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Volumn 17, Issue 1, 2016, Pages

The GLP-1 receptor agonists exendin-4 and liraglutide alleviate oxidative stress and cognitive and micturition deficits induced by middle cerebral artery occlusion in diabetic mice

Author keywords

Cerebral microcirculation; GLP 1 agonist; Middle cerebral artery occlusion; Oxidative stress; Pelvic nerve; Voiding function

Indexed keywords

CASPASE 3; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LIRAGLUTIDE; MANGANESE SUPEROXIDE DISMUTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; ANTIDIABETIC AGENT; GLP1R PROTEIN, MOUSE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; NOOTROPIC AGENT; PEPTIDE; PROTECTIVE AGENT; VENOM;

EID: 84973901403     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/s12868-016-0272-9     Document Type: Article
Times cited : (52)

References (50)
  • 1
    • 34249817115 scopus 로고    scopus 로고
    • Short-term risk for stroke is doubled in persons with newly treated type 2 diabetes compared with persons without diabetes: a population-based cohort study
    • Jeerakathil T, et al. Short-term risk for stroke is doubled in persons with newly treated type 2 diabetes compared with persons without diabetes: a population-based cohort study. Stroke. 2007;38(6):1739-43.
    • (2007) Stroke , vol.38 , Issue.6 , pp. 1739-1743
    • Jeerakathil, T.1
  • 2
    • 0037320874 scopus 로고    scopus 로고
    • Mortality from cerebrovascular disease in a cohort of 23000 patients with insulin-treated diabetes
    • Laing SP, et al. Mortality from cerebrovascular disease in a cohort of 23000 patients with insulin-treated diabetes. Stroke. 2003;34(2):418-21.
    • (2003) Stroke , vol.34 , Issue.2 , pp. 418-421
    • Laing, S.P.1
  • 3
    • 84946498967 scopus 로고    scopus 로고
    • Exendin-4-loaded PLGA microspheres relieve cerebral ischemia/reperfusion injury and neurologic deficits through long-lasting bioactivity-mediated phosphorylated Akt/eNOS signaling in rats
    • Chien CT, et al. Exendin-4-loaded PLGA microspheres relieve cerebral ischemia/reperfusion injury and neurologic deficits through long-lasting bioactivity-mediated phosphorylated Akt/eNOS signaling in rats. J Cereb Blood Flow Metab. 2015;35(11):1790-803.
    • (2015) J Cereb Blood Flow Metab , vol.35 , Issue.11 , pp. 1790-1803
    • Chien, C.T.1
  • 4
    • 0031897387 scopus 로고    scopus 로고
    • Hyperglycemia-induced circulating ICAM-1 increase in diabetes mellitus: the possible role of oxidative stress
    • Ceriello A, et al. Hyperglycemia-induced circulating ICAM-1 increase in diabetes mellitus: the possible role of oxidative stress. Horm Metab Res. 1998;30(3):146-9.
    • (1998) Horm Metab Res , vol.30 , Issue.3 , pp. 146-149
    • Ceriello, A.1
  • 5
    • 0030970856 scopus 로고    scopus 로고
    • E-selectin plasma concentration is influenced by glycaemic control in NIDDM patients: possible role of oxidative stress
    • Cominacini L, et al. E-selectin plasma concentration is influenced by glycaemic control in NIDDM patients: possible role of oxidative stress. Diabetologia. 1997;40(5):584-9.
    • (1997) Diabetologia , vol.40 , Issue.5 , pp. 584-589
    • Cominacini, L.1
  • 6
    • 0037109184 scopus 로고    scopus 로고
    • Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress
    • Esposito K, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002;106(16):2067-72.
    • (2002) Circulation , vol.106 , Issue.16 , pp. 2067-2072
    • Esposito, K.1
  • 7
    • 33947525763 scopus 로고    scopus 로고
    • Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction
    • Kamada H, et al. Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction. Stroke. 2007;38(3):1044-9.
