Can Coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage?

Journal of Assisted Reproduction and Genetics

Volumn 33, Issue 9, 2016, Pages 1223-1230

  Özcan, Pınar ^a,b   Fıçıcıoğlu, Cem ^c   Kizilkale, Ozge ^c   Yesiladali, Mert ^c   Tok, Olgu Enis ^a   Ozkan, Ferda ^c   Esrefoglu, Mukaddes ^a  

^a BEZMIALEM VAKIF UNIVERSITY   (Turkey)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c YEDITEPE UNIVERSITY   (Turkey)

Author keywords

8'OHdG; AMH; Coenzyme Q10; Ovarian reserve; Oxidative damage

Indexed keywords

CISPLATIN; MUELLERIAN INHIBITING FACTOR; UBIDECARENONE; ANTIOXIDANT; UBIQUINONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GRANULOSA CELL; HISTOLOGY; HORMONE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; OVARIAN RESERVE; OVARY FOLLICLE; OXIDATIVE STRESS; PRIMORDIUM; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; SUPPLEMENTATION; ADULT; AGING; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; DIETARY SUPPLEMENT; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HUMAN; OVARY; PATHOLOGY; PREGNANCY;

ADULT; AGING; ANIMALS; ANTI-MULLERIAN HORMONE; ANTIOXIDANTS; DIETARY SUPPLEMENTS; FEMALE; HUMANS; OVARIAN RESERVE; OVARY; OXIDATIVE STRESS; PREGNANCY; RATS; UBIQUINONE;

EID: 84973131119     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-016-0751-z     Document Type: Article

References (36)

1. Wilson DM, Sofinowski TM, McNeill DR. Repair mechanisms for oxidative DNA damage. Front Biosci. 2003;1(8):963–81.
2. Kasai H, Tanooka H, Nishimura S. Formation of 8-hydroxyguanine residues in DNA by X-irradiation. Gan. 1984;75(12):1037–9.
3. Kasai H. Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res. 1997;387(3):147–63.
4. Klaunig JE, Wang Z, Pu X, Zhou S. Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicol Appl Pharmacol. 2011;254(2):86–99.
5. Nickel A, Kohlhaas M, Maack C. Mitochondrial reactive oxygen species production and elimination. J Mol Cell Cardiol. 2014;73:26–33.
6. Meldrum DR. Aging gonads, glands, and gametes: immutable or partially reversible changes? Fertil Steril. 2013;99(1):1–4.
7. Li Q, Geng X, Zheng W, Tang J, Xu B, Shi Q. Current understanding of ovarian aging. Sci China Life Sci. 2012;55(8):659–69.
8. Bentov Y, Casper RF. The aging oocyte—can mitochondrial function be improved? Fertil Steril. 2013;99(1):18–22.
9. Santos-Ocana C, Do TQ, Padilla S, Navas P, Clarke CF. Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants. J Biol Chem. 2002;277(13):10973–81.
10. Villalba JM, Navas P. Plasma membrane redox system in the control of stress-induced apoptosis. Antioxid Redox Signal. 2000;2000(2):213–30.
11. Pignatti C, Cocchi M, Weiss H. Coenzyme Q10 levels in rat heart of different age. Biochem Exp Biol. 1980;16(1):39–42.
12. Quinzii CM, Hirano M, DiMauro S. CoQ10 deficiency diseases in adults. Mitochondrion. 2007;(7Suppl):122–6
13. Balercia G, Mosca F, Mantero F, Boscaro M, Mancini A, Ricciardo-Lamonica G, et al. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004;81(1):93–8.
14. Bentinger M, Tekle M, Brismar K, Chojnacki T, Swiezewska E, Dallner G. Stimulation of coenzyme Q synthesis. Biofactors. 2008;32(1-4):99–111.
15. Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, et al. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. J Int Soc Sports Nutr. 2008;4(5):8.
16. Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, et al. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008;24(4):293–9.
17. Siddik Z. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene. 2003;22:7265–79.
18. Morgan S, Anderson RA, Gourley C, Wallace WH, Spears N. How do chemotherapeutic agents damage the ovary? Hum Reprod Update. 2012;18(5):525–35.
19. Tangir J, Zelterman D, Ma W, Schwartz PE. Reproductive function after conservative surgery and chemotherapy for malignant germ cell tumors of the ovary. Obstet Gynecol. 2003;101(2):251–7.
20. Yuksel A, Bildik G, Senbabaoglu F, Akin N, Arvas M, Unal F, et al. The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depending upon the category of the drugs and the type of granulosa cells. Hum Reprod. 2015;30(12):2926–35.
21. Chirino YI, Pedraza-Chaverri J. Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Exp Toxicol Pathol. 2009;61(3):223–42.
22. Yucebilgin MS, Terek MC, Ozsaran A, Akercan F, Zekioglu O, Isik E, et al. Effect of chemotherapy on primordial follicular reserve of rat: an animal model of premature ovarian failure and infertility. Aust N Z J Obstet Gynaecol. 2004;44(1):6–9.
23. Ozcan P, Fıçıcıoğlu C, Yıldırım ÖK, Özkan F, Akkaya H, Aslan İ. Protective effect of resveratrol against oxidative damage to ovarian reserve in female Sprague-Dawley rats. Reprod Biomed Online. 2015;31(3):404–10.
24. Li X, Yang S, Lv X, Sun H, Weng J, Liang Y, et al. The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats. J Gynecol Oncol. 2013;24(2):177–85.
25. Dale O, Mortensen B, Thommesen L, Hagen B. Cisplatin toxicity in the rat may be influenced by anaesthetic agents. Acta Anaesthesiol Scand. 2000;44(6):770.
26. Kwong LK, Kamzalov S, Rebrin I, Bayne AC, Jana CK, Morris P, et al. Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med. 2002;33(5):627–38.
27. Tilly JL. Ovarian follicle counts—not as simple as 1, 2, 3. Reprod Biol Endocrinol. 2003;6(1):11.
28. Yeh J, Kim BS, Peresie J. Protection against cisplatin-induced ovarian damage by the antioxidant sodium 2-mercaptoethanesulfonate (mesna) in female rats. Am J Obstet Gynecol. 2008;198(4):463.e1-6.
29. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11(3):298–300.
30. Bentov Y, Esfandiari N, Burstein E, Casper RF. The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Fertil Steril. 2010;93(1):272–5.
31. Gendelman M, Roth Z. Incorporation of coenzyme Q10 into bovine oocytes improves mitochondrial features and alleviates the effects of summer thermal stress on developmental competence. Biol Reprod. 2012;87(5):118.
32. Quinzii CM, Tadesse S, Naini A, Hirano M. Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. PLoS ONE. 2012;7(2):30606.
33. Burstein E, Perumalsamy A, Bentov Y, Esfandiari N, Jurisicova A, Casper RF. Co-enzyme Q10 supplementation improves ovarian response and mitochondrial function in aged mice. Fertil Steril. 2009;92(3-1):31.
34. Ben-Meir A, Burstein E, Borrego-Alvarez A, Chong J, Wong E, Yavorska T, et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015;14(5):887–95.
35. Bentov Y, Hannam T, Jurisicova A, Esfandiari N, Casper RF. Coenzyme Q10 Supplementation and Oocyte Aneuploidy in Women Undergoing IVF-ICSI Treatment. Clin Med Insights Reprod Health. 2014;8:31–6.
36. El Refaeey A, Selem A, Badawy A. Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome. Reprod Biomed Online. 2014;29(1):119–24.