Integrated bone tissue physiology: Anatomy and physiology

Bone Mechanics Handbook, Second Edition

Volumn , Issue , 2001, Pages 1-1-1-68

  Jee, Webster S S ^a  

^a UNIVERSITY OF UTAH   (United States)

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EID: 84974648947     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (263)

1. Jee, W. S. S., The skeletal tissues, in Cell and Tissue Biology, A Textbook of Histology, Weiss, L., Ed., Urban and Schwarzenberg, Baltimore, 1988, chap. 7.
2. Frost, H. M., Introduction to a New Skeletal Physiology, Vol. I and II, Pajaro Group, Pueblo, 1995.
3. Jee, W. S. S., Structure and function of bone tissue, in Orthopaedics, Principles of Basic and Clinical Science, Bronner, F. and Worrell, R. V., Eds., CRC Press, Boca Raton, FL, 1999, chap. 1.
4. Baron, R., Anatomy and ultrastructure of bone, in Primer on the Metabolic Bone Disease and Disorder of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 1.
5. Parfitt, A. M., The physiologic and clinical significance of bone histomorphometric data, in Bone Histomorphometry: Techniques and Interpretation, Recker, R. R., Ed., CRC Press, Boca Raton, FL, 1983, 143.
6. Schenk, R. K., Felix, R., and Hofstetter, W., Morphology of connective tissue: bone, in Connective Tissue and Its Heritable Disorders: Molecular, Genetic and Medical Aspects, Royce, P. M. and Steinmann, B., Eds., Wiley-Liss, New York, 1993, 85.
7. Ericksen, E. F., Axelrod, D. W., and Melsen, F., Bone Histomorphology, Raven Press, New York, 1994.
8. Martin, R. B. and Burr, D. B., Mechanical adaptation, in Sructure, Function and Adaptation of Compact Bone, Raven Press, New York, 1989, chaps. 2, 4, 7, and 8.
9. Marotti, G., Palazzini, S., Palumbo, D., and Ferretti, M., Ultrastructural evidence of the existence of a dentritic network throughout the cells of the osteogenic lineage: the novel concept of wiring-and volume-transmission in bone, Bone, 19, 151S, 1996.
10. Donahue, H. J., Gap junctional intercellular communication in bone: a cellular basis for mecha-nostat set point, Calcif. Tissue Int., 62, 85, 1998.
11. Gehron-Robey, P. and Boskey, A. L., The biochemistry of bone, in Osteoporosis, Marcus, F., Feldman, D., and Kelsey, J., Eds., Academic Press, San Diego, 1996, chap. 4.
12. Lian, J. B., Stein, G. S., Canalis, E., Gehron-Robey, P., and Boskey, A. L., Bone formation: osteoblast lineage cells, growth factors, matrix proteins and the mineralization process, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippin-cott/Williams & Wilkins, Philadelphia, 1999, chap. 3.
13. Gorski, J. P., Is all bone the same? Distinctive distributions and properties of non-collagenous matrix proteins in lamellar and woven bone imply the existence of different underlying osteogenic mechanisms, Crit. Rev. Oral Biol., 9, 201, 1998.
14. Khosla, S. and Kleerekoper, M., Biochemical markers and bone turnover, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 22.
15. Kelly, P. J., Montgomery, R. J., and Bronk, J. T., Reaction of the circulatory system to injury and regeneration, Clin. Orthop., 254, 275, 1990.
16. Verhas, M., Martinello, Y., Mone, M., Heilporn, A., Bergmann, P., Tricot, A., and Schoutens, A., Demineralization and pathological physiology of the skeleton in paraplegic rats, Calcif. Tissue Int., 30, 83, 1980.
17. Schoutens, A., Verhas, M., L’Hermite, M., Tricot, A., Verschaeren, A., Dourov, N., and Heilporn, A., Increase of bone blood flow, an initial step of bone demineralization in the rat, Calcif. Tissue Int., 36(Suppl. 2), S3, 1984.
18. Verhas, M., Schoutens, A., L’Hermite-Baleriaux, M., Dourov, N., Verschaeren, A., Mone, M., and Heilporn, A., The effect of orchiectomy on bone metabolism in aging rats, Calcif. Tissue Int., 39, 74, 1986.
19. Kapitola, J., Kubickova, J., and Andrle, J., Blood flow and mineral content of the tibia of female and male rats: changes following castration and/or administration of estradiol or testosterone, Bone, 16, 69, 1995.
20. 2 on bone blood flow and strontium clearance in the rat in vivo, J. Endocrinol., 131, 359, 1991.
21. Kita, K., Kawai, K., and Hirohata, K., Changes in bone marrow blood flow with aging, J. Orthop. Res., 5, 569, 1987.
22. Thurston, T. J., Distribution of nerves in long bones as shown by silver impregnation, J. Anat., 134, 719, 1982.
23. Miller, M. R. and Kashara, M., Observations on the innervation of human long bones, Anat. Rec., 145, 13, 1963.
24. Serre, C. M., Farlay, D., Delmas, P. D., and Chenu, C., Evidence for a dense and intimate innervation of the bone tissue, including glutamate-containing fibers, Bone, 25, 623, 1999.
25. Mason, D. J., Suva, L. J., Genever, P. G., Patton, A. J., Steuckle, S., Hillam, R. A., and Skerry, T. M., Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents, Bone, 20, 199, 1997.
26. Chenu, C., Serre, C. M., Raynal, D., Burt-Pichet, B., and Delmas, P. D., Glutamate receptors are expressed by bone cells and are involved in bone resorption, Bone, 22, 295, 1998.
27. Patton, A. J., Genever, P. G., Birch, M. A., Suva, L. J., and Skerry, T. M., Expression of an N-methyl-D-aspartate-type receptor by human and rat osteoblasts and osteoclasts suggest a novel glutamate signaling pathway in bone, Bone, 22, 645, 1998.
28. Mayer, M. L. and Westbrook, G. L., The physiology of excitatory amino acids in the vertebrate central nervous system, Prog. Neurobio., 28, 197, 1987.
29. Rodan, G. A. and Rodan, S. B., The cells of bone, in Osteoporosis: Etiolology, Diagnosis and Management, 2nd ed., Riggs, B. L. and Melton III, L. J., Eds., Lippincott-Raven, Philadelphia, 1995, chap. 1.
30. Teitelbaum, S. L., Tondravi, M. M., and Ross, F. P., Osteoclast Biology, in Osteoporosis, Marcus, R., Feldman, D., and Kelsey, J., Eds., Academic Press, San Diego, 1996, chap. 3.
31. Suda, T., Takahashi, N., and Martin, T. J., Modulation of osteoclast differentiation, Endocrinol. Rev., 13, 66, 1992.
