Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia: An open, uncontrolled pilot study

Fertility and Sterility

Volumn 81, Issue 1, 2004, Pages 93-98

  Balercia, Giancarlo ^a   Mosca, Fabrizio ^b   Mantero, Franco ^c   Boscaro, Marco ^a   Mancini, Antonio ^d   Ricciardo Lamonica, Giuseppe ^b   Littarru, GianPaolo ^b  

^a Azienda Ospedaliera Umberto I   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

Asthenozoospermia; Coenzyme Q10 therapy; Male infertility

Indexed keywords

PHOSPHATIDYLCHOLINE; UBIQUINONE;

ADULT; ARTICLE; AZOOSPERMIA; CELL MOTILITY; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ANALYSIS; FOLLOW UP; HUMAN; IDIOPATHIC DISEASE; INTRACELLULAR SPACE; KINETICS; MALE; MALE INFERTILITY; OPEN STUDY; PILOT STUDY; PRIORITY JOURNAL; SAMPLING; SEMINAL PLASMA; SPERM; SUPPLEMENTATION;

EID: 0346725828     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2003.05.009     Document Type: Article

References (39)

1. Alvarez J.G., Storey B. Spontaneous lipid peroxidation in rabbit epididymal spermatozoa its effect on sperm motility . Biol Reprod. 27:1982;1102-1108.
2. Aitken R.J., Clarkson J.S. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil. 81:1987;459-469.
3. Aitken R.J., Clarkson J.S., Fishel S. Generation of reactive oxygen species, lipid peroxidation and human sperm function. Biol Reprod. 40:1989;183-197.
4. Rao B., Soufir J.C., Martin M., David G. Lipid peroxidation in human spermatozoa as related to midpiece abnormalities and motility. Gamete Res. 24:1989;127-134.
5. Suleiman S.A., Ali M.E., Zaki Z.M., El-Malik E.M., Nasr M.A. Lipid peroxidation and human sperm motility protective role of vitamin E . J Androl. 17:1996;530-537.
6. Aitken R.J., Krausz C. Oxidative stress, DNA damage and the Y chromosome. Reproduction. 122:2001;497-506.
7. Aitken R.J., Baker M.A. Reactive oxygen species generation by human spermatozoa a continuing enigma . Int J Androl. 25:2002;191-194.
8. 10 as protective agent against radical formation in man. Adv Myochem. 1:1987;305-308.
9. Ernster L., Forsmark-Andrée P. Ubiquinol an endogenous antioxidant in aerobic organisms . Clin Invest. 71:1993;60-65.
10. Kalèn A., Appelkvist E.L., Chojnaki T., Dallner G. Nonaprenyl-4-hydroxibenzoate transferase, an enzyme involved in ubiquinone biosynthesis in endoplasmic reticulum-Golgi system. J Biol Chem. 25:1990;1158-1164.
11. 10 concentration in normal and pathological human seminal fluid. J Androl. 15:1994;591-594.
12. 10 in preventing peroxidation of LDL subfraction. Proc Natl Acad Sci USA. 92:1995;9388-9391.
13. Mancini A., Conte G., Milardi D., De Marinis L., Littarru G. Relationship between sperm cell ubiquinone and seminal parameters in subjects with and without varicocele. Andrologia. 30:1998;1-4.
14. Kelso K.A., Redpath A., Noble R.C., Speake B.K. Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. J Reprod Fertil. 109:1997;1-6.
15. 10 levels in idiopathic and varicocele-associated asthenozoospermia. Andrologia. 34:2002;107-111.
16. Balercia G., Mantero F., Armeni T., Principato G., Regoli F. Oxyradical scavenging capacity toward different reactive species in seminal plasma and sperm cells. A possible influence on kinetic parameters. Clin Chem Lab Med. 41:2003;13-19.
17. WHO laboratory manual for examination of semen and semen-cervical mucus interaction. 1999;Cambridge University Press, Cambridge.
18. Rossato M., Balercia G., Lucarelli G., Foresta C., Mantero F. Role of seminal osmolarity in the reduction of human sperm motility. Int J Androl. 25:2002;230-235.
