메뉴 건너뛰기




Volumn 41, Issue , 2016, Pages 39-46

New concepts in HIV-1 vaccine development

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ENVELOPE PROTEIN; EPITOPE; GAG PROTEIN; GLYCOPROTEIN GP 140; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY;

EID: 84973177464     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2016.05.011     Document Type: Review
Times cited : (61)

References (86)
  • 1
    • 84928396982 scopus 로고    scopus 로고
    • Retention of adult patients on antiretroviral therapy in low- and middle-income countries
    • Fox M.P., Rosen S. Retention of adult patients on antiretroviral therapy in low- and middle-income countries. JAIDS J Acquir Immune Defic Syndr 2015, 69:98-108.
    • (2015) JAIDS J Acquir Immune Defic Syndr , vol.69 , pp. 98-108
    • Fox, M.P.1    Rosen, S.2
  • 2
    • 84896321638 scopus 로고    scopus 로고
    • The importance of treatment adherence in HIV
    • Schaecher K.L. The importance of treatment adherence in HIV. Am J Manage Care 2013, 19. s231-7.
    • (2013) Am J Manage Care , vol.19 , pp. S231-S237
    • Schaecher, K.L.1
  • 3
    • 80053318318 scopus 로고    scopus 로고
    • Challenges of HIV treatment in resource-poor countries: a review
    • Obiako O.R., Muktar H.M. Challenges of HIV treatment in resource-poor countries: a review. Niger J Med 2010, 19:361-368.
    • (2010) Niger J Med , vol.19 , pp. 361-368
    • Obiako, O.R.1    Muktar, H.M.2
  • 5
    • 84904128252 scopus 로고    scopus 로고
    • Immunologic strategies for HIV-1 remission and eradication
    • Barouch D.H., Deeks S.G. Immunologic strategies for HIV-1 remission and eradication. Science 2014, 345:169-174.
    • (2014) Science , vol.345 , pp. 169-174
    • Barouch, D.H.1    Deeks, S.G.2
  • 6
    • 78549235738 scopus 로고    scopus 로고
    • Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication
    • Chun T.-W., Justement J.S., Murray D., Hallahan C.W., Maenza J., Collier A.C., Sheth P.M., Kaul R., Ostrowski M., Moir S., et al. Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication. AIDS 2010, 24:2803-2808.
    • (2010) AIDS , vol.24 , pp. 2803-2808
    • Chun, T.-W.1    Justement, J.S.2    Murray, D.3    Hallahan, C.W.4    Maenza, J.5    Collier, A.C.6    Sheth, P.M.7    Kaul, R.8    Ostrowski, M.9    Moir, S.10
  • 7
    • 84929853490 scopus 로고    scopus 로고
    • HIV reservoirs as obstacles and opportunities for an HIV cure
    • Chun T.-W., Moir S., Fauci A.S. HIV reservoirs as obstacles and opportunities for an HIV cure. Nat Immunol 2015, 16:584-589.
    • (2015) Nat Immunol , vol.16 , pp. 584-589
    • Chun, T.-W.1    Moir, S.2    Fauci, A.S.3
  • 8
    • 80052395837 scopus 로고    scopus 로고
    • Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy
    • Sigal A., Kim J.T., Balazs A.B., Dekel E., Mayo A., Milo R., Baltimore D. Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature 2011, 477:95-98.
    • (2011) Nature , vol.477 , pp. 95-98
    • Sigal, A.1    Kim, J.T.2    Balazs, A.B.3    Dekel, E.4    Mayo, A.5    Milo, R.6    Baltimore, D.7
  • 9
    • 84858081250 scopus 로고    scopus 로고
    • The origin and diversity of the HIV-1 pandemic
    • Hemelaar J. The origin and diversity of the HIV-1 pandemic. Trends Mol Med 2012, 18:182-192.