    • (2007) Stroke , vol.38 , Issue.3 , pp. 1044-1049
    • Kamada, H.1
  • 8
    • 75549083624 scopus 로고    scopus 로고
    • Is hyperglycemia a causal factor in cardiovascular disease? Does proving this relationship really matter? Yes
    • Davidson JA, Parkin CG. Is hyperglycemia a causal factor in cardiovascular disease? Does proving this relationship really matter? Yes. Diabetes Care. 2009;32(Suppl 2):S331-3.
    • (2009) Diabetes Care , vol.32 , pp. S331-S333
    • Davidson, J.A.1    Parkin, C.G.2
  • 9
    • 10744227294 scopus 로고    scopus 로고
    • Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma
    • Khatri JJ, et al. Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma. Circulation. 2004;109(4):520-5.
    • (2004) Circulation , vol.109 , Issue.4 , pp. 520-525
    • Khatri, J.J.1
  • 10
    • 0033535974 scopus 로고    scopus 로고
    • Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis
    • von Harsdorf R, Li PF, Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation. 1999;99(22):2934-41.
    • (1999) Circulation , vol.99 , Issue.22 , pp. 2934-2941
    • Harsdorf, R.1    Li, P.F.2    Dietz, R.3
  • 11
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813-20.
    • (2001) Nature , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 12
    • 0025236630 scopus 로고
    • Analysis of voiding disorders in patients with cerebrovascular accidents
    • Khan Z, et al. Analysis of voiding disorders in patients with cerebrovascular accidents. Urology. 1990;35(3):265-70.
    • (1990) Urology , vol.35 , Issue.3 , pp. 265-270
    • Khan, Z.1
  • 13
    • 0026094264 scopus 로고
    • Cholinergic deafferentation after focal cerebral infarct in rats
    • Kataoka K, et al. Cholinergic deafferentation after focal cerebral infarct in rats. Stroke. 1991;22(10):1291-6.
    • (1991) Stroke , vol.22 , Issue.10 , pp. 1291-1296
    • Kataoka, K.1
  • 14
    • 33745853538 scopus 로고    scopus 로고
    • Mild brain ischemia produces bladder hyperactivity without brain damage in rats
    • Yotsuyanagi S, Narimoto K, Namiki M. Mild brain ischemia produces bladder hyperactivity without brain damage in rats. Urol Int. 2006;77(1):57-63.
    • (2006) Urol Int , vol.77 , Issue.1 , pp. 57-63
    • Yotsuyanagi, S.1    Narimoto, K.2    Namiki, M.3
  • 15
    • 33748793646 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitor acting on the brain improves detrusor overactivity caused by cerebral infarction in rats
    • Nakai M, et al. Acetylcholinesterase inhibitor acting on the brain improves detrusor overactivity caused by cerebral infarction in rats. Neuroscience. 2006;142(2):475-80.
    • (2006) Neuroscience , vol.142 , Issue.2 , pp. 475-480
    • Nakai, M.1
  • 16
    • 0035106978 scopus 로고    scopus 로고
    • Minireview: the glucagon-like peptides
    • Drucker DJ. Minireview: the glucagon-like peptides. Endocrinology. 2001;142(2):521-7.
    • (2001) Endocrinology , vol.142 , Issue.2 , pp. 521-527
    • Drucker, D.J.1
  • 18
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. 2000;49(5):741-8.
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 741-748
    • Stoffers, D.A.1
  • 19
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • Zhou J, et al. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes. 1999;48(12):2358-66.
    • (1999) Diabetes , vol.48 , Issue.12 , pp. 2358-2366
    • Zhou, J.1
  • 20
    • 84908501502 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist activation ameliorates venous thrombosis-induced arteriovenous fistula failure in chronic kidney disease
    • Chien CT, et al. Glucagon-like peptide-1 receptor agonist activation ameliorates venous thrombosis-induced arteriovenous fistula failure in chronic kidney disease. Thromb Haemost. 2014;112(5):1051-64.
