-
1
-
-
30444437486
-
Treatment of acute lymphoblastic leukemia
-
Pui, C.-H. & Evans, W. E. Treatment of acute lymphoblastic leukemia. N. Engl. J. Med. 354, 166-178 (2006).
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 166-178
-
-
Pui, C.-H.1
Evans, W.E.2
-
2
-
-
70449719091
-
IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report
-
Martinelli, G. et al. IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report. J. Clin. Oncol. 27, 5202-5207 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 5202-5207
-
-
Martinelli, G.1
-
3
-
-
84893766383
-
Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011
-
Olsson, L. et al. Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011. Leukemia 28, 302-310 (2014).
-
(2014)
Leukemia
, vol.28
, pp. 302-310
-
-
Olsson, L.1
-
4
-
-
58749097408
-
A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: A genome-wide classification study
-
Den Boer, M. L. et al. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol. 10, 125-134 (2009).
-
(2009)
Lancet Oncol.
, vol.10
, pp. 125-134
-
-
Den Boer, M.L.1
-
5
-
-
58749109707
-
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
-
Mullighan, C. G. et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N. Engl. J. Med. 360, 470-480 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 470-480
-
-
Mullighan, C.G.1
-
6
-
-
78649742010
-
Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: Correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome
-
Harvey, R. C. et al. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood 116, 4874-4884 (2010).
-
(2010)
Blood
, vol.116
, pp. 4874-4884
-
-
Harvey, R.C.1
-
7
-
-
84865118132
-
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia
-
Roberts, K. G. et al. Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell 22, 153-166 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 153-166
-
-
Roberts, K.G.1
-
8
-
-
84907080295
-
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia
-
Roberts, K. G. et al. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N. Engl. J. Med. 371, 1005-1015 (2014).
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 1005-1015
-
-
Roberts, K.G.1
-
9
-
-
84895803000
-
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia
-
Papaemmanuil, E. et al. RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat. Genet. 46, 116-125 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 116-125
-
-
Papaemmanuil, E.1
-
10
-
-
84940575993
-
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options
-
Fischer, U. et al. Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat. Genet. 47, 1020-1029 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 1020-1029
-
-
Fischer, U.1
-
11
-
-
84930089675
-
The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia
-
Paulsson, K. et al. The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia. Nat. Genet. 47, 672-676 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 672-676
-
-
Paulsson, K.1
-
12
-
-
84874647204
-
The genomic landscape of hypodiploid acute lymphoblastic leukemia
-
Holmfeldt, L. et al. The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat. Genet. 45, 242-252 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 242-252
-
-
Holmfeldt, L.1
-
13
-
-
84925841593
-
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
-
Andersson, A. K. et al. The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias. Nat. Genet. 47, 330-337 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 330-337
-
-
Andersson, A.K.1
-
14
-
-
84891850778
-
An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions
-
Clappier, E. et al. An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions. Leukemia 28, 70-77 (2014).
-
(2014)
Leukemia
, vol.28
, pp. 70-77
-
-
Clappier, E.1
-
15
-
-
84891877413
-
ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic
-
Zaliova, M. et al. ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic. Leukemia 28, 182-185 (2014).
-
(2014)
Leukemia
, vol.28
, pp. 182-185
-
-
Zaliova, M.1
-
16
-
-
77957327192
-
A unifying genetic model for facioscapulohumeral muscular dystrophy
-
Lemmers, R. J. L. F. et al. A unifying genetic model for facioscapulohumeral muscular dystrophy. Science 329, 1650-1653 (2010).
-
(2010)
Science
, vol.329
, pp. 1650-1653
-
-
Lemmers, R.J.L.F.1
-
17
-
-
78449250235
-
Facioscapulohumeral dystrophy: Incomplete suppression of a retrotransposed gene
-
Snider, L. et al. Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene. PLoS Genet. 6, e1001181 (2010).
-
(2010)
PLoS Genet.