    • (2012) Trends Mol Med , vol.18 , pp. 182-192
    • Hemelaar, J.1
  • 10
    • 33750253231 scopus 로고    scopus 로고
    • Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004
    • Hemelaar J., Gouws E., Ghys P.D., Osmanov S. Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. AIDS 2006, 20. W13-23.
    • (2006) AIDS , vol.20 , pp. W13-W23
    • Hemelaar, J.1    Gouws, E.2    Ghys, P.D.3    Osmanov, S.4
  • 11
    • 84862737670 scopus 로고    scopus 로고
    • On HIV diversity
    • Ndung'u T., Weiss R.A. On HIV diversity. AIDS 2012, 26:1255-1260.
    • (2012) AIDS , vol.26 , pp. 1255-1260
    • Ndung'u, T.1    Weiss, R.A.2
  • 16
    • 84861057293 scopus 로고    scopus 로고
    • Nomenclature for immune correlates of protection after vaccination
    • Plotkin S.A., Gilbert P.B. Nomenclature for immune correlates of protection after vaccination. Clin Infect Dis 2012, 54:1615-1617.
    • (2012) Clin Infect Dis , vol.54 , pp. 1615-1617
    • Plotkin, S.A.1    Gilbert, P.B.2
  • 19
    • 84871724103 scopus 로고    scopus 로고
    • Characterization of humoral and cellular immune responses elicited by a recombinant adenovirus serotype 26 HIV-1 Env vaccine in healthy adults (IPCAVD 001)
    • Barouch D.H., Liu J., Peter L., Abbink P., Iampietro M.J., Cheung A., Alter G., Chung A., Dugast A.-S., Frahm N., et al. Characterization of humoral and cellular immune responses elicited by a recombinant adenovirus serotype 26 HIV-1 Env vaccine in healthy adults (IPCAVD 001). J Infect Dis 2013, 207:248-256.
    • (2013) J Infect Dis , vol.207 , pp. 248-256
    • Barouch, D.H.1    Liu, J.2    Peter, L.3    Abbink, P.4    Iampietro, M.J.5    Cheung, A.6    Alter, G.7    Chung, A.8    Dugast, A.-S.9    Frahm, N.10
  • 23
    • 34248168722 scopus 로고    scopus 로고
    • Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate
    • Forthal D.N., Gilbert P.B., Landucci G., Phan T. Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate. J Immunol 2007, 178:6596-6603.
    • (2007) J Immunol , vol.178 , pp. 6596-6603
    • Forthal, D.N.1    Gilbert, P.B.2    Landucci, G.3    Phan, T.4
  • 24
    • 13944250922 scopus 로고    scopus 로고
    • Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial
    • Gilbert P.B., Peterson M.L., Follmann D., Hudgens M.G., Francis D.P., Gurwith M., Heyward W.L., Jobes D.V., Popovic V., Self S.G., et al. Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial. J Infect Dis 2005, 191:666-677.
    • (2005) J Infect Dis , vol.191 , pp. 666-677
    • Gilbert, P.B.1    Peterson, M.L.2    Follmann, D.3    Hudgens, M.G.4    Francis, D.P.5    Gurwith, M.6    Heyward, W.L.7    Jobes, D.V.8    Popovic, V.9    Self, S.G.10
  • 25
    • 13944254982 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    • Flynn N.M., Forthal D.N., Harro C.D., Judson F.N., Mayer K.H., Para M.F. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis 2005, 191:654-665.
    • (2005) J Infect Dis , vol.191 , pp. 654-665
    • Flynn, N.M.1    Forthal, D.N.2    Harro, C.D.3    Judson, F.N.4    Mayer, K.H.5    Para, M.F.6
  • 26
    • 33845433434 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    • Pitisuttithum P., Gilbert P., Gurwith M., Heyward W., Martin M., van Griensven F., Hu D., Tappero J.W., Choopanya K. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis 2006, 194:1661-1671.