32. Roodman, G. D., Advances in bone biology: the osteoclast, Endocrinol. Rev., 17, 308-332, 1996.
33. Baron, R., Chakraborty, M., Chatterjee, D., Horne, W., Lomri, A., and Ravesloot, J.-H., Biology of the osteoclast, in Physiology and Pharmacology of Bone, Mundy, G. R., and Martin, T. J., Eds., Springer-Verlag, New York, 1993, 111.
34. Mundy, F. R., Bone remodeling, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 4.
35. Puzas, E. J. and Lewis, G. D., Biology of osteoclasts and osteoblasts, in Orthopaedics. Principles of Basic and Clinical Science, Bronner, F., and Worrell, R. V., Eds., CRC Press, Boca Raton, FL, 1999, chap. 3.
36. Pacifici, R., Aging and cytokine production, Calcif. Tissue Int., 65, 345, 1999.
37. Lian, J. B., and Stein, G. S., Osteoblast biology, in Osteoporosis, Marcus, R., Feldman, D., and Kelsey, J., Eds., Academic Press, San Diego, 1996, chap. 2.
38. Marie, P. J., Cellular and molecular alterations of osteoblasts in human disorders of bone formation, Histol. Histopathol., 14, 525, 1999.
39. Barnes, G. L., Kostenuik, P. J., Gerstenfield, L. C., and Einhorn, T. A., Perspective, growth factor regulation of fracture repair, J. Bone Mineral Res., 14, 1805, 1999.
40. Recker, R. R., Ed., Bone Histomorphometry: Techniques and Interpretation, CRC Press, Boca Raton, FL, 1983.
41. Parfitt, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M., and Recker, R. R., Bone histomorphometry: standardization of nomenclature, symbols and units. Report of the ASBMR histomorphometry nomenclature committee, J. Bone Mineral Res., 2, 595, 1987.
42. Frost, H. M., Tetracycline-based histological analysis of bone remodeling, Calcif. Tissue Res., 3, 211, 1969.
43. Harris, W. H., Haywood, E. A., Lavorgna, J., and Hamblen, D. L., Spatial and temporal variations in cortical bone formation in dogs, J. Bone Joint Surg., 50A, 118, 1968.
44. Miller, S. C. and Jee, W. S. S., The bone lining cell: a distinct phenotype? Calcif. Tissue Int., 41, 1, 1992.
45. Merz, W. and Schenk, R., A quantitative histological study on bone formation in human cancellous bone, Acta Anat., 76, 1, 1970.
46. Dobnig, H. and Turner, R., Evidence that intermittent treatment with parathyroid hormone increase bone formation in adult rats by activation of bone lining cells, Endocrinology, 136, 3632, 1995.
47. Jee, W. S. S. and Ma, Y. F., The in vivo anabolic actions of prostaglandins in bone, Bone, 21, 297, 1997.
48. Miller, S. C., Bowman, B. M., Smith, J. M., and Jee, W. S. S., Characterization of endosteal bonelining cells from fatty marrow bone sites in adult beagles, Anat. Rec., 198, 163, 1980.
49. Talmage, R. V., Calcium homeostasis-calcium transport-parathyroid action, Clin. Orthop. Relat. Res., 67, 210, 1969.
50. Holtrop, M. E. and Weinger, J. M., Ultrastructural evidence for a transport system in bone, in Calcium, Parathyroid Hormone and Calcitonins, Talmage, R. V. and Munson, P. L., Eds., Excerpta Medica, Amsterdam, 1972, chap. 2.
51. Lanyon, L. E., Osteocytes, strain detection, bone modeling and remodeling, Calcif. Tissue Int., 53 (Suppl.), 102, 1993.
52. Lanyon, L. E., Using functional loading to influence bone mass and architecture, Bone, 18, 375, 1996.
53. Schiller, P. C., Parmender Mehta, P., Roos, B. A., and Howard, G. A., Hormonal regulation of intercellular communication: parathyroid hormone increases connexin 43 gene expression and gap junctional communication in osteoblastic cells, Mol. Endocrinol., 6, 1443, 1992.
54. Mori, S. and Burr, D. B., Increased intracortical remodeling following fatigue damage, Bone, 14, 103, 1993.
55. Bentolila, V., Boyce, T. M., Fyhrie, D. P., Drumb, R., Skerry, T. M., and Schaffler, M. B., Intracortical bone remodeling in adult rat long bones after fatigue loading, Bone, 23, 275, 1998.
56. Noble, B., Stevens, H., Loveridge, N., and Reeve, J., Identification of apoptotic changes in osteocytes in normal and pathological human bone, Bone, 20, 273, 1997.
57. Tomkinson, A., Reeve, J., Shaw, R. W., and Noble, B. S., The death of osteocyte by apoptosis in human bone is observed following estrogen withdrawal by GnRH analog, J. Clin. Endocrinol. Metab., 82, 3128, 1997.
58. Frost, H. M., Bone Modeling and Skeletal Modeling Errors, Charles C Thomas, Springfield, 1973.
59. Frost, H. M., Osteoporoses: New Concepts and Some Implications for Future Diagnosis, Treatment and Research (based on insights from the Utah paradigm), Ernst Schering Research Foundation, Berlin, 1998, 7.
60. Frost, H. M., Bone development during childhood, a tutorial (some insights of a new paradigm), in Paediatric Osteology, Schönau, E., Ed., Elsevier, Amsterdam, 1996, 3.
61. Frost, H. M., A determinant of bone architecture: the minimum effective strain, Clin. Orthop. Relat. Res., 175, 286, 1983.
62. Cowin, S. C., Mechanical modeling of the stress adaptation process in bone, Calcif. Tissue Int., 36, 598, 1984.
63. Carter, D. R., Harris, W. H., Vasu, R., and Caler, W. E., The mechanical and biological response of cortical bone to in vivo strain histories, in Mechanical Properties of Bone, Cowin, S. C., Ed., ASME, New York, 1981, chap. 6.
64. Carter, D. R., The relationship between in vivo strains and cortical bone remodeling, Criti. Rev. Biomed. Eng., 87, 1, 1982.
65. Frost, H. M., Bone “mass” and the “mechanostat,” a proposal, Anat. Rec., 219, 1, 1987.
66. Frost, H. M., The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents, Bone Miner., 2, 73, 1987.
67. Frost, H. M., Structural adaptations to mechanical usage (SATMU): 1. Redefining Wolff’s law: the bone modeling problem, Anat. Rec., 226, 403, 1990.
68. Parfitt, A. M., The skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteoporosis, in Osteoporosis, Marcus, R., Feldman, D., and Kelsey, J., Eds., Academic Press, San Diego, 1996, chap. 12.
69. Frost, H. M., Structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff’s Law: The bone remodeling problem, Anat. Rec., 226, 414, 1990.