, vol.6
, pp. e1001181
-
-
Snider, L.1
-
18
-
-
40749150603
-
Acute lymphoblastic leukaemia
-
Pui, C.-H., Robison, L. L. & Look, A. T. Acute lymphoblastic leukaemia. Lancet 371, 1030-1043 (2008).
-
(2008)
Lancet
, vol.371
, pp. 1030-1043
-
-
Pui, C.-H.1
Robison, L.L.2
Look, A.T.3
-
19
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
-
20
-
-
84884664999
-
Runx1 is essential at two stages of early murine B-cell development
-
Niebuhr, B. et al. Runx1 is essential at two stages of early murine B-cell development. Blood 122, 413-423 (2013).
-
(2013)
Blood
, vol.122
, pp. 413-423
-
-
Niebuhr, B.1
-
21
-
-
84894413913
-
Stage-specific control of early B cell development by the transcription factor Ikaros
-
Schwickert, T. A. et al. Stage-specific control of early B cell development by the transcription factor Ikaros. Nat. Immunol. 15, 283-293 (2014).
-
(2014)
Nat. Immunol.
, vol.15
, pp. 283-293
-
-
Schwickert, T.A.1
-
22
-
-
84874534042
-
IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
-
Dörge, P. et al. IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol. Haematologica 98, 428-432 (2013).
-
(2013)
Haematologica
, vol.98
, pp. 428-432
-
-
Dörge, P.1
-
23
-
-
84888253484
-
Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL
-
van der, Veer, A. et al. Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL. Blood 122, 2622-2629 (2013).
-
(2013)
Blood
, vol.122
, pp. 2622-2629
-
-
Van Der-Veer, A.1
-
25
-
-
84951567387
-
A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia
-
Gocho, Y. et al. A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia. Leukemia 29, 2445-2448 (2015).
-
(2015)
Leukemia
, vol.29
, pp. 2445-2448
-
-
Gocho, Y.1
-
26
-
-
9844230424
-
nrb) to the TFE3 gene in papillary renal cell carcinoma
-
nrb) to the TFE3 gene in papillary renal cell carcinoma. Oncogene 15, 2233-2239 (1997).
-
(1997)
Oncogene
, vol.15
, pp. 2233-2239
-
-
Clark, J.1
-
27
-
-
84880967722
-
Integrated molecular analysis of clear-cell renal cell carcinoma
-
Sato, Y. et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat. Genet. 45, 860-867 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 860-867
-
-
Sato, Y.1
-
28
-
-
20144387358
-
ETV6/RUNX1 fusion at diagnosis and relapse: Some prognostic indications
-
Martineau, M. et al. ETV6/RUNX1 fusion at diagnosis and relapse: some prognostic indications. Genes Chromosomes Cancer 43, 54-71 (2005).
-
(2005)
Genes Chromosomes Cancer
, vol.43
, pp. 54-71
-
-
Martineau, M.1
-
29
-
-
85006219583
-
Determination of ETV6-RUNX1 genomic breakpoint by nextgeneration sequencing
-
Jin, Y. et al. Determination of ETV6-RUNX1 genomic breakpoint by nextgeneration sequencing. Cancer Med. 5, 337-351 (2016).
-
(2016)
Cancer Med.
, vol.5
, pp. 337-351
-
-
Jin, Y.1
-
30
-
-
84929858006
-
The emerging complexity of gene fusions in cancer
-
Mertens, F., Johansson, B., Fioretos, T. & Mitelman, F. The emerging complexity of gene fusions in cancer. Nat. Rev. Cancer 15, 371-381 (2015).
-
(2015)
Nat. Rev. Cancer
, vol.15
, pp. 371-381
-
-
Mertens, F.1
Johansson, B.2
Fioretos, T.3
Mitelman, F.4
-
31
-
-
84925356651
-
Cooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations of IKZF1
-
Olsson, L. et al. Cooperative genetic changes in pediatric B-cell precursor acute lymphoblastic leukemia with deletions or mutations of IKZF1. Genes. Chromosomes Cancer 54, 315-325 (2015).
