Rosmarinic acid in Prunella vulgaris ethanol extract inhibits lipopolysaccharide-Lnduced prostaglandin E2 and nitric oxide in RAW 264.7 mouse macrophages

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 22, 2009, Pages 10579-10589

  Huang, Nan ^a   Hauck, Cathy ^a   Yum, Man Yu ^a,b   Rizshsky, Ludmila ^a   Widrlechner, Mark P ^a,c   McCoy, Joe Ann ^c,d   Murphy, Patricia A ^a   Dixon, Philip M ^a,b   Nikolau, Basil J ^a   Birt, Diane F ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b Iowa State University   (United States)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

^d NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Anti inflammatory; Extracts; Fractionation; Nitric oxide; Prostaglandin e2; Prunella vulgaris; Rosmarinic acid

Indexed keywords

ALCOHOL; CINNAMIC ACID DERIVATIVE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DEPSIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; ROSMARINIC ACID;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; MACROPHAGE; METABOLISM; MOUSE; PRUNELLA;

ANIMALS; CELL LINE; CINNAMATES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DEPSIDES; DINOPROSTONE; ETHANOL; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PRUNELLA;

PRUNELLA VULGARIS;

EID: 72449169400     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf9023728     Document Type: Article

References (30)

1. (1) Psotova, J.; Kolar, M.; Sousek, J.; Svagera, Z.; Vicar, J.; Ulrichova, J. Biological activities of Prunella vulgaris extract. Res. 2003, 17(9), 1082-1087. (Pubitemid 37351585)
2. (2) Sun, H. X.; Qin, F.; Pan, Y. J. In vitro and in vivo immunosuppressive activity of Spica Prunellae ethanol. extract on the immune responses in mice. J. Ethnonharmacol. 2005, 101 (1-3), 31-36. (Pubitemid 41265597)
3. (3) Kim, S. Y.; Kim, S. H.; Shin, H. Y.; Lim, J. P.; Chae, B. S.; Park, J. S.; Hong, S. G.; Kim, M. S.; Jo, D. G.; Park, W. H.; Shin, T. Y. Effects of Prunella vulgaris on mast cell-mediated allergic reaction, and inflammatory cytokine production, Exp. Biol. Med. (Maywood) 2007, 232 (7), 921-926. (Pubitemid 47026798)
4. Han, E. H.; Choi, J. H.; Hwang, Y. P.; Park, H. J.; Choi, C. Y.; Chung, Y. C.; Seo, J. K.; Jeong, H. G. Immunostimulatory activity of aqueous extract isolated from Prunella vulgaris. Food Chem. Toxicol. 2009, 47(1), 62-69.
5. Brindley, M. A.; Widrlechner, M. P.; McCoy, J. A.; Murphy, P.; Hauck, C.; Rizshsky, L.; Nikolau, B.; Maury, W. Inhibition of lentivirus replication by aqueous extracts of Prunella vulgaris. Virol. J. 2009, 6(1), 8.
6. Chiu, L. C.; Zhu, W.; Ooi, V. E. A polysaccharide fraction from, medicinal herb Prunella vulgaris downregulates the expression of herpes simplex virus antigen in Vero cells, J. Ethnopharmacol. 2004, 93 (1), 63-68.
7. Hartog, A.; Hougee, S.; Faber, J.; Sanders, A.; Zuurman, C.; Smit, H. F.; van der Kraan, P. M.; Hoijer, M. A.; Garssen, J. The multicomponent phytopharmaceutical SKI306X inhibits in vitro cartilage degradation and the production of inflammatory mediators, Phytomedicine 2008, 15 (5), 313-320.
8. Zdarilova, A.; Svobodova, A.; Simanek, V.; Ulrichova, J. Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharideinduced alteration in human gingival fibroblasts, Toxicol In Vitro 2009, 23 (3), 386-392.
9. Collins, N. H.; Lessey, E. C.; Dusell, C. D.; McDonnell, D. P.; Fowler, L.; Palomino, W. A.; Mera, M. J.; Yu, X.; Mo, B.; Houwing, A. M.; Lessey, B. A. Characterization of antiestrogenic activity of the Chinese herb, Prunella vulgaris, using in vitro and in vivo (mouse xenograft) models. Biol. Reprod. 2009, 80 (1), 375-383; erratum 2009, 80 (6), 1306.
10. Ryu, S. Y.; Oak, M. H.; Yoon, S. K.; Cho, D. I.; Yoo, G. S.; Kim, T. S.; Kim, K, M. Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris. Planta Med. 2000, 66 (4), 358-360.
11. Wang, L.; Tu, Y. C.; Lian, T. W.; Hung, J. T.; Yen, J. H.; Wu, M. J. Distinctive antioxidant and antiinflammatory effects of flavonols. J. Agric. Food Chem. 2006, 54, 9798-9804.
12. Cao, X. Y.; Dong, M,; Shen, J. Z.; Wu, B. B.; Wu, C. M.; Du, X. D.; Wang, Z.; Qi, Y. T.; Li, B. Y. Tilmicosin and tylosin have antiinflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes. Int. J. Antimicrob. Agents 2006, 27 (5), 431-438.