70. Marotti, G., Map of bone formation rate values recorded throughout the skeleton of the dog, in Proceedings of First Workshop on Bone Morphometry, Jaworski, Z. F. G., Ed., University of Ottawa Press, Ottawa, 1976, 202.
71. Kimmel, D. B. and Jee, W. S. S., A quantitative histologic study of bone turnover in young adult beagles, Anat. Rec., 203, 31, 1982.
72. Burr, D. B., Martin, R. B., Schaffler, M. B., and Radin, E. L., Bone remodeling in response to in vivo fatigue damage, J. Biomech., 18, 189, 1985.
73. Frost, H. M. and Jee, W. S. S., Perspectives: a vital biomechanical mode of endochondral ossification mechanism, Anat. Rec., 240, 435, 1994.
74. 239Pu on trabecular bone surfaces of the beagle: implications for the induction of osteosarcoma, Radiat. Res., 83, 74, 1980.
75. Wronski, T. J., Smith, J. M., and Jee, W. S. S., Variations in mineral apposition rate of trabecular bone within the beagle skeleton, Calcif. Tissue Int., 33, 583, 1981.
76. Heaney, R. P. and Matkovic, V., Inadequate peak bone mass, in Osteoporosis, Etiology, Diagnosis and Management, 2nd ed., Riggs, B. L. and Melton III, L. J., Eds., Lippincott-Raven, Philadelphia, 1995, chap. 5.
77. O’Connor, J. A., Lanyon, L. E., and MacFie, H., The influence of strain rate on adaptive bone remodeling, J. Biomech., 15, 767, 1982.
78. Jee, W. S. S., Li, X. J., and Ke, H. Z., The skeletal adaptation to mechanical usage in the rat, Cells Mater., Suppl., 1, 131, 1991.
79. Jee, W. S. S. and Frost, H. M., Skeletal adaptations during growth, Triangle, 31, 77, 1992.
80. Forwood, M. R. and Turner, C. H., Skeletal adaptations to mechanical usage: results from tibial loading studies in rats, Bone, Suppl., 17, 197, 1995.
81. Kiratli, B. J., Immobilization osteopenia, in Osteoporosis, Marcus, R., Feldman, D., and Kelsey, J., Eds., Academic Press, San Diego, 1996, chap. 42.
82. Carter, D. R., van der Meulen, M. C. H., and Beaupre, G. S., Skeletal development: mechanical consequences of growth, aging and disease, in Osteoporosis, Marcus, R., Feldman, D., and Kelsey, J., Eds., Academic Press, San Diego, 1996, chap. 13.
83. Mosley, J. R. and Lanyon, L. E., Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats, Bone, 23, 313, 1998.
84. Rubin, C. T. and Rubin, J., Biomechanics of bone, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 5.
85. Marcus, R., Physical activity and regulation of bone mass, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 48.
86. Frost, H. M., Perspective, on our age-related bone loss: insights from a new paradigm, J. Bone Miner. Res., 12, 1539, 1997.
87. Frost, H. M., On defining osteopenias and osteoporoses: problems! Another view (with insights from a new paradigm), Bone, 20, 385, 1997.
88. Frost, H. M., On rho, a marrow mediator and estrogen: their roles in bone strength and ‘mass’ in human females, osteopenias and osteoporoses (insights from a new paradigm), J. Bone Miner. Metab., 16, 113, 1998.
89. Rodan, G. A., Mechanical loading, estrogen deficiency and the coupling of bone formation to bone resorption, J. Bone Miner. Res., 6, 527, 1991.
90. Burr, D. B. and Martin R. B., Errors in bone remodeling: toward a unified theory of metabolic bone disease, Am. J. Anat., 186, 186, 1989.
91. Frost, H. M., The pathomechanics of osteoporoses, Clin. Orthop. Relat. Res., 200, 198, 1985.
92. Jee, W. S. S., Ma, Y. F., Li, M., Liang, X. Q., Lin, B. Y., Li, X. J., Ke, H. Z., Mori, S., Setterberg, R. B., and Kimmel, D. B., Sex steroids and prostaglandin in bone metabolism, in Sex Steroids and Bone, Ziegler, R., Pfeilschifter, J., and Brautigam, M., Eds., Springer, Berlin, 1994, 119.
93. Yeh, J. K., Aloia, J. F., and Chen, M., Growth hormone administration potentiates the effect of treadmill exercise on long bone formation but not on the vertebrae in middle-aged rats, Calcif. Tissue Int., 54, 38, 1994.
94. Tam, C. S., Akhter, M. P., Johnston, E., Covey, M. A., Pearse, A., Ringer, L., and Recker, R. R., A new peptide for bone formation with its action related to exercise, Bone, 23, S613, 1998.
95. Tang, L. Y., Raab-Cullen, D. M., Yee, J. A., Jee, W. S. S., and Kimmel, D. B., Prostaglandin E2 increases the skeletal response to mechanical loading, J. Bone Miner. Res., 12, 276, 1997.
96. Chow, J. W. M., Fox, S. W., Jagger C. J., and Chambers, T. J., Role for parathyroid hormone in mechanical responsiveness of rat bone, Am. J. Physiol., 274, E146, 1998.
97. Mosekilde, L., Thomsen, J. S., Orhii, P. B., McCarter, R. J., Meya, W., and Kalu, D. N., Additive effect of voluntary exercise and growth hormone treatment on bone strength assessed at four different skeletal sites in an aged rat model, Bone, 244, 71, 1999.
98. Gasser, J. A., Quantitative assessment of bone mass and geometry by pQCT in rats in vivo and site specificity of changes at different skeletal sites, J. Jpn Soc. Bone Morphometry, 7; 107-114, 1997.
99. Gasser, J. A., Modulation of strain sensing: a new approach for the treatment of osteoporosis, in Musculoskeletal Interactions, Vol. 2, Lyritis, G. P., Ed., Hylonome Editions, Athens, 1999, 77.
100. Jee, W. S. S., Zhou, H., Yao, W., Cui, L., and Ma, Y. F., The interaction of mechanical loading and bone anabolic agents, in Osteoporosis Update 1999, Proceedings, Third International Congress on Osteoporosis, Xi’an, P.R. China, Beijing, China, 1999, 78.
101. Marcus, R., Feldman, D., and Kelsey, J., Eds., J. Osteoporosis, Academic Press, San Diego, 1996.
102. Eastell, R., Pathogenesis of postmenopausal osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 47.
103. Frost, H. M., “Osteoporosis”: a rationale for further definitions? Calcif. Tissue Int., 62, 89, 1998.
104. Orwell, E. S., Osteoporosis in men, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 54.
105. Lukert, B. P., Glucocorticoid-induced osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 55.
106. Lindsay, R., Prevention of osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 49.
107. Wasnich, R. D., Epideminology of osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 46.
108. Dawson-Hughes, B., Pharmocologic treatment of postmenopausal osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Lippincott/Williams & Wilkins, Philadelphia, 1999, chap. 53.
