Metabolites profile of Xian-Ling-Gu-Bao capsule, a traditional Chinese medicine prescription, in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis

Journal of Pharmaceutical and Biomedical Analysis

Volumn 96, Issue , 2014, Pages 90-103

  Geng, Jian liang ^a   Dai, Yi ^b   Yao, Zhi hong ^b   Qin, Zi fei ^b   Wang, Xin luan ^c   Qin, Ling ^c   Yao, Xin sheng ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Metabolites profile; Representative structure based homologous xenobiotics identification strategy; Traditional Chinese medicine prescription; UPLC Q TOF MS; Xian Ling Gu Bao capsule

Indexed keywords

FLAVONOID; FLAVONOID GLYCOSIDE; HERBACEOUS AGENT; PRESCRIPTION DRUG; SAPONIN DERIVATIVE; TANSHINONE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; XIAN LING GU BAO CAPSULE; XIAN LING GU BAO;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; CHEMICAL COMPOSITION; CHINESE MEDICINE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG GLUCURONIDATION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG SULFATION; DRUG URINE LEVEL; MALE; MASS DEFECT FILTER; NONHUMAN; PRENYLATION; PRESCRIPTION; PRIORITY JOURNAL; QUADRUPOLE TIME OF FLIGHT TANDEM MASS SPECTROMETRY; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PROCEDURES; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; MALE; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; XENOBIOTICS;

EID: 84898840538     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.03.024     Document Type: Article

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