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Volumn 128, Issue , 2016, Pages 302-312

Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract

Author keywords

1H NMR based metabolomics; Diabetes mellitus; Metabolic pathway; Multivariate data analysis; Phyllanthus niruri

Indexed keywords

2 OXOGLUTARIC ACID; 3 HYDROXYBUTYRIC ACID; ACETIC ACID; ACETOACETIC ACID; ACETONE; ALANINE; CHOLESTEROL; CHOLINE; CREATINE; CREATININE; DICARBOXYLIC ACID; DIMETHYLGLYCINE; FORMIC ACID; FUMARIC ACID; GLUCOSE; GLYCINE; GLYOXYLIC ACID; HIGH DENSITY LIPOPROTEIN; HYPOTAURINE; LACTIC ACID; LOW DENSITY LIPOPROTEIN; METFORMIN; PHYLLANTHUS NIRURI EXTRACT; PYRUVIC ACID; SERINE; STREPTOZOCIN; SUCCINIC ACID; TAURINE; THREONINE; TRIACYLGLYCEROL; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; LIPID; PLANT EXTRACT;

EID: 84974602992     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2016.06.003     Document Type: Article
Times cited : (47)

References (30)
  • 1
    • 84974629873 scopus 로고    scopus 로고
    • accessed on March 2015.
    • WHO (2014) accessed on March 2015. http://www.who.int/mediacentre/factsheets/fs312/en/.
    • (2014)
  • 2
    • 84918827689 scopus 로고    scopus 로고
    • Anti-diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat-rich combination diet
    • Cheng Q., Zhang X., Wang O., Liu J., Cai S., Wang R., Zhou F., Ji B. Anti-diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat-rich combination diet. J. Sci. Food Agric. 2015, 95:401-408.
    • (2015) J. Sci. Food Agric. , vol.95 , pp. 401-408
    • Cheng, Q.1    Zhang, X.2    Wang, O.3    Liu, J.4    Cai, S.5    Wang, R.6    Zhou, F.7    Ji, B.8
  • 3
    • 77951229157 scopus 로고    scopus 로고
    • Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable mechanisms of action of Ruta graveolens infusion and rutin in nicotinamide-streptozotocin-induced diabetic rats
    • Ahmed O.M., Moneim A.A., Yazid I.A., Mahmoud A.M. Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable mechanisms of action of Ruta graveolens infusion and rutin in nicotinamide-streptozotocin-induced diabetic rats. Diabetol Croat 2010, 39:15-35.
    • (2010) Diabetol Croat , vol.39 , pp. 15-35
    • Ahmed, O.M.1    Moneim, A.A.2    Yazid, I.A.3    Mahmoud, A.M.4
  • 5
    • 80755128301 scopus 로고    scopus 로고
    • Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats
    • Gandhi G.R., Ignacimuthu S., Paulraj M.G., Sasikumar P. Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats. Eur. J. Pharmacol. 2011, 670:623-631.
    • (2011) Eur. J. Pharmacol. , vol.670 , pp. 623-631
    • Gandhi, G.R.1    Ignacimuthu, S.2    Paulraj, M.G.3    Sasikumar, P.4
  • 6
    • 84923358913 scopus 로고    scopus 로고
    • Antihyperglycemic activity of Anoectochilus roxburghii polysaccharose in diabetic mice induced by high-fat diet and streptozotocin
    • Zhang J., Liu Q., Liu Z., Li L., Yi L. Antihyperglycemic activity of Anoectochilus roxburghii polysaccharose in diabetic mice induced by high-fat diet and streptozotocin. J. Ethnopharmacol. 2015, 164:180-185.
    • (2015) J. Ethnopharmacol. , vol.164 , pp. 180-185
    • Zhang, J.1    Liu, Q.2    Liu, Z.3    Li, L.4    Yi, L.5
  • 7
  • 8
    • 77952339975 scopus 로고    scopus 로고
    • Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes
    • Connor S.C., Hansen M.K., Corner A., Smith R.F., Ryan T.E. Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. Mol. Biosyst. 2010, 6:909-921.
    • (2010) Mol. Biosyst. , vol.6 , pp. 909-921
    • Connor, S.C.1    Hansen, M.K.2    Corner, A.3    Smith, R.F.4    Ryan, T.E.5
  • 9
    • 84898840538 scopus 로고    scopus 로고
    • Metabolites profile of Xian-Ling-Gu-Bao capsule a traditional Chinese medicine prescription, in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis
