Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

Oncotarget

Volumn 7, Issue 23, 2016, Pages 34084-34099

  Fiorillo, Marco ^a,b,c   Lamb, Rebecca ^a   Tanowitz, Herbert B ^d   Mutti, Luciano ^e   Krstic Demonacos, Marija ^e   Cappello, Anna Rita ^c   Martinez Outschoorn, Ubaldo E ^f   Sotgia, Federica ^a,b   Lisanti, Michael P ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF CALABRIA   (Italy)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF SALFORD   (United Kingdom)

^f THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Atovaquone; Cancer stem like cells (CSCs); Mitochondria; OXPHOS; Tumor initiating cells (TICs)

Indexed keywords

ATOVAQUONE; CD24 ANTIGEN; HERMES ANTIGEN; HYPOXIA INDUCIBLE FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UBIDECARENONE; UBIQUINOL CYTOCHROME C REDUCTASE; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT;

AEROBIC GLYCOLYSIS; AEROBIC METABOLISM; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CANCER STEM CELL ERADICATION; CANCER SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; MCF 7 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROGRESSION FREE SURVIVAL; SURVIVAL PREDICTION; ANTAGONISTS AND INHIBITORS; CANCER STEM CELL; DRUG EFFECTS; DRUG REPOSITIONING; MCF-7 CELL LINE;

ANTIMALARIALS; ANTINEOPLASTIC AGENTS; ATOVAQUONE; DRUG REPOSITIONING; ELECTRON TRANSPORT COMPLEX III; HUMANS; MCF-7 CELLS; NEOPLASTIC STEM CELLS; OXIDATIVE PHOSPHORYLATION;

EID: 84973598886     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9122     Document Type: Article

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