메뉴 건너뛰기




Volumn 14, Issue 1, 2016, Pages 499-508

Enhanced anti-inflammatory effects of DHA and quercetin in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-κB and MAPK activation

Author keywords

Docosahexaenoic acid; Inflammatory cytokines; Mitogen activated protein kinase; Nitric oxide; Nuclear factor B; Quercetin

Indexed keywords

CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN P50; QUERCETIN; STRESS ACTIVATED PROTEIN KINASE 1; SYNAPTOTAGMIN I; ANTIINFLAMMATORY AGENT; AUTACOID; BIOLOGICAL MARKER; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE;

EID: 84973440970     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5259     Document Type: Article
Times cited : (50)

References (40)
  • 2
    • 84876711374 scopus 로고    scopus 로고
    • Suppressive effect of carotenoid extract of Dunaliella salina alga on production of LPS-stimulated pro-inflammatory mediators in RAW264.7 cells via NF-kB and JNK inactivation
    • Yang D, Lin J, Chen Y, Liu S, Lu F, Chang T, Wang M, Lin H and Chang Y: Suppressive effect of carotenoid extract of Dunaliella salina alga on production of LPS-stimulated pro-inflammatory mediators in RAW264.7 cells via NF-kB and JNK inactivation. J Funct Foods 5: 607-615, 2013.
    • (2013) J Funct Foods , vol.5 , pp. 607-615
    • Yang, D.1    Lin, J.2    Chen, Y.3    Liu, S.4    Lu, F.5    Chang, T.6    Wang, M.7    Lin, H.8    Chang, Y.9
  • 3
    • 78651067589 scopus 로고    scopus 로고
    • Anti-inflammatory activity of natural dietary flavonoids
    • Pan MH, Lai CS and Ho CT: Anti-inflammatory activity of natural dietary flavonoids. Food Funct 1: 15-31, 2010.
    • (2010) Food Funct , vol.1 , pp. 15-31
    • Pan, M.H.1    Lai, C.S.2    Ho, C.T.3
  • 4
    • 84880911365 scopus 로고    scopus 로고
    • Anti-inflammatory effects of phenolic compounds isolated from the flowers of Nymphaea mexicana Zucc
    • Hsu CL, Fang SC and Yen GC: Anti-inflammatory effects of phenolic compounds isolated from the flowers of Nymphaea mexicana Zucc. Food Funct 4: 1216-1222, 2013.
    • (2013) Food Funct , vol.4 , pp. 1216-1222
    • Hsu, C.L.1    Fang, S.C.2    Yen, G.C.3
  • 6
    • 79957655529 scopus 로고    scopus 로고
    • Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-?B signaling pathways
    • Lai C, Lai Y, Kuo D, Wu C, Ho C and Pan M: Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-?B signaling pathways. J Funct 3: 198-206, 2011.
    • (2011) J Funct , vol.3 , pp. 198-206
    • Lai, C.1    Lai, Y.2    Kuo, D.3    Wu, C.4    Ho, C.5    Pan, M.6
  • 7
    • 45549098626 scopus 로고    scopus 로고
    • Tomatidine inhibits iNOS and COX-2 through suppression of NF-?B and JNK pathways in LPS-stimulated mouse macrophages
    • Chiu FL and Lin JK: Tomatidine inhibits iNOS and COX-2 through suppression of NF-?B and JNK pathways in LPS-stimulated mouse macrophages. FEBS Lett 582: 2407-2412, 2008.
    • (2008) FEBS Lett , vol.582 , pp. 2407-2412
    • Chiu, F.L.1    Lin, J.K.2
  • 8
    • 84870773196 scopus 로고    scopus 로고
    • Low molecular weight fucoidan from the sporophyll of Undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases and oxidative stress in RAW264.7 cells
    • Kim KJ, Yoon KY and Lee BY: Low molecular weight fucoidan from the sporophyll of Undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases and oxidative stress in RAW264.7 cells. Fitoterapia 83: 1628-1635, 2012.
    • (2012) Fitoterapia , vol.83 , pp. 1628-1635
    • Kim, K.J.1    Yoon, K.Y.2    Lee, B.Y.3
  • 9
    • 84878704614 scopus 로고    scopus 로고
    • Flavonoids as dietary regulators of nuclear receptor activity
    • Avior Y, Bomze D, Ramon O and Nahmias Y: Flavonoids as dietary regulators of nuclear receptor activity. Food Funct 4: 831-844, 2013.
    • (2013) Food Funct , vol.4 , pp. 831-844
    • Avior, Y.1    Bomze, D.2    Ramon, O.3    Nahmias, Y.4
  • 10
    • 48949115243 scopus 로고    scopus 로고
    • The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
    • Ahn J, Lee H, Kim S, Park J and Ha T: The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun 373: 545-549, 2008.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 545-549
