Negatively-charged amino acids at the peptide-binding pocket of HLA-DPB1 alleles are associated with susceptibility to anti-topoisomerase I-positive systemic sclerosis

Human Immunology

Volumn 77, Issue 7, 2016, Pages 550-554

  Lee, Jeong Seok ^a   Park, Jin Kyun ^a   Kim, Heung Jae ^b   Lee, Hyung Ki ^b   Song, Yeong Wook ^a   Lee, Eun Bong ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Dong A Pharmaceutical Company   (South Korea)

Author keywords

Epitope; HLA; Systemic sclerosis; Topoisomerase I

Indexed keywords

AMINO ACID; ASPARTIC ACID; DNA TOPOISOMERASE; GLUTAMIC ACID; HLA DP ANTIGEN; HLA DPB1 ANTIGEN; PEPTIDE FRAGMENT; AUTOANTIBODY; EPITOPE; HLA-DPB1 ANTIGEN; PROTEIN BINDING;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; GENETIC ANALYSIS; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MOLECULAR DYNAMICS; NEGATIVELY CHARGED TRIPLET; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN STRUCTURE; RISK ASSESSMENT; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; SYSTEMIC SCLEROSIS; BLOOD; COMPUTER SIMULATION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; KOREA; METABOLISM; RISK; STRUCTURE ACTIVITY RELATION;

AMINO ACID MOTIFS; AMINO ACIDS; AUTOANTIBODIES; COMPUTER SIMULATION; DNA TOPOISOMERASES, TYPE I; EPITOPES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HLA-DP BETA-CHAINS; HUMANS; KOREA; PEPTIDE FRAGMENTS; POLYMORPHISM, GENETIC; PROTEIN BINDING; RISK; SCLERODERMA, SYSTEMIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84973878944     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2016.05.012     Document Type: Article

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