Autoreactive T cells to topoisomerase I in monozygotic twins discordant for systemic sclerosis

Arthritis and Rheumatism

Volumn 44, Issue 7, 2001, Pages 1654-1659

  Kuwana, Masataka ^a,b   Feghali, Carol A ^a   Medsger, Thomas A ^a   Wright, Timothy M ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; HLA DR ANTIGEN; T LYMPHOCYTE RECEPTOR;

AGED; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CASE REPORT; FEMALE; HUMAN; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MONOZYGOTIC TWINS; PRIORITY JOURNAL; SYSTEMIC SCLEROSIS; T LYMPHOCYTE; TWIN DISCORDANCE;

AGED; AUTOANTIBODIES; B-LYMPHOCYTES; CELL DIVISION; DNA FINGERPRINTING; DNA TOPOISOMERASES, TYPE I; FEMALE; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; IMMUNOLOGIC MEMORY; KINETICS; PHENOTYPE; SCLERODERMA, SYSTEMIC; T-LYMPHOCYTES; TWINS, MONOZYGOTIC;

EID: 0034945770     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200107)44:7<1654::AID-ART288>3.0.CO;2-O     Document Type: Article

References (15)

1. Systemic sclerosis (scleroderma): Clinical aspects
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3. Clinical and prognostic associations based on serum antinuclear antibodies in Japanese patients with systemic sclerosis
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5. T and B cell collaboration is essential for the autoantibody response to DNA topoisomerase I in systemic sclerosis
6. Highly restricted TCR-alpha beta usage by autoreactive human T cell clones specific for DNA topoisomerase I: Recognition of an immunodominant epitope
7. Analysis of soluble and cell surface factors regulating anti-DNA topoisomerase I autoantibody production demonstrates synergy between Th1 and Th2 autoreactive T cells
8. Epidemiologic and clinical study of twins with scleroderma
9. Routine applications of DNA fingerprinting with the oligonucleotide probe (CAC)5/(GTG)5
10. PCR-RFLP
11. Detection of anti-DNA topoisomerase I antibody by an enzyme-linked immunosorbent assay using overlapping recombinant polypeptides
12. Longitudinal analysis of autoantibody response to topoisomerase I in systemic sclerosis
13. Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura: Role in production of anti-platelet autoantibody
14. How can cryptic epitopes trigger autoimmunity?
15. The T cell repertoire against cryptic self determinants and its involvement in autoimmunity and cancer