    • Ahn, J.1    Lee, H.2    Kim, S.3    Park, J.4    Ha, T.5
  • 11
    • 0141888287 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1
    • Lin HY, Juan SH, Shen SC, Hsu FL and Chen YC; Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1. Biochem Pharmacol 66 1821-1832, 2003
    • (2003) Biochem Pharmacol , vol.66 , pp. 1821-1832
    • Lin, H.Y.1    Juan, S.H.2    Shen, S.C.3    Hsu, F.L.4    Chen, Y.C.5
  • 12
    • 20344382953 scopus 로고    scopus 로고
    • Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages
    • Chow JM, Shen SC, Huan SK, Lin HY and Chen YC: Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol 69: 1839-1851, 2005.
    • (2005) Biochem Pharmacol , vol.69 , pp. 1839-1851
    • Chow, J.M.1    Shen, S.C.2    Huan, S.K.3    Lin, H.Y.4    Chen, Y.C.5
  • 13
    • 15944419535 scopus 로고    scopus 로고
    • Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes
    • Strobel P, Allard C, Perez-Acle T, Calderon R, Aldunate R and Leighton F: Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem J 386: 471-478, 2005.
    • (2005) Biochem J , vol.386 , pp. 471-478
    • Strobel, P.1    Allard, C.2    Perez-Acle, T.3    Calderon, R.4    Aldunate, R.5    Leighton, F.6
  • 15
    • 84907856669 scopus 로고    scopus 로고
    • Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent against prostate cancer in an in vivo model by inhibiting the EGFR signaling pathway
    • Firdous AB, Sharmila G, Balakrishnan S, RajaSingh P, Suganya S, Srinivasan N and Arunakaran J: Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent against prostate cancer in an in vivo model by inhibiting the EGFR signaling pathway. Food Funct 5: 2632-2645, 2014.
    • (2014) Food Funct , vol.5 , pp. 2632-2645
    • Firdous, A.B.1    Sharmila, G.2    Balakrishnan, S.3    RajaSingh, P.4    Suganya, S.5    Srinivasan, N.6    Arunakaran, J.7
  • 17
    • 76549107629 scopus 로고    scopus 로고
    • An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids
    • Venegas-Calerón M, Sayanova O and Napier JA: An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids. Prog Lipid Res 49: 108-119, 2010.
    • (2010) Prog Lipid Res , vol.49 , pp. 108-119
    • Venegas-Calerón, M.1    Sayanova, O.2    Napier, J.A.3
  • 18
    • 77951497987 scopus 로고    scopus 로고
    • Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages
    • Mullen A, Loscher CE and Roche H: Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages. J Nutr Biochem 21: 444-450, 2010.
    • (2010) J Nutr Biochem , vol.21 , pp. 444-450
    • Mullen, A.1    Loscher, C.E.2    Roche, H.3
  • 19
    • 84858298597 scopus 로고    scopus 로고
    • Additive, antagonistic, and synergistic effects of procyanidins and polyunsaturated fatty acids over inflammation in RAW 264.7 macrophages activated by lipopolysaccharide
    • Pallarès V, Calay D, Cedó L, Castell-Auví A, Raes M, Pinent M, Ardévol A, Arola L and Blay M: Additive, antagonistic, and synergistic effects of procyanidins and polyunsaturated fatty acids over inflammation in RAW 264.7 macrophages activated by lipopolysaccharide. Nutrition 28: 447-457, 2012.
    • (2012) Nutrition , vol.28 , pp. 447-457
    • Pallarès, V.1    Calay, D.2    Cedó, L.3    Castell-Auví, A.4    Raes, M.5    Pinent, M.6    Ardévol, A.7    Arola, L.8    Blay, M.9
  • 20
    • 84900497061 scopus 로고    scopus 로고
    • DHA suppresses Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages
    • Choi EY, Jin JY, Choi JI, Choi IS and Kim SJ: DHA suppresses Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages. Br J Nutr 111: 1221-1230, 2014.
    • (2014) Br J Nutr , vol.111 , pp. 1221-1230
    • Choi, E.Y.1    Jin, J.Y.2    Choi, J.I.3    Choi, I.S.4    Kim, S.J.5
  • 21
    • 0344327080 scopus 로고    scopus 로고
    • Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-? Production in murine macrophages
    • Manjeet KR and Ghosh B: Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-? production in murine macrophages. Int J Immunopharmacol 21: 435-443, 1999.
