Aster spathulifolius Maxim extract reduces body weight and fat mass in obese humans

Nutrition Research

Volumn 36, Issue 7, 2016, Pages 671-678

  Cho, In Jin ^a   Choung, Se Young ^b   Hwang, You Cheol ^c   Ahn, Kyu Jeung ^c   Chung, Ho Yeon ^c   Jeong, In Kyung ^c  

^a Kyung Hee University Hospital   (South Korea)

^b Kyung Hee University   (South Korea)

^c Kyung Hee University College of Medicine   (South Korea)

Author keywords

Aster spathulifolius; Fat mass; Obesity; Weight loss

Indexed keywords

ANTIOBESITY AGENT; ASTER SPATHULIFOLIUS EXTRACT; GLUCOSE; HEMOGLOBIN A1C; LIPID; PLACEBO; PLANT EXTRACT; UNCLASSIFIED DRUG; CHOLESTEROL; GLYCOSYLATED HEMOGLOBIN; TRIACYLGLYCEROL;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; ASTER (GENUS); ASTER SPATHULIFOLIUS; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DUAL ENERGY X RAY ABSORPTIOMETRY; FAT MASS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; IMPEDANCE; MALE; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WAIST CIRCUMFERENCE; WEIGHT REDUCTION; BLOOD; BODY WEIGHT LOSS; CHEMISTRY; DRUG EFFECTS; METABOLISM; MIDDLE AGED; PHOTON ABSORPTIOMETRY; SOUTH KOREA;

ABSORPTIOMETRY, PHOTON; ADULT; ANTI-OBESITY AGENTS; ASTER PLANT; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL; DOUBLE-BLIND METHOD; ELECTRIC IMPEDANCE; FEMALE; GLYCATED HEMOGLOBIN A; HUMANS; MALE; MIDDLE AGED; OBESITY; PLANT EXTRACTS; REPUBLIC OF KOREA; TRIGLYCERIDES; WAIST CIRCUMFERENCE; WEIGHT LOSS;

EID: 84973162735     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2016.03.001     Document Type: Article

References (35)

