Intranasal vaccination with γ -irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses

Clinical Science

Volumn 130, Issue 9, 2016, Pages 697-710

  Babb, Rachelle ^a   Chen, Austen ^a   Hirst, Timothy R ^a,b   Kara, Ervin E ^a   McColl, Shaun R ^a   Ogunniyi, Abiodun D ^a   Paton, James C ^a   Alsharifi, Mohammed ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b Gamma Vaccines Pty Ltd   (Australia)

Author keywords

Protective immunity; Serotype independent; Streptococcus pneumoniae; Vaccine

Indexed keywords

AUTOLYSIN; GAMMA INTERFERON; INTERLEUKIN 17; PNEUMOCOCCUS VACCINE; PNEUMOLYSIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; BACTERIAL COLONIZATION; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOKINE RESPONSE; FLOW CYTOMETRY; GENE DELETION; GENETIC MANIPULATION; HEMOLYSIS ASSAY; HOST RESISTANCE; IMMUNOGENICITY; IN VIVO STUDY; INNATE IMMUNITY; LUNG; LUNG ALVEOLUS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SEROTYPE; SPLEEN CELL; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; TH17 CELL; VACCINATION; ANIMAL; C57BL MOUSE; CD4+ T LYMPHOCYTE; CLASSIFICATION; COMPLICATION; GAMMA RADIATION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; METABOLISM; MICROBIOLOGY; PNEUMOCOCCAL INFECTIONS; RADIATION RESPONSE; SEROTYPING; T LYMPHOCYTE; TREATMENT OUTCOME;

ADMINISTRATION, INTRANASAL; ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; GAMMA RAYS; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; INTERLEUKIN-17; MICE, INBRED C57BL; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; SEPSIS; SEROTYPING; STREPTOCOCCUS PNEUMONIAE; T-LYMPHOCYTES; TREATMENT OUTCOME; VACCINATION;

EID: 84973569726     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20150699     Document Type: Article

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