    • (2006) J Infect Dis , vol.194 , pp. 1661-1671
    • Pitisuttithum, P.1    Gilbert, P.2    Gurwith, M.3    Heyward, W.4    Martin, M.5    van Griensven, F.6    Hu, D.7    Tappero, J.W.8    Choopanya, K.9
  • 27
    • 43949124825 scopus 로고    scopus 로고
    • HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control
    • Emu B., Sinclair E., Hatano H., Ferre A., Shacklett B., Martin J.N., McCune J.M., Deeks S.G. HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control. J Virol 2008, 82:5398-5407.
    • (2008) J Virol , vol.82 , pp. 5398-5407
    • Emu, B.1    Sinclair, E.2    Hatano, H.3    Ferre, A.4    Shacklett, B.5    Martin, J.N.6    McCune, J.M.7    Deeks, S.G.8
  • 28
    • 0028847578 scopus 로고
    • Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection
    • Cao Y., Qin L., Zhang L., Safrit J., Ho D.D. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med 1995, 332:201-208.
    • (1995) N Engl J Med , vol.332 , pp. 201-208
    • Cao, Y.1    Qin, L.2    Zhang, L.3    Safrit, J.4    Ho, D.D.5
  • 29
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
    • Buchbinder S.P., Mehrotra D.V., Duerr A., Fitzgerald D.W., Mogg R., Li D., Gilbert P.B., Lama J.R., Marmor M., Del Rio C., et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 2008, 372:1881-1893.
    • (2008) Lancet , vol.372 , pp. 1881-1893
    • Buchbinder, S.P.1    Mehrotra, D.V.2    Duerr, A.3    Fitzgerald, D.W.4    Mogg, R.5    Li, D.6    Gilbert, P.B.7    Lama, J.R.8    Marmor, M.9    Del Rio, C.10
  • 30
    • 84862904805 scopus 로고    scopus 로고
    • Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step Study)
    • Duerr A., Huang Y., Buchbinder S., Coombs R.W., Sanchez J., del Rio C., Casapia M., Santiago S., Gilbert P., Corey L., et al. Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step Study). J Infect Dis 2012, 206:258-266.
    • (2012) J Infect Dis , vol.206 , pp. 258-266
    • Duerr, A.1    Huang, Y.2    Buchbinder, S.3    Coombs, R.W.4    Sanchez, J.5    del Rio, C.6    Casapia, M.7    Santiago, S.8    Gilbert, P.9    Corey, L.10
  • 31
    • 79959301474 scopus 로고    scopus 로고
    • Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study
    • Gray G.E., Allen M., Moodie Z., Churchyard G., Bekker L.-G., Nchabeleng M., Mlisana K., Metch B., de Bruyn G., Latka M.H., et al. Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study. Lancet Infect Dis 2011, 11:507-515.
    • (2011) Lancet Infect Dis , vol.11 , pp. 507-515
    • Gray, G.E.1    Allen, M.2    Moodie, Z.3    Churchyard, G.4    Bekker, L.-G.5    Nchabeleng, M.6    Mlisana, K.7    Metch, B.8    de Bruyn, G.9    Latka, M.H.10
  • 33
    • 79961048088 scopus 로고    scopus 로고
    • A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204)
    • Churchyard G.J., Morgan C., Adams E., Hural J., Graham B.S., Moodie Z., Grove D., Gray G., Bekker L.-G., McElrath M.J., et al. A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204). PLoS ONE 2011, 6:e21225.
    • (2011) PLoS ONE , vol.6
    • Churchyard, G.J.1    Morgan, C.2    Adams, E.3    Hural, J.4    Graham, B.S.5    Moodie, Z.6    Grove, D.7    Gray, G.8    Bekker, L.-G.9    McElrath, M.J.10
  • 35
    • 17144432813 scopus 로고    scopus 로고
    • The prime-boost concept applied to HIV preventive vaccines
    • Excler J.L., Plotkin S. The prime-boost concept applied to HIV preventive vaccines. AIDS 1997, 11(Suppl. A). S127-37.