    • (2014) Thromb Haemost , vol.112 , Issue.5 , pp. 1051-1064
    • Chien, C.T.1
  • 21
    • 70350341465 scopus 로고    scopus 로고
    • Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic benefits beyond glycaemic control?
    • Grieve DJ, Cassidy RS, Green BD. Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic benefits beyond glycaemic control? Br J Pharmacol. 2009;157(8):1340-51.
    • (2009) Br J Pharmacol , vol.157 , Issue.8 , pp. 1340-1351
    • Grieve, D.J.1    Cassidy, R.S.2    Green, B.D.3
  • 22
    • 0028867442 scopus 로고
    • Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites
    • Goke R, et al. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci. 1995;7(11):2294-300.
    • (1995) Eur J Neurosci , vol.7 , Issue.11 , pp. 2294-2300
    • Goke, R.1
  • 23
    • 69549128161 scopus 로고    scopus 로고
    • Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system
    • Hamilton A, Holscher C. Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. NeuroReport. 2009;20(13):1161-6.
    • (2009) NeuroReport , vol.20 , Issue.13 , pp. 1161-1166
    • Hamilton, A.1    Holscher, C.2
  • 24
    • 0036721026 scopus 로고    scopus 로고
    • Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4
    • Perry T, et al. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther. 2002;302(3):881-8.
    • (2002) J Pharmacol Exp Ther , vol.302 , Issue.3 , pp. 881-888
    • Perry, T.1
  • 25
    • 84871875423 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury
    • Hirata Y, et al. Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury. Eur J Pharmacol. 2013;699(1-3):106-11.
    • (2013) Eur J Pharmacol , vol.699 , Issue.1-3 , pp. 106-111
    • Hirata, Y.1
  • 26
    • 84865224952 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits cell apoptosis induced by lipotoxicity in pancreatic beta-cell line
    • Wei Q, Sun YQ, Zhang J. Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits cell apoptosis induced by lipotoxicity in pancreatic beta-cell line. Peptides. 2012;37(1):18-24.
    • (2012) Peptides , vol.37 , Issue.1 , pp. 18-24
    • Wei, Q.1    Sun, Y.Q.2    Zhang, J.3
  • 27
    • 84878240826 scopus 로고    scopus 로고
    • Exendin-4 ameliorates high glucose- and TNF-alpha-induced vascular endothelial cell damage by inhibiting p38 MAPK and NF-kappaB p65 translocation
    • Ke S, et al. Exendin-4 ameliorates high glucose- and TNF-alpha-induced vascular endothelial cell damage by inhibiting p38 MAPK and NF-kappaB p65 translocation. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32(8):1182-5.
    • (2012) Nan Fang Yi Ke Da Xue Xue Bao , vol.32 , Issue.8 , pp. 1182-1185
    • Ke, S.1
  • 28
    • 84866732695 scopus 로고    scopus 로고
    • GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases
    • Hendarto H, et al. GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases. Metabolism. 2012;61(10):1422-34.
    • (2012) Metabolism , vol.61 , Issue.10 , pp. 1422-1434
    • Hendarto, H.1
  • 29
    • 84862776751 scopus 로고    scopus 로고
    • IL-17A produced by alpha beta T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
    • Kudo M, et al. IL-17A produced by alpha beta T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med. 2012;18(4):547-54.
    • (2012) Nat Med , vol.18 , Issue.4 , pp. 547-554
    • Kudo, M.1
  • 30
    • 38849196303 scopus 로고    scopus 로고
    • Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease
    • Bertilsson G, et al. Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease. J Neurosci Res. 2008;86(2):326-38.
    • (2008) J Neurosci Res , vol.86 , Issue.2 , pp. 326-338
    • Bertilsson, G.1
  • 31
    • 45549108268 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
    • Harkavyi A, et al. Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease. J Neuroinflammation. 2008;5:19.
