STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells

European Journal of Immunology

Volumn 46, Issue 6, 2016, Pages 1504-1510

  Gonzales van Horn, Sarah R ^a   Estrada, Leonardo D ^a   van Oers, Nicolai S C ^a   Farrar, J David ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

CD4 T cells; Cytokines; Gene regulation; IFNs; Transcription factors

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; INTERFERON STIMULATED GENE FACTOR 3; INTERLEUKIN 13; INTERLEUKIN 5; MESSENGER RNA; STAT4 PROTEIN; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; DIMERIZATION; GENE; GENE EXPRESSION; GENE REPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IL13 GENE; IL5 GENE; IMMUNE RESPONSE; INFLAMMATION; INTRACELLULAR SIGNALING; MEMORY CELL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR UPREGULATION; TH2 CELL;

EID: 84973626854     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201546050     Document Type: Article

References (29)

1. Davis, A. M., Ramos, H. J., Davis, L. S. and Farrar, J. D., Cutting edge: a T-bet-independent role for IFN-alpha/beta in regulating IL-2 secretion in human CD4+ central memory T cells. J. Immunol. 2008. 181: 8204–8208.
2. Ramos, H. J., Davis, A. M., Cole, A. G., Schatzle, J. D., Forman, J. and Farrar, J. D., Reciprocal responsiveness to interleukin-12 and interferon-alpha specifies human CD8+ effector versus central memory T-cell fates. Blood 2009. 113: 5516–5525.
3. Chowdhury, F. Z., Ramos, H. J., Davis, L. S., Forman, J. and Farrar, J. D., IL-12 selectively programs effector pathways that are stably expressed in human CD8+ effector memory T cells in vivo. Blood 2011. 118: 3890–3900.
4. Huber, J. P. and Farrar, J. D., Regulation of effector and memory T-cell functions by type I interferon. Immunology 2011. 132: 466–474.
5. Chowdhury, F. Z., Estrada, L. D., Murray, S., Forman, J. and Farrar, J. D., Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions. PLoS One 2014. 9: e92187.
6. Huber, J. P., Gonzales-van Horn, S. R., Roybal, K. T., Gill, M. A. and Farrar, J. D., IFN-alpha suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells. J. Immunol. 2014. 192: 5687–5694.
7. Huber, J. P., Ramos, H. J., Gill, M. A. and Farrar, J. D., Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J. Immunol. 2010. 185: 813–817.
8. Kaser, A., Molnar, C. and Tilg, H., Differential regulation of interleukin 4 and interleukin 13 production by interferon alpha. Cytokine 1998. 10: 75–81.
9. Shibuya, H. and Hirohata, S., Differential effects of IFN-alpha on the expression of various TH2 cytokines in human CD4+ T cells. J. Allergy Clin. Immunol. 2005. 116: 205–212.
10. Pritchard, A. L., White, O. J., Burel, J. G. and Upham, J. W., Innate interferons inhibit allergen and microbial specific T(H)2 responses. Immunol. Cell Biol. 2012. 90: 974–977.
11. Cosmi, L., Annunziato, F., Galli, M. I. G., Maggi, R. M. E., Nagata, K. and Romagnani, S., CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur. J. Immunol. 2000. 30: 2972–2979.
12. Pritchard, A. L., Carroll, M. L., Burel, J. G., White, O. J., Phipps, S. and Upham, J. W., Innate IFNs and plasmacytoid dendritic cells constrain Th2 cytokine responses to rhinovirus: a regulatory mechanism with relevance to asthma. J. Immunol. 2012. 188: 5898–5905.
13. Mathelier, A., Zhao, X., Zhang, A. W., Parcy, F., Worsley-Hunt, R., Arenillas, D. J., Buchman, S. et al., JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles. Nucleic Acids Res. 2014. 42: D142–D147.
14. Kaminuma, O., Mori, A., Kitamura, N., Hashimoto, T., Kitamura, F., Inokuma, S. and Miyatake, S., Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients. Int. Arch. Allergy Immunol. 2005. 137 Suppl 1: 55–59.
15. Farrar, J. D., Smith, J. D., Murphy, T. L., Leung, S., Stark, G. R. and Murphy, K. M., Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2. Nat. Immunol. 2000. 1: 65–69.
16. Wei, L., Vahedi, G., Sun, H. W., Watford, W. T., Takatori, H., Ramos, H. L., Takahashi, H. et al., Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity 2010. 32: 840–851.
17. Rogge, L. and Sinigaglia, F., Early events controlling T-helper cell differentiation: the role of the IL-12 receptor. Chem. Immunol. 1997. 68: 38–53.
18. Wei, G., Abraham, B. J., Yagi, R., Jothi, R., Cui, K., Sharma, S., Narlikar, L. et al., Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 2011. 35: 299–311.
19. Kelso, A., Groves, P., Ramm, L. and Doyle, A. G., Single-cell analysis by RT-PCR reveals differential expression of multiple type 1 and 2 cytokine genes among cells within polarized CD4+ T cell populations. Int. Immunol. 1999. 11: 617–621.
20. Tanaka, S., Motomura, Y., Suzuki, Y., Yagi, R., Inoue, H., Miyatake, S. and Kubo, M., The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells. Nat. Immunol. 2011. 12: 77–85.
21. Rowe, R. K. and Gill, M. A., Asthma: the interplay between viral infections and allergic diseases. Immunol. Allergy Clin. North Am. 2015. 35: 115–127.
22. Gonzales-van Horn, S. R. and Farrar, J. D., Interferon at the crossroads of allergy and viral infections. J. Leukoc. Biol. 2015. 98: 185–194.
23. Park, B. L., Cheong, H. S., Kim, L. H., Choi, Y. H., Namgoong, S., Park, H. S., Hong, S. J. et al., Association analysis of signal transducer and activator of transcription 4 (STAT4) polymorphisms with asthma. J. Hum. Genet. 2005. 50: 133–138.
24. Hoey, T., Zhang, S., Schmidt, N., Yu, Q., Ramchandani, S., Xu, X., Naeger, L. K. et al., Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. Embo J. 2003. 22: 4237–4248.
25. Jabeen, R., Miller, L., Yao, W., Gupta, S., Steiner, S. and Kaplan, M. H., Altered STAT4 isoform expression in patients with inflammatory bowel disease. Inflamm. Bowel Dis. 2015. 21: 2383–2392.
26. Lewis, C. C., Aronow, B., Hutton, J., Santeliz, J., Dienger, K., Herman, N., Finkelman, F. D. et al., Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung. J. Allergy Clinical Immunol. 2009. 123: 795–804 e798.
27. Finkelman, F. D., Hogan, S. P., Hershey, G. K., Rothenberg, M. E. and Wills-Karp, M., Importance of cytokines in murine allergic airway disease and human asthma. J. Immunol. 2010. 184: 1663–1674.
28. Livak, K. J. and Schmittgen, T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001. 25: 402–408.
29. Fan, J., Zeller, K., Chen, Y. C., Watkins, T., Barnes, K. C., Becker, K. G., Dang, C. V. et al., Time-dependent c-Myc transactomes mapped by array-based nuclear run-on reveal transcriptional modules in human B cells. PLoS One 2010. 5: e9691.