Role of GATA-3 in IL-5 gene transcription by CD4+ T cells of asthmatic patients

International Archives of Allergy and Immunology

Volumn 137, Issue SUPPL., 2005, Pages 55-59

  Kaminuma, Osamu ^a   Mori, Akio ^c   Kitamura, Noriko ^a   Hashimoto, Tomomi ^c   Kitamura, Fujiko ^a   Inokuma, Shigeko ^b   Miyatake, Shoichiro ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

^c SAGAMIHARA NATIONAL HOSPITAL   (Japan)

Author keywords

Asthma; CD4+ T cell; GATA 3; IL 5

Indexed keywords

CORTICOSTEROID; INTERLEUKIN 5; MESSENGER RNA; TRANSCRIPTION FACTOR GATA 3; DNA BINDING PROTEIN; GATA3 PROTEIN, HUMAN; GREEN FLUORESCENT PROTEIN; TRANSACTIVATOR PROTEIN;

ADULT; ASTHMA; BINDING SITE; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; GENE ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENE SYNTHESIS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; UPREGULATION; ARTICLE; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ASTHMA; BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; DNA-BINDING PROTEINS; GATA3 TRANSCRIPTION FACTOR; GREEN FLUORESCENT PROTEINS; HUMANS; INTERLEUKIN-5; MIDDLE AGED; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION;

EID: 20844434154     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000085433     Document Type: Conference Paper

References (30)