    • (1997) AIDS , vol.11 , pp. S127-S137
    • Excler, J.L.1    Plotkin, S.2
  • 36
    • 84867902474 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    • Bonsignori M., Pollara J., Moody M.A., Alpert M.D., Chen X., Hwang K.-K., Gilbert P.B., Huang Y., Gurley T.C., Kozink D.M., et al. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J Virol 2012, 86:11521-11532.
    • (2012) J Virol , vol.86 , pp. 11521-11532
    • Bonsignori, M.1    Pollara, J.2    Moody, M.A.3    Alpert, M.D.4    Chen, X.5    Hwang, K.-K.6    Gilbert, P.B.7    Huang, Y.8    Gurley, T.C.9    Kozink, D.M.10
  • 37
    • 84872809067 scopus 로고    scopus 로고
    • Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
    • Liao H.-X., Bonsignori M., Alam S.M., McLellan J.S., Tomaras G.D., Moody M.A., Kozink D.M., Hwang K.-K., Chen X., Tsao C.-Y., et al. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity 2013, 38:176-186.
    • (2013) Immunity , vol.38 , pp. 176-186
    • Liao, H.-X.1    Bonsignori, M.2    Alam, S.M.3    McLellan, J.S.4    Tomaras, G.D.5    Moody, M.A.6    Kozink, D.M.7    Hwang, K.-K.8    Chen, X.9    Tsao, C.-Y.10
  • 40
    • 0029422476 scopus 로고
    • Selection of potent immunological adjuvants for vaccine construction
    • McElrath M.J. Selection of potent immunological adjuvants for vaccine construction. Semin Cancer Biol 1995, 6:375-385.
    • (1995) Semin Cancer Biol , vol.6 , pp. 375-385
    • McElrath, M.J.1
  • 41
    • 67650678152 scopus 로고    scopus 로고
    • Translational mini-review series on vaccines for HIV: harnessing innate immunity for HIV vaccine development
    • Rhee E.G., Barouch D.H. Translational mini-review series on vaccines for HIV: harnessing innate immunity for HIV vaccine development. Clin Exp Immunol 2009, 157:174-180.
    • (2009) Clin Exp Immunol , vol.157 , pp. 174-180
    • Rhee, E.G.1    Barouch, D.H.2
  • 47
  • 54
    • 84869020041 scopus 로고    scopus 로고
    • Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys
    • Stephenson K.E., SanMiguel A., Simmons N.L., Smith K., Lewis M.G., Szinger J.J., Korber B., Barouch D.H. Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys. J Virol 2012, 86:11434-11440.
    • (2012) J Virol , vol.86 , pp. 11434-11440
    • Stephenson, K.E.1    SanMiguel, A.2    Simmons, N.L.3    Smith, K.4    Lewis, M.G.5    Szinger, J.J.6    Korber, B.7    Barouch, D.H.8
  • 56
    • 84862641275 scopus 로고    scopus 로고
    • HIV vaccine design: the neutralizing antibody conundrum
    • Stamatatos L. HIV vaccine design: the neutralizing antibody conundrum. Curr Opin Immunol 2012, 24:316-323.
    • (2012) Curr Opin Immunol , vol.24 , pp. 316-323
    • Stamatatos, L.1
  • 59
    • 69149083668 scopus 로고    scopus 로고
    • Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?
    • Stamatatos L., Morris L., Burton D.R., Mascola J.R. Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?. Nat Med 2009, 15:866-870.
    • (2009) Nat Med , vol.15 , pp. 866-870
    • Stamatatos, L.1    Morris, L.2    Burton, D.R.3    Mascola, J.R.4
  • 61
    • 77954042425 scopus 로고    scopus 로고
    • Few and far between: how HIV may be evading antibody avidity
    • Klein J.S., Bjorkman P.J. Few and far between: how HIV may be evading antibody avidity. PLoS Pathog 2010, 6:e1000908.
