The magnitude of gonadotoxicity of chemotherapy drugs on ovarian follicles and granulosa cells varies depenDing upon the category of the drugs and the type of granulosa cells

Human Reproduction

Volumn 30, Issue 12, 2015, Pages 2926-2935

  Yuksel, Aytac ^a   Bildik, Gamze ^b   Senbabaoglu, Filiz ^b   Akin, Nazli ^b   Arvas, MacIt ^a   Unal, Fehmi ^c   Kilic, Yagmur ^b   Karanfil, Isil ^b   Erylmaz, Baldan ^b   Yilmaz, Pelin ^b   Ozkanbas, Can ^b   Taskiran, Cagatay ^b   Aksoy, Senai ^d   Guzel, Ylmaz ^d   Balaban, Basak ^d   Ince, Umit ^e   Iwase, Akira ^f   Urman, Bulent ^b,d   Oktem, Ozgur ^b,d  

^a ISTANBUL UNIVERSITY   (Turkey)

^b KOÇ UNIVERSITY   (Turkey)

^c Istanbul Research and Teaching and Research Hospital   (Turkey)

^d AMERICAN HOSPITAL   (Turkey)

^e ACIBADEM UNIVERSITY   (Turkey)

^f NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cisplatin; Cyclophosphamide; Cytotoxicity; Gemcitabine; Granulosa cells; Ovary

Indexed keywords

CASPASE 3; CISPLATIN; CYCLOPHOSPHAMIDE; ESTRADIOL; GEMCITABINE; MUELLERIAN INHIBITING FACTOR; PROGESTERONE; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; EXTRACELLULAR MATRIX; FEMALE; GONADAL DISEASE; GONADOTOXICITY; GRANULOSA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OVARY FOLLICLE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; TRANSLATIONAL RESEARCH; ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; BLOOD; DRUG EFFECTS; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-MULLERIAN HORMONE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CISPLATIN; CYCLOPHOSPHAMIDE; DEOXYCYTIDINE; ESTRADIOL; FEMALE; GRANULOSA CELLS; OVARIAN FOLLICLE; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84983095872     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev256     Document Type: Article

References (25)

1. Bayasula, Iwase A, KiyonoT, Takikawa S, GotoM, NakamuraT, NagatomoY, Nakahara T, Kotani T, Kobayashi H et al. Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status. Endocrinology 2012;153:2851-2860.
2. Bird C, Kirstein S. Real-time, label-free monitoring of cellular invasion and migration with the xCELLigence system. Nat Methods 2009;6:622.
3. Bonetti A, Apostoli P, Zaninelli M, Pavanel F, Colombatti M, Cetto GL, Franceschi T, Sperotto L, Leone R. Inductively coupled plasma mass spectroscopy quantitation of platinum-DNA adducts in peripheral blood leukocytes of patients receiving cisplatin-or carboplatin-based chemotherapy. Clin Cancer Res 1996;2:1829-1835.
4. Felici A, Di Segni S, Milella M, Colantonio S, Sperduti I, Nuvoli B, Contestabile M, Sacconi A, Zaratti M, Citro G et al. Pharmacokinetics of gemcitabine at fixed-dose rate infusion in patients with normal and impaired hepatic function. Clin Pharmacokinet 2009;48:131-141.
5. Gougeon A. Humanovarian follicular development: fromactivation of resting follicles to preovulatory maturation. Ann Endocrinol (Paris) 2010;71: 132-143.
6. Kalich-Philosoph L, Roness H, Carmely A, Fishel-Bartal M, Ligumsky H, Paglin S, Wolf I, Kanety H, Sredni B, Meirow D. Cyclophosphamide triggers follicle activation and burnout; AS101 prevents follicle loss and preserves fertility. Sci Transl Med 2013;5:185ra162.
7. Laquente B, Lacasa C, Ginesta MM, Casanovas O, Figueras A, Galan M, Ribas IG, Germa JR, Capella G, Vinals F. Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model. Mol Cancer Ther 2008;7:638-647.
8. Mackey JR, Yao SY, Smith KM, Karpinski E, Baldwin SA, Cass CE, Young JD. Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters. J Natl Cancer Inst 1999;91:1876-1881.
9. Mini E, Nobili S, Caciagli B, Landini I, Mazzei T. Cellular pharmacology of gemcitabine. Ann Oncol 2006;17(Suppl 5):v7-v12.
10. Morgan M, El Shaikh MA, Abu-Isa E, Davis MA, Lawrence TS. Radiosensitization by gemcitabine fixed-dose-rate infusion versus bolus injection in a pancreatic cancer model. Transl Oncol 2008;1:44-49.
11. Morgan S, Anderson RA, Gourley C, Wallace WH, Spears N. How do chemotherapeutic agents damage the ovary? Hum Reprod Update 2012; 18:525-535.
12. Morgan S, Lopes F, Gourley C, Anderson RA, Spears N. Cisplatin and doxorubicin induce distinct mechanisms of ovarian follicle loss; imatinib provides selective protection only against cisplatin. PLoS One 2013; 8:e70117.
13. Navid F, Willert JR, McCarville MB, Furman W, Watkins A, Roberts W, Daw NC. Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma. Cancer 2008; 113:419-425.
14. Oktem O, Oktay K. A novel ovarian xenografting model to characterize the impact of chemotherapy agents on human primordial follicle reserve. Cancer Res 2007;67:10159-10162.
15. Oktem O, Oktay K. Preservation of menstrual function in adolescent and young females. Ann N Y Acad Sci 2008;1135:237-243.
16. Oktem O, Urman B. Options of fertility preservation in female cancer patients. Obstet Gynecol Surv 2010a;65:531-542.
17. Oktem O, Urman B. UnderstanDing follicle growth in vivo. Hum Reprod 2010b;25:2944-2954.
18. Oktem O, Buyuk E, Oktay K. Preantral follicle growth is regulated by c-Jun-N-terminal kinase (JNK) pathway. Reprod Sci 2011;18:269-276.
19. Oktem O, Muftuoglu M, Senbabaoglu F, Urman B. Real-time analysis of the growth of human granulosa cells using an impedance-based signal processing system: a new technology for translational research in human reproduction. Hum Reprod 2013;28:i52-i55.
20. Plowchalk DR, Mattison DR. Phosphoramide mustard is responsible for the ovarian toxicity of cyclophosphamide. Toxicol Appl Pharmacol 1991; 107:472-481.
21. Roness H, Kalich-Philosoph L, Meirow D. Prevention of chemotherapyinduced ovarian damage: possible roles for hormonal and non-hormonal attenuating agents. Hum Reprod Update 2014;20:759-774.
22. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014; 64:9-29.
23. Stein LS, Stoica G, Tilley R, Burghardt RC. Rat ovarian granulosa cell culture: a model system for the study of cell-cell communication during multistep transformation. Cancer Res 1991;51:696-706.
24. TeicherBA, HoldenSA, GoffDA, Wright JE, TretyakovO, Ayash LJ. Antitumor efficacy and pharmacokinetic analysis of 4-hydroperoxycyclophosphamide in comparison with cyclophosphamide +/-hepatic enzyme effectors. Cancer Chemother Pharmacol 1996;38:553-560.
25. Zhang H, Vollmer M, De Geyter M, Litzistorf Y, Ladewig A, Durrenberger M, Guggenheim R, Miny P, HolzgreveW, De Geyter C. Characterization of an immortalized human granulosa cell line (COV434). Mol Hum Reprod 2000; 6:146-153.