1. Ogden C.L., Carroll M.D., Curtin L.R., McDowell M.A., Tabak C.J., Flegal K.M. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006, 295:1549-1555.
2. WHO Global status report on noncommunicable diseases 2014 2015, World Health Organization, Geneva.
3. Kim M.K., Lee W.Y., Kang J.H., Kang J.H., Kim B.T., Kim S.M., et al. 2014 Clinical practice guidelines for overweight and obesity in Korea. Endocrinol Metab (Seoul) 2014, 29:405-409.
4. World Health Organization, International Association for the Study of Obesity, International Obesity TaskForce The Asia-Pacific perspective: redefining obesity and its treatment 2000, Health Communications, Sydney.
5. Kim D.M., Ahn C.W., Nam S.Y. Prevalence of obesity in Korea. Obes Rev 2005, 6:117-121.
6. Park J.H., Yoon S.J., Lee H., Jo H.S., Lee S.I., Kim Y., et al. Burden of disease attributable to obesity and overweight in Korea. Int J Obes (Lond) 2006, 30:1661-1669.
7. Oh S.W., Yoon Y.S., Shin S.A. Effects of excess weight on cancer incidences depending on cancer sites and histologic findings among men: Korea National Health Insurance Corporation Study. J Clin Oncol 2005, 23:4742-4754.
8. Zheng W., McLerran D.F., Rolland B., Zhang X., Inoue M., Matsuo K., et al. Association between body-mass index and risk of death in more than 1 million Asians. N Engl J Med 2011, 364:719-729.
9. Oh S.W. Obesity and metabolic syndrome in Korea. Diabetes Metab J 2011, 35:561-566.
10. Kim C.S., Ko S.H., Kwon H.S., Kim N.H., Kim J.H., Lim S., et al. Prevalence, awareness, and management of obesity in Korea: data from the Korea national health and nutrition examination survey (1998-2011). Diabetes Metab J 2014, 38:35-43.
11. Pittler M.H., Ernst E. Dietary supplements for body-weight reduction: a systematic review. Am J Clin Nutr 2004, 79:529-536.
12. Manore M.M. Dietary supplements for improving body composition and reducing body weight: where is the evidence?. Int J Sport Nutr Exerc Metab 2012, 22:139-154.
13. Lee C.B. Illustrated flora of Korea 1999, Hyangmoonsa, Seoul, Korea.
14. Kim T.J. Wild flowers of Korea 1996, Kugilmedia, Seoul, Korea.
15. Won J.N., Lee S.Y., Song D.S., Poo H. Antiviral activity of the plant extracts from Thuja orientalis, Aster spathulifolius, and Pinus thunbergii against influenza virus A/PR/8/34. J Microbiol Biotechnol 2013, 23:125-130.
16. Lee S.O., Choi S.Z., Choi S.U., Lee K.C., Chin Y.W., Kim J., et al. Labdane diterpenes from Aster spathulifolius and their cytotoxic effects on human cancer cell lines. J Nat Prod 2005, 68:1471-1474.
17. An I.J., Kwon J.K., Lee J.S., Park H.S., Kim D.C., Choi B.J., et al. Induction of apoptosis in human cancer cells with compositae extracts. J Korean Soc Food Sci Nutr 2012, 41:584-590.
18. Yin X., Huang Y., Jung D.W., Chung H.C., Choung S.Y., Shim J.H., et al. Anti-diabetic effect of Aster sphathulifolius in C57BL/KsJ-db/db mice. J Med Food 2015, 18:987-998.
19. Kim S.J., Bang C.Y., Guo Y.R., Choung S.Y. Anti-obesity effects of Aster spathulifolius extract in high-fat diet-induced obese rats. J Med Food 2015, [in press].
20. Kim S.J., Choung S.Y. Inhibitory effects of Aster spathulifolius extract on adipogenesis and lipid accumulation in 3T3-L1 preadipocytes. J Pharm Pharmacol 2015, [Epub ahead of print].
21. Kushner R.F., Ryan D.H. Assessment and lifestyle management of patients with obesity: clinical recommendations from systematic reviews. JAMA 2014, 312:943-952.
22. Yanovski S.Z., Yanovski J.A. Long-term drug treatment for obesity: a systematic and clinical review. JAMA 2014, 311:74-86.
23. Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Levi-Meyrueis C., et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 1997, 15:269-272.
24. Nordfors L., Hoffstedt J., Nyberg B., Thorne A., Arner P., Schalling M., et al. Reduced gene expression of UCP2 but not UCP3 in skeletal muscle of human obese subjects. Diabetologia 1998, 41:935-939.
25. Oberkofler H., Liu Y.M., Esterbauer H., Hell E., Krempler F., Patsch W. Uncoupling protein-2 gene: reduced mRNA expression in intraperitoneal adipose tissue of obese humans. Diabetologia 1998, 41:940-946.
26. Clifford M.N. Chlorogenic acids and other cinnamates-nature, occurrence and dietary burden. J Sci Food Agric 1999, 79:362-372.
27. Ghadieh H.E., Smiley Z.N., Kopfman M.W., Najjar M.G., Hake M.J., Najjar S.M. Chlorogenic acid/chromium supplement rescues diet-induced insulin resistance and obesity in mice. Nutr Metab (Lond) 2015, 12:19.
28. Cho A.S., Jeon S.M., Kim M.J., Yeo J., Seo K.I., Choi M.S., et al. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced obese mice. Food Chem Toxicol 2010, 48:937-943.
29. Ma Y., Gao M., Liu D. Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice. Pharm Res 2015, 32:1200-1209.
30. Martinez-Saez N., Ullate M., Martin-Cabrejas M.A., Martorell P., Genoves S., Ramon D., et al. A novel antioxidant beverage for body weight control based on coffee silverskin. Food Chem 2014, 150:227-234.
31. Sato Y., Itagaki S., Kurokawa T., Ogura J., Kobayashi M., Hirano T., et al. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int J Pharm 2011, 403:136-138.
32. Yin X., Jeon Y., Chung H., Choung S., Shim J.-H., Kang I.-J. In vitro efficacy evaluation for prevention of diabetes and diabetic complications using Aster sphathulifolius. Food Sci Biotechnol 2015, 24:301-306.
33. Drent M.L., van der Veen E.A. First clinical studies with orlistat: a short review. Obes Res 1995, 3(Suppl. 4):623S-625S.
34. Davidson M.H., Hauptman J., DiGirolamo M., Foreyt J.P., Halsted C.H., Heber D., et al. Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial. JAMA 1999, 281:235-242.
35. Fidler M.C., Sanchez M., Raether B., Weissman N.J., Smith S.R., Shanahan W.R., et al. A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial. J Clin Endocrinol Metab 2011, 96:3067-3077.