13. Hammer, K. D.; Hillwig, M. L.; Soleo, A. K.; Dixon, P. M.; Delate, K.; Murphy, P. A.; Wurtele, E. S.; Birt, D. F. Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 mouse macrophage cells. J. Agric. Food Chem. 2007, 55, 7323-7331.
14. LaLone, C. A.; Hammer, K. D.; Wu, L.; Bae, J.; Leyva, N.; Liu, Y.; Soleo, A. K.; Kraus, G. A.; Murphy, P. A.; Wurtele, E. S.; Kim, O. K.; Seo, K. I.; Widrlechner, M. P.; Birt, D. F. Echinacea species and alkamides inhibit prostaglandin E(2) production in RAW264.7 mouse macrophage cells. J. Agric. Food Chem, 2007, 55, 7314-7322.
15. Kim, J. K.; Oh, S. M.; Kwon, H. S.; Oh, Y. S.; Lim, S. S.; Shin, H. K, Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide- induced inflammatory responses in murine macrophages, Biochem. Biophys. Res. Commun. 2006, 345 (3), 1215-1223.
16. Cheung, H. Y.; Zhang, Q. F. Enhanced analysis of triterpenes flavonoids and phenolic compounds in Prunella vulgaris L. by capillary zone electrophoresis with the addition of running buffer modifiers. J. Chromatogr., A 2008, 1213 (2), 231-238.
17. Schmitt, L. A.; Liu, Y.; Murphy, P. A.; Birt, D. F. Evaluation of the light-sensitive cytotoxicity of Hypericum perforatum extracts, fractions, and pure compounds. J. Agric. Food Chem. 2006, 54, 2881-2890.
18. Lee, I. K.; Kim do, H.; Lee, S. Y.; Kim, K. R.; Choi, S. U.; Hong, J. K.; Lee, J. H.; Park, Y. H.; Lee, K. R. Triterpenoic acids of Prunella vulgaris var. lilacina and their cytotoxic activities in vitro, Arch. Pharm. Res. 2008, 31 (12), 1578-1583.
19. Cho, H. J.; Seon, M. R.; Lee, Y. M.; Kim, J.; Kim, J.-K.; Kim, S. G.; Park, J. H. Y. 3,3′-Diindolylmethane suppresses the inflammatory response to lipopolysaccharide in murine macrophages. J. Nutr. 2008, 138 (1), 17-23.
20. Amano, F.; Noda, T. Improved detection, of nitric oxide radical (NO•) production in an activated macrophage culture with, a radical scavenger, carboxy PTIO and Griess reagent. FEBS Lett. 1995, 368 (3), 425-428.
21. Hammer, K. D.; Hillwig, M. L.; Neighbors, J. D.; Sim, Y. J.; Kohut, M. L.; Wiemer, D. F.; Wurtele, E. S.; Birt, D. F. Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction. Phytochemistry 2008, 69 (12), 2354-2362.
22. Scheckel, K. A.; Degner, S. C.; Romagnolo, D. F. Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. J. Nutr. 2008, 138 (11), 2098-2105.
23. (23) Psotova, J.; Svobodova, A.; Kolarova, H.; Walterova, D. Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes. J. Photochem. Photohiol. B 2006,84 (3), 167-174. (Pubitemid 44184914)
24. Song, Y. W.; Lee, E. Y.; Koh, E. M.; Cha, H. S.; Yoo, B.; Lee, C. K.; Baek, H. J.; Kim, H. A.; Suh, Y. I.; Kang, S. W.; Lee, Y. J.; Jung, H. G. Assessment of comparative pain relief and tolerability of SKI306X compared with celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, doubledummy, phase III, noninferiority clinical trial. Clin. Ther. 2007, 29 (5), 862-873.
25. (25) Foster, S. L.; Hargreaves, D. C.; Medzhitov, R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007,447 (7147), 972-978. (Pubitemid 46975746)
26. (26) Qiao, S.; Li, W.; Tsubouchi, R.; Haneda, M.; Murakami, K.; Takeuchi, F.; Nisimoto, Y.; Yoshino, M. Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages, Free Radical Res. 2005, 39 (9), 995-1003. (Pubitemid 41227036)
27. Kim, H. K.; Lee, J. J.; Lee, J. S.; Park, Y. M.; Yoon, T. R. Rosmarinic acid down-regulates the LPS-induced production of monocyte chemoattractant protein-1 (MCP-I) and macrophage inflammatory protein-1 alpha (MIP-I alpha) via the MAPK pathway in bone-marrow derived dendritic cells. Mol. Cells 2008, 26(6), 583-589.
28. Chizzola, R.; Michitsch, H.; Franz, C. Antioxidative properties of Thymus vulgaris leaves: comparison, of different extracts and essential oil chemotypes. J. Agric Food Chem. 2008, 56, 6897-6904.
29. Lee, M. K.; Ahn, Y. M.; Lee, K. R.; Jung, J. H.; Jung, O. S.; Hong, J. Development of a validated liquid chromatographic method for the quality control of Prunellae Spica: determination of triterpenic acids. Anal. Chim. Acta 2009, 633 (2), 271-277.
30. (30) Jirovsky, D.; Kosina, P.; Myslinova, M.; Styskala, J.; Ulrichova, J.; Simanek, V. HPLC analysis of rosmarinic acid in feed enriched with aerial parts of Prunella vulgaris and its metabolites in pig plasma using dual-channel coulometric detection. J. Agric. Food Chem. 2007,55,7631-7637. (Pubitemid 47522165)