Comparative studies on level of androgens in hair and plasma with premature male-pattern baldness

Journal of Dermatological Science

Volumn 34, Issue 1, 2004, Pages 11-16

  Bang, Hyo Jung ^a,b   Yang, Yoon Jung ^a   Lho, Dong Seok ^a   Lee, Won Yong ^b   Sim, Woo Young ^c   Chung, Bong Chul ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Yonsei University   (South Korea)

^c Kyung Hee University Hospital   (South Korea)

Author keywords

Androgenic steroid; GC MS; Plasma; Premature MPB; Vertex hair

Indexed keywords

ANDROGEN; ANDROSTANOLONE; EPITESTOSTERONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACTION; GAS CHROMATOGRAPHY; HAIR; HAIR LEVEL; HORMONE DETERMINATION; HUMAN; HUMAN TISSUE; HYDROLYSIS; ION MONITORING; MALE; MALE TYPE ALOPECIA; MASS SPECTROMETRY; PRIORITY JOURNAL;

EID: 1642578875     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2003.11.005     Document Type: Article

References (17)

1. Ebling F.J.G. The biology of hair. Dermatol. Clin. 5:1987;467-481.
2. Schweikert H.U., Wilson J.D. Regulation of human hair growth by steroid hormone. Testosterone metabolism in isolated hair. J. Clin. Endocrinol. Metab. 113:1974;588-592.
3. Kaufman K.D. Androgen metabolism as it affects hair growth in androgenetic alopecia. Dermatol. Clin. 14:1996;697-711.
4. Ralph M.T. Molecular mechanisms of androgenetic alopecia. Exp. Gerontol. 37:2002;981-990.
5. Harris G.S., Kozarich J.W. Sterpod 5α-reductase inhibitors in androgen-dependent disorders. Curr. Opin. Chem. Biol. 1:1997;254-259.
6. Barbara A., Nuck B.S., Anne W.L. Epitestosterone: a potential new antiandrogen. J. Invest. Dermatol. 89:1987;209-211.
7. Strárka L., Biciková M., Hampl R. Epitestosterone: an endogenous antiandrogen? J. Steroid Biochem. 33:1989;1019-1021.
8. Sawaya M.E., Price V.H. Different levels of 5α-reductase type 1 and 2, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J. Invest. Dermatol. 109:1997;296-300.
9. Graham G.G., Severi G., Sinclar R. Androgenetic alopecia and prostate cancer: findings from an Australian case-control study. Cancer Epidemiol. Biomarkers Prev. 11:2002;549-553.
10. Demark-Wahnefried W., Leako S.M., Conaway M.R., Robertson C.N., Clark R.V., Lobaugh B.et al. Serum androgens: associations with prostate cancer risk and hair patterning. J. Androl. 18:1997;495-500.
11. Choi M.H., Kim J.Y., Chung B.C. Determination of testosterone: epitestosterone ratio after pentafluorophenyldimethylsilyl-trimethylsilyl derivatisation using gas chromatography-mass spectrometry in equine urine. Analyst. 124:1999;675-678.
12. Choi M.H., Yoo Y.S., Chung B.C. Biochemical roles of testosterone and epitestosterone to 5α-reductase as indicators of male-pattern baldness. J. Invest. Dermatol. 116:2001;57-61.
13. Schmidt J.B., Lindmaier A.S. Hormonal parameters in androgenetic hair loss in the male. J. Dermatol. 182:1991;214-217.
14. Choi M.H., Yoo Y.S., Chung B.C. Measurement of testosterone and pregnenolone in nails using gas chromatography-mass spectrometry. J. Chromatogr. B. 754:2001;495-501.
15. Lerch A., Nieschlag E. Diurnal variations of serum and testicular testosterone and dihydrotestosterone (DHT) in Djungarian hamsters (phodopus sungorus): testes are the main source for circulating DHT. Gen. Comp. Endocrinol. 98:1995;129-136.
16. Monsalve A., Blaquier J.A. Partial characterization of epididymal 5α-reductase in the rat. Steroids. 30:1977;41-51.
17. Cipriani R., Ruzza G., Foresta C., Veller Fornasa C., Peserico A. Sex hormone-binding globulin and saliva testosterone levels in men with androgenetic alopecia. Br. J. Dermatol. 109:1983;249-252.