19. Alleva R., Scaramucci A., Mantero F., Bompadre S., Leone L., Littarru G. Protective role of ubiquinol content against formation of lipid hydroperoxide in human seminal fluid. Mol Asp Med. 18:1997;S221-228.
20. Frei B., Yamamoto Y., Niclas D., Ames B.N. Evaluation of an isoluminol chemiluminescence assay for detection of hydroperoxides in human blood plasma. Annal Biochem. 175:1998;120-130.
21. Yamamoto Y., Kambayashi Y., Ueda T. Assay of phospholipid hydroperoxides by cheminescence-based high-performance liquid chromatography. Meth Mol Biol. 108:1998;63-70.
22. Aitken R.J., Irvine D.S., Wu F.C. Prospective analysis of spermoocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility. Am J Obstet Gynecol. 164:1991;542-551.
23. Lewis S., Boyle P., McKinney M.B., Young I., Thompson W. Total antioxidant capacity of seminal plasma is different in fertile and infertile men. Fertil Steril. 64:1995;868-870.
24. Rhemrev J.P., Van Overveld F.W., Haenen G.R., Teerlink T., Bast A., Vermeiden J.P. Quantification of the nonenzymatic fast and slow TRAP in a postaddition assay in human seminal plasma and the antioxidant contribution of various seminal compounds. J Androl. 21:2000;913-920.
25. Stocker R., Bowry V.W., Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does α-tocopherol. Proc Natl Acad Sci USA. 88:1991;1646-1650.
26. Moncada M.L., Vicari E., Cimino C., Calogero A.E., Mongioi A., D'Agata R., et al. Effect of acetylcarnitine treatment in oligoasthenospermic patients. Acta Eur Fertil. 23:1992;221-224.
27. Lenzi A., Culasso F., Gandini L., Lombardo F., Dondero F. Placebo-controlled, double blind, cross-over trial of glutathione therapy in male infertility. Hum Reprod. 8:1993;1657-1662.
28. Costa M., Canale D., Filicori M., D'Iddio S., Lenzi A. L-carnitine in idiopathic asthenozoospermia a multicenter study . Andrologia. 26:1994;155-159.
29. Sikka S.C., Rajasekaran M., Hellstrom W.J.G. Role of oxidative stress and antioxidant in male infertility. J Androl. 16:1995;464-468.
30. Vitali G., Parente R., Melotti C. Carnitine supplementation in human idiopathic asthenozoospermia clinical results . Drugs Exp Clin Res. 21:1995;157-159.
31. Ford W.C.L., Whittington K. Antioxidant treatment for male subfertility a promise that remains unfulfilled . Hum Reprod. 13:1998;1416-1419.
32. Geva E., Lessing J.B., Lerner-Geva L., Amit A. Free radicals, antioxidants and human spermatozoa clinical implications . Hum Reprod. 13:1998;1415-1424.
33. Lenzi A., Gandini L., Picardo M. A rationale for glutathione therapy. Hum Reprod. 13:1998;1419-1421.
34. Tarin J.J., Brines J., Cano A. Antioxidants may protect against infertility. Hum Reprod. 13:1998;1415-1416.
35. Comhaire F.H., Mahmoud A.M., Depuydt C.E., Zalata A.A., Christophe A.B. Mechanisms and effects of male genital tract infections on semen quality and fertilizing potential the andrologist's viewpoint . Hum Reprod Update. 5:1999;393-398.
36. Lenzi A., Lombardo F., Sgro P., Salacone P., Caponecchia L., Dondero F., et al. Use of carnitine therapy in selected cases of male factor infertility a double blind cross-over trial . Fertil Steril. 79:2003;796-801.
37. Vicari E., Calogero A.E. Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis. Hum Reprod. 16:2001;2338-2342.
38. Fato R., Cavazzoni M., Castelluccio C., Parenti Castelli G., Lenaz G. Steady state kinetics of ubiquinol-cytochrome c reductase in bovine heart submitochondrial particles diffusional effects . Biochem J. 290:1993;225-236.
39. 10. Mol Asp Med. 8:(suppl):1997;145-151.