak A.W., Pearlman A.M., Lai W.S., et al. Testosterone replacement therapy in patients with prostate cancer after radical prostatectomy. J Urol 2013, 190:639-644.
    • (2013) J Urol , vol.190 , pp. 639-644
    • Pastuszak, A.W.1    Pearlman, A.M.2    Lai, W.S.3


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