-
(2015)
Genes. Chromosomes Cancer
, vol.54
, pp. 315-325
-
-
Olsson, L.1
-
33
-
-
84899973908
-
Targeting bromodomains: Epigenetic readers of lysine acetylation
-
Filippakopoulos, P. & Knapp, S. Targeting bromodomains: epigenetic readers of lysine acetylation. Nat. Rev. Drug Discov. 13, 337-356 (2014).
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, pp. 337-356
-
-
Filippakopoulos, P.1
Knapp, S.2
-
34
-
-
34147224008
-
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
-
Mullighan, C. G. et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446, 758-764 (2007).
-
(2007)
Nature
, vol.446
, pp. 758-764
-
-
Mullighan, C.G.1
-
35
-
-
78650158554
-
TEL/AML1-positive patients lacking TEL exon 5 resemble canonical TEL/AML1 cases
-
Zaliova, M. et al. TEL/AML1-positive patients lacking TEL exon 5 resemble canonical TEL/AML1 cases. Pediatr. Blood Cancer 56, 217-225 (2011).
-
(2011)
Pediatr. Blood Cancer
, vol.56
, pp. 217-225
-
-
Zaliova, M.1
-
36
-
-
19044399684
-
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
-
Yeoh, E.-J. et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1, 133-143 (2002).
-
(2002)
Cancer Cell
, vol.1
, pp. 133-143
-
-
Yeoh, E.-J.1
-
37
-
-
0141993002
-
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling
-
Ross, M. E. et al. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 102, 2951-2959 (2003).
-
(2003)
Blood
, vol.102
, pp. 2951-2959
-
-
Ross, M.E.1
-
38
-
-
22144472624
-
Prospective gene expression analysis accurately subtypes acute leukaemia in children and establishes a commonality between hyperdiploidy and t(12;21) in acute lymphoblastic leukaemia
-
van Delft, F. W. et al. Prospective gene expression analysis accurately subtypes acute leukaemia in children and establishes a commonality between hyperdiploidy and t(12;21) in acute lymphoblastic leukaemia. Br. J. Haematol. 130, 26-35 (2005).
-
(2005)
Br. J. Haematol.
, vol.130
, pp. 26-35
-
-
Van Delft, F.W.1
-
39
-
-
34249676963
-
Microarray-based classification of a consecutive series of 121 childhood acute leukemias: Prediction of leukemic and genetic subtype as well as of minimal residual disease status
-
Andersson, A. et al. Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status. Leukemia 21, 1198-1203 (2007).
-
(2007)
Leukemia
, vol.21
, pp. 1198-1203
-
-
Andersson, A.1
-
40
-
-
57549098807
-
The catalogue of somatic mutations in cancer (COSMIC)
-
Forbes, S. A. et al. The Catalogue of Somatic Mutations in Cancer (COSMIC). Curr. Protoc. Hum. Genet. 57, 10.11.1-10.11.26 (2008).
-
(2008)
Curr. Protoc. Hum. Genet.
, vol.57
, pp. 1-26
-
-
Forbes, S.A.1
-
41
-
-
36549062445
-
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia
-
Paulsson, K. et al. Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer 47, 26-33 (2008).
-
(2008)
Genes Chromosomes Cancer
, vol.47
, pp. 26-33
-
-
Paulsson, K.1
-
42
-
-
53049109135
-
Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia
-
Case, M. et al. Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia. Cancer Res. 68, 6803-6809 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 6803-6809
-
-
Case, M.1
-
43
-
-
33745283008
-
Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation
-
Kawamura-Saito, M. et al. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum. Mol. Genet 15, 2125-2137 (2006).
-
(2006)
Hum. Mol. Genet
, vol.15
, pp. 2125-2137
-
-
Kawamura-Saito, M.1
-
44
-
-
84855956147
-
DUX4 activates germline genes, retroelements, and immune mediators: Implications for facioscapulohumeral dystrophy
-
Geng, L. N. et al. DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy. Dev. Cell 22, 38-51 (2012).