    • (2010) PLoS Pathog , vol.6
    • Klein, J.S.1    Bjorkman, P.J.2
  • 64
    • 0034864776 scopus 로고    scopus 로고
    • Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro
    • Parren P.W.H.I., Marx P.A., Hessell A.J., Luckay A., Harouse J., Cheng-Mayer C., Moore J.P., Burton D.R. Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro. J Virol 2001, 75:8340-8347.
    • (2001) J Virol , vol.75 , pp. 8340-8347
    • Parren, P.W.H.I.1    Marx, P.A.2    Hessell, A.J.3    Luckay, A.4    Harouse, J.5    Cheng-Mayer, C.6    Moore, J.P.7    Burton, D.R.8
  • 65
    • 73949154006 scopus 로고    scopus 로고
    • Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L
    • Hessell A.J., Rakasz E.G., Tehrani D.M., Huber M., Weisgrau K.L., Landucci G., Forthal D.N., Koff W.C., Poignard P., Watkins D.I., et al. Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. J Virol 2010, 84:1302-1313.
    • (2010) J Virol , vol.84 , pp. 1302-1313
    • Hessell, A.J.1    Rakasz, E.G.2    Tehrani, D.M.3    Huber, M.4    Weisgrau, K.L.5    Landucci, G.6    Forthal, D.N.7    Koff, W.C.8    Poignard, P.9    Watkins, D.I.10
  • 68
    • 84924195208 scopus 로고    scopus 로고
    • HIV-1 vaccine immunogen design strategies
    • Mann J.K., Ndung'u T. HIV-1 vaccine immunogen design strategies. Virol J 2015, 12:3.
    • (2015) Virol J , vol.12 , pp. 3
    • Mann, J.K.1    Ndung'u, T.2
  • 69
    • 84884678235 scopus 로고    scopus 로고
    • A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies
    • Sanders R.W., Derking R., Cupo A., Julien J.-P., Yasmeen A., de Val N., Kim H.J., Blattner C., de la Peña A.T., Korzun J., et al. A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies. PLoS Pathog 2013, 9:e1003618.
    • (2013) PLoS Pathog , vol.9
    • Sanders, R.W.1    Derking, R.2    Cupo, A.3    Julien, J.-P.4    Yasmeen, A.5    de Val, N.6    Kim, H.J.7    Blattner, C.8    de la Peña, A.T.9    Korzun, J.10
  • 70
    • 0034063445 scopus 로고    scopus 로고
    • Variable-loop-deleted variants of the human immunodeficiency virus type 1 envelope glycoprotein can be stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits
    • Sanders R.W., Schiffner L., Master A., Kajumo F., Guo Y., Dragic T., Moore J.P., Binley J.M. Variable-loop-deleted variants of the human immunodeficiency virus type 1 envelope glycoprotein can be stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits. J Virol 2000, 74:5091-5100.
    • (2000) J Virol , vol.74 , pp. 5091-5100
    • Sanders, R.W.1    Schiffner, L.2    Master, A.3    Kajumo, F.4    Guo, Y.5    Dragic, T.6    Moore, J.P.7    Binley, J.M.8
  • 72
    • 84860759632 scopus 로고    scopus 로고
    • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study
    • Haynes B.F., Kelsoe G., Harrison S.C., Kepler T.B. B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol 2012, 30:423-433.
    • (2012) Nat Biotechnol , vol.30 , pp. 423-433
    • Haynes, B.F.1    Kelsoe, G.2    Harrison, S.C.3    Kepler, T.B.4
  • 73
    • 68349150945 scopus 로고    scopus 로고
    • Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
    • Johnson P.R., Schnepp B.C., Zhang J., Connell M.J., Greene S.M., Yuste E., Desrosiers R.C., Clark K.R. Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat Med 2009, 15:901-906.