    • (2008) J Neuroinflammation , vol.5 , pp. 19
    • Harkavyi, A.1
  • 32
    • 0036198285 scopus 로고    scopus 로고
    • Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
    • Kastin AJ, Akerstrom V, Pan W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J Mol Neurosci. 2002;18(1-2):7-14.
    • (2002) J Mol Neurosci , vol.18 , Issue.1-2 , pp. 7-14
    • Kastin, A.J.1    Akerstrom, V.2    Pan, W.3
  • 33
    • 0141620177 scopus 로고    scopus 로고
    • Peptide transport across the blood-brain barrier
    • 14674609
    • Kastin AJ, Pan W. Peptide transport across the blood-brain barrier. Prog Drug Res. 2003;61(14674609):79-7100.
    • (2003) Prog Drug Res , vol.61 , pp. 79-7100
    • Kastin, A.J.1    Pan, W.2
  • 34
    • 79960996273 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia
    • Teramoto S, et al. Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia. J Cereb Blood Flow Metab. 2011;31(8):1696-705.
    • (2011) J Cereb Blood Flow Metab , vol.31 , Issue.8 , pp. 1696-1705
    • Teramoto, S.1
  • 35
    • 84908377065 scopus 로고    scopus 로고
    • Neuroprotective and anti-apoptotic effects of liraglutide in the rat brain following focal cerebral ischemia
    • Briyal S, Shah S, Gulati A. Neuroprotective and anti-apoptotic effects of liraglutide in the rat brain following focal cerebral ischemia. Neuroscience. 2014;281c:269-81.
    • (2014) Neuroscience , vol.281C , pp. 269-281
    • Briyal, S.1    Shah, S.2    Gulati, A.3
  • 36
    • 84858722980 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats
    • Darsalia V, et al. Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats. Clin Sci (Lond). 2012;122(10):473-83.
    • (2012) Clin Sci (Lond) , vol.122 , Issue.10 , pp. 473-483
    • Darsalia, V.1
  • 37
    • 0032924640 scopus 로고    scopus 로고
    • Oxidative stress in brain ischemia
    • Love S. Oxidative stress in brain ischemia. Brain Pathol. 1999;9(1):119-31.
    • (1999) Brain Pathol , vol.9 , Issue.1 , pp. 119-131
    • Love, S.1
  • 38
    • 23644454848 scopus 로고    scopus 로고
    • The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation
    • Hui L, et al. The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation. Brain Res. 2005;1052(1):1-9.
    • (2005) Brain Res , vol.1052 , Issue.1 , pp. 1-9
    • Hui, L.1
  • 39
    • 33745252164 scopus 로고    scopus 로고
    • Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide
    • Rizk NN, Rafols JA, Dunbar JC. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain Res. 2006;1096(1):204-12.
    • (2006) Brain Res , vol.1096 , Issue.1 , pp. 204-212
    • Rizk, N.N.1    Rafols, J.A.2    Dunbar, J.C.3
  • 40
    • 0023571428 scopus 로고
    • Genetic susceptibility to diabetes in inbred strains of mice: measurements of proinsulin mRNA and response to dexamethasone
    • Orland MJ, Permutt MA. Genetic susceptibility to diabetes in inbred strains of mice: measurements of proinsulin mRNA and response to dexamethasone. Diabetologia. 1987;30(12):934-9.
    • (1987) Diabetologia , vol.30 , Issue.12 , pp. 934-939
    • Orland, M.J.1    Permutt, M.A.2
  • 41
    • 84866546292 scopus 로고    scopus 로고
    • Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways
    • Han L, et al. Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways. Diabetes Res Clin Pract. 2012;97(3):453-60.
    • (2012) Diabetes Res Clin Pract , vol.97 , Issue.3 , pp. 453-460
    • Han, L.1
  • 42
    • 12844255861 scopus 로고    scopus 로고
    • CREB-mediated Bcl-2 protein expression after ischemic preconditioning
    • Meller R, et al. CREB-mediated Bcl-2 protein expression after ischemic preconditioning. J Cereb Blood Flow Metab. 2005;25(2):234-46.
