Exendin-4-loaded PLGA microspheres relieve cerebral ischemia/reperfusion injury and neurologic deficits through long-lasting bioactivity-mediated phosphorylated Akt/eNOS signaling in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 11, 2015, Pages 1790-1803

  Chien, Chiang Ting ^a   Jou, Ming Jia ^b   Cheng, Tai Yu ^a,c   Yang, Chih Hui ^b   Yu, Tzu Ying ^b   Li, Ping Chia ^b  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^b I SHOU UNIVERSITY   (Taiwan)

^c Ta Tung University   (Taiwan)

Author keywords

diabetes; exendin 4 PLGA microsphere; ischemia reperfusion; neuroinflammation

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; EXENDIN 4; EXENDIN 4 LOADED POLY(DEXTRO LEVO LACTIDE CO GLYCOLIDE); GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MICROSPHERE; NEUROPROTECTIVE AGENT; POLYGLACTIN; PROTEIN KINASE B; UNCLASSIFIED DRUG; DRUG CARRIER; LACTIC ACID; ONCOPROTEIN; PEPTIDE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLEEDING; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN MICROCIRCULATION; CAROTID ARTERY OBSTRUCTION; CHEMOLUMINESCENCE; COGNITION; CONTROLLED STUDY; DRUG CEREBROSPINAL FLUID LEVEL; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; INDUCED HYPOTENSION; MALE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BRAIN CIRCULATION; CAROTID ARTERY; CAROTID STENOSIS; COGNITION DISORDERS; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; MICROCIRCULATION; PATHOPHYSIOLOGY; PSYCHOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION; WISTAR RAT;

ANIMALS; BRAIN ISCHEMIA; CAROTID ARTERIES; CAROTID STENOSIS; CEREBROVASCULAR CIRCULATION; COGNITION DISORDERS; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; INJECTIONS, SUBCUTANEOUS; LACTIC ACID; MAGNETIC RESONANCE IMAGING; MALE; MICROCIRCULATION; MICROSPHERES; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE III; ONCOGENE PROTEIN V-AKT; PEPTIDES; POLYGLYCOLIC ACID; RATS; RATS, WISTAR; REPERFUSION INJURY; SIGNAL TRANSDUCTION; VENOMS;

EID: 84946498967     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.126     Document Type: Article

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