    • (2009) Nat Med , vol.15 , pp. 901-906
    • Johnson, P.R.1    Schnepp, B.C.2    Zhang, J.3    Connell, M.J.4    Greene, S.M.5    Yuste, E.6    Desrosiers, R.C.7    Clark, K.R.8
  • 74
    • 84855466746 scopus 로고    scopus 로고
    • Antibody-based protection against HIV infection by vectored immunoprophylaxis
    • Balazs A.B., Chen J., Hong C.M., Rao D.S., Yang L., Baltimore D. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature 2012, 481:81-84.
    • (2012) Nature , vol.481 , pp. 81-84
    • Balazs, A.B.1    Chen, J.2    Hong, C.M.3    Rao, D.S.4    Yang, L.5    Baltimore, D.6
  • 77
    • 84874465405 scopus 로고    scopus 로고
    • Short communication: HIV type 1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly neutralizing antibodies directed against quaternary and CD4-binding site epitopes
    • Russell E.S., Ojeda S., Fouda G.G., Meshnick S.R., Montefiori D., Permar S.R., Swanstrom R. Short communication: HIV type 1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly neutralizing antibodies directed against quaternary and CD4-binding site epitopes. AIDS Res Hum Retroviruses 2013, 29:511-515.
    • (2013) AIDS Res Hum Retroviruses , vol.29 , pp. 511-515
    • Russell, E.S.1    Ojeda, S.2    Fouda, G.G.3    Meshnick, S.R.4    Montefiori, D.5    Permar, S.R.6    Swanstrom, R.7
  • 83
    • 84860343750 scopus 로고    scopus 로고
    • Replicating adenovirus-simian immunodeficiency virus (SIV) vectors efficiently prime SIV-specific systemic and mucosal immune responses by targeting myeloid dendritic cells and persisting in rectal macrophages, regardless of immunization route
    • Patterson L.J., Kuate S., Daltabuit-Test M., Li Q., Xiao P., McKinnon K., DiPasquale J., Cristillo A., Venzon D., Haase A., et al. Replicating adenovirus-simian immunodeficiency virus (SIV) vectors efficiently prime SIV-specific systemic and mucosal immune responses by targeting myeloid dendritic cells and persisting in rectal macrophages, regardless of immunization route. Clin Vaccine Immunol 2012, 19:629-637.
    • (2012) Clin Vaccine Immunol , vol.19 , pp. 629-637
    • Patterson, L.J.1    Kuate, S.2    Daltabuit-Test, M.3    Li, Q.4    Xiao, P.5    McKinnon, K.6    DiPasquale, J.7    Cristillo, A.8    Venzon, D.9    Haase, A.10
  • 84
    • 84860317371 scopus 로고    scopus 로고
    • Replicating adenovirus-simian immunodeficiency virus (SIV) recombinant priming and envelope protein boosting elicits localized, mucosal IgA immunity in rhesus macaques correlated with delayed acquisition following a repeated low-dose rectal SIV(mac251) ch
    • Xiao P., Patterson L.J., Kuate S., Brocca-Cofano E., Thomas M.A., Venzon D., Zhao J., DiPasquale J., Fenizia C., Lee E.M., et al. Replicating adenovirus-simian immunodeficiency virus (SIV) recombinant priming and envelope protein boosting elicits localized, mucosal IgA immunity in rhesus macaques correlated with delayed acquisition following a repeated low-dose rectal SIV(mac251) ch. J Virol 2012, 86:4644-4657.
    • (2012) J Virol , vol.86 , pp. 4644-4657
    • Xiao, P.1    Patterson, L.J.2    Kuate, S.3    Brocca-Cofano, E.4    Thomas, M.A.5    Venzon, D.6    Zhao, J.7    DiPasquale, J.8    Fenizia, C.9    Lee, E.M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.