The immobilized adult cancellous bone site in a growing rat as an animal model of human osteoporosis

Journal of Histotechnology

Volumn 20, Issue 3, 1997, Pages 201-206

  Jee, W S S ^a,b   Ma, Y F ^a   Li, X J ^a,c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c Genetics Institute Inc   (United States)

Author keywords

Human; Immobilization; Osteopenic models; Ovariectomy; Rat

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE TURNOVER; CANCELLOUS BONE; FEMALE; IMMOBILIZATION; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; OVARIECTOMY; RAT;

ANIMALIA;

EID: 0030821878     PISSN: 01478885     EISSN: None     Source Type: Journal    
DOI: 10.1179/his.1997.20.3.201     Document Type: Article

References (61)

1. Riggs BL, Joseph Melton III L: Involutional osteoporosis. N Engl J Med 314:1676-1686, 1986
2. Khosla S, Joseph Melton III L: Secondary osteoporosis. Osteoporosis, Riggs BL, Melton III L (eds). Raven Press, New York, 1995, pp 183-204
3. Johnston CC, Norton J, Khairi MRA et al: Heterogeneity of fracture syndromes in postmenopausal women. J Clin Endocrinol Metab 61:551-556, 1985
4. Lips P, Netelenbos JC, Jongen MJM et al: Histomorphometric profile and vitamin D status in patients with femoral neck fracture. Memb Bone Dis Relat Res 2:85-89, 1982
5. Duarte MEL, Lauria R, Gameiro VS: Structural changes in trabecular bone in patients with hip fractures. Bone Min 17(Suppl 1):254 (abst), 1992
6. Courpron P, Meunier P, Edouard C et al: Donnees histologiques quantitaves sur le vieillissement osseux humain. Rev Rhum 40:469-483, 1973
7. Meunier PF, Sellami S, Briancon D, Edouard C: Histological heterogeneity of apparently idiopathic osteoporosis. In Osteoporosis: Recent Advances in Pathogenesis and Treatment, De Luca HF, Frost H, Jee W et al (eds). University Park Press, Baltimore, 1981, pp 293-301
8. Teitlebaum SL, Bergfeld MA, Avioli LV, Whyte MP: Failure of routine biochemical studies to predict the histological heterogeneity of untreated postmenopausal osteoporosis. In Osteoporosis: Recent Advances in Pathogenesis and Treatment. De Luca HF, Frost H, Jee W et al (eds). University Park Press, Baltimore, 1981, pp 303-309
9. Whyte MP, Bergfeld MA, Murphy WA et al: Postmenopausal osteoporosis: a heterogeneous disorder as assessed by histomorphometric analysis of iliac crest bone from untreated patients. Am J Med 72:193-201, 1982
10. Parfitt AM, Kleerekoper M: Diagnostic value of bone histomorphometry and comparison of histologic measurements and biochemical indices of bone remodeling. In Osteoporosis: Proceedings of Copenhagen International Symposium on Osteoporosis, Christiansen C, Arnaud CD, Nordin BEC et al (eds). Stiftsbog trykkeri, Aalborg, 1984, pp111-120
11. Arlot ME, Delmas PD, Chappard D, Meunier PJ: Trabecular and endocortical bone remodeling in postmenopausal osteoporosis: comparison with normal postmenopausal women. Osteoporosis Int 1:41-49, 1990
12. Eriksen SF, Hodgson SF, Eastell R et al: Cancellous bone remodeling in Type I (postmenopausal) osteoporosis: Quantitative assessment of rates of formation resorption, and bone loss at tissue and cellular levels. J Bone Min Res 5:311-319, 1990
13. Eriksen EF, Steiniche T, Mosekilde L, Melsen F: Histomorphometric analysis of bone in metabolic bone disease. Endocrinol Metab Clin North Am 18:919-954, 1989
14. Frost HM: Mathematical Elements of Lamellar Bone Remodelling. Charles C. Thomas, Springfield, 1964
15. Frost HM: Bone Dynamics in Osteoporosis and Osteomalacia. Charles C. Thomas, Springfield, 1966
16. Frost HM: Intermediary Organization of the Skeleton, Vols I, II, CRC Press, Boca Raton, 1986
17. Frost HM: Structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff's Law: The bone remodeling problem. Anat Rec 226, 414, 1990
18. Frost HM: Introduction to a New Skeletal Physiology. I: Bone and Bones. The Pajaro Group, Inc, Pueblo, CO, 1995
19. Jee WSS: The skeletal tissues. In Cell and Tissue Biology. A Textbook of Histology, Weiss L (ed). Urban and Schwartzenbergm, Baltimore, 1989, pp 211-253
20. Dempster DW: Bone remodeling. Disorders of Bone and Mineral Metabolism, Coe FL, Favus MJ (eds). Raven Press, New York, 1992, pp 355-380
21. Wiener N: Cybernetics. MIT Press, Cambridge, 1964
22. Li XJ, Jee WSS, Ke Hz et al: Age-related changes of cancellous and cortical bone histomorphometry in female Sprazgue-Dawley rats. Cells Mater (Suppl) 1:25-35, 1991
23. Jee WSS, Ma YF, Li M et al: Sex steroids and prostaglandins in bone metabolism. In Sex Steroids and Bone, Ziegler R, Pfeilschafter J, Brautigam M (eds). Schering Foundation Workshop Series, 9:119-146, 1994
24. Wronski TJ, Dann LM, Scott KS, Cintron M: Long-term effects of ovariectomy and aging on the rat skeleton. Calcif Tiss Int 45:360-366, 1989
25. Kalu Dike N: The ovariectomized rat model of postmenopausal bone loss. Bone Min 15:175-192, 1991
