Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

Oncotarget

Volumn 6, Issue 7, 2015, Pages 4569-4584

  Lamb, Rebecca ^a,b   Ozsvari, Bela ^a,b   Lisanti, Camilla L ^c   Tanowitz, Herbert B ^d   Howell, Anthony ^a,b   Martinez Outschoorn, Ubaldo E ^e   Sotgia, Federica ^a,b   Lisanti, Michael P ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c The Moor Allerton Preparatory School   (United Kingdom)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Antibiotics; Cancer stem cells; Mitochondria; Mitochondrial biogenesis; Tumor initiating cells

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; AZITHROMYCIN; CHLORAMPHENICOL; DOXYCYCLINE; ERYTHROMYCIN; GLYCYLCYCLINE DERIVATIVE; PYRVINIUM EMBONATE; TETRACYCLINE; TIGECYCLINE; VEMURAFENIB; ANTIINFECTIVE AGENT;

ARTICLE; BIOGENESIS; BREAST CANCER; CANCER PATIENT; CANCER STEM CELL; CELL SURVIVAL; CONTROLLED STUDY; DISTANT METASTASIS; DRUG MECHANISM; DRUG TARGETING; ERADICATION THERAPY; GLIOBLASTOMA; HUMAN; HUMAN CELL; INFECTION; INTRADUCTAL CARCINOMA; LUNG CANCER; MELANOMA; METASTASIS; MITOCHONDRION; MORPHOLOGICAL TRAIT; OVARY CANCER; PANCREAS CANCER; PROSTATE CANCER; TUMOR CLASSIFICATION; TUMOR RECURRENCE; APOPTOSIS; CELL PROLIFERATION; DRUG EFFECTS; DRUG RESISTANCE; NEOPLASMS; PATHOLOGY; TUMOR CELL CULTURE;

ANTI-BACTERIAL AGENTS; APOPTOSIS; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; HUMANS; MITOCHONDRIA; NEOPLASMS; NEOPLASTIC STEM CELLS; TUMOR CELLS, CULTURED;

EID: 84924267475     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3174     Document Type: Article

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