-
(2012)
Dev. Cell
, vol.22
, pp. 38-51
-
-
Geng, L.N.1
-
45
-
-
85008372514
-
An analysis of Ph-like ALL in Japanese patients
-
Iijima, K. et al. An analysis Of Ph-like ALL in Japanese patients. Blood 122, 352-352 (2013).
-
(2013)
Blood
, vol.122
, pp. 352
-
-
Iijima, K.1
-
46
-
-
84898466517
-
RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib
-
Lilljebjörn, H. et al. RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib. Leukemia 28, 977-979 (2014).
-
(2014)
Leukemia
, vol.28
, pp. 977-979
-
-
Lilljebjörn, H.1
-
47
-
-
76749115697
-
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia
-
Schmiegelow, K. et al. Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia. Leukemia 24, 345-354 (2009).
-
(2009)
Leukemia
, vol.24
, pp. 345-354
-
-
Schmiegelow, K.1
-
48
-
-
77951441599
-
Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: Results in 3184 patients of the AIEOP-BFM ALL 2000 study
-
Conter, V. et al. Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study. Blood 115, 3206-3214 (2010).
-
(2010)
Blood
, vol.115
, pp. 3206-3214
-
-
Conter, V.1
-
49
-
-
80054003528
-
ChimeraScan: A tool for identifying chimeric transcription in sequencing data
-
Iyer, M. K., Chinnaiyan, A. M. & Maher, C. A. ChimeraScan: a tool for identifying chimeric transcription in sequencing data. Bioinformatics 27, 2903-2904 (2011).
-
(2011)
Bioinformatics
, vol.27
, pp. 2903-2904
-
-
Iyer, M.K.1
Chinnaiyan, A.M.2
Maher, C.A.3
-
50
-
-
84876996918
-
TopHat2: Accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
-
Kim, D. et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 14, R36 (2013).
-
(2013)
Genome Biol.
, vol.14
, pp. R36
-
-
Kim, D.1
-
51
-
-
77952123055
-
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
-
Trapnell, C. et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28, 511-515 (2010).
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 511-515
-
-
Trapnell, C.1
-
53
-
-
84907023732
-
SAMBLASTER: Fast duplicate marking and structural variant read extraction
-
Faust, G. G. & Hall, I. M. SAMBLASTER: fast duplicate marking and structural variant read extraction. Bioinformatics 30, 2503-2505 (2014).
-
(2014)
Bioinformatics
, vol.30
, pp. 2503-2505
-
-
Faust, G.G.1
Hall, I.M.2
-
54
-
-
84864153492
-
Strelka: Accurate somatic small-variant calling from sequenced tumor-normal sample pairs
-
Saunders, C. T. et al. Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs. Bioinformatics 28, 1811-1817 (2012).
-
(2012)
Bioinformatics
, vol.28
, pp. 1811-1817
-
-
Saunders, C.T.1
-
56
-
-
84871809302
-
STAR: Ultrafast universal RNA-seq aligner
-
Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15-21 (2013).
-
(2013)
Bioinformatics
, vol.29
, pp. 15-21
-
-
Dobin, A.1
-
57
-
-
84863229597
-
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
-
Koboldt, D. C. et al. VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res. 22, 568-576 (2012).
-
(2012)
Genome Res.
, vol.22
, pp. 568-576
-
-
Koboldt, D.C.1
-
58
-
-
77956534324
-
ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data
-
Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164-e164 (2010).
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. e164-e164
-
-
Wang, K.1
Li, M.2
Hakonarson, H.3
-
59
-
-
69649109364
-
Circos: An information aesthetic for comparative genomics
-
Krzywinski, M. et al. Circos: an information aesthetic for comparative genomics. Genome Res. 19, 1639-1645 (2009).
-
(2009)
Genome Res.
, vol.19
, pp. 1639-1645
-
-
Krzywinski, M.1
|