109. WHO Study Group, Assessment of fracture risk and its applications to screening for postmenopausal osteoporosis, WHO Technical Report Series 843, WHO, Geneva, 1994.
110. Cooper, G. S., Editorial. Genetic studies of osteoporosis! What have we learned? J. Bone Miner. Res., 14, 1646, 1999.
111. Garn, S. M., Rohmann, C. G., and Wagner, B., Bone loss, a general phenomenon in man, Fed. Proc., 26, 1729, 1967.
112. Garn, S. M., Wagner, B., Rohmann, C. G., and Ascoli, W., Further evidence for continuing bone expansion, Am. J. Physiol. Anthropol., 28, 219, 1968.
113. Blumshon, A. and Eastell, R., Age-related factors, in Osteoporosis, Etiology, Diagnosis and Management, 2nd ed., Riggs, B. L. and Melton III, L. J., Eds., Lippincott-Raven, Philadelphia, 1995, chap. 7.
114. Rosen, C. J. and Kiel, D. P., The aging skeleton, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 9.
115. Sherman, S., Heaney, R. P., Parfitt, A. M., Hadley, E. C., and Dutta, C., Eds., NIA Workshop on Aging and Bone Quality, Calcif. Tissue Int., 53, Supplement 1, 1993.
116. Lindsay, R., Estrogen deficiency, in Osteoporosis, Etiology, Diagnosis and Management, 2nd ed., Riggs, B. L. and Melton III, L. J., Lippincott-Raven, Philadelphia, 1995, chap. 6.
117. Reid, I. R., Menopause, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 8.
118. Frost, H. M., On the estrogen-bone relationship and postmenopausal bone loss: a new model, J. Bone Miner. Res., 14, 1473, 1999.
119. Peacock, M., Effects of calcium and vitamin D insufficiency on the skeleton, Osteoporosis Int., 8, S45, 1998.
120. Schacht, E., Rationale for treatment of involutional osteoporosis in women and for prevention and treatment of corticosteroid-induced osteoporosis with alfacalcidol, Calcif. Tissue Int., 65, 317, 1999.
121. Lau, K. H., and Baylink, D. J., Vitamin D therapy of osteoporosis: plain vitamin D therapy versus active vitamin D analog (D-hormone) therapy, Calcif. Tissue Int., 65, 295, 1999.
122. Holick, M., Vitamin D: photodensity, metabolism mechanism of action and clinical applications, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M. J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 15.
123. Hollis, B. W., Clemens, T. L., and Adams, J. S., Vitamin D metabolites, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed., Favus, M.J., Ed., Lippincott/Williams & Wilkins, 1999, chap. 21.
124. Rosen, C. and Wuster, C., Growth hormone, insulin-like growth factor. Potential applications and limitations in the management of osteoporosis, in Osteoporosis, Marcus, R., Feldman, D., and Kelsey, J., Eds., Academic Press, San Diego, 1996, chap. 69.
125. Buckwalter, J. A., Woo, S. L. Y., Goldberg, V. M., Hadley, E. C., Booth, R., Oregema, T. R., and Eyre, D. R., Soft tissue aging and musculoskeletal function, J. Bone Joint. Surg., 75A, 1533, 1993.
126. Schönau, E., Westermann, F., Mokow, E., Scheidhauer, K., Werhahn, E., Stabrey, A., and MüllerBerghaus, J., The functional muscle-bone-unit in health and disease, in Paediatric Osteology. Prevention of Osteoporosis—A Paediatric Task? Schönau, E. and Matkovic V., Eds., Excerpta Medica, Amsterdam, 1998, 191.
127. Frost, H. M., Perspective, why do bone strength and ‘mass’ in aging adults become unresponsive to vigorous exercise? Insights of the Utah paradigm, J. Bone Miner. Metab., 17, 90, 1999.
128. Burr, D. B., Muscle strength, bone mass and age related bone loss, J. Bone Miner. Res., 12, 1547, 1997.
129. Jee, W. S. S., The interactions of muscles and skeletal tissue, in Musculoskeletal Interactions, Vol. II, Lyritis, G. P., Ed., Hylonome Editions, Athens, 1999, 35.
130. Aniansson, A., Zetterberg, C., Hedberg, M., and Henriksson K., Impaired muscle function with aging: a background factor in the incidence of fractures of the proximal end of the femur, Clin. Orthop, 191, 193, 1984.
131. Faulkner, J. A., Brooks, S. V., and Zerva, E., Skeletal muscle weakness and fatigue in old age: underlying mechanisms, in Annual Review of Gerontology and Geriatrics, Cristofalo, V. J. and Lawton, M.P., Eds., Springer-Verlag, New York, 1990, 147.
132. Kritz-Silverstein, M. and Barrett-Connor, E., Grip strength and bone mineral density in older women, J. Bone Miner. Res., 9, 45, 1994.
133. McCarter, R., Age-related changes in skeletal muscle function, Aging, 2, 27, 1990.
134. Murray, M., Gardner, G., Mollinger, L., and Sepic, S., Strength of isometric and isokinetic contractions: knee muscles of men aged 20 to 86, Phys. Therapy, 60, 412, 1980.
135. Raloff, J., Vanishing flesh: muscle loss in the elderly finally gets some respect, Sci. News, 150, 90, 1996.
136. Sinaki, M., Musculoskeleal rehabilitation, in Osteoporosis, Etiolology, Diagnosis and Management, 2nd ed., Riggs, B. L. and Melton III, L. J., Eds., Lippincott-Raven, Philadelphia, 1995, chap. 20.
137. Frost, H. M., Presence of microscopic cracks in vivo in bone, Bull. Henry Ford Hosp., 8, 25, 1960.
138. Frost, H. M., Bone microdamage: factors that impair its repair, in Current Concepts in Bone Fragility, Uhthoff, H. K., Ed., Springer, Berlin, 1985, 123.
139. Kannus, P., Haapasalo, H., Sankelo, M., Sievanen, H., Pasanen, M., Heinomem, A., Oja, P., and Vuori, I., Effect of starting age of physical activity on bone mass in the dominant arm of tennis and squash players, Ann. Intern. Med., 123, 27, 1995.
140. Gehron-Robey, P. and Bianco, P., Cellular mechanisms of age-related bone loss, in The Aging Skeleton, Bilezikian, J. P., Rosen, C. J., and Glowacki, J., Eds., Academic Press, San Diego, 1999, 145.