    • Geng J.L., Dai Y., Yao Z.H., Qin Z.F., Wang X.L., Qin L., Yao X.S. Metabolites profile of Xian-Ling-Gu-Bao capsule a traditional Chinese medicine prescription, in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis. J. Pharm. Biomed. Anal. 2014, 96:90-103.
    • (2014) J. Pharm. Biomed. Anal. , vol.96 , pp. 90-103
    • Geng, J.L.1    Dai, Y.2    Yao, Z.H.3    Qin, Z.F.4    Wang, X.L.5    Qin, L.6    Yao, X.S.7
  • 10
    • 84949950525 scopus 로고    scopus 로고
    • A metabolomic approach to understanding the metabolic link between obesity and diabetes
    • Park S., Sadanala K.C., Kim E.K. A metabolomic approach to understanding the metabolic link between obesity and diabetes. Mol. Cells 2015, 38:587-596.
    • (2015) Mol. Cells , vol.38 , pp. 587-596
    • Park, S.1    Sadanala, K.C.2    Kim, E.K.3
  • 13
    • 81255135960 scopus 로고    scopus 로고
    • Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review
    • Patel J.R., Tripathi P., Sharma V., Chauhan N.S., Dixit V.K. Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review. J. Ethnopharmacol. 2011, 138:286-313.
    • (2011) J. Ethnopharmacol. , vol.138 , pp. 286-313
    • Patel, J.R.1    Tripathi, P.2    Sharma, V.3    Chauhan, N.S.4    Dixit, V.K.5
  • 14
    • 33748565005 scopus 로고    scopus 로고
    • α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus
    • Ali H., Houghton P.J., Soumyanath A. α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. J. Ethnopharmacol. 2006, 107:449-455.
    • (2006) J. Ethnopharmacol. , vol.107 , pp. 449-455
    • Ali, H.1    Houghton, P.J.2    Soumyanath, A.3
  • 15
    • 84939982779 scopus 로고    scopus 로고
    • Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction
    • Mediani A., Abas F., Khatib A., Tan C.P., Ismail I.S., Shaari K., Ismail A., Lajis N.H. Relationship between metabolites composition and biological activities of Phyllanthus niruri extracts prepared by different drying methods and solvents extraction. Plant Food Hum. Nutr. 2015, 70:184-192.
    • (2015) Plant Food Hum. Nutr. , vol.70 , pp. 184-192
    • Mediani, A.1    Abas, F.2    Khatib, A.3    Tan, C.P.4    Ismail, I.S.5    Shaari, K.6    Ismail, A.7    Lajis, N.H.8
  • 17
    • 52649086293 scopus 로고    scopus 로고
    • Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats
    • Jalil A.M.M., Ismail A., Pei C.P., Hamid M., Kamaruddin S.H.S. Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats. J. Agric. Food. Chem. 2008, 56:7877-7884.
    • (2008) J. Agric. Food. Chem. , vol.56 , pp. 7877-7884
    • Jalil, A.M.M.1    Ismail, A.2    Pei, C.P.3    Hamid, M.4    Kamaruddin, S.H.S.5
  • 18
    • 77956647066 scopus 로고    scopus 로고
    • Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats
    • Liu J., He T., Lu Q., Shang J., Sun H., Zhang L. Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats. Diabetes Metab. Res. 2010, 26:448-454.
    • (2010) Diabetes Metab. Res. , vol.26 , pp. 448-454
    • Liu, J.1    He, T.2    Lu, Q.3    Shang, J.4    Sun, H.5    Zhang, L.6
  • 19
    • 39149126712 scopus 로고    scopus 로고
    • Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
    • Beckonert O., Keun H.C., Ebbels T.M., Bundy J., Holmes E., Lindon J.C., Nicholson J.K. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat. Protoc. 2007, 2:2692-2703.
    • (2007) Nat. Protoc. , vol.2 , pp. 2692-2703
    • Beckonert, O.1    Keun, H.C.2    Ebbels, T.M.3    Bundy, J.4    Holmes, E.5    Lindon, J.C.6    Nicholson, J.K.7
  • 20
    • 84908099211 scopus 로고    scopus 로고
    • Metabolomic profiling and antioxidant activity of some Acacia species