    • (2005) J Cereb Blood Flow Metab , vol.25 , Issue.2 , pp. 234-246
    • Meller, R.1
  • 43
    • 0027485461 scopus 로고
    • Bcl-2 functions in an antioxidant pathway to prevent apoptosis
    • Hockenbery DM, et al. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 1993;75(2):241-51.
    • (1993) Cell , vol.75 , Issue.2 , pp. 241-251
    • Hockenbery, D.M.1
  • 44
    • 34249726705 scopus 로고    scopus 로고
    • Protective role of PI3-kinase-Akt-eNOS signalling pathway in intestinal injury associated with splanchnic artery occlusion shock
    • Roviezzo F, et al. Protective role of PI3-kinase-Akt-eNOS signalling pathway in intestinal injury associated with splanchnic artery occlusion shock. Br J Pharmacol. 2007;151(3):377-83.
    • (2007) Br J Pharmacol , vol.151 , Issue.3 , pp. 377-383
    • Roviezzo, F.1
  • 45
    • 2142654943 scopus 로고    scopus 로고
    • Permanent occlusion of the middle cerebral artery upregulates expression of cytokines and neuronal nitric oxide synthase in the spinal cord and urinary bladder in the adult rat
    • Fu D, et al. Permanent occlusion of the middle cerebral artery upregulates expression of cytokines and neuronal nitric oxide synthase in the spinal cord and urinary bladder in the adult rat. Neuroscience. 2004;125(4):819-31.
    • (2004) Neuroscience , vol.125 , Issue.4 , pp. 819-831
    • Fu, D.1
  • 46
    • 33644528136 scopus 로고    scopus 로고
    • Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide
    • Zeynalov E, et al. Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide. J Cereb Blood Flow Metab. 2006;26(3):414-20.
    • (2006) J Cereb Blood Flow Metab , vol.26 , Issue.3 , pp. 414-420
    • Zeynalov, E.1
  • 47
    • 84863993429 scopus 로고    scopus 로고
    • Network analysis of rat spatial cognition: behaviorally-established symmetry in a physically asymmetrical environment
    • e40760
    • Weiss S, et al. Network analysis of rat spatial cognition: behaviorally-established symmetry in a physically asymmetrical environment. PLoS One. 2012;7(7):e40760.
    • (2012) PLoS One , vol.7 , Issue.7
    • Weiss, S.1
  • 48
    • 0034661432 scopus 로고    scopus 로고
    • Reduction in renal haemodynamics by exaggerated vesicovascular reflex in rats with acute urinary retention
    • Chien CT, et al. Reduction in renal haemodynamics by exaggerated vesicovascular reflex in rats with acute urinary retention. J Physiol. 2000;526(Pt 2):397-408.
    • (2000) J Physiol , vol.526 , pp. 397-408
    • Chien, C.T.1
  • 49
    • 84863630050 scopus 로고    scopus 로고
    • Inhibitory effect of botulinum toxin type A on the NANC system in rat respiratory models of neurogenic inflammation
    • Chien CT, et al. Inhibitory effect of botulinum toxin type A on the NANC system in rat respiratory models of neurogenic inflammation. Arch Biochem Biophys. 2012;524(2):106-13.
    • (2012) Arch Biochem Biophys , vol.524 , Issue.2 , pp. 106-113
    • Chien, C.T.1
  • 50
    • 84858184990 scopus 로고    scopus 로고
    • Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol 3-kinase/Akt-dependent heat-shock protein/endothelial nitric oxide synthase signaling
    • Li PC, et al. Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol 3-kinase/Akt-dependent heat-shock protein/endothelial nitric oxide synthase signaling. J Vasc Surg. 2012;56(1):159-70.
    • (2012) J Vasc Surg , vol.56 , Issue.1 , pp. 159-170
    • Li, P.C.1


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