141. Bergman, R. J., Gazit, D., Kahn, A. J., Gruber, H., McDougall, S., and Hahn, T. J., Age-related changes in osteogenic stem cells in mice, J. Bone Miner. Res., 11, 568, 1996.
142. Owan, I., Burr, D. B., Turner, C. H., Qiu, J., Tu, Y., Onyia, J. E., and Duncan, R. L., Mechanotrans-duction in bone: osteoblasts are more responsive to fluid forces than mechanical strain, Am. J. Physiol., 273, C810, 1997.
143. Singh, Y. M., Nagarth, A. R., and Maini, P. S., Changes in trabecular pattern of the upper end of the femur as an index of osteoporosis, J. Bone Joint Surg., 52A, 457, 1970.
144. Fleisch, H., Bisphosphonates in Bone Diseases. From the Laboratory to the Patient, 3rd ed., Parthenon Publishing Group, New York, 1997, chap. 1.
145. Harris, W. H., A microscopic method for determining rates of bone growth, Nature, 188, 1038, 1960.
146. Miller, S. C. and Jee, W. S. S., The effect of dichloromethylene diphosphonate, a pyrophosphate analog, on bone and bone cell structure in the growing rat, Anat. Rec., 193, 439, 1979.
147. Schenk, R., Merz, W. A., Muhlbauer, R., Russell, R. G. G., and Fleisch, H., Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl2MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats, Calcif. Tissue Res., 11, 196, 1973.
148. Miller, S. C., Bowman, B. M., Smith, J. M., and Jee, W. S. S., Characterization of endosteal lining cells from fatty marrow bone sites in adult beagles, Anat. Rec., 198, 163, 1980.
149. Baron, R., Vignery, A., and Tran Van, P., The significance of lacunar erosion without osteoclasts: Studies on the reversal phase of the remodeling sequence, in Bone Histomorphometry, Jee, W. S. S. and Parfitt, A. M., Eds., Pergamon Press/Societe-Nouvelle de Publications Medicales et Dentaires, Paris, 1981, 35.
150. Parfitt, A. M., The actions of parathyroid hormone on bone. Relation to bone remodeling and turnover, calcium homeostasis and metabolic bone disease. II. PTH and bone cells: bone turnover and plasma calcium regulation, Metabolism, 25, 909, 1976.
151. Ericksen, E. F., Gundersen, H. J. G., Melsen, F., and Mosekilde, L., Reconstruction of the formative site in iliac trabecular bone in 20 normal individuals employing a kinetic model for matrix and mineral apposition, Metab. Bone Dis. Relat. Res., 5, 243, 1984.
152. Frost, H. M., In vivo osteocyte death, J. Bone Joint Surg, 42A, 138, 1960.
153. Frost, H. M., Micropetrosis, J. Bone Joint Surg., 42A, 144, 1960.
154. Schiessl, H., Frost H. M., and Jee, W. S. S., Estrogen and bone muscle strength and mass relationship, Bone, 22, 1, 1998.
155. Weinstein, R. S., Jilka, R. L., Parfitt, A. M., and Manolagas, S. C., Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids, J. Clin. Invest., 102, 274, 1998.
156. Tomkinson, A., Bevers, E. F., Wit, J. M., Reeve, J., and Noble, B. S., The role of estrogen in the control of rat osteocyte apoptosis, J. Bone Miner. Res., 13, 1243, 1998.
157. Noble, B. S., Stevens, H., Mosley, J. R., Pitsillides, A. A., Reeve, J., and Lanyon, L., Bone loading changes the number and distribution of apoptotic osteocytes in cortical bone, J. Bone Miner. Res., 12, 5111, 1997.
158. Hofbauer, L. C., Khosla, S., Dunstan, C. R., Lacey, D. L., Boyle, W. J., and Riggs, B. L., The role of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption, J. Bone Miner. Res., 15, 2, 2000.
159. Chambers, T. J., Revell, P. J., Fuller, K. et al., Resorption of bone by isolated osteoclasts, J. Cell Sci., 66, 383, 1984.
160. Jaworski, Z. F. G., Lok, E., and Wellington, J. L., Impaired osteoclastic function and linear bone erosion rate in secondary hyperthyroidism associated with chronic renal failure, Clin. Orthop., 107, 298, 1975.
161. Martin, R. B., Toward a unifying theory of bone remodeling, Bone, 26, 1, 2000.
162. Marotti, G., The structure of bone tissues and the cellular control of their deposition, Ital. J. Anat. Embryol., 101, 25, 1996.
163. Marotti, G., Ferretti, M., Muglia, M. A., Palumbo, C., and Palazzini, S., A quantitative evaluation of osteoblast-osteocyte relationships on growing endosteal surface of rabbit tibiae, Bone, 13, 363, 1992.
164. Manolagas, S. C. and Weinstein, R. S., New developments in the pathogenesis and treatment of steroid-induced osteoporosis, J. Bone Miner. Res., 14, 1061, 1999.
165. Abe, E., Yamamoto, M., Taguchi, Y., Lecka-Czernik, B., Economides A. N., Stahl, N., Jilka, R. L., and Manolagas, S. C., Requirement of BMPs2/4 for postnatal osteoblast and osteoclast formation: antagonism by noggin, Bone, 23, S242, 1998.
166. Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., and Karsenty, G., Osf2/Cbfal: a transciptional activator of osteoblast differentiation; Cell, 89, 747, 1997.
167. Kimmel, D. B., Animal models for in vivo experimentation in osteoporosis reasearch, in Osteoporosis, Marcus, R., Feldman, D., and Kelsey, J., Eds., Academic Press, San Diego, 1996, chap. 33.
168. Kimmel, D. B., Quantitative histologic changes in the proximal tibial epiphyseal growth cartilage of aged female rats, Cells Mater., 1 (Suppl.), 11, 1992.
169. Dawson, A. B., The age order of epiphyseal union in the long bones of the albino rat, Anat. Rec., 31, 1, 1925.
170. Erben, R. G., Trabecular and endocortical bone surfaces in the rat: modeling and remodeling, Anat. Rec., 246, 39, 1996.
171. Brommage, R., Hotchkiss, C. E., Lees, C. J., Stancill, M. W., Hock, J. M., and Jerome, C. P., Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for one year increases bone mass in ovariectomized monkeys, J. Clin. Endocrinol. Metab., 84, 3757, 1999.
172. Burr, D. B., Hirano, T., Turner, C. H., Hotchkiss, C. E., Brommage, R., and Hock, J. M., Intermittently administered hPTH (1-34) treatment increases intracortical bone turnover and porosity without reducing bone strength in the humerus of ovariectomized cynomolgus monkeys, J. Bone Miner. Res., 15, 157, 2001.
173. Bain, S. D., Bailey, S. C., Celino, D. L., Lantry, M. M., and Edwards, M. W., High-dose estrogen inhibits bone resorption and stimulates bone formation in the ovariectomized mouse, J. Bone Miner. Res., 8, 435, 1993.