    • (1999) Int J Immunopharmacol , vol.21 , pp. 435-443
    • Manjeet, K.R.1    Ghosh, B.2
  • 22
    • 43049176634 scopus 로고    scopus 로고
    • Health effects of quercetin: From antioxidant to nutraceutical
    • Boots AW, Haenen GR and Bast A: Health effects of quercetin: From antioxidant to nutraceutical. Eur J Pharmacol 585: 325-337, 2008.
    • (2008) Eur J Pharmacol , vol.585 , pp. 325-337
    • Boots, A.W.1    Haenen, G.R.2    Bast, A.3
  • 23
    • 70449657770 scopus 로고    scopus 로고
    • Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: Docosahexaenoic acid or eicosapentaenoic acid
    • Saw CL, Huang Y and Kong AN: Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: Docosahexaenoic acid or eicosapentaenoic acid. Biochem Pharmacol 79: 421-430, 2010.
    • (2010) Biochem Pharmacol , vol.79 , pp. 421-430
    • Saw, C.L.1    Huang, Y.2    Kong, A.N.3
  • 24
    • 67349155571 scopus 로고    scopus 로고
    • Relative bioavailability and pharmacokinetics of two oral formulations of docosahexaenoic acid/eicosapentaenoic acid after multiple-dose administration in healthy volunteers
    • Rusca A, Di Stefano AF, Doig MV, Scarsi C and Perucca E: Relative bioavailability and pharmacokinetics of two oral formulations of docosahexaenoic acid/eicosapentaenoic acid after multiple-dose administration in healthy volunteers. Eur J Clin Pharmacol 65: 503-510, 2009.
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 503-510
    • Rusca, A.1    Di Stefano, A.F.2    Doig, M.V.3    Scarsi, C.4    Perucca, E.5
  • 25
    • 84871717518 scopus 로고    scopus 로고
    • Phytochemicals and their impact on adipose tissue inflammation and diabetes
    • Leiherer A, Mündlein A and Drexel H: Phytochemicals and their impact on adipose tissue inflammation and diabetes. Vascul Pharmacol 58: 3-20, 2013.
    • (2013) Vascul Pharmacol , vol.58 , pp. 3-20
    • Leiherer, A.1    Mündlein, A.2    Drexel, H.3
  • 26
    • 84884383222 scopus 로고    scopus 로고
    • Quercetin-nanostructured lipid carriers: Characteristics and anti-breast cancer activities in vitro
    • Sun M, Nie S, Pan X, Zhang R, Fan Z, Wang S: Quercetin-nanostructured lipid carriers: Characteristics and anti-breast cancer activities in vitro. Colloids Surf Biointerfaces 113: 15-24, 2014.
    • (2014) Colloids Surf Biointerfaces , vol.113 , pp. 15-24
    • Sun, M.1    Nie, S.2    Pan, X.3    Zhang, R.4    Fan, Z.5    Wang, S.6
  • 27
    • 81855164783 scopus 로고    scopus 로고
    • The flavonoid quercetin in disease prevention and therapy: Facts and fancies
    • Russo M, Spagnuolo C, Tedesco I, Bilotto S and Russo GL: The flavonoid quercetin in disease prevention and therapy: Facts and fancies. Biochem Pharmacol 83: 6-15, 2012.
    • (2012) Biochem Pharmacol , vol.83 , pp. 6-15
    • Russo, M.1    Spagnuolo, C.2    Tedesco, I.3    Bilotto, S.4    Russo, G.L.5
  • 28
    • 84885930898 scopus 로고    scopus 로고
    • Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-?B-induced inflammatory mediators production in RAW 264.7 cells
    • Endale M, Park SC, Kim S, Kim SH, Yang Y, Cho JY and Rhee MH: Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-?B-induced inflammatory mediators production in RAW 264.7 cells. Immunobiology 218: 1452-1467, 2013.
    • (2013) Immunobiology , vol.218 , pp. 1452-1467
    • Endale, M.1    Park, S.C.2    Kim, S.3    Kim, S.H.4    Yang, Y.5    Cho, J.Y.6    Rhee, M.H.7
  • 29
    • 48249112172 scopus 로고    scopus 로고
    • Molecular mechanisms of anti-inflammatory activity mediated by flavonoids
    • Gomes A, Fernandes E, Lima JL, Mira L and Corvo ML: Molecular mechanisms of anti-inflammatory activity mediated by flavonoids. Curr Med Chem 15: 1586-1605, 2008.
    • (2008) Curr Med Chem , vol.15 , pp. 1586-1605
    • Gomes, A.1    Fernandes, E.2    Lima, J.L.3    Mira, L.4    Corvo, M.L.5
  • 30
    • 84655174598 scopus 로고    scopus 로고
    • (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: Mechanistic insights
    • Kalupahana NS, Claycombe KJ and Moustaid-Moussa N: (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: Mechanistic insights. Adv Nutr 2: 304-316, 2011.