    • Abdel-Farid I., Sheded M., Mohamed E. Metabolomic profiling and antioxidant activity of some Acacia species. Saudi J. Biol. Sci. 2014, 21:400-408.
    • (2014) Saudi J. Biol. Sci. , vol.21 , pp. 400-408
    • Abdel-Farid, I.1    Sheded, M.2    Mohamed, E.3
  • 22
    • 84935002911 scopus 로고    scopus 로고
    • Metabolomics-the complementary field in systems biology: a review on obesity and type 2 diabetes
    • Bakar M.H.A., Sarmidi M.R., Cheng K.K., Khan A.A., Suan C.L., Huri H.Z., Yaakob H. Metabolomics-the complementary field in systems biology: a review on obesity and type 2 diabetes. Mol. Biosyst. 2015, 11:1742-1774.
    • (2015) Mol. Biosyst. , vol.11 , pp. 1742-1774
    • Bakar, M.H.A.1    Sarmidi, M.R.2    Cheng, K.K.3    Khan, A.A.4    Suan, C.L.5    Huri, H.Z.6    Yaakob, H.7
  • 24
    • 75749158540 scopus 로고    scopus 로고
    • Evaluation of antidiabetic potentials of Phyllanthus niruri in alloxan diabetic rats
    • Okoli C., Ibiam A., Ezike A., Akah P., Okoye T. Evaluation of antidiabetic potentials of Phyllanthus niruri in alloxan diabetic rats. Afr. J. Biotechnol. 2010, 9:248-259.
    • (2010) Afr. J. Biotechnol. , vol.9 , pp. 248-259
    • Okoli, C.1    Ibiam, A.2    Ezike, A.3    Akah, P.4    Okoye, T.5
  • 25
    • 79951745519 scopus 로고    scopus 로고
    • Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri
    • Okoli C., Obidike I., Ezike A., Akah P., Salawu O. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharm. Biol. 2011, 49:248-255.
    • (2011) Pharm. Biol. , vol.49 , pp. 248-255
    • Okoli, C.1    Obidike, I.2    Ezike, A.3    Akah, P.4    Salawu, O.5
  • 26
    • 84878198375 scopus 로고    scopus 로고
    • 1H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values
    • 1H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values. J. Pharm. Biomed. Anal. 2013, 83:43-48.
    • (2013) J. Pharm. Biomed. Anal. , vol.83 , pp. 43-48
    • Deja, S.1    Barg, E.2    Mlynarz, P.3    Basiak, A.4    Willak-Janc, E.5
  • 27
    • 77954874168 scopus 로고    scopus 로고
    • Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats
    • Musabayane C., Tufts M., Mapanga R. Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats. Ren. Fail. 2010, 32:832-839.
    • (2010) Ren. Fail. , vol.32 , pp. 832-839
    • Musabayane, C.1    Tufts, M.2    Mapanga, R.3
  • 28
    • 80052739723 scopus 로고    scopus 로고
    • The medicinal value of honey: a review on its benefits to human health, with a special focus on its effects on glycemic regulation
    • Cortés M.E., Vigil P., Montenegro G. The medicinal value of honey: a review on its benefits to human health, with a special focus on its effects on glycemic regulation. Cien. Inv. Agr. 2011, 38:303-317.
    • (2011) Cien. Inv. Agr. , vol.38 , pp. 303-317
    • Cortés, M.E.1    Vigil, P.2    Montenegro, G.3
  • 29
    • 84953636348 scopus 로고    scopus 로고
    • Antidiabetic effect of combined spices of Allium sativum, Zingiber officinale and Capsicum frutescens in alloxan-induced diabetic rats
    • Otunola G.A., Afolayan A.J. Antidiabetic effect of combined spices of Allium sativum, Zingiber officinale and Capsicum frutescens in alloxan-induced diabetic rats. Front. Life Sci. 2015, 8:1-10.
    • (2015) Front. Life Sci. , vol.8 , pp. 1-10
    • Otunola, G.A.1    Afolayan, A.J.2
  • 30
    • 84974645457 scopus 로고    scopus 로고
    • Glycemic control efficacy of Phyllanthus niruri. Linn extract in diabetic mice model
    • Rani S., Kumar B. Glycemic control efficacy of Phyllanthus niruri. Linn extract in diabetic mice model. Int. J. Curr. Microbiol. Appl. Sci. 2015, 4:599-609.
    • (2015) Int. J. Curr. Microbiol. Appl. Sci. , vol.4 , pp. 599-609
    • Rani, S.1    Kumar, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.