174. Bain, S. D., Jensen, E., Celino, D. L., Bailey, M. C., Lantry, M. M., and Edwards, M. W., High-dose gestagens modulate bone resorption and formation and enhance estrogen-induced endosteal bone formation in ovariectomized mouse, J. Bone Miner. Res., 8, 219, 1993.
175. Akhter, M. P., Raab, D. M., Turner, C. H., Kimmel, D. B., and Recker, R. R., Characterization of in vivo strain in the rat tibia during external application of four-point bending load, J. Biomechs., 25, 1241, 1992.
176. Boppart, M. D., Kimmel, D. B., Yee, J. A., and Cullen, D. M., Time course of osteoblast appearance after in vivo mechanical loading, Bone, 23, 409, 1998.
177. Cann, C. E., Genant, H. K., and Young, D. R., Comparison of vertebral and peripheral mineral losses in disuse osteoporosis in monkeys, Radiology, 134, 525, 1980.
178. Cann, C. E. and Young, D. R., Bone formation rate in experimental disuse osteoporosis in monkeys (M. nemestrina), Physiologist, 19, 147, 1976.
179. Chambers, T. J., Evans, M., Gardner, T. N., Turner-Smith, A., and Chow, J. W. M., Induction of bone formation in rat tail vertebrae by mechanical loading, Bone Miner., 20, 167, 1993.
180. Chow, J. W. M., Jagger, C. J., and Chambers, T. J., Characterization of osteogenic response to mechanical stimulation in cancellous bone of rat caudal vertebrae, Am. J. Physiol., 265, E340, 1993.
181. Chow, J. W. M., Jagger, C. J., and Chambers, T. J., Reduction in dynamic indices of cancellous bone formation in rat tail vertebra after caudal neurectomy, Calcif. Tissue Int., 59, 117, 1996.
182. Dehority, W., Halloran, B. P., Bikle, D. D., Curren, T., Kostenuik, P. J., Wronski, T. J., Shen, Y., Rabkin, B., Bouraoui, A., and Morey-Holten, E., Bone and hormonal changes induced by skeletal unloading in the mature male rat, Am. J. Physiol., 276(1 Pt. 1), E62, 1999.
183. Forwood, M. R., Owan, I., Takano, Y., and Curner, C. H., Increased bone formation in rat tibiae after a single short period of dynamic loading in vivo, Am. J. Physiol., 270, E419, 1996.
184. Frost, H. M., The regional acceleratory phenomenon. A review, Henry Ford Hosp. Med. J., 31, 3, 1983.
185. Frost, H. M., Perspectives: the role of changes in mechanical usage set points in the pathogenesis of osteoporosis, J. Bone Miner. Res., 7, 253, 1992.
186. Gross, A. L., Roberrtson, K. T., and Krough, L. H., Jr., A study of calcium, phosphorus and nitrogen mobilization resulting from conditions of inactivity in Macaca irus monkeys, USAF School of Aerospace Medicine, Brooks AFB, SAM-TR-66-94, 1966.
187. Howard, W. H., Parcher, J. W., and Young, D. R., Primate restraint system for studies of metabolic responses during recumbency, Lab. Anim. Sci., 21, 112, 1971.
188. Ijiri, K., Jee, W. S. S., Ma, Y. F., and Yuan, Z., Remobilization partially restored bone mass in a nongrowing cancellous bone site following long term immobilization, Bone, 17(S), 213S, 1995.
189. Ijiri, K., Ma, Y. F., Jee, W. S. S., Akamine, T., and Liang, X., Adaptation of non-growing former epiphyses and metaphyseal bones to aging and immobilization in rat, Bone, 17, 207S, 1995.
190. Izawa, Y., Makita, T., Hino, S., Hashimoto, Y., Kushida, K., Inoue, T., and Orimo, H., Immobilization osteoporosis and active vitamin D: effect of active vitamin D analogs on the development of immobilization osteoporosis in rats, Calcif. Tissue Int., 33, 623, 1981.
191. Jaworski, Z. F. G. and Uhthoff, H. K., Disuse osteoporosis: current status and problems, in Current Concepts of Bone Fragility, Uhthoff H. K., Ed., Springer-Verlag, New York, 1986, 181-194.
192. Jaworski, Z. F. G., Liskova-Kiar, M., and Uhthoff, H. K., Effect of long term immobilization on the pattern of bone loss in older dogs, J. Bone Joint Surg., 62B, 104, 1980.
193. Jee, W. S. S., Ma, Y. F., and Li, X. J., The immobilized adult cancellous bone site in a growing rat as an animal model of human osteoporosis, J. Histotechnol., 20, 201, 1997.
194. Jee, W. S. S. and Ma, Y. F., Animal models of immobilization osteopenia, Morphologie, 83, 25, 1999.
195. Kazarain, L. E. and Von Gierke, H. E., Bone loss as a result of immobilization and chelation. Preliminary result in Macaca mulatta, Clin. Orthop. Relat. Res., 65, 67, 1969.
196. Lanyon, L. E. and Rubin, C. T., Static vs. dynamic loads as an influence on bone remodeling, J. Biomech., 17, 897, 1984.
197. Lean, J. M., Jagger, C. J., Chambers, T. J., and Chow, J. W., Increased insulin-like growth factor 1 mRNA expression in rat osteocytes in response to mechanical stimulation, Am. J. Physiol., 268, E318, 1995.
198. Li, X. J. and Jee, W. S. S., Adaptation of diaphyseal structure to aging and decreased mechanical loading in the adult rat: a densitometric and histomorphometric study, Anat. Rec., 229, 291, 1991.
199. Li, X. J., Jee, W. S. S., Chow, S. Y., and Woodbury, D. M., Adaptation of cancellous bone to aging and immobilization in the rat: a single photon absorptiometry and histomorphometry study, Anat. Rec., 227, 12, 1990.
200. Morey, E. R., Spaceflight and bone turnover: correlation with a new rat model of weightlessness, BioScience, 29(3), 168, 1979.
201. Morey, E. R. and Baylink, D. J., Inhibition of bone formation during space flight, Science, 201, 1138, 1978.
202. Rittweger, J., Gunga, H. C., Felsenberg, D., and Kirsch, K. A., Muscle and bone—aging and space, J. Gravitational Physiol., 6, 133, 1999.
203. Mosekilde, L., Danielsen, C. C., Sogaard, C. H., and Thorling, E., The effect of long-term exercise on vertebral and femoral bone mass, dimensions, and strength-assessed in a rat model, Bone, 15, 292, 1994.