    • (2011) Adv Nutr , vol.2 , pp. 304-316
    • Kalupahana, N.S.1    Claycombe, K.J.2    Moustaid-Moussa, N.3
  • 32
    • 77953904162 scopus 로고    scopus 로고
    • Fatty acids from fish: The anti-inflammatory potential of long-chain omega-3 fatty acids
    • Wall R, Ross RP, Fitzgerald GF and Stanton C: Fatty acids from fish: The anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr Rev 68: 280-289, 2010.
    • (2010) Nutr Rev , vol.68 , pp. 280-289
    • Wall, R.1    Ross, R.P.2    Fitzgerald, G.F.3    Stanton, C.4
  • 33
    • 0032585932 scopus 로고    scopus 로고
    • I?B Kinases ? And ? Show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin
    • Peet GW and Li J: I?B Kinases ? and ? show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin. J Biol Chem 274: 32655-32661, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 32655-32661
    • Peet, G.W.1    Li, J.2
  • 34
    • 77949270779 scopus 로고    scopus 로고
    • Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-kappaB in macrophages
    • Feng D, Ling WH and Duan RD: Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-kappaB in macrophages. Inflamm Res 59: 115-121, 2010.
    • (2010) Inflamm Res , vol.59 , pp. 115-121
    • Feng, D.1    Ling, W.H.2    Duan, R.D.3
  • 35
    • 58149232582 scopus 로고    scopus 로고
    • Systems analysis of MAPK signal transduction
    • Blüthgen N and Legewie S: Systems analysis of MAPK signal transduction. Essays Biochem 45: 95-107, 2008.
    • (2008) Essays Biochem , vol.45 , pp. 95-107
    • Blüthgen, N.1    Legewie, S.2
  • 36
    • 34248572839 scopus 로고    scopus 로고
    • MAP kinases and the control of nuclear events
    • Turjanski AG, Vaqué JP and Gutkind JS: MAP kinases and the control of nuclear events. Oncogene 26: 3240-3253, 2007.
    • (2007) Oncogene , vol.26 , pp. 3240-3253
    • Turjanski, A.G.1    Vaqué, J.P.2    Gutkind, J.S.3
  • 37
    • 0033860284 scopus 로고    scopus 로고
    • Fish oil modulates macrophage P44/P42 mitogen-activated protein kinase activity induced by lipopolysaccharide
    • Lo CJ, Chiu KC, Fu M, Chu A and Helton S: Fish oil modulates macrophage P44/P42 mitogen-activated protein kinase activity induced by lipopolysaccharide. JPEN J Parenter Enteral Nutr 24: 159-163, 2000.
    • (2000) JPEN J Parenter Enteral Nutr , vol.24 , pp. 159-163
    • Lo, C.J.1    Chiu, K.C.2    Fu, M.3    Chu, A.4    Helton, S.5
  • 38
    • 0346250201 scopus 로고    scopus 로고
    • Deoxynivalenol-induced mitogen-activated protein kinase phosphorylation and IL-6 expression in mice suppressed by fish oil
    • Moon Y and Pestka JJ: Deoxynivalenol-induced mitogen-activated protein kinase phosphorylation and IL-6 expression in mice suppressed by fish oil. J Nutr Biochem 14: 717-726, 2003.
    • (2003) J Nutr Biochem , vol.14 , pp. 717-726
    • Moon, Y.1    Pestka, J.J.2
  • 39
    • 0037281331 scopus 로고    scopus 로고
    • Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kappaB pathway in lipopolysaccharide-stimulated macrophage
    • Cho SY, Park SJ, Kwon MJ, Jeong TS, Bok SH, Choi WY, Jeong WI, Ryu SY, Do SH, Lee CS, et al: Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kappaB pathway in lipopolysaccharide-stimulated macrophage. Mol Cell Biochem 243: 153-160, 2003.
    • (2003) Mol Cell Biochem , vol.243 , pp. 153-160
    • Cho, S.Y.1    Park, S.J.2    Kwon, M.J.3    Jeong, T.S.4    Bok, S.H.5    Choi, W.Y.6    Jeong, W.I.7    Ryu, S.Y.8    Do, S.H.9    Lee, C.S.10
  • 40
    • 0025924381 scopus 로고
    • Maintenance of NF-kappa B activity is dependent on protein synthesis and the continuous presence of external stimuli
    • Hohmann HP, Remy R, Scheidereit C and van Loon AP: Maintenance of NF-kappa B activity is dependent on protein synthesis and the continuous presence of external stimuli. Mol Cell Biol 11: 259-266, 1991.
    • (1991) Mol Cell Biol , vol.11 , pp. 259-266
    • Hohmann, H.P.1    Remy, R.2    Scheidereit, C.3    Van Loon, A.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.