26. Miller SC, Wronski TJ: Long-term osteopenic changes in cancellous bone structure in ovariectomized rats. Anat Rec 236: 433-441, 1993
27. Jee WSS, Frost HM: Skeletal adaptations during growth. Triangle 31:77-88, 1992
28. Thompson DD, Simmons HA, Pirie CM, Ke HZ: FDA guidelines and animal models for osteoporosis Bone 17:125S-134S, 1995
29. 2 increased rat cortical bone mass when administered immediately following ovariectomy. Bone Min 21:189-201, 1993
30. Ma YF, Ke HZ, Jee WSS: Prostaglandin E2 adds bone to a cancellous bone site with a closed growth plate and low bone turnovers in ovariectomized rats. Bone 15:137-146, 1994
31. Turner RT, Riggs BL, Spelsberg TC: Skeletal effects of estrogen. Endocrine Rev 15:275-300, 1994
32. 2 alone in maintaining the added bone after withdrawal in a non-growing cancellous bone site. Bone 17: 335S-339S, 1995
33. Li L, Shen Y, Qi H, Wronski TJ: Comparative study of skeletal response to estrogen depletion at red and yellow marow sites in rats. Anat Rec 245:472-480, 1996
34. 2α on the skeleton of adult osteopenic ovariectomized rats. Bone 17:549-5554, 1995
35. 2 alone are equally anabolic on tibial shaft of ovariectomized rats. Bone 17:291S-296S, 1995
36. Li XJ, Jee WSS, Chow SY, Woodbury DM: Adaptation of cancellous bone to aging and immobilization in the rat: A single photon absorptiometry and histomorphometry study. Anat Rec 227:12-24, 1990
37. Li XJ, Jee WSS: Adaptation of diaphyseal structure to aging and decreased mechanical loading in the adult rat: A densitometric and histomorphometric study. Anal Rec 229:291-297, 1991
38. 2 prevents disuse-induced cancellous bone loss and adds extra bone to immobilized bones. Bone 13:11-22, 1992
39. 2 prevents disuse-induced cortical bone loss. Bone 13:153-159, 1992
40. Chen MM, Jee WSS, Ke HZ et al: Adaptation of cancellous bone to aging and immobilization in the growing rats. Anat Rec 234:317-334, 1992
41. Li M, Jee WSS, Ke HZ et al: Prostaglandin E2 restores cancellous bone to immobilized limb and adds bone to overloaded limb in right hindlimb immobilization rats. Bone 14:283-288, 1993
42. Maede H, Kimmel DB, Raab DM, Lane NE: Musculoskeletal recovery following hindlimb immobilization in adult female rats. Bone 14:153-159, 1993
43. Ijiri K, Jee WSS, Ma YF, Zhongzhi Y: Remobilization partially restored the bone mass in a non-growing cancellous bone site following long term immobilization. Bone 17:213S-218S, 1995
44. Ijiri K, Ma YF, Jee WSS et al: Adaptation of non-growing former epiphyses and metaphyseal bones to aging and immobilization in rat. Bone 17:207S-212S, 1995
45. Ma YF, Jee WSS, Ke HZ et al: Human parathyroid hormones (1-38) restores cancellous bone to immobilized, osteopenic proximal tibial metaphysis in rats. J Bone Min Res 10:496-505, 1995
46. Ma YF, Jee WSS, Chen YY et al: Partial maintenance of extra cancellous bone mass by antiresorptive agents after discontinuation of human parathyroid hormone (1-38) in right hindlimb immobilized rats. J Bone Min Res 10:1726-1734, 1995
47. Yuan ZZ, Jee WSS, Ma YF et al: Parathyroid hormone therapy accelerates recovery from immobilization-induced osteopenia. Bone 17:219S-224S, 1995
48. Lin BY, Jee WSS, Chen MM et al: Mechanical loading modifies ovariectomy-induced cancellous bone loss. Bone Min 25: 199-210, 1994
49. 2 prevents ovariectomy-induced cancellous bone loss in the rats. Bone Min 19: 45-62, 1992
50. Ke HZ, Jee WSS, Ito H et al: Greater bone formation induction in aged than young cancellous bone sites. Bone 14:481-485, 1993
51. Wronski TJ, Yen C.-F: Anabolic effects of parathyroid hormone on cortical bone in ovariectomized rats. Bone 15, No. 1:51-58, 1994
52. Baumann BD, Wronski TJ: Response of cortical bone to antiresorptive agents and parathyroid hormone in aged ovariectomized rats. Bone 16(2):247-253, 1995
53. Kimmel DB: Quantitative histologic changes in the proximal tibial growth cartilage of aged female rats. Cells Mater Suppl 1:11-19, 1991
54. Lin BY, Jee WSS, Ma YF, Ke HZ: Rat cortical bone of tibial shaft response to ovariectomy plus immobilization (in preparation)
55. Erben RG: Trabecular and endocortical bone surfaces in the rat: Modeling or remodeling. Anat Rec 246:39-46, 1996
56. Recker RR, Kimmel DB, Parfitt AM et al: Static and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females. J Bone Min Res 3:133-144, 1988
57. Dawson AB: The age order of epiphyseal union in the long bones of the albino rat. Anat Rec 31:1-17, 1925
58. 2 in the rat. Bone Mineral 21:219-236, 1993
59. 2 alone in maintaining the added bone in adult cancellous bone site of rat. (in preparation)
60. Parfitt AM: The physiologic and clinical significance of bone histomorphometric data. In Bone Histomorphometry: Techniques and Interpretation, Recker RR (ed). CRC Press, Boca Raton, 1983, pp 143-224
61. 2 on production of new cancellous bone in the axial skeleton of ovariectomized rats. Bone 11:103-111, 1990