204. Myburgh, K. H., Noakes, T. D., Roodr, M., and Hough, F. S., Effects of exercise on the development of osteoporosis in adult rats, J. Appl. Physiol., 66(1), 14, 1989.
205. Niklowitz, W. J., Bunch, T. E., and Young, D. R., The effects of immobilization on cortical bone in monkeys (M. nemestrina), Physiologist, 26, S115, 1983.
206. Okumura, H., Yamamuro, T., Kasai, R., Ichisaka, A., Hayashi, T., and Matsushita, M., The effects of immobilization on osteoporosis in rats, Jpn J. Bone Miner. Metab., 1986, 4, 75, 1986.
207. 3 on osteoporosis induced by immobilization combines with ovariectomy in rats, Bone, 8, 351, 1988.
208. Pead, M. J., Skerry, T. M., and Lanyon, L. E., Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading, J. Bone Miner. Res., 3, 647, 1988.
209. Shaker, J. L., Fallon, M. D., Goldfarb, S., Farber, J., and Attie, M. F., WR-2721 reduces bone loss after hindlimb tenotomy in rats, J. Bone Miner. Res., 4, 885, 1989.
210. Raab-Cullen, D. M., Akhter, M. P., Kimmel, D. B., and Recker, R. R., Bone response to alternate day mechanical loading of the rat tibia, J. Bone Miner. Res., 9, 203, 1994.
211. Raab-Cullen, D. M., Thiede, M. A., Petersen, D. N., Kimmel, D. B., and Recker, R. R., Mechanical loading stimulates rapid changes in periosteal gene expression, Calcif. Tissue Int., 55, 473, 1994.
212. Rubin, C. T. and Lanyon, L. E., Dynamic strain similarity in vertebrates: an alternative to allometric limb bone scaling, J. Theore. Biol., 107, 321, 1984.
213. Rubin, C. T. and Lanyon, L. E., Regulation of bone mass by mechanical strain magnitude, Calcif. Tissue Int., 37, 411, 1985.
214. Skerry, T. M., Bitensky, L., Chayen, J., and Lanyon, L. E., Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo, J. Bone Miner. Res., 4, 783, 1989.
215. Sogaard, C. H., Danielsen, C. C., Thorling, E. B., and Mosekilde, L., Long term exercise of young and adult female rats: Effect on femoral neck biomechanical competence and bone structure, J. Bone Miner. Res., 9, 409, 1994.
216. Steinberg, M. E. and Trueta, J., Effects of activity on bone growth and development in the rat, Clin. Orthop. Relat. Res., 156, 52, 1981.
217. Thompson, D. D. and Rodan, G. A., Effects of indomethacin on bone resorption produced by tenotomy, J. Bone Miner. Res., 3, 409, 1988.
218. Torrance, A. G., Mosley, J. R., Suswillo, R. R. L., and Lanyon, L. E., Noninvasive loading of the rat ulna in vivo induces a strain-related modeling response uncomplicated by trauma or periosteal pressure, Calcif. Tissue Int., 54, 241, 1994.
219. Turner, C. H., Akhter, M. P., Raab, D. M., Kimmel, D. B., and Recker, R. R., A non-invasive, in vivo model for studying strain adaptive bone modeling, Bone, 12, 73, 1991.
220. Turner, C. H., Forwood, M. R., Rho, J. Y., and Yoshikawa T., Mechanical loading thresholds for lamellar and woven bone formation, J. Bone Miner. Res., 9, 87, 1994.
221. Turner, C. H., Owen, I., Alvey, T., Hulman, J., and Hock, J. M., Recruitment and proliferative responses of osteoblasts after mechanical loading in vivo determined using sustained release bro-modeoxyuridine, Bone, 22, 463, 1998.
222. Tuukkanen, J., Wallmark, B., Jalovaara, P., Takala, T., Sjogren, S., and Vaananen, K., Changes induced in growing rat bone by immobilization and remobilization, Bone, 12, 113, 1991.
223. Uhthoff, J. K. and Jaworski, Z. F. G. Bone loss in response to long-term immobilization, J. Bone Joint Surg., 60-B, 420, 1978.
224. Umemura, Y., Ishiko, T., Yamauchi, T., Kurono, M., and Mashiko S., Five jumps per day increase bone mass and breaking force in rats, J. Bone Miner. Res., 9, 1480, 1997.
225. Weinreb, M., Rodan, G. A., and Thompson, D. D., Osteopenia in the immobilized rat hindlimb is associated with increased bone resorption and decreased bone formation, Bone, 10, 187, 1989.
226. Yeh, J. K., Liu, C. C., and Aloia, J. F., Effects of exercise and immobilization on bone formation and resorption in young rats, Am. J. Physiol., E182, 1993.
227. Yeh, J. K., Aloia, J. F., Chen, M. M., Koo, H. C., and Millard, W. J., Effects of growth hormone administration and treadmill exercise on serum and skeletal IGF-1 in rats, Am. J. Physiol., E129, 1994.
228. Young, D. R., Nikowitz, W. J., and Steele, C. R., Tibial changes in experimental disuse osteoporosis in the monkey, Calcif. Tissue Int., 35, 304, 1983.
229. Young, D. R., Niklowitz, W. J., Brown, R. J., and Jee, W. S. S., Immobilization-associated osteoporosis in primates, Bone, 7, 109, 1986.
230. Zeng, Q. Q., Jee, W. S. S., Ke, H. Z., and Wechter W. J., S-Ketoprofen inhibits tenotomy-induced bone loss and dynamics in weanling rats, Bone Miner., 21, 203, 1993.
231. Zeng, Q. Q., Jee, W. S. S., Bigornia, A. E., King, J. G., D’Souza, S. M., Li, X. J., Ma, Y. F., and Wechter, W. J., Time responses of cancellous and cortical bones to sciatic neurectomy in growing female rats, Bone, 19, 13, 1996.
232. Kaneps, A. J., Stover, S. M., and Lane, N. E., Changes in canine cortical and cancellous bone mechanical properties following immobilization and remobilization with exercise, Bone, 21, 419, 1987.
233. Ito, H., Ke, H. Z., Jee, W. S. S., and Sakou, T., Anabolic responses of an adult cancellous bone site to prostaglandin E2 in the rat, Bone Miner., 21, 219, 1993.
234. Ke, H. Z., Jee, W. S. S., Ito, H., Setterberg, R. B., Li, M., Lin, B. Y., Liang, X. G., and Ma, Y. F., Greater bone formation induction occurred in aged than young cancellous bone sites, Bone, 14, 481, 1993.
235. Iwamoto, J., Yeh, J. K., and Aloia, J. F., Different effect of treadmill exercise on three cancellous bone sites in the young growing rats, Bone, 24, 163, 1999.
236. Yeh, J. K., Aloia, J. F., Chen, M. M., Tierney, J. M., and Sprintz, S., Influence of exercise on cancellous bone of aged female rats, J. Bone Miner. Res., 9, 1117, 1993.
237. Yeh, J. K., Aloia, J. F., Chen, M. M., Koo, H. C., and Millard, W. J., Effects of growth hormone administration and treadmill exercise on serum and skeletal IGF-1 in rats, Am. J. Physiol., E129, 1994.
238. Chen, M. M., Yeh, J. K., Aloia, J. F., Tierney, J. M., and Sprintz, S., Effect of treadmill exercise on tibial cortical bone in aged female rats: a histomorphometry and dual energy X-ray absorptiometry study, Bone, 15, 313, 1994.
239. Newhall, K. M., Rodnick, K. J., van der Meulen, M. C., Carter, D. R., and Marcus, R. T., Effects of voluntary exercise on bone mineral content in rats, J. Bone Miner. Res., 6, 289, 1991.
240. Banu, M. J., Orhii, P. B., Wejia, W., McCarter, R. J. M., Mosekilde, L., Thomsen, J. S., and Kalu, D. N., Analysis of the effects of growth hormone, voluntary exercise, and food restriction on diaphyseal bone in female F344 rats, Bone, 25, 469, 1999.
241. Mosekilde, L., Thomsen, J. S., Orhii, P. B., McCarter, R. J., Mejia, W., and Kalu, D. N., Additive effect of voluntary exercise and growth hormone treatment on bone strength assessed at four different skeleton sites in an aged rat model, Bone, 24, 71, 1999.
242. Bourrin, S., Ghaemmaghami, F., Vico, L., Chappard, D., Gharib, C., and Alexandre, C., Effect of a five-week swimming program on rat bone: a histomorphometric study, Calcif. Tissue Int., 51, 137, 1992.
243. Swissa-Sivan, A., Simkin, A., Leichter, I., Nyska, A., Nyska, M., Statter, M., Bivas, A., Menczel, J., and Samueloff, S., Effect of swimming on bone growth and development in young rats, Bone Miner., 7, 91, 1989.
244. Sedillot, M. C., Des modification que subissent les membres reseques pendant leur periode de developpement, et en particulier du siege et des degres du raccourvissement oberve a la suite de la resection coxo-femorale, C. R. Acad. Sci., 68, 1444, 1869.
245. Wermel, J., Untersuchungen uber die Kinetogenese und ihre Bedeutung in der onto- und phylogenetischen Entwicklung (Experimente und Vergleichungen an Wirbeltierextremitaten). Regeneration der Knochen und Gelenke, sowoe Newbuldung der Letzteren, Morphol Jahrb., 75, 445, 1935.
246. Goodship, A. E., Lanyon, L. E., and McFie, H., Functional adaption of bone to increased stress, J. Bone Joint Surg., 61A, 539, 1979.
247. Lanyon, L. E., Goodship, A. E., Pye, C. J., and MacFie, J. H., Mechanically adaptive bone remodeling, J. Biomech., 15, 141, 1982.
248. Rubin, C. T. and Lanyon, L. E., Regulation of bone formation by applied dynamic loads, J. Bone Joint Surg., 66A, 397, 1984.
249. Raab, D. M., Smith, E. L., Crenshaw, T. D., and Thomas, D. P., Bone mechanical properties after exercise training in young and old rats, Am. J. Physiol., 68, 130, 1990.
250. Forwood, M. R. and Parker, A. W., Repetitive loading, in vivo of the tibiae and femora of rats: effects of repeated bouts of treadmill-running, Bone Miner., 13, 35, 1991.
251. Oxlund, H., Andersen, N. B., Ortoft, G., Orskov, H., and Andreassen, T. T., Growth hormone and mild exercise in combination markedly enhance cortical bone formation and strength in old rats, Endocrinology, 139, 1899, 1998.
252. Barengolts, E. I., Curry, D. J., Bapna, M. S., and Kukreja S. C., Effects of endurance exercise on bone mass and mechanical properties in intact and ovariectomized rats, J. Bone Miner. Res., 8, 937, 1993.
253. Mosekilde, L., Thomsen, J. S., Orhii, P. B., McCarter, R. J., Mejia, W., and Kalu, D. N., Additive effect of voluntary exercise and growth hormone treatment on bone strength assessed at four different skeleton sites in an aged rat model, Bone, 24, 71, 1999.
254. Peng, J., Tuukkanen, J., and Vaananen, H. K., Exercise can provide protection against bone loss and prevent the decrease in mechanical strength of femoral neck in ovariectomized rats, J. Bone Miner. Res., 10, 1559, 1994.
255. Turner, C. H., Duncan, R. L., and Pavalko, F. M., Mechanotransduction: an inevitable process for skeletal maintenance, in Novel Approaches to Treatment of Osteoporosis, Russell, R. G. G., Skerry, T. M., and Kollenkirchen, U., Eds., Springer, Berlin, 1998, Ernst Schering Research Foundation Workshop, 25, chap. 7.
256. Skerry, T. M., The regulation of gene expression in bone by mechanical loading, in Novel Approaches to Treatment of Osteoporosis, Russell, R. G. G., Skerry, T. M., and Kollenkirchen, U., Eds., Springer, Berlin, 1998, Ernst Schering Research Foundation Workshop, 25, chap. 8.
257. Lanyon, L. E., Amplification of the osteogenic stimulus of load-bearing as a logical therapy for the treatment and prevention of osteoporosis, in Novel Approaches to Treatment of Osteoporosis, Russell, R. G. G., Skerry, T. M., and Kollenkirchen, U., Eds., Springer, Berlin, 1998, Ernst Schering Research Foundation Workshop, 25, chap. 9.
258. Parfitt, A. M., The mechanism of coupling: a role for the vasculature, Bone, 26, 319, 2000.
259. Gimble, J. M., Robinson, C. E., Wu, X., and Kelly, K. A., The function of adipocytes in the bone marrow stroma: an update, Bone, 19, 421, 1996.
260. Maurin, A. C., Chavassieux, P. M., Frappart, L., Delmas, P. D., Serre, C. M., and Meunier, P. J., Influence of mature adipocytes on osteoblast proliferation in human primary co-cultures, Bone, 26, 485, 2000.
261. Jilka, R. L., Weinstein, R. S., Bellido, T., Roberson, P., Parfitt, A. M., and Manolagas, S., Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone, J. Clin. Invest., 104, 439, 1999.
262. Machwate, M., Rodan, S. B., Rodan, G. A., and Harada, S. I., Sphingosine kinase mediates cyclic AMP suppression in rat periosteal cells, Mol. Pharmacol., 64, 70, 1995.
263. Jee, W. S. S. and Nolan, P. D., Origin of osteoclasts from the fusion of phagocytes, Nature, 208, 225, 1963.