A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

PLoS Pathogens

Volumn 12, Issue 5, 2016, Pages

  Chan, John D ^a   McCorvy, John D ^b   Acharya, Sreemoyee ^c   Johns, Malcolm E ^a   Day, Timothy A ^c   Roth, Bryan L ^b,d   Marchant, Jonathan S ^a,e  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c IOWA STATE UNIVERSITY   (United States)

^d University of North Carolina   (United States)

^e UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOCRIPTINE; DIHYDROERGOTAMINE; ERGOTAMINE; G PROTEIN COUPLED RECEPTOR; LISURIDE; METITEPINE; PRAZIQUANTEL; RHODOPSIN; SEROTONIN RECEPTOR; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMPHALARIA GLABRATA; BIOSENSOR; CAMP ASSAY; CELL VIABILITY; CONTROLLED STUDY; DNA SEQUENCE; DRUG EXPOSURE; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MALE; MOLECULAR CLONING; NONHUMAN; POLYMERASE CHAIN REACTION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SCHISTOSOMIASIS MANSONI; SCHISTOSOMULUM; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; ANIMAL; HEK293 CELL LINE; METABOLISM; MOUSE; PRECLINICAL STUDY; PROCEDURES;

ANIMALS; BLOTTING, WESTERN; DRUG EVALUATION, PRECLINICAL; FEMALE; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; RECEPTORS, G-PROTEIN-COUPLED; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI;

EID: 84973334825     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005651     Document Type: Article

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