1. Sanderson CJ: Interleukin-5, eosinophils, and disease. Blood 1992;79:3101-3109.
2. Corrigan CJ, Kay AB: T cells and eosinophils in the pathogenesis of asthma. Immunol Today 1992;13:501-507.
3. Yamaguchi Y, Duda T, Suda J, Eguchi M, Miura Y, Harada N, Tominaga A, Takatsu K: Purified interleukin-5 supports the terminal differentiation and proliferation of murine eosinophil precursors. J Exp Med 1988;167:43-56.
4. Sehmi R, Wardlaw AJ, Cromwell O, Kurihara K, Waltmann P, Kay AB: Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects. Blood 1992;79:2952-2959.
5. Rothenberg ME, Peterson J, Stevens RL: IL-5 dependent conversion of normodense human eosinophils to the hypodense phenotype using 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody dependent cytotoxicity. J Immunol 1989;143:2311-2316.
6. Hamid Q, Azzawi M, Ying S, Moqbel R, Wardlaw AJ, Corrigan CJ, Bradley B, Durham SR, Collins JV, Jeffery PK, Quint J, Kay AB: Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991;87:1541-1546.
7. Walker C, Bode E, Boer L, Hansel TT, Blaser K, Virchow JC Jr: Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1992;146:109-115.
8. Corrigan CJ, Haczku A, Gemou Engesaeth V, Doi S, Kikuchi Y, Takatsu K, Durham SR, Kay AB: CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin- 5. Effect of glucocorticoid therapy. Am Rev Respir Dis 1993;147:540-547.
9. Mosmann TR, Coffman RL: TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
10. Bohjanen PR, Okajima M, Hodes RJ: Differential regulation of interleukin 4 and interleukin 5 gene expression: A comparison of T-cell gene induction by anti-CD3 antibody or by exogenous lymphokines. Proc Natl Acad Sci USA 1990;87:5283-5287.
11. Mori A, Suko M, Nishizaki Y, Kaminuma O, Kobayashi S, Matsuzaki G, Yamamoto K, Ito K, Tsuruoka N, Okudaira H: IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A. Int Immunol 1995;7:449-457.
12. Mori A, Kaminuma O, Mikami T, Inoue S, Okumura Y, Akiyama K, Okudaira H: Transcriptional control of the IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis. J Allergy Clin Immunol 1999;103:S429-436.
13. Gruart-Gouilleux V, Engels P, Sullivan M: Characterization of the human interleukin-5 gene promoter: Involvement of octamer binding sites in the gene promoter activity. Eur J Immunol 1995;25:1431-1435.
14. Prieschl EE, Gouilleux-Gruart V, Walker C, Harrer NE, Baumruker T: A nuclear factor of activated T cell-like transcription factor in mast cells is involved in IL-5 gene regulation after IgE plus antigen stimulation. J Immunol 1995;154:6112-6119.
15. Yamagata T, Nishida J, Sakai R, Tanaka T, Honda H, Hirano N, Mano H, Yazaki Y, Hirai H: Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins. Mol Cell Biol 1995;15:3830-3839.
16. Yamagata T, Mitani K, Ueno H, Kanda Y, Yazaki Y, Hirai H: Triple synergism of human T-lymphotropic virus type 1-encoded Tax, GATA-binding protein, and AP-1 is required for constitutive expression of the interleukin-5 gene in adult T-cell leukemia cells. Mol Cell Biol 1997;17:4272-4281.
17. Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J: Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Taxi. J Biol Chem 1999;274:12910-12916.
18. Mordvinov VA, Schwenger GT, Fournier R, De Boer ML, Peroni SE, Singh AD, Karlen S, Holland JW, Sanderson CJ: Binding of YY1 and Oct1 to a novel element that downregulates expression of IL-5 in human T cells. J Allergy Clin Immunol 1999;103:1125-1135.
19. Zhang DH, Yang L, Ray A: Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J Immunol 1998;161:3817-3821.
20. Zhang DH, Cohn L, Ray P, Bottomly K, Ray A: Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of interleukin-5 gene. J Biol Chem 1997;272:21597-21603.
21. Lee HJ, O'Garra A, Arai K, Arai N: Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: A role for a GATA-binding protein. J Immunol 1998;160:2343-2352.
22. Zheng DH, Flavell RA: The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997;89:587-596.
23. Nakamura Y, Ghaffar O, Olivenstein R, Taha RA, Soussi-Gounni A, Zhang DH, Ray A, Hamid Q: Gene expression of the GATA-3 transcription factor is increased in atopic asthma. J Allergy Clin Immunol 1999;103:215-222.
24. Nakamura Y, Christodoulopoulos P, Cameron L, Wright E, Lavigne F, Toda M, Muro S, Ray A, Eidelman DH, Minshall E, Hamid Q: Upregulation of the transcription factor GATA-3 in upper airway mucosa after in vivo and in vitro allergen challenge. J Allergy Clin Immunol 2000;105:1146-1152.
25. Schwenger GT, Fournier R, Kok CC, Mordvinov VA, Yeoman D, Sanderson CJ: GATA-3 has dual regulatory functions in human interleukin-5 transcription. J Biol Chem 2001;276: 48502-48509.
26. Mori A, Kaminuma O, Suko M, Mikami T, Nishizaki Y, Ohmura T, Hoshino A, Asakura Y, Miyazawa K, Ando T, Okumura Y, Yamamoto K, Okudaira H: Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases: A study with allergen-specific human helper T cells. J Allergy Clin Immunol 1997;100:s56-s64.
27. Kaminuma O, Kitamura F, Kitamura N, Miyagishi M, Taira K, Yamamoto K, Miura O, Miyatake S: GATA-3 suppresses IFN-γ promoter activity independently of binding to cis-regulatory elements. FEBS Let 2004;570:63-68.
28. Ogawa K, Kaminuma O, Okudaira H, Kikkawa H, Ikezawa K, Sakurai A, Mori A: Transcriptional regulation of the IL-5 gene in peripheral T cells of asthmatic patients. Clin Exp Immunol 2002;130:475-483.
29. Kurata H, Lee HJ, McClanahan T, Coffman RL, O'Garra A, Arai N: Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development. J Immunol 2002;168:4538-4545.
30. Bevan MJ, Goldrath AW: T-cell memory: You must remember this... Curr